S M Palmer

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Rabbit antithymocyte globulin decreases acute rejection after lung transplantation: results of a randomized, prospective study
    S M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 116:127-33. 1999
  2. ncbi Innate immunity influences long-term outcomes after human lung transplant
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 171:780-5. 2005
  3. ncbi Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14
    S M Palmer
    Departments of Medicine, University of Arizona, Tucson, AZ, USA
    Am J Transplant 7:693-9. 2007
  4. ncbi The role of innate immunity in acute allograft rejection after lung transplantation
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Respir Crit Care Med 168:628-32. 2003
  5. ncbi Delay of CMV infection in high-risk CMV mismatch lung transplant recipients due to prophylaxis with oral ganciclovir
    Scott M Palmer
    Department of Medicine, Division of Pulmonary and Critical Care, Duke University Medical Center, Durham, NC, USA
    Clin Transplant 18:179-85. 2004
  6. ncbi Lung transplantation: evolving concepts and controversies
    Scott M Palmer
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Respir Crit Care Med 27:439-40. 2006
  7. ncbi Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats
    Scott M Palmer
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e17644. 2011
  8. ncbi Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 74:799-804. 2002
  9. ncbi Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Transplant 20:30-6. 2006
  10. ncbi Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation
    S M Palmer
    Department of Medicine, Duke University Medical Center, Durham NC, USA
    Chest 118:1214-7. 2000

Research Grants

  1. Innate Immune Responses in Obliterative Bronchiolitis
    Scott Palmer; Fiscal Year: 2006

Detail Information

Publications92

  1. ncbi Rabbit antithymocyte globulin decreases acute rejection after lung transplantation: results of a randomized, prospective study
    S M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 116:127-33. 1999
    ..We hypothesized that rabbit antithymocyte globulin (RATG) induction therapy would decrease acute rejection after lung transplantation, and we designed a single-center, randomized, prospective study to test this hypothesis...
  2. ncbi Innate immunity influences long-term outcomes after human lung transplant
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 171:780-5. 2005
    ....
  3. ncbi Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14
    S M Palmer
    Departments of Medicine, University of Arizona, Tucson, AZ, USA
    Am J Transplant 7:693-9. 2007
    ..Inhibition of innate immune activation through CD14 represents a novel and potentially important therapeutic target to prevent post-transplant rejection and improve outcomes after human lung transplantation...
  4. ncbi The role of innate immunity in acute allograft rejection after lung transplantation
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Respir Crit Care Med 168:628-32. 2003
    ..Therapies directed at inhibition of innate immune responses mediated by TLR4 may represent a novel and effective means to prevent acute rejection after lung transplantation...
  5. ncbi Delay of CMV infection in high-risk CMV mismatch lung transplant recipients due to prophylaxis with oral ganciclovir
    Scott M Palmer
    Department of Medicine, Division of Pulmonary and Critical Care, Duke University Medical Center, Durham, NC, USA
    Clin Transplant 18:179-85. 2004
    ..A larger prospective randomized study is needed to confirm the benefits of oral ganciclovir on CMV prevention...
  6. ncbi Lung transplantation: evolving concepts and controversies
    Scott M Palmer
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Respir Crit Care Med 27:439-40. 2006
  7. ncbi Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats
    Scott M Palmer
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e17644. 2011
    ....
  8. ncbi Development of an antibody specific to major histocompatibility antigens detectable by flow cytometry after lung transplant is associated with bronchiolitis obliterans syndrome
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 74:799-804. 2002
    ..The use of flow cytometry based panel reactive antibody (flow-PRA) provides a highly sensitive means to identify the development of de novo anti-HLA antibodies in lung recipients...
  9. ncbi Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Transplant 20:30-6. 2006
    ..In the present investigation, we sought to evaluate the role of innate immune activation through TLR4, in either donor or recipient, upon the development of renal allograft rejection...
  10. ncbi Gastroesophageal reflux as a reversible cause of allograft dysfunction after lung transplantation
    S M Palmer
    Department of Medicine, Duke University Medical Center, Durham NC, USA
    Chest 118:1214-7. 2000
    ..We suggest that GER should be considered among the potential causes of allograft dysfunction after lung transplantation...
  11. ncbi Successful bilateral lung transplant outcomes in recipients 61 years of age and older
    Scott M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:862-5. 2006
    ..We hypothesize that BLT offers comparable, if not superior, clinical outcomes to SLT in all patients independent of recipient age...
