Thomas L Ortel

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Continuing anticoagulation following venous thromboembolism
    Elizabeth Krakow
    JAMA 294:3088; author reply 3088-9. 2005
  2. ncbi request reprint The antiphospholipid syndrome: what are we really measuring? How do we measure it? And how do we treat it?
    Thomas L Ortel
    Division of Hematology, Departments of Medicine and Pathology, Duke University Medical Center, Box 3422, Durham, NC 27710, USA
    J Thromb Thrombolysis 21:79-83. 2006
  3. ncbi request reprint Prevention and treatment of deep venous thrombosis
    Thomas L Ortel
    Duke Hemostasis and Thrombosis Center, Duke University Medical Center, Durham, NC, USA
    Vascular 16:S64-70. 2008
  4. doi request reprint Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial
    Wei Jiang
    Department of Medicine, Duke University Medical Center, DUMC Box 3366, Durham, NC 27710, USA
    JAMA 309:2139-49. 2013
  5. pmc High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass
    Grace M Lee
    Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 121:2828-35. 2013
  6. ncbi request reprint Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure
    Karen E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L21-31. 2006
  7. ncbi request reprint Regulatable aptamers in medicine: focus on antithrombotic strategies
    Anil Potti
    Duke University Medical Center, Department of Medicine, Division of Haematology, Durham, NC 27710, USA
    Expert Opin Biol Ther 4:1641-7. 2004
  8. pmc Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia
    Nicole L Whitlatch
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Thromb Haemost 100:678-84. 2008
  9. ncbi request reprint Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding
    Deborah A Lewis
    Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Blood Coagul Fibrinolysis 14:361-8. 2003
  10. ncbi request reprint Clinical practice. Heparin-induced thrombocytopenia
    Gowthami M Arepally
    Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 355:809-17. 2006

Detail Information

Publications78

  1. ncbi request reprint Continuing anticoagulation following venous thromboembolism
    Elizabeth Krakow
    JAMA 294:3088; author reply 3088-9. 2005
  2. ncbi request reprint The antiphospholipid syndrome: what are we really measuring? How do we measure it? And how do we treat it?
    Thomas L Ortel
    Division of Hematology, Departments of Medicine and Pathology, Duke University Medical Center, Box 3422, Durham, NC 27710, USA
    J Thromb Thrombolysis 21:79-83. 2006
    ..Patients with the antiphospholipid syndrome are treated with long-term oral anticoagulation to prolong the INR to 2.0 to 3.0. For most patients, a more intense level of treatment with a higher INR is not needed...
  3. ncbi request reprint Prevention and treatment of deep venous thrombosis
    Thomas L Ortel
    Duke Hemostasis and Thrombosis Center, Duke University Medical Center, Durham, NC, USA
    Vascular 16:S64-70. 2008
    ..Effective thrombo-prophylactic strategies exist and include both pharmacologic and nonpharmacologic approaches. For those surgical patients who develop a VTE, antithrombotic therapy remains the treatment of choice...
  4. doi request reprint Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial
    Wei Jiang
    Department of Medicine, Duke University Medical Center, DUMC Box 3366, Durham, NC 27710, USA
    JAMA 309:2139-49. 2013
    ..Mental stress can induce myocardial ischemia and also has been implicated in triggering cardiac events. However, pharmacological interventions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied...
  5. pmc High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass
    Grace M Lee
    Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 121:2828-35. 2013
    ..These studies show that Abs to PRT/H occur commonly after cardiac bypass surgery, share a number of serologic features with HIT Abs, including platelet activation, and may pose health risks to patients requiring drug reexposure...
  6. ncbi request reprint Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure
    Karen E Welty-Wolf
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 290:L21-31. 2006
    ..Blockade of factor X binding to the tissue factor-factor VIIa complex attenuates lung and organ injuries in established E. coli sepsis by attenuating the neutrophilic response and inflammatory pathways...
  7. ncbi request reprint Regulatable aptamers in medicine: focus on antithrombotic strategies
    Anil Potti
    Duke University Medical Center, Department of Medicine, Division of Haematology, Durham, NC 27710, USA
    Expert Opin Biol Ther 4:1641-7. 2004
    ....
  8. pmc Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia
    Nicole L Whitlatch
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Thromb Haemost 100:678-84. 2008
    ..Future studies should compare higher ELISA OD values with the confirmatory procedure as strategies to improve ELISA diagnostic specificity for HIT...
