William Parker

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Is autism a member of a family of diseases resulting from genetic/cultural mismatches? Implications for treatment and prevention
    Staci D Bilbo
    Systems and Integrative Neuroscience Group, Department of Psychology and Neuroscience, Duke University, Durham, NC 27710, USA
    Autism Res Treat 2012:910946. 2012
  2. doi request reprint A prescription for clinical immunology: the pills are available and ready for testing. A review
    William Parker
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Curr Med Res Opin 28:1193-202. 2012
  3. ncbi request reprint Organization of regions with amphiphilic alpha-helical potential within the three-dimensional structure of beta-sheet proteins
    W Parker
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Protein Eng 14:315-9. 2001
  4. ncbi request reprint In pursuit of xenoreactive antibodies: where has it gotten us?
    William Parker
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunol Cell Biol 83:413-7. 2005
  5. ncbi request reprint Polyreactive antibodies and their association with xenotransplantation
    William Parker
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Xenotransplantation 10:542-4. 2003
  6. ncbi request reprint Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction
    Jeffrey G Gaca
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1686-94. 2006
  7. ncbi request reprint Depletion of pulmonary intravascular macrophages prevents hyperacute pulmonary xenograft dysfunction
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1157-64. 2006
  8. doi request reprint Gastroesophageal reflux-associated aspiration alters the immune response in asthma
    Anitra D Thomas
    Department of Surgery, Duke University Medical Center, DUMC Box 2605, Durham, NC 27710, USA
    Surg Endosc 24:1066-74. 2010
  9. doi request reprint Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel
    Andrew S Barbas
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Biol Med (Maywood) 234:1174-85. 2009
  10. doi request reprint Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity
    Tacy E Downing
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Biol Med (Maywood) 233:1202-12. 2008

Collaborators

Detail Information

Publications49

  1. pmc Is autism a member of a family of diseases resulting from genetic/cultural mismatches? Implications for treatment and prevention
    Staci D Bilbo
    Systems and Integrative Neuroscience Group, Department of Psychology and Neuroscience, Duke University, Durham, NC 27710, USA
    Autism Res Treat 2012:910946. 2012
    ..Thus, if indeed autism is an epidemic of postindustrial society associated with immune hypersensitivity, we can expect that the disease is readily preventable...
  2. doi request reprint A prescription for clinical immunology: the pills are available and ready for testing. A review
    William Parker
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Curr Med Res Opin 28:1193-202. 2012
    ..It is the purpose of this review to outline the literature pointing toward the causes and potential treatments of these problems...
  3. ncbi request reprint Organization of regions with amphiphilic alpha-helical potential within the three-dimensional structure of beta-sheet proteins
    W Parker
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Protein Eng 14:315-9. 2001
    ....
  4. ncbi request reprint In pursuit of xenoreactive antibodies: where has it gotten us?
    William Parker
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Immunol Cell Biol 83:413-7. 2005
    ....
  5. ncbi request reprint Polyreactive antibodies and their association with xenotransplantation
    William Parker
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Xenotransplantation 10:542-4. 2003
  6. ncbi request reprint Effect of an anti-C5a monoclonal antibody indicates a prominent role for anaphylatoxin in pulmonary xenograft dysfunction
    Jeffrey G Gaca
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1686-94. 2006
    ..The current study investigates the role of C5a in pulmonary xenograft failure in baboons...
  7. ncbi request reprint Depletion of pulmonary intravascular macrophages prevents hyperacute pulmonary xenograft dysfunction
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1157-64. 2006
    ..Recent findings have suggested that donor pulmonary intravascular macrophages may play a critical role in the hyperacute dysfunction of pulmonary xenografts...
  8. doi request reprint Gastroesophageal reflux-associated aspiration alters the immune response in asthma
    Anitra D Thomas
    Department of Surgery, Duke University Medical Center, DUMC Box 2605, Durham, NC 27710, USA
    Surg Endosc 24:1066-74. 2010
    ..This study examined the effect of chronic aspiration on the airway-associated immune response to allergens using a model of experimentally induced airway hypersensitivity in Balb/c mice...