  12. ncbi Spirometrically significant acute rejection increases the risk for BOS and death after lung transplantation
    W A Davis
    Department of Medicine, Duke University, Durham, NC, USA
    Am J Transplant 12:745-52. 2012
    ..Further studies are needed to determine mechanisms of airflow impairment and whether aggressive clinical interventions could improve post-SSAR outcomes...
  13. ncbi Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation
    B D Reams
    Department of Pharmacy, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 7:2802-8. 2007
    ..Thus, we provide the first evidence that alemtuzumab is a potentially useful therapy in lung transplant recipients with RAR or BOS...
  14. ncbi Lung transplantation after long-term mechanical ventilation : results and 1-year follow-up
    M A Baz
    Department of Medicine, University of Florida, Gainesville, FL 32610, USA
    Chest 119:224-7. 2001
    ..We report on the results of transplantation in nine patients requiring long-term mechanical ventilation at two lung transplant centers...
  15. ncbi Laparoscopic antireflux surgery in the lung transplant population
    C L Lau
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Surg Endosc 16:1674-8. 2002
    ..We report here on the safety of laparoscopic fundoplication surgery for the treatment of GERD in lung transplant patients...
  16. ncbi Results of a randomized, prospective, multicenter trial of mycophenolate mofetil versus azathioprine in the prevention of acute lung allograft rejection
    S M Palmer
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 71:1772-6. 2001
    ..CONCLUSIONS: Acute rejection rates and overall survival at 6 months are similar in lung transplant recipients treated with either MMF- or AZA-based immunosuppression...
  17. ncbi Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis
    L D Snyder
    Department of Medicine Department of Surgery and Immunology Department of Biostatistics and Bioinformatics, Duke University, Durham, NC
    Am J Transplant 11:553-60. 2011
    ..Thus, valganciclovir prophylaxis does not appear to impair the development of CMV-specific immunity in lung transplantation...
  18. ncbi Symptomatic pulmonary allograft Kaposi's sarcoma in two lung transplant recipients
    S J Sathy
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 8:1951-6. 2008
    ..Our report highlights the importance of secondary malignancies in patients with transplant-related KS and supports the association between HHV-8 infection and EBV-negative PTLD...
  19. ncbi Critical care perspective on immunotherapy in lung transplantation
    Jennifer L Taylor
    Duke University Medical Center, Durham, NC 27710, USA
    J Intensive Care Med 21:327-44. 2006
    ..The main focus of this review is to provide a comprehensive summary of modern immunotherapy in lung transplantation and to increase awareness of the serious and potentially life-threatening complications of these medications...
  20. ncbi A single-center experience with ganciclovir-resistant cytomegalovirus in lung transplant recipients: treatment and outcome
    Anita J Reddy
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Heart Lung Transplant 26:1286-92. 2007
    ..A review of the results of glanciclovir susceptibility testing in lung transplant recipients was performed...
  21. ncbi Current concepts and controversies in lung transplantation
    Anil J Trindade
    Duke University School of Medicine, Durham, NC, USA
    Respir Care Clin N Am 10:427-47, v. 2004
    ....
  22. ncbi Diagnosis and outcome of early pleural space infection following lung transplantation
    Momen M Wahidi
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 135:484-91. 2009
    ..We sought to determine the predictors and clinical significance of pleural infection in this population...
  23. ncbi Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis
    J M Diamond
    Pulmonary, Allergy, and Critical Care Division, Department of Anesthesia and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 11:2517-22. 2011
    ..4, p = 0.008 at 24 h). Elevated PTX3 levels were associated with the development of PGD after lung transplantation in IPF patients. Future studies evaluating the role of innate immune activation in IPF and PGD are warranted...
  24. ncbi Prognostic value of serum carcinoembryonic antigen levels in patients who undergo lung transplantation
    D Hadjiliadis
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 20:1305-9. 2001
    ..0001). CONCLUSIONS: CEA levels are high in patients with end-stage lung disease, especially IPF. Their levels appear to be a marker of the underlying disease and do not predict the post-transplant survival or development of malignancy...
  25. ncbi Influenza pneumonia in lung transplant recipients: clinical features and association with bronchiolitis obliterans syndrome
    S Garantziotis
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 119:1277-80. 2001
    ..Additional research, therefore, is needed to clarify the relationship between influenza infection, acute rejection, and obliterative bronchiolitis...