  9. ncbi request reprint Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding
    Deborah A Lewis
    Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Blood Coagul Fibrinolysis 14:361-8. 2003
    ..These results agree with the model of the phospholipid-binding site determined by crystal structure of the C2 domain of factor VIII...
  10. ncbi request reprint Clinical practice. Heparin-induced thrombocytopenia
    Gowthami M Arepally
    Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, NC, USA
    N Engl J Med 355:809-17. 2006
  11. ncbi request reprint Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII
    Deborah A Lewis
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Thromb Haemost 93:833-41. 2005
    ....
  12. ncbi request reprint Management of lepirudin therapy for a patient with antiphospholipid antibody syndrome using the whole blood ecarin clot time and activated partial thromboplastin time
    Stephanie L Perry
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Blood Coagul Fibrinolysis 14:601-4. 2003
    ..Four patients had normalization of the aPTT, suggesting that a subset of patients with APS may benefit from the TAS aPTT assay when monitoring heparin or other anticoagulation therapy...
  13. doi request reprint Plasmapheresis and heparin reexposure as a management strategy for cardiac surgical patients with heparin-induced thrombocytopenia
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, DUMC Box 3094, Durham, NC 27710, USA
    Anesth Analg 110:30-5. 2010
    ..Alternative anticoagulants are available, but there are concerns about dosing, efficacy, monitoring, thrombosis, and hemorrhage...
  14. doi request reprint Characteristics of abdominal vein thrombosis in children and adults
    Daniel Landi
    Thomas L Ortel, MD, PhD, Duke Thrombosis and Hemostasis Center, Box 3422 DUMC, Durham, NC 27710, USA
    Thromb Haemost 109:625-32. 2013
    ..In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE...
  15. ncbi request reprint Thrombosis, thrombophilia, and thromboprophylaxis in pregnancy
    Andra H James
    Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Adv Hematol Oncol 3:187-97. 2005
    ..The risk of thrombosis is higher postpartum than during pregnancy, so anticoagulation therapy is usually continued for at least 6 weeks after delivery...
  16. pmc Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events
    Deepak Voora
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina Department of Medicine, Duke University, Durham, North Carolina Electronic address
    J Am Coll Cardiol 62:1267-76. 2013
    ..The aim of this study was to develop ribonucleic acid (RNA) profiles that could serve as novel biomarkers for the response to aspirin...
  17. doi request reprint Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease
    Stephen H Boyle
    Duke University Medical Center, Box 3366, Durham, NC 27710
    Psychosom Med 75:822-31. 2013
    ..The aim of this study was to examine the associations between depressive symptoms and mental stress-induced myocardial ischemia (MSIMI) in patients with coronary heart disease (CHD)...
  18. doi request reprint Prevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 61:714-22. 2013
    ..The goal of this study was to evaluate the prevalence and clinical characteristics of mental stress-induced myocardial ischemia...
  19. pmc Validation of the high-dose heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia
    Nicole L Whitlatch
    Divisions of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 116:1761-6. 2010
    ..On the basis of data from the heparin/PF4 enzyme-linked immunosorbent assay and confirmatory assays, a predictive computer algorithm could distinguish patients likely to have HIT from those who do not...
  20. ncbi request reprint Prothrombin and beta 2-glycoprotein I frequently contribute to antiphospholipid antibody interactions with phospholipids and the generation of abnormal waveform profiles in coagulation assays
    Zuowei Su
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, N C 27710, USA
    Thromb Haemost 90:218-26. 2003
    ..In conclusion, these results showed that the interactions of IgG with phospholipids via beta(2) GPI or prothrombin constitute the core mechanisms of the abnormal waveforms...
  21. ncbi request reprint Direct-to-patient expert system and home INR monitoring improves control of oral anticoagulation
    Susan I O'Shea
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    J Thromb Thrombolysis 26:14-21. 2008
    ....
  22. ncbi request reprint Heparin-induced thrombocytopenia in left ventricular assist device bridge-to-transplant patients
    Jacob N Schroder
    Department of Surgery, Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27703, USA
    Ann Thorac Surg 84:841-5; discussion 845-6. 2007
    ..Owing to this concern, we compared outcomes of HIT-positive versus control bridge-to-transplantation VAD patients; both groups were reexposed to heparin for cardiopulmonary bypass during transplant...