  9. doi request reprint Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel
    Andrew S Barbas
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Biol Med (Maywood) 234:1174-85. 2009
    ..This novel in vivo model may be useful in evaluating persistence time in a variety of current and future probiotic regimens...
  10. doi request reprint Pulmonary histopathology in an experimental model of chronic aspiration is independent of acidity
    Tacy E Downing
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Exp Biol Med (Maywood) 233:1202-12. 2008
    ....
  11. pmc Characterization of the innate immune response to chronic aspiration in a novel rodent model
    James Z Appel
    Transplant Immunobiology Laboratory, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Respir Res 8:87. 2007
    ..A novel rodent model of chronic aspiration was therefore developed in order to investigate the resulting innate immune response in the lung...
  12. doi request reprint Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma
    Kuei Ying Su
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Inflamm Res 61:863-73. 2012
    ..The hypothesis that aspiration of gastric fluid drives the anti-ovalbumin response toward a Th2 reaction even in animals not prone to Th2 responses was evaluated...
  13. doi request reprint Coagulopathy in α-galactosyl transferase knockout pulmonary xenotransplants
    Errol L Bush
    Department of Surgery, Duke University, Durham, NC, USA
    Xenotransplantation 18:6-13. 2011
    ..The onset of DIC is particularly rapid in recipients of pulmonary xenografts, usually occurring within the first days or even hours of reperfusion...
  14. ncbi request reprint The role of antibodies and von Willebrand factor in discordant pulmonary xenotransplantation
    Christine L Lau
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Transplant 3:1065-75. 2003
    ..These findings suggest that porcine vWF plays a major role in the pathogenesis of pulmonary xenograft dysfunction, and suggests promising strategies to treat lung xenograft dysfunction...
  15. ncbi request reprint The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation
    Jeffrey G Gaca
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Transplantation 74:1596-603. 2002
    ....
  16. doi request reprint Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin
    Yu Huei Lee
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Microbiol Immunol 55:174-83. 2011
    ..These findings suggest that incorporation of host-derived molecules into the extracellular matrix of symbiotic biofilms might profoundly alter the properties of those biofilms, including the resistance of those biofilms to antibiotics...
  17. ncbi request reprint Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili
    R Randal Bollinger
    Department of Surgery, Duke University Medical Center, Box 2605, Durham, NC 27710, USA
    Mol Immunol 43:378-87. 2006
    ..These studies also provide the first procedures for the growth of bacterial biofilms on live epithelial cells in vitro, an important development that may facilitate future studies on the effects of bacterial biofilms on epithelial cells...
  18. ncbi request reprint Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate
    Jeffrey G Gaca
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 112:19-25. 2003
    ..We used liposomal clodronate to eliminate the PIM population in a model of acute swine lung injury...
  19. pmc Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments
    Ashley M Trama
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cell Mol Immunol 9:163-74. 2012
    ..The results potentially lend insight into the pathogenesis of post-industrial epidemics of allergy and autoimmune disease...
  20. ncbi request reprint Cromolyn ameliorates acute and chronic injury in a rat lung transplant model
    Jui Chih Chang
    Department of Surgery, Duke University Medical Center, Durham, North Carolina Department of Pathology, Duke University Medical Center, Durham, North Carolina Department of Surgery, Tzu Chi General Hospital, Hualien, Taiwan
    J Heart Lung Transplant 33:749-57. 2014
    ..Mast cells have been associated with obliterative bronchiolitis (OB) in human pulmonary allografts, although their role in the development of OB remains unknown...
  21. doi request reprint Aspiration of gastric fluid in pulmonary allografts: effect of pH
    Tao Tang
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Surg Res 181:e31-8. 2013
    ..It remains unknown whether pharmaceutical-induced increases in gastric pH might effectively prevent any putative pulmonary injury associated with chronic aspiration...