  26. ncbi Gastroesophageal reflux and altered motility in lung transplant rejection
    J M Castor
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Neurogastroenterol Motil 22:841-50. 2010
    ..The article will conclude with a discussion of the evaluation and management of patients undergoing lung transplantation at our center...
  27. ncbi Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial
    Scott M Palmer
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
    Ann Intern Med 152:761-9. 2010
    ..Cytomegalovirus (CMV) is the most prevalent opportunistic infection after lung transplantation. Current strategies do not prevent CMV in most at-risk patients...
  28. ncbi Lung transplantation in advanced COPD: is it worth it?
    Jamie L Todd
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina
    Semin Respir Crit Care Med 31:365-72. 2010
    ..Further work to refine recipient selection, improve lung allocation algorithms, and develop better treatments of chronic allograft dysfunction will lead to an even greater benefit to lung transplantation in this ill patient population...
  29. ncbi Safety of aerosolized amphotericin B lipid complex in lung transplant recipients
    S M Palmer
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 22710, USA
    Transplantation 72:545-8. 2001
    ..Additional prospective, randomized studies are needed to determine the efficacy of aerosolized ABLC alone or in conjunction with systemic therapies in the prevention of fungal infections in lung transplant recipients...
  30. ncbi Pathologic correlates of bronchiolitis obliterans syndrome in pulmonary retransplant recipients
    Tereza Martinu
    Duke University Medical Center, Box 3876, Durham, NC 27710, USA
    Chest 129:1016-23. 2006
    ..We conclude that significant histologic heterogeneity exists among patients undergoing retransplantation for BOS, potentially contributing to the variability of patient responses to treatment...
  31. ncbi Role of flow cytometry to define unacceptable HLA antigens in lung transplant recipients with HLA-specific antibodies
    James Z Appel
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 81:1049-57. 2006
    ..Using this virtual crossmatch strategy, crossmatching can be safely omitted prior to lung transplantation, thereby decreasing waiting list time and mortality rates for candidates with HLA-specific antibodies...
  32. ncbi Psychiatric disorder and quality of life in patients awaiting lung transplantation
    Priti I Parekh
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Chest 124:1682-8. 2003
    ..04) than their counterparts without a psychiatric diagnosis. CONCLUSIONS: Psychiatric comorbidity affects a significant portion of patients awaiting lung transplantation and is associated with decreased health-related quality of life...
  33. ncbi Complications (excluding hyperinflation) involving the native lung after single-lung transplantation: incidence, radiologic features, and clinical importance
    H P McAdams
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 218:233-41. 2001
    ..To determine the incidence, importance, and radiologic features of native lung complications after single-lung transplantation...
  34. ncbi Reperfusion edema after lung transplantation: effect of daclizumab
    E M Marom
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 221:508-14. 2001
    ..To determine if daclizumab, an interleukin-2 antagonist, reduced the severity of reperfusion edema in lung transplant recipients...
  35. ncbi Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia cepacia complex
    B D Alexander
    Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Am J Transplant 8:1025-30. 2008
    ..00005). Following LT, infection with Bcc species other than B. cenocepacia does not significantly impact 5-year survival whereas infection with B. cenocepacia pretransplant is associated with decreased survival...
  36. ncbi Emotional distress and quality of life in caregivers of patients awaiting lung transplant
    Robyn Lewis Claar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Psychosom Res 59:1-6. 2005
    ....
  37. ncbi Coping and quality of life in patients awaiting lung transplantation
    Jessica L Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27710, USA
    J Psychosom Res 65:71-9. 2008
    ..Although coping strategies are related to QOL in patients with ESLD, the extent to which specific native lung disease moderates this relationship is unknown...
  38. ncbi Hepatitis B core antibody positive donors as a safe and effective therapeutic option to increase available organs for lung transplantation
    Matthew G Hartwig
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Transplantation 80:320-5. 2005
    ..However, the use of HBcAb+ pulmonary allografts in recipients with prior hepatitis B vaccination seems to be a safe and effective strategy to increase organ availability...
