Mark W Onaitis

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients
    Mark W Onaitis
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg 244:420-5. 2006
  2. ncbi request reprint Ileal pouch-anal anastomosis for ulcerative colitis and familial adenomatous polyposis: historical development and current status
    Mark W Onaitis
    Department of Surgery, Duke University, Durham, NC 27710, USA
    Ann Surg 238:S42-8. 2003
  3. pmc Sleeve lobectomy for non-small cell lung cancer with N1 nodal disease does not compromise survival
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina Electronic address
    Ann Thorac Surg 97:230-5. 2014
  4. pmc Impact of T status and N status on perioperative outcomes after thoracoscopic lobectomy for lung cancer
    Nestor R Villamizar
    Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 145:514-20; discussion 520-1. 2013
  5. pmc Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: a Society of Thoracic Surgeons Database analysis
    Duykhanh P Ceppa
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg 256:487-93. 2012
  6. ncbi request reprint Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity
    Matthew F Kalady
    Department of Surgery, Duke University Medical Center and Durham VA Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 116:24-31. 2004
  7. ncbi request reprint Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses
    Zeinab Abdel-Wahab
    Department of Surgery, Duke University, Durham, NC 27710, USA
    J Surg Res 124:264-73. 2005
  8. ncbi request reprint Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution
    Zeinab Abdel-Wahab
    Department of Surgery, Duke University Medical Center, P O Box 2624 MSRB, Durham, NC 27710, USA
    Cell Immunol 224:86-97. 2003
  9. doi request reprint Risk factors for morbidity after lobectomy for lung cancer in elderly patients
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 88:1093-9. 2009
  10. ncbi request reprint Differential prognostic significance of extralobar and intralobar nodal metastases in patients with surgically resected stage II non-small cell lung cancer
    John C Haney
    Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC
    J Thorac Cardiovasc Surg 147:1164-8. 2014

