Mark Onaitis

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle
    Eric B Meltzer
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    BMC Med Genomics 4:70. 2011
  2. doi request reprint Risk factors for atrial fibrillation after lung cancer surgery: analysis of the Society of Thoracic Surgeons general thoracic surgery database
    Mark Onaitis
    Department of Surgery, Duke University, DUMC Box 3305, Durham, NC 27710, USA
    Ann Thorac Surg 90:368-74. 2010
  3. doi request reprint Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastases
    Mark W Onaitis
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 87:1684-8. 2009
  4. pmc A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma
    Mark Onaitis
    Department of Surgery, Duke University, Durham, North Carolina, USA
    Ann Thorac Surg 91:1046-50; discussion 1050. 2011
  5. ncbi request reprint CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy
    Mark W Onaitis
    Department of Surgery, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    Surgery 134:300-5. 2003
  6. pmc Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:880-7. 2009
  7. doi request reprint Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery
    Madhav Swaminathan
    Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 91:1844-50. 2011
  8. pmc Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients
    Mark W Onaitis
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg 244:420-5. 2006
  9. doi request reprint Outcomes of video-assisted thoracoscopic decortication
    Betty C Tong
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:220-5. 2010
  10. pmc Pulmonary function tests do not predict pulmonary complications after thoracoscopic lobectomy
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:1044-51; discussion 1051-2. 2010