  23. ncbi request reprint Point-of-care testing of the international normalized ratio in patients with antiphospholipid antibodies
    Stephanie L Perry
    Division of Hematology, Department of Medicine, Department of Pathology, Duke University Health System, Durham, North Carolina 27710, USA
    Thromb Haemost 94:1196-202. 2005
    ..For this subset of APS patients, we suggest using an alternative method to monitor warfarin...
  24. doi request reprint Perioperative management of patients on chronic antithrombotic therapy
    Thomas L Ortel
    Hemostasis and Thrombosis Center, Duke University Medical Center, Durham, NC 27710, USA
    Hematology Am Soc Hematol Educ Program 2012:529-35. 2012
    ....
  25. pmc Time-dependent changes in non-COX-1-dependent platelet function with daily aspirin therapy
    Deepak Voora
    Institute for Genome Sciences and Policy, Duke University, 905 S Lasalle Dr, DUMC Box 3445, Durham, NC 27710, USA
    J Thromb Thrombolysis 33:246-57. 2012
    ..Despite suppression of COX-1 activity, NCDPF during aspirin therapy is predictably dynamic: those with heightened NCDPF continue to decline whereas those with low/normal NCDPF return to pre-aspirin levels over time...
  26. ncbi request reprint A multi-dose pharmacokinetic study of dalteparin in haemodialysis patients
    Stephanie L Perry
    Hemostasis and Thrombosis Center, Duke University Health System, Box 3422, Room 0563, Stead Building, Durham, NC 27710, USA
    Thromb Haemost 96:750-5. 2006
    ..Future studies to evaluate the PK parameters of dalteparin in patients receiving chronic HD may have to use weight-based dosing and will need to be performed over a longer period of time...
  27. pmc Heparin modifies the immunogenicity of positively charged proteins
    Shalini L Chudasama
    Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 116:6046-53. 2010
    ....
  28. ncbi request reprint Hemostatic activation in a chemically induced rat model of severe hemolysis and thrombosis
    Deborah A Lewis
    Hemostasis and Thrombosis Center, Department of Medicine, Duke University Medical Center, Duke University Health System, Box 3422 Durham, NC 27710, USA
    Thromb Res 118:747-53. 2006
    ....
  29. ncbi request reprint Hypercoagulable states and antithrombotic strategies in recurrent vascular access site thrombosis
    Susan I O'Shea
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Vasc Surg 38:541-8. 2003
    ..Prospective studies are needed to evaluate the role and safety of antithrombotic agents in improving vascular access graft patency...
  30. ncbi request reprint Alternative methods of anticoagulation for dialysis-dependent patients with heparin-induced thrombocytopenia
    Susan I O'Shea
    Divisions of Hematology and Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Dial 16:61-7. 2003
    ..In this report the currently available alternatives to heparin for dialysis, including dosing and monitoring recommendations, are reviewed...
  31. ncbi request reprint Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review
    Soheir S Adam
    Duke University Medical Center, Department of Medicine, Box 3939, Durham, NC 27710, USA
    Ann Intern Med 157:796-807. 2012
    ..New oral anticoagulants (NOACs), including direct thrombin inhibitors (DTIs) and factor Xa (FXa) inhibitors, are emerging alternatives for prophylaxis and treatment of atrial fibrillation (AF) and venous thromboembolism (VTE)...
  32. ncbi request reprint The kaolin-activated Thrombelastograph predicts bleeding after cardiac surgery
    Ian J Welsby
    Department of Anesthesiology, Division of Cardiothoracic Anesthesia and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 20:531-5. 2006
    ....
  33. pmc The effect of aspirin on endothelial progenitor cell biology: preliminary investigation of novel properties
    Junyang Lou
    Department of Medicine, Division of Cardiology, Duke Clinical Research Institute, Durham, NC 27705, USA
    Thromb Res 126:e175-9. 2010
    ..We tested the hypothesis that the nonselective cyclooxygenase (COX) inhibitor aspirin (ASA) exerts an effect on circulating EPCs...
  34. pmc Characterization of the hypercoagulable state in patients with sickle cell disease
    Nirmish Shah
    Division of Hematology Oncology, Department of Pediatrics, Duke University, Durham, NC, USA
    Thromb Res 130:e241-5. 2012
    ..The pathophysiology of sickle cell disease (SCD) is complex, with increasing evidence of a pronounced prothrombotic state...