  39. ncbi Is prevention the best treatment? CMV after lung transplantation
    N Patel
    Department of Pharmacy Department of Medicine, Duke University, Durham, NC, USA
    Am J Transplant 12:539-44. 2012
    ..Although some areas of controversy remain, the clinical implications of these recent studies suggest that extending prophylaxis with valganciclovir up to 12 months is clearly beneficial for CMV prevention after lung transplantation...
  40. ncbi Impact of lung transplant operation on bronchiolitis obliterans syndrome in patients with chronic obstructive pulmonary disease
    D Hadjiliadis
    University of Pennsylvania, Allergy, Pulmonary and Critical Care, Philadelphia, Pennsylvania, USA
    Am J Transplant 6:183-9. 2006
    ..SLT: 67.5% vs. 61.1% and 60.7% vs. 34.1%, respectively; p = 0.018). Similar trends on survival were observed after development of BOS. BLT results in lower rates of BOS in patients with COPD that are eligible for both SLT and BLT...
  41. ncbi Successful bilateral lung transplantation for lymphangiomatosis
    C V Kinnier
    Division of Pulmonary Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 8:1946-50. 2008
    ....
  42. ncbi Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction
    J M Diamond
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Transplant 11:561-7. 2011
    ..02. Elevated CC16 levels were associated with increased odds of PGD after lung transplantation. Damage to airway epithelium or altered alveolar permeability as a result of lung ischemia and reperfusion may explain this association...
  43. ncbi Psychosocial issues in the assessment and management of patients undergoing lung transplantation
    Krista A Barbour
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Chest 129:1367-74. 2006
    ..This review summarizes the extant literature on the psychosocial factors in lung transplantation and highlights several innovative efforts to improve psychological outcomes in this challenging patient population...
  44. ncbi Telephone-based coping skills training for patients awaiting lung transplantation
    James A Blumenthal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Consult Clin Psychol 74:535-44. 2006
    ..Despite the severity of pulmonary disease in this patient population, significant improvements in quality of life, but not somatic measures or survival to transplant, were achieved...
  45. ncbi Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients
    C Ashley Finlen Copeland
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Crit Care Med 182:784-9. 2010
    ..Despite the importance of bronchiolitis obliterans syndrome (BOS) in lung transplantation, little is known regarding the factors that influence survival after the onset of this condition, particularly among bilateral transplant recipients...
  46. ncbi Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation
    Laurie D Snyder
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 181:1391-6. 2010
    ....
  47. ncbi High frequency of bronchogenic carcinoma after single-lung transplantation
    Robert P Dickson
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 25:1297-301. 2006
    ..001). CONCLUSIONS: Single-lung transplant confers a significantly elevated risk of developing primary post-transplant lung cancer as compared with BLTx in patients with comparable native disease, age and tobacco history...
  48. ncbi Toll-like receptors, innate immunity and lung transplantation
    Laurie D Snyder
    Department of Medicine, Duke University Medical Center, Box 103002, Durham, NC 27710, USA
    Front Biosci (Elite Ed) 1:600-4. 2009
    ..This report will review the current understanding of innate immunity in lung allograft rejection in both murine and human studies...
  49. ncbi Progressive multifocal leukoencephalopathy following heightened immunosuppression after lung transplant
    Jesse Waggoner
    Department of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 28:395-8. 2009
    ....
  50. ncbi Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide
    Stavros Garantziotis
    Department of Medicine, Duke University Medical Center, Durham, NC 27709, USA
    Transplantation 84:1012-9. 2007
    ..We have developed and pursued the hypothesis that local activation of pulmonary innate immunity through toll-like receptor (TLR)-4 is critical to the development of posttransplant alloimmune lung injury...
  51. ncbi Rabbit anti-thymocyte globulin induction therapy does not prolong survival after lung transplantation
    Matthew G Hartwig
    Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 27:547-53. 2008
    ..Thus, we hypothesized that RATG induction would translate to reduced BOS and improved long-term graft survival...
  52. ncbi Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant
    Laurie D Snyder
    Division of Pulmonary, Allergy and Critical Care, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 25:1330-5. 2006
    ..Cytokine polymorphisms are inconsistently associated with transplant rejection and other adverse outcomes. To address this controversy, we evaluated cytokine single nucleotide polymorphisms (SNPs) in a lung transplant cohort...