Collaborators

Detail Information

Publications29

  1. pmc Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principle
    Eric B Meltzer
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    BMC Med Genomics 4:70. 2011
    ..The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue...
  2. doi request reprint Risk factors for atrial fibrillation after lung cancer surgery: analysis of the Society of Thoracic Surgeons general thoracic surgery database
    Mark Onaitis
    Department of Surgery, Duke University, DUMC Box 3305, Durham, NC 27710, USA
    Ann Thorac Surg 90:368-74. 2010
    ..Atrial fibrillation is responsible for significant morbidity after lung cancer surgery, and preoperative and perioperative risk factors are not well described...
  3. doi request reprint Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastases
    Mark W Onaitis
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 87:1684-8. 2009
    ..This study was undertaken to review a large series of resections of colorectal pulmonary metastases in the era of modern chemotherapy...
  4. pmc A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma
    Mark Onaitis
    Department of Surgery, Duke University, Durham, North Carolina, USA
    Ann Thorac Surg 91:1046-50; discussion 1050. 2011
    ..By contrast, late progenitors are only able to produce alveolar cells. We sought to create a lung-specific progenitor cell signature for possible prognosis prediction in human lung cancer...
  5. ncbi request reprint CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy
    Mark W Onaitis
    Department of Surgery, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
    Surgery 134:300-5. 2003
    ..This study evaluated the effects of exogenous soluble CD40 ligand (sCD40L) on RNA-transfected DC preparations and their subsequent ability to generate antimelanoma cytolytic T cells...
  6. pmc Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:880-7. 2009
    ..Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass...
  7. doi request reprint Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgery
    Madhav Swaminathan
    Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 91:1844-50. 2011
    ....
  8. pmc Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patients
    Mark W Onaitis
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Ann Surg 244:420-5. 2006
    ..The outcomes after thoracoscopic lobectomy in patients with more complex pulmonary conditions are analyzed to determine safety, efficacy, and versatility...
  9. doi request reprint Outcomes of video-assisted thoracoscopic decortication
    Betty C Tong
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:220-5. 2010
    ..This study compared indications for and outcomes associated with VATSD and OD...
  10. pmc Pulmonary function tests do not predict pulmonary complications after thoracoscopic lobectomy
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:1044-51; discussion 1051-2. 2010
    ..Pulmonary function tests predict respiratory complications and mortality after lung resection through thoracotomy. We sought to determine the impact of pulmonary function tests upon complications after thoracoscopic lobectomy...
  11. ncbi request reprint Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses
    Zeinab Abdel-Wahab
    Department of Surgery, Duke University, Durham, NC 27710, USA
    J Surg Res 124:264-73. 2005
    ..Cotransfection of dendritic cells (DC) with MART-1 and constitutively active TLR4 (caTLR4) RNA enhances the maturation of DC...
  12. ncbi request reprint Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution
    Zeinab Abdel-Wahab
    Department of Surgery, Duke University Medical Center, P O Box 2624 MSRB, Durham, NC 27710, USA
    Cell Immunol 224:86-97. 2003
    ..The ease with which such a mutation can be made in RNA presents another potential advantage of using RNA for immunotherapy. Our results support considering this strategy for enhancing the immunogenicity of DC-based RNA vaccines...
  13. pmc A comprehensive evaluation for aspiration after esophagectomy reduces the incidence of postoperative pneumonia
    Mark F Berry
    Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 140:1266-71. 2010
    ..This study assesses the effect of using a comprehensive swallowing evaluation before starting oral feedings on aspiration detection and pneumonia occurrence after esophagectomy...
  14. ncbi request reprint Ileal pouch-anal anastomosis for ulcerative colitis and familial adenomatous polyposis: historical development and current status
    Mark W Onaitis
    Department of Surgery, Duke University, Durham, NC 27710, USA
    Ann Surg 238:S42-8. 2003
    ..Although research in this area will continue, the evolution of this operation has allowed it to become the gold standard for the treatment of ulcerative colitis and familial adenomatous polyposis...
  15. ncbi request reprint Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity
    Matthew F Kalady
    Department of Surgery, Duke University Medical Center and Durham VA Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 116:24-31. 2004
    ....
  16. pmc Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury
    David L McDonagh
    Department of Anesthesiology and Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 112:852-9. 2010
    ..Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation...
  17. doi request reprint Risk factors for morbidity after lobectomy for lung cancer in elderly patients
    Mark F Berry
    Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 88:1093-9. 2009
    ..Studies evaluating risk factors for complications after lobectomy in elderly patients have not adequately analyzed the effect of using minimally invasive approaches...
  18. ncbi request reprint The Kraske procedure: a critical analysis of a surgical approach for mid-rectal lesions
    Mark Onaitis
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Surg Oncol 94:194-202. 2006
    ..To analyze the Kraske procedure as an approach to mid-rectal disease...
  19. doi request reprint Thoracoscopic lobectomy is associated with lower morbidity compared with thoracotomy
    Nestor R Villamizar
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 138:419-25. 2009
    ..The incidence of postoperative complications has not been thoroughly assessed. This study analyzes morbidity after lobectomy to compare the thoracoscopic approach and thoracotomy...
  20. ncbi request reprint Thoracoscopic lobectomy: a safe and effective strategy for patients with stage I lung cancer
    Larkin J Daniels
    Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 74:860-4. 2002
    ..Thoracoscopic lobectomy is emerging as a potential alternative to thoracotomy for early stage lung cancer. The issues of safety and oncologic efficacy should be analyzed before recommending this procedure for widespread use...
  21. ncbi request reprint Enhanced dendritic cell antigen presentation in RNA-based immunotherapy
    Matthew F Kalady
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Surg Res 105:17-24. 2002
    ....
  22. pmc A randomized phase II study of immunization with dendritic cells modified with poxvectors encoding CEA and MUC1 compared with the same poxvectors plus GM-CSF for resected metastatic colorectal cancer
    Michael A Morse
    Departments of Medicine, Biostatistics and Bioinformatics, Surgery, Duke University Medical Center Duke Comprehensive Cancer Center, Department of Immunology, Duke University Medical Center, Durham, NC Georgetown University, Washington, DC MD Anderson Cancer Center, Houston, TX Wake Forest University Baptist Medical Center, Winston Salem, NC Earle Chiles Cancer Center, Providence Portland Medical Center, Portland, OR Medical University of South Carolina, Charleston, SC Moffitt Cancer Center, Tampa, FL Dr Chang is now with Virginia Oncology Associates, Newport News, VA Dr Clay is now with GlaxoSmithKline, Rixensart, Belgium
    Ann Surg 258:879-86. 2013
    ..To determine whether 1 of 2 vaccines based on dendritic cells (DCs) and poxvectors encoding CEA (carcinoembryonic antigen) and MUC1 (PANVAC) would lengthen survival in patients with resected metastases of colorectal cancer (CRC)...
  23. ncbi request reprint Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response
    Thomas A Aloia
    Division of Surgical