  22. ncbi request reprint Pulmonary xenotransplantation: rapidly progressing into the unknown
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 4:25-35. 2004
    ..This progress provides a basis for future work and for a hope that the shortage of human lungs for transplantation will not always be a matter of life and death...
  23. pmc Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days
    Sean M Lee
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Appl Environ Microbiol 76:4655-63. 2010
    ..These results suggest that monoassociated mice might be used as a tool for characterizing niches occupied by the intestinal flora and potentially as a method of targeting the evolution of bacteria for applications in biotechnology...
  24. ncbi request reprint Disseminated intravascular coagulation in association with pig-to-primate pulmonary xenotransplantation
    Jeffrey G Gaca
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 73:1717-23. 2002
    ..Disseminated intravascular coagulation (DIC) has been observed with the rejection of renal and bone marrow xenografts but has not yet been described in pulmonary xenografts...
  25. ncbi request reprint Microbial biofilms in the gut: visualization by electron microscopy and by acridine orange staining
    Daniel Palestrant
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ultrastruct Pathol 28:23-7. 2004
    ....
  26. ncbi request reprint Sensitization with xenogeneic tissues alters the heavy chain repertoire of human anti-Galalpha1-3Gal antibodies
    Paul B Yu
    Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA
    Transplantation 80:102-9. 2005
    ..We asked how sensitization with the carbohydrate Galalpha1-3Gal modifies antibody heavy chain use...
  27. ncbi request reprint Association of age-dependent liver injury and fibrosis with immune cell populations
    Bradley H Collins
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Liver Int 33:1175-86. 2013
    ..The liver's response to injury is fibrosis, and when chronic, cirrhosis. Age is a critical factor impacting many immune-mediated processes, potentially including the liver's wounding response to injury...
  28. ncbi request reprint Relative purity of thrombin-based hemostatic agents used in surgery
    Jonathan G Schoenecker
    Department of Pathology, Duke University Medical Center, Durham, NC, USA
    J Am Coll Surg 197:580-90. 2003
    ....
  29. ncbi request reprint Biofilms in the large bowel suggest an apparent function of the human vermiform appendix
    R Randal Bollinger
    Department of Surgery, Duke University Medical Center, Box 2605, Durham, NC 27710, USA
    J Theor Biol 249:826-31. 2007
    ....
  30. doi request reprint Reconstitution of the human biome as the most reasonable solution for epidemics of allergic and autoimmune diseases
    Staci D Bilbo
    Department of Psychology and Neuroscience, Systems and Integrative Neuroscience Group, Duke University, Durham, NC 27710, United States
    Med Hypotheses 77:494-504. 2011
    ..Based on these considerations, commitment of considerable resources toward understanding the effects of "biome depletion" and systematically evaluating the most effective approach toward biome reconstitution is strongly encouraged...
  31. ncbi request reprint Cultivation of epithelial-associated microbiota by the immune system
    Anitra D Thomas
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Future Microbiol 5:1483-92. 2010
    ....
  32. ncbi request reprint The footprint of antibody bound to pig cells: evidence of complex surface topology
    Mary Lou Everett
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Biophys Res Commun 301:751-7. 2003
    ....
  33. ncbi request reprint Antihuman factor V antibodies after use of relatively pure bovine thrombin
    Jeffrey H Lawson
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 79:1037-8. 2005
    ..This report calls into question the safety of even relatively pure bovine thrombin...
  34. ncbi request reprint Increased IL-4 production and attenuated proliferative and pro-inflammatory responses of splenocytes from wild-caught rats (Rattus norvegicus)
    Aaron Lesher
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Cell Biol 84:374-82. 2006
    ..These observations may have substantial implications for the hygiene hypothesis and provide considerable insight into the roles played by the environment during immune system development and modulation...
  35. ncbi request reprint Evidence for polyreactive xenoreactive antibodies in the repertoire of human anti-swine antibodies: the 'next' humoral barrier to xenotransplantation?