  35. pmc Perioperative management of patients on chronic antithrombotic therapy
    Thomas L Ortel
    Hemostasis and Thrombosis Center, Duke University Medical Center, Durham, NC 27710, USA
    Blood 120:4699-705. 2012
    ....
  36. pmc Whole blood gene expression analyses in patients with single versus recurrent venous thromboembolism
    Deborah A Lewis
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Thromb Res 128:536-40. 2011
    ..Identification of patients at risk for recurrent venous thromboembolism would facilitate decisions concerning the duration of anticoagulant therapy...
  37. doi request reprint Antiphospholipid syndrome: laboratory testing and diagnostic strategies
    Thomas L Ortel
    Division of Hematology, Duke University Medical Center, Durham, North Carolina, USA
    Am J Hematol 87:S75-81. 2012
    ..New tests and diagnostic strategies are in various stages of development and should help improve our ability to accurately diagnose this important clinical disorder...
  38. pmc Gene-expression patterns predict phenotypes of immune-mediated thrombosis
    Anil Potti
    Department of Medicine, Duke University Medical Center, Box 3841 Red Zone, Durham, NC 27710, USA
    Blood 107:1391-6. 2006
    ....
  39. ncbi request reprint Anti-beta(2)-glycoprotein I antibody-mediated inhibition of activated protein C requires binding of beta(2)-glycoprotein I to phospholipids
    Tomonori Izumi
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Thromb Haemost 88:620-6. 2002
    ..This study confirms that anti-beta(2)GPI antibodies from APS patients inhibit APC activity, and demonstrates the requirement of phospholipid binding of beta(2)GPI for expression of the inhibitory activity of these antibodies...
  40. ncbi request reprint Antihuman factor V antibodies after use of relatively pure bovine thrombin
    Jeffrey H Lawson
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 79:1037-8. 2005
    ..This report calls into question the safety of even relatively pure bovine thrombin...
  41. ncbi request reprint Invited commentary
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, Room 3409A, DUMC Box 3094, Erwin Rd, Durham, NC 27710, USA
    Ann Thorac Surg 84:168-9. 2007
  42. ncbi request reprint Influence of sample collection and storage on the detection of platelet factor 4-heparin antibodies
    Elizabeth F Krakow
    Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am J Clin Pathol 128:150-5. 2007
    ..These findings suggest that PF4-heparin antibodies are largely insensitive to the effects of sample preparation and storage...
  43. pmc Impact of venous thromboembolism and anticoagulation on cancer and cancer survival
    Nicole M Kuderer
    Division of Hematology, Oncology and Cellular Therapy, Duke Comprehensive Cancer Center, Duke University Medical Center, DUMC 3841, Durham, NC 27710, USA
    J Clin Oncol 27:4902-11. 2009
    ..Although the LMWHs and related agents hold promise for improving outcomes in patients with cancer, additional studies of their efficacy and safety in this setting are needed...
  44. ncbi request reprint Low-molecular-weight heparin for thromboprophylaxis in pregnant women with mechanical heart valves
    Andra H James
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    J Matern Fetal Neonatal Med 19:543-9. 2006
    ..Unfortunately, fatal thromboses have occurred with low-molecular-weight heparin as well...
  45. ncbi request reprint Blockade of tissue factor: treatment for organ injury in established sepsis
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 167:1200-9. 2003
    ..These results show that blockade of coagulation attenuates acute lung and renal injury in established Gram-negative sepsis accompanied by antiinflammatory effects of therapy...
  46. doi request reprint Heparin-induced thrombocytopenia
    Gowthami M Arepally
    Division of Hematology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Med 61:77-90. 2010
    ..This review summarizes our current understanding of the pathogenesis, clinical features, diagnostic criteria, and management approaches in HIT...
  47. ncbi request reprint Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    Barton F Haynes
    Duke University School of Medicine, Durham, NC 27710, USA
    Science 308:1906-8. 2005
    ..These results may have important implications for generating effective neutralizing antibody responses by using HIV-1 vaccines...
  48. doi request reprint Clinical causes and treatment of the thrombotic storm
    Thomas L Ortel
    Hemostasis and Thrombosis Center, Duke University Medical Center, Durham, NC 27710, USA
    Expert Rev Hematol 5:653-9. 2012
    ..Ongoing studies are focused on identifying underlying genetic factors that may predispose patients to develop this extreme clinical phenotype...
  49. ncbi request reprint Heparin-induced thrombocytopenia in cancer
    Benjamin J Miriovsky
    Divisions of Hematology, Medical Oncology, and Cellular Therapy, Duke University Medical Center, Durham, North Carolina, USA
    J Natl Compr Canc Netw 9:781-7. 2011
    ..Additionally, thrombocytopenia is a common finding in cancer patients. The convergence of these variables highlights the importance of an increased understanding of the disease in cancer patients...
  50. pmc Associations of depressive symptoms, trait hostility, and gender with C-reactive protein and interleukin-6 response after emotion recall
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 72:333-9. 2010
    ..Depressive symptoms moderate the effect of trait hostility on circulating levels of CRP and IL-6...
  51. ncbi request reprint Heparin-induced thrombocytopenia: clinical presentations and therapeutic management
    Zoë L Larned
    Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Adv Hematol Oncol 1:356-64. 2003
    ..Complications of HIT can result in significant morbidity and mortality. We review the clinical presentations of HIT, laboratory and diagnostic workup, and treatment agents available or being evaluated...
  52. ncbi request reprint Frequency of anti-heparin-platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis
    Susan I O'Shea
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Hematol 69:72-3. 2002
    ..In our study, the presence of anti-PF4/heparin antibodies was rare and was not increased in patients with a history of vascular access thrombosis...
  53. ncbi request reprint Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia
    Andra H James
    Department of Obstetrics and Gynecology, Division of Hematology, Duke University Medical Center, Durham, NC, USA
    Am J Obstet Gynecol 191:449-55. 2004
    ..The purpose of this study was to assess the usefulness of a new platelet function analyzer in the detection of von Willebrand disease and platelet dysfunction in women with menorrhagia...
  54. doi request reprint Thrombophilias: when should we test and how does it help?
    Nicole L Whitlatch
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Semin Respir Crit Care Med 29:25-39. 2008
    ....
  55. ncbi request reprint Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding
    Deborah A Lewis
    Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    Thromb Haemost 89:795-802. 2003
    ..All mutant proteins were still recognized by a monoclonal antibody and two factor VIII inhibitors that neutralized cofactor activity and blocked factor VIII binding to phospholipids...
  56. pmc Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am Heart J 163:20-6. 2012
    ..Depression is a risk factor of MSIMI. The REMIT trial investigates whether selective serotonin reuptake inhibitor (SSRI) treatment can improve MSIMI. The rationale and outline of the study are described...
  57. doi request reprint Laboratory diagnosis of the lupus anticoagulant
    Thomas L Ortel
    Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Rheumatol Rep 14:64-70. 2012
    ....
  58. doi request reprint Acquired thrombotic risk factors in the critical care setting
    Thomas L Ortel
    Duke Hemostasis and Thrombosis Center, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 38:S43-50. 2010
    ..g., a direct thrombin inhibitor) in the acute setting. The duration of anticoagulant therapy would vary depending on the specific clinical setting...
  59. pmc Evolution of adverse changes in stored RBCs
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:17063-8. 2007
    ....
  60. ncbi request reprint Thrombophilia and thrombosis in thrombotic thrombocytopenic purpura
    Anil Potti
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina
    Semin Thromb Hemost 31:652-8. 2005
    ....
  61. ncbi request reprint Clinical implications for patients on antithrombotic therapy while taking supplements
    Thomas L Ortel
    Medicine and Pathology, Hemostasis and Thrombosis Center, Room 0563 Stead Building, Box 3422 Duke University Medical Center, Durham, NC 27710, USA
    Thromb Res 117:75-80; discussion 113-5. 2005
  62. ncbi request reprint Preoperative anti-PF4/heparin antibody level predicts adverse outcome after cardiac surgery
    Elliott Bennett-Guerrero
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 130:1567-72. 2005
    ....
  63. ncbi request reprint Coagulation and inflammation in acute lung injury
    Karen E Welty-Wolf
    Division of Infectious Diseases, Department of Medicine, Duke University, Durham, NC, USA
    Thromb Haemost 88:17-25. 2002
    ....