  53. ncbi Cytomegalovirus infection presenting as bronchial polyps in lung transplant recipients
    Jennifer M Naber
    Department of Pathology, Duke University and Durham VA Medical Centers, Durham, North Carolina, USA
    J Heart Lung Transplant 24:2109-13. 2005
    ..Our results suggest that biopsy of endobronchial lesions in pulmonary allografts should be pursued to establish a definitive etiology...
  54. ncbi Atrial fibrillation after pulmonary transplant
    Thomas D Nielsen
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 126:496-500. 2004
    ..Prospective studies designed to prevent posttransplant AF are needed to clarify the extent to which AF impacts on posttransplant outcomes...
  55. ncbi Comparative safety of amphotericin B lipid complex and amphotericin B deoxycholate as aerosolized antifungal prophylaxis in lung-transplant recipients
    Richard H Drew
    Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA
    Transplantation 77:232-7. 2004
    ..The incidence of invasive fungal infections in patients receiving aerosolized amphotericin B formulations as sole prophylaxis was determined...
  56. ncbi J. Maxwell Chamberlain Memorial Paper. Early fundoplication prevents chronic allograft dysfunction in patients with gastroesophageal reflux disease
    Edward Cantu
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 78:1142-51; discussion 1142-51. 2004
    ..We hypothesized that treatment of reflux with early fundoplication would prevent bronchiolitis obliterans syndrome and improve survival...
  57. ncbi Acute renal failure after lung transplantation: incidence, predictors and impact on perioperative morbidity and mortality
    Paulo N Rocha
    Duke University Medical Center, Department of Medicine, Division of Nephrology, Durham, NC 17710, USA
    Am J Transplant 5:1469-76. 2005
    ..77, CI 4.00-11.44, p < 0.0001). In conclusion, ARF occurs commonly after lung transplantation and affects important clinical outcomes, especially when dialysis is required...
  58. ncbi Laparoscopic Nissen fundoplication for treating reflux in lung transplant recipients
    James D Reynolds
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gastrointest Surg 8:132-7. 2004
    ..The average hospital stay is longer and there are more frequent readmissions in this population, but this does not appear to be due to any Nissen-related morbidity...
  59. ncbi Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation
    R Duane Davis
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:533-42. 2003
    ..Although alloimmune events are important, nonimmune events, such as gastroesophageal reflux, might contribute to lung injury and the development of bronchiolitis obliterans syndrome...
  60. ncbi Progression of idiopathic pulmonary fibrosis in native lungs after single lung transplantation
    Momen M Wahidi
    Department of Internal Medicine, Division of Pulmonary and Critical Care, Duke University Medical Center, Durham, NC 27710, USA
    Chest 121:2072-6. 2002
    ..However, fibrotic changes progressed in all five patients. In patients with advanced IPF, a potent cyclosporine-based immunosuppressive regimen is not likely to have an effect on the progression of the disease...
  61. ncbi Mood disorders and chronic obstructive pulmonary disease: current research and future needs
    Greg L Clary
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, PO Box 3519 Medical Center, Durham, NC 27710, USA
    Curr Psychiatry Rep 4:213-21. 2002
    ..Also reviewed is the impact of pulmonary rehabilitation on psychologic status and quality of life issues in the daily functioning of the COPD patient...
  62. ncbi Outcome of lung transplantation in patients with mycetomas
    Denis Hadjiliadis
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 121:128-34. 2002
    ..Additional research is needed to define the best therapeutic strategy for these patients during transplantation...
  63. ncbi Immune mechanisms of lung allograft rejection
    Laurie D Snyder
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Respir Crit Care Med 27:534-43. 2006
    ..We also identify areas for further research critical to improving transplant outcomes...
  64. ncbi Baseline 6-min walk distance predicts survival in lung transplant candidates
    T Martinu
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 8:1498-505. 2008
    ..The 6MWD is thus a useful measure of both urgency and utility among patients awaiting lung transplantation...
  65. ncbi Acute rejection and humoral sensitization in lung transplant recipients
    Tereza Martinu
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Proc Am Thorac Soc 6:54-65. 2009
    ..A greater mechanistic understanding of cellular and humoral forms of rejection and their role in the pathogenesis of BOS is critical in developing therapies that extend long-term survival after lung transplantation...
  66. ncbi Acute cellular rejection and humoral sensitization in lung transplant recipients
    Tereza Martinu
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Respir Crit Care Med 31:179-88. 2010
    ..Herein, we review the clinical presentation, diagnosis, mechanisms, and treatment of cellular and humoral rejection after lung transplantation...