    J G Gaca
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transpl Immunol 9:19-27. 2001
    ..These findings indicate that germline polyreactive antibodies are, for the most part, xenoreactive. These data suggest that polyreactive antibodies, although autoreactive, may be more xenoreactive than autoreactive...
  36. ncbi request reprint Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts
    E Cantu
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Transplant 7:66-75. 2007
    ..These data provide initial evidence that vWF plays a role in the 'delayed' (24 h) dysfunction observed in pulmonary xenotransplantation using PIM depleted hMCP organs...
  37. ncbi request reprint Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma
    A S Barbas
    Department of Surgery, Duke University Medical Centre, Durham, NC27710, USA
    Eur J Clin Invest 38:596-602. 2008
    ..This study describes the effect of chronic aspiration on a model of experimentally induced airway hypersensitivity in Balb/c mice...
  38. ncbi request reprint Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation
    Matthew G Hartwig
    Department of Surgery, Duke University, Durham, NC, USA
    J Thorac Cardiovasc Surg 131:209-17. 2006
    ..In this study, we used a model of rat lung transplantation to test the hypothesis that chronic aspiration of gastric contents accelerates pulmonary allograft dysfunction...
  39. pmc Human secretory immunoglobulin A may contribute to biofilm formation in the gut
    R Randal Bollinger
    Departments of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Immunology 109:580-7. 2003
    ..Mucin, another defence factor thought to play a key role in immune exclusion, was found to facilitate biofilm formation by E. coli. Our findings suggest that sIgA may contribute to biofilm formation in the gut...
  40. ncbi request reprint Binding of polyreactive antibodies to self versus foreign antigens
    Winston Lee
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Immunobiology 205:95-107. 2002
    ..These data shed light on the fundamental nature of polyreactive antibodies, and may provide additional insight into their putative biological roles...
  41. pmc Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology
    Nathan L Sanders
    Nathan L Sanders, R Randal Bollinger, Ryan Lee, Steven Thomas, William Parker, Department of Surgery, Duke University Medical Center, Durham, NC 27710, United States
    World J Gastroenterol 19:5607-14. 2013
    ..Further, these observations point to the idea that historically important threats to the microbiome such as infectious gastrointestinal pathogens have been supplanted by other threats, particularly the use of broad spectrum antibiotics. ..
  42. ncbi request reprint Non-anti-Gal alpha1-3Gal antibody mechanisms are sufficient to cause hyperacute lung dysfunction in pulmonary xenotransplantation
    Gonzalo V Gonzalez-Stawinski
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Surg 194:765-73. 2002
    ....
  43. ncbi request reprint Antigen expression in xenotransplantation: how low must it go?
    W Parker
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 71:313-9. 2001
    ..The extent to which antigen expression would have to be decreased to achieve such a goal is unknown...
  44. ncbi request reprint Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants
    B Li
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 8:1614-21. 2008
    ..This study provides experimental evidence linking chronic aspiration to the development of OB and suggests that strategies aimed at preventing aspiration-related injuries might improve outcomes in clinical lung transplantation...
  45. doi request reprint Amphiphilic α-helical potential: a putative folding motif adding few constraints to protein evolution
    S Y Ryan Lee
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Mol Evol 73:166-80. 2011
    ....
  46. ncbi request reprint Biophysical characteristics of anti-Gal(alpha)1-3Gal IgM binding to cell surfaces: implications for xenotransplantation
    W Parker
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Transplantation 71:440-6. 2001
    ....
  47. ncbi request reprint Increased levels of IgE and autoreactive, polyreactive IgG in wild rodents: implications for the hygiene hypothesis
    A P Devalapalli
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Scand J Immunol 64:125-36. 2006
    ....
  48. ncbi request reprint Hapten-induced primary and memory humoral responses are inhibited by the infusion of anti-CD20 monoclonal antibody (IDEC-C2B8, Rituximab)
    G V Gonzalez-Stawinski
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, 27710, USA
    Clin Immunol 98:175-9. 2001
    ..Furthermore, we provide evidence that anti-CD20 blocks the humoral response by eliminating those B-cells capable of responding to the hapten...