Collaborators

Detail Information

Publications41

  1. pmc Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients
    Mark W Onaitis
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg 244:420-5. 2006
    ..The outcomes after thoracoscopic lobectomy in patients with more complex pulmonary conditions are analyzed to determine safety, efficacy, and versatility...
  2. ncbi request reprint Ileal pouch-anal anastomosis for ulcerative colitis and familial adenomatous polyposis: historical development and current status
    Mark W Onaitis
    Department of Surgery, Duke University, Durham, NC 27710, USA
    Ann Surg 238:S42-8. 2003
    ..Although research in this area will continue, the evolution of this operation has allowed it to become the gold standard for the treatment of ulcerative colitis and familial adenomatous polyposis...
  3. pmc Sleeve lobectomy for non-small cell lung cancer with N1 nodal disease does not compromise survival
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina Electronic address
    Ann Thorac Surg 97:230-5. 2014
    ..We evaluated if sleeve lobectomy had worse survival compared with pneumonectomy for non-small cell lung cancer (NSCLC) with N1 disease, which may be a risk factor for locoregional recurrence...
  4. pmc Impact of T status and N status on perioperative outcomes after thoracoscopic lobectomy for lung cancer
    Nestor R Villamizar
    Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 145:514-20; discussion 520-1. 2013
    ..We sought to evaluate the effect of tumor size, location, and clinical nodal status on outcomes after thoracoscopic lobectomy for lung cancer...
  5. pmc Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: a Society of Thoracic Surgeons Database analysis
    Duykhanh P Ceppa
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg 256:487-93. 2012
    ..Using a national database, we asked whether video-assisted thoracoscopic surgery (VATS) lobectomy is beneficial in high-risk pulmonary patients...
  6. ncbi request reprint Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity
    Matthew F Kalady
    Department of Surgery, Duke University Medical Center and Durham VA Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 116:24-31. 2004
    ....
  7. ncbi request reprint Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses
    Zeinab Abdel-Wahab
    Department of Surgery, Duke University, Durham, NC 27710, USA
    J Surg Res 124:264-73. 2005
    ..Cotransfection of dendritic cells (DC) with MART-1 and constitutively active TLR4 (caTLR4) RNA enhances the maturation of DC...
  8. ncbi request reprint Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution
    Zeinab Abdel-Wahab
    Department of Surgery, Duke University Medical Center, P O Box 2624 MSRB, Durham, NC 27710, USA
    Cell Immunol 224:86-97. 2003
    ..The ease with which such a mutation can be made in RNA presents another potential advantage of using RNA for immunotherapy. Our results support considering this strategy for enhancing the immunogenicity of DC-based RNA vaccines...
  9. doi request reprint Risk factors for morbidity after lobectomy for lung cancer in elderly patients
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 88:1093-9. 2009
    ..Studies evaluating risk factors for complications after lobectomy in elderly patients have not adequately analyzed the effect of using minimally invasive approaches...
  10. ncbi request reprint Differential prognostic significance of extralobar and intralobar nodal metastases in patients with surgically resected stage II non-small cell lung cancer
    John C Haney
    Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC
    J Thorac Cardiovasc Surg 147:1164-8. 2014
    ..We sought to determine the prognostic significance of extralobar nodal metastases versus intralobar nodal metastases in patients with lung cancer and pathologic stage N1 disease...
  11. pmc Feasibility of hybrid thoracoscopic lobectomy and en-bloc chest wall resection
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Cardiothorac Surg 41:888-92. 2012
    ..We reviewed our experience with an en-bloc chest wall resection and lobectomy to evaluate the outcomes of a hybrid approach using thoracoscopic lobectomy combined with the chest wall resection where rib spreading is avoided...
  12. pmc Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma
    Xia Xu
    Department of Surgery, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 109:4910-5. 2012
    ..However, only type II cells appear to progress to adenocarcinoma...
  13. doi request reprint Thoracoscopic lobectomy is associated with lower morbidity compared with thoracotomy
    Nestor R Villamizar
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 138:419-25. 2009
    ..The incidence of postoperative complications has not been thoroughly assessed. This study analyzes morbidity after lobectomy to compare the thoracoscopic approach and thoracotomy...
  14. pmc A model for morbidity after lung resection in octogenarians
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Cardiothorac Surg 39:989-94. 2011
    ..Age is an important risk factor for morbidity after lung resection. This study was performed to identify specific risk factors for complications after lung resection in octogenarians...
  15. ncbi request reprint Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells
    Matthew F Kalady
    Department of General Surgery, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, USA
    J Gastrointest Surg 8:175-81; discussion 181-2. 2004
    ..These data suggest that total tumor RNA-pulsed dendritic cells may have potential as an adjuvant immunotherapy for patients with pancreatic cancer...
  16. doi request reprint Efficacy of mediastinal lymph node dissection during lobectomy for lung cancer by thoracoscopy and thoracotomy
    Thomas A D'Amico
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 92:226-31; discussion 231-2. 2011
    ..This study analyzed the National Comprehensive Cancer Network's (NCCN) NSCLC Database to compare the efficacy of MLND during lobectomy by video-assisted thoracoscopy surgery (VATS) and thoracotomy (open)...
  17. doi request reprint Does pneumonectomy have a role in the treatment of stage IIIA non-small cell lung cancer?
    Asad A Shah
    Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 95:1700-7. 2013
    ..The role of surgical resection for stage IIIA non-small cell lung cancer (NSCLC) is unclear. We sought to examine outcomes after pneumonectomy for patients with stage IIIA disease...
  18. doi request reprint Does method of sternal repair influence long-term outcome of postoperative mediastinitis?
    B Zane Atkins
    Department of Surgery, Durham Veterans Affairs Medical Center, Durham, NC, USA
    Am J Surg 202:565-7. 2011
    ..The aim of this study was to evaluate survival after different methods for sternal reconstruction in mediastinitis...
  19. pmc Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle
    Eric B Meltzer
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    BMC Med Genomics 4:70. 2011
    ..The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue...
  20. doi request reprint Persistent N2 disease after neoadjuvant chemotherapy for non-small-cell lung cancer
    Kristin A Higgins
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 142:1175-9. 2011
    ..How to best manage this latter group of patients is unknown, prompting a review of our institutional experience...
  21. pmc Pulmonary function tests do not predict pulmonary complications after thoracoscopic lobectomy
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:1044-51; discussion 1051-2. 2010