  67. ncbi Significance of and risk factors for the development of central airway stenosis after lung transplantation
    S L Shofer
    Division of Pulmonary and Critical Care, Duke University Medical Center, Durham, NC
    Am J Transplant 13:383-9. 2013
    ..While CAS was not associated with BOS or worse survival, it remains an important complication after lung transplant with potentially preventable risk factors...
  68. ncbi Clinical outcome after coronary artery revascularization and lung transplantation
    Vijay S Patel
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 75:372-7; discussion 377. 2003
    ....
  69. ncbi Bronchiolitis obliterans syndrome in lung transplant recipients: correlation of computed tomography findings with bronchiolitis obliterans syndrome stage
    Yo Won Choi
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Imaging 18:72-9. 2003
    ..CT findings are relatively poor indices of airflow obstruction in lung transplant recipients with BOS, particularly in those with single-lung transplants for emphysema...
  70. ncbi Mycobacterium abscessus chest wall and pulmonary infection in a cystic fibrosis lung transplant recipient
    Jennifer L Taylor
    Division of Pulmonary/Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 25:985-8. 2006
    ..The combination of the virulent pre-transplant pathogen M abscessus and foreign bodies in the chest likely acted synergistically to contribute to the unfortunate outcome in this patient...
  71. ncbi Sublingual tacrolimus for immunosuppression in lung transplantation: a potentially important therapeutic option in cystic fibrosis
    B Diane Reams
    Department of Pharmacy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Respir Med 1:91-8. 2002
    ..Ultimately, SL tacrolimus may prove efficacious for short-term use in the early postoperative lung transplant recipients, particularly in patients with malabsorption problems such as CF transplant recipients...
  72. ncbi Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria
    Denis Hadjiliadis
    Department of Medicine, Division of Pulmonary Critical Care, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 10104, USA
    J Heart Lung Transplant 26:834-8. 2007
    ..The impact of panresistant bacteria, other than Burkholderia cepacia, on the survival after lung transplantation in patients with cystic fibrosis (CF) remains controversial...
  73. ncbi Plasma levels of receptor for advanced glycation end products, blood transfusion, and risk of primary graft dysfunction
    Jason D Christie
    Pulmonary, Allergy, and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Respir Crit Care Med 180:1010-5. 2009
    ..We hypothesized that patients with primary graft dysfunction (PGD) after lung transplantation would have higher RAGE levels in plasma than patients without PGD...
  74. ncbi Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation
    F L Kelly
    Division of Pulmonary and Critical Care Medicine Duke University Medical Center, Durham, North Carolina
    Am J Transplant 12:3076-84. 2012
    ..Collectively, these complementary results illustrate that BOS involves a selective alteration in the distribution and function of bronchiolar Clara cells...
  75. ncbi Pleural effusions in lung transplant recipients: image-guided small-bore catheter drainage
    Edith M Marom
    Department of Radiology, Duke University Medical Center, Durham, NC, USA
    Radiology 228:241-5. 2003
    ..To assess the efficacy of treating pleural effusions in lung transplant recipients with small-bore catheter drainage...
  76. ncbi Pulmonary embolization of microcrystalline cellulose in a lung transplant recipient
    Timothy A Fields
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Heart Lung Transplant 24:624-7. 2005
    ....
  77. ncbi Posttransplant lymphoproliferative disorder: incidence, presentation, and response to treatment in lung transplant recipients
    B Diane Reams
    Department of Pharmacy, Duke University Medical Center, Durham, NC 27710, USA
    Chest 124:1242-9. 2003
    ..Rituximab appears effective as a first-line therapy for PTLD, but additional studies are needed in order to define its efficacy and side effect profile in this population of patients...
  78. ncbi Improved results treating lung allograft failure with venovenous extracorporeal membrane oxygenation
    Matthew G Hartwig
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 80:1872-9; discussion 1879-80. 2005
    ..9 mg/dL. CONCLUSIONS: For lung recipients with primary graft failure, venovenous membrane oxygenation provides better outcomes, with fewer complications, than venoarterial membrane oxygenation...
  79. ncbi Pseudomonas aeruginosa elastase degrades surfactant proteins A and D
    William I Mariencheck
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 28:528-37. 2003
    ..We speculate that degradation of SP-A and SP-D is a virulence mechanism in the pathogenesis of chronic P. aeruginosa infection...
  80. ncbi Respiratory failure early after lung transplantation: now that we know the extent of the problem, what are the solutions?
    David Zaas
    Chest 123:14-6. 2003
  81. ncbi Is transplant operation important in determining posttransplant risk of bronchiolitis obliterans syndrome in lung transplant recipients?
    Denis Hadjiliadis
    Lung Transplant Program, University of Toronto, Toronto, Ontario, Canada
    Chest 122:1168-75. 2002
    ..We hypothesized that double-lung transplantation leads to decreased rates of BOS...
  82. ncbi Treatment of refractory acute rejection in a lung transplant recipient with campath 1H
    B Diane Reams
    Transplantation 74:903-4. 2002
  83. ncbi Quality, quantity, or both? Life after lung transplantation
    Laurie D Snyder
    Chest 128:1086-7. 2005
  84. ncbi Critical care aspects of lung transplantation
    Christine L Lau
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO, USA
    J Intensive Care Med 19:83-104. 2004
    ..Because the ICU is also the most common setting where a potential donor is identified, donor issues will briefly be addressed...
  85. ncbi Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation
    Daniel R Goldstein
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8018, USA
    J Heart Lung Transplant 24:1721-9. 2005
    ..Future therapeutic modalities that target innate rather than adaptive immune mechanisms represent a promising avenue for future studies in thoracic organ transplantation...
  86. ncbi Upper lobe fibrosis: a novel manifestation of chronic allograft dysfunction in lung transplantation
    Smita Sakha Pakhale
    Toronto Lung Transplant Program, University Health Network, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:1260-8. 2005
    ..CONCLUSION: Upper lobe fibrosis is a novel presentation of chronic allograft dysfunction in lung transplant recipients and is differentiated from bronchiolitis obliterans syndrome on the basis of physiologic and radiologic findings...
  87. ncbi Pre-transplant panel reactive antibody in lung transplant recipients is associated with significantly worse post-transplant survival in a multicenter study
    Denis Hadjiliadis
    Department of Medicine, Division of Respirology, Toronto General Hospital, Toronto, Ontario, Canada
    J Heart Lung Transplant 24:S249-54. 2005
    ..This may be due to a direct effect of anti-HLA antibodies on the allograft. The effectiveness of treatments such as plasmapheresis and intravenous immunoglobulin prior to transplantation needs to be evaluated...
  88. ncbi Gastroesophageal reflux disease in lung transplant recipients
    Denis Hadjiliadis
    Lung Transplant Program, University of Toronto, Toronto, Canada
    Clin Transplant 17:363-8. 2003
    ..A link between gastric aspiration and post-transplant lung dysfunction has been suggested, but little is known about the significance of gastroesophageal reflux disease (GERD) after lung transplantation...
  89. ncbi Living-related lobar lung transplantation
    Cornelis Veeken
    University of Leiden, Leiden, The Netherlands
    J Cardiothorac Vasc Anesth 18:506-11. 2004
  90. ncbi Outcome of lung transplant patients admitted to the medical ICU
    Denis Hadjiliadis
    Toronto Lung Transplant Program, Toronto, ON, Canada
    Chest 125:1040-5. 2004
    ..Little is known about the epidemiology, clinical outcomes, and risk factors for survival among lung transplant recipients admitted to the ICU...
  91. ncbi Lung transplantation exacerbates gastroesophageal reflux disease
    Lisa R Young
    Division of Medicine and Pediatrics, University of Cincinnati, Cincinnati, OH, USA
    Chest 124:1689-93. 2003
    ..Further research is needed to determine the physiologic mechanisms of posttransplant GER and its impact on long-term allograft function...
  92. ncbi Respiratory toxicity of diacetyl in C57BL/6 mice
    Daniel L Morgan
    Respiratory Toxicology, Laboratory of Molecular Toxicology, National Toxicology Program National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Sci 103:169-80. 2008
    ..Collectively these results indicate that clinically relevant diacetyl exposures result in a pattern of injury that replicates features of human OB...

Research Grants2

  1. Innate Immune Responses in Obliterative Bronchiolitis
    Scott Palmer; Fiscal Year: 2006
    ..He will apply these skills to direct future investigations of patient oriented research problems in pulmonary medicine...