  64. ncbi request reprint von Willebrand's disease diagnosed after menorrhagia worsened from levonorgestrel intrauterine system
    Andrea S Lukes
    Department of Obstetrics and Gynecology and Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Obstet Gynecol 105:1223-6. 2005
    ..Adult females with menorrhagia may have unrecognized mild von Willebrand's disease. Most females with known von Willebrand's disease report menorrhagia...
  65. ncbi request reprint RNA aptamers as reversible antagonists of coagulation factor IXa
    Christopher P Rusconi
    Department of Surgery, Program in Combinatorial Therapeutics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 419:90-4. 2002
    ..This generalizable strategy for rationally designing a drug-antidote pair thus opens up the way for developing safer regulatable therapeutics...
  66. ncbi request reprint Issues in the utilization of low molecular weight heparins
    Susan I O'Shea
    Division of Hematology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Semin Hematol 39:172-8. 2002
    ..Therapeutic monitoring also may be useful for the morbidly obese, in children, and for patients with malignancy...
  67. ncbi request reprint Antiphospholipid antibodies after surgical exposure to topical bovine thrombin
    Zuowei Su
    Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, NC 27710, USA
    J Lab Clin Med 139:349-56. 2002
    ..Nevertheless, our findings support the recommendation that the clinical safety of these commonly used hemostatic agents should be reassessed...
  68. ncbi request reprint Clinical and laboratory evaluation of thrombophilia
    Stephanie L Perry
    Division of Medical Oncology, Division of Hematology, Duke University Medical Center, Trent Drive, Durham, NC 27710, USA
    Clin Chest Med 24:153-70. 2003
    ....
  69. ncbi request reprint Antiphospholipid antibodies
    Stephan Moll
    Arch Intern Med 162:1783-4; author reply 1786-7. 2002
  70. ncbi request reprint Coagulation abnormalities in patients with hip osteonecrosis
    Anastasios V Korompilias
    Department of Orthopaedic Surgery, University of Ioannina School of Medicine, Ioannina, 45110, Greece
    Orthop Clin North Am 35:265-71, vii. 2004
    ..Early diagnosis of hypercoagulability in the group of patients at risk may allow pharmacologic intervention that may prevent this devastating process from developing...
  71. ncbi request reprint Age and dose sensitivities in the 2-butoxyethanol F344 rat model of hemolytic anemia and disseminated thrombosis
    Yuval Ramot
    Hadassah Medical Center, Hebrew University, Jerusalem, Israel
    Exp Toxicol Pathol 58:311-22. 2007
    ..Because our findings show age- and dose-related sensitivities, we suggest that 12-week-old rats and doses of 250 mg/kg be used in the 2-BE model...
  72. ncbi request reprint Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII
    Edward N van den Brink
    Department of Plasma Proteins, CLB, Amsterdam, The Netherlands
    Blood 99:2828-34. 2002
    ..Together these data indicate that antibodies assembled from V(H) gene segments DP-5 and the closely related germline gene segments DP-10, DP-14, and DP-88 target 2 distinct antigenic sites in the C2 domain of factor VIII...
  73. ncbi request reprint Warfarin in antiphospholipid syndrome--time to explore new horizons
    Doruk Erkan
    J Rheumatol 32:208-12. 2005
  74. ncbi request reprint Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 104:2783-90. 2004
    ..This "annexin A5 resistance" identifies a novel mechanism for thrombosis in the aPL syndrome...
  75. pmc Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project
    Charles L Bennett
    VA Center for Management of Complex Chronic Care at Jesse Brown VA Medical Center, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 50:1138-43. 2007
    ..We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP)...
  76. ncbi request reprint A review of the therapeutic uses of thrombin
    Roger L Lundblad
    Department of Pathology, University of North Carolina at Chapel Hill, USA
    Thromb Haemost 91:851-60. 2004
    ..However, the availability of a safe human thrombin preparation will be critical for the continued use of thrombin as a therapeutic...
  77. ncbi request reprint Venous thromboembolic disease. Clinical practice guidelines in oncology
    Lawrence D Wagman
    City of Hope Cancer Center, USA
    J Natl Compr Canc Netw 4:838-69. 2006
  78. ncbi request reprint Dialogue with patient care organizations
    Rebecca Costello
    Office of Dietary Supplements, National Institutes of Health Bethesda, MD 20892, USA
    Thromb Res 117:211-22; discussion 223-5. 2005