    ..Pulmonary function tests predict respiratory complications and mortality after lung resection through thoracotomy. We sought to determine the impact of pulmonary function tests upon complications after thoracoscopic lobectomy...
  22. ncbi request reprint Sex differences in early outcomes after lung cancer resection: Analysis of the Society of Thoracic Surgeons General Thoracic Database
    Betty C Tong
    Section of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC Electronic address
    J Thorac Cardiovasc Surg 148:13-8. 2014
    ..This study was undertaken to determine differences in perioperative outcomes after lung cancer surgery on the basis of sex...
  23. doi request reprint Outcomes after surgical management of synchronous bilateral primary lung cancers
    Asad A Shah
    Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 93:1055-60; discussion 1060. 2012
    ..The objective of this study is to examine outcomes associated with a strategy of performing staged bilateral resections in patients without N2 disease based on invasive mediastinal staging and without distant metastases...
  24. pmc Survival in the elderly after pneumonectomy for early-stage non-small cell lung cancer: a comparison with nonoperative management
    Paul J Speicher
    Department of Surgery, Duke University Medical Center, Durham, NC
    J Am Coll Surg 218:439-49. 2014
    ..The impact of age on long-term outcomes has not been well described. The purpose of this study was to quantify the impact of patient age on long-term survival after pneumonectomy for early-stage non-small cell lung cancer...
  25. pmc Perioperative management of patients on clopidogrel (Plavix) undergoing major lung resection
    Duykhanh P Ceppa
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 92:1971-6. 2011
    ..We reviewed our experience with patients treated with clopidogrel perioperatively to examine outcomes, including results of a new strategy for high-risk patients...
  26. pmc A comprehensive evaluation for aspiration after esophagectomy reduces the incidence of postoperative pneumonia
    Mark F Berry
    Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 140:1266-71. 2010
    ..This study assesses the effect of using a comprehensive swallowing evaluation before starting oral feedings on aspiration detection and pneumonia occurrence after esophagectomy...
  27. ncbi request reprint Robotic benign esophageal procedures
    Jennifer M Hanna
    Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Box 3305, Erwin Road, Durham, NC 21170, USA
    Thorac Surg Clin 24:223-9, vii. 2014
    ..Given the early application of the technology and paucity of clinical evidence, there are currently no procedures for which robotic esophageal surgery is the clinically proven preferred approach. ..
  28. ncbi request reprint Thoracoscopic lobectomy: a safe and effective strategy for patients with stage I lung cancer
    Larkin J Daniels
    Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 74:860-4. 2002
    ..Thoracoscopic lobectomy is emerging as a potential alternative to thoracotomy for early stage lung cancer. The issues of safety and oncologic efficacy should be analyzed before recommending this procedure for widespread use...
  29. doi request reprint How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM 6 and 7 systems
    Joseph M Pepek
    Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
    J Thorac Oncol 6:757-61. 2011
    ..To evaluate how well the tumor, node, metastasis (TNM) 6 and TNM 7 staging systems predict rates of local/regional recurrence (LRR) after surgery alone for non-small cell lung cancer...
  30. ncbi request reprint Iodine-131 metaiodobenzylguanidine treatment for metastatic carcinoid. Results in 98 patients
    Shawn D Safford
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Cancer 101:1987-93. 2004
    ..The authors now report their results on the therapeutic utility of high-dose 131I-MIBG treatment in a large group of patients with metastatic carcinoid tumors...
  31. doi request reprint Outcomes of video-assisted thoracoscopic decortication
    Betty C Tong
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:220-5. 2010
    ..This study compared indications for and outcomes associated with VATSD and OD...
  32. doi request reprint Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastases
    Mark W Onaitis
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 87:1684-8. 2009
    ..This study was undertaken to review a large series of resections of colorectal pulmonary metastases in the era of modern chemotherapy...
  33. doi request reprint Incorporating research into thoracic surgery practice
    Thomas A D'Amico
    Division of Thoracic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Thorac Surg Clin 21:369-77. 2011
    ..In addition to the rigors of conducting research, strategies for reserving protected time and obtaining grant support must be considered to be successful in academic surgery...
  34. ncbi request reprint Thoracoscopic approach to lobectomy for lung cancer does not compromise oncologic efficacy
    Mark F Berry
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina Electronic address
    Ann Thorac Surg 98:197-202. 2014
    ..We compared survival between video-assisted thoracoscopic surgery (VATS) and thoracotomy approaches to lobectomy for non-small cell lung cancer...
  35. ncbi request reprint Pancreatic duct strictures: identifying risk of malignancy
    Matthew F Kalady
    Department of Surgery, Duke University Medical Center, Box 3118, Durham, NC 27710, USA
    Ann Surg Oncol 11:581-8. 2004
    ..This study aimed to define PDS characteristics that predict malignancy and would thus invoke further diagnostic evaluation or aggressive treatment...
  36. pmc Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux
    Matthew G Hartwig
    Division of Thoracic Surgery, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 92:462-8; discussion; 468-9. 2011
    ..Gastroesophageal reflux disease (GERD) in lung recipients is associated with decreased survival and attenuated allograft function. This study evaluates fundoplication in preventing GERD-related allograft dysfunction...
  37. ncbi request reprint Carcinoid and chylous ascites: an unusual association
    Alan P Kypson
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gastrointest Surg 6:781-3. 2002
    ..Chylous ascites caused by carcinoid tumors is extremely rare. While carcinoid tumors usually have an indolent course, their association with chylous ascites is a harbinger of a poor outcome...
  38. ncbi request reprint Smoking cessation and the success of lung cancer surgery
    Loretta Erhunmwunsee
    Duke University Medical Center, Durham, NC 27710, USA
    Curr Oncol Rep 11:269-74. 2009
    ..Thus, smoking not only leads to lung cancer but also lowers the survival of those who undergo treatment of their cancer...
  39. ncbi request reprint Enhanced dendritic cell antigen presentation in RNA-based immunotherapy
    Matthew F Kalady
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 105:17-24. 2002
    ....
  40. ncbi request reprint CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy
    Mark W Onaitis
    Department of Surgery, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    Surgery 134:300-5. 2003
    ..This study evaluated the effects of exogenous soluble CD40 ligand (sCD40L) on RNA-transfected DC preparations and their subsequent ability to generate antimelanoma cytolytic T cells...
  41. pmc Evidence that SOX2 overexpression is oncogenic in the lung
    Yun Lu
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 5:e11022. 2010
    ..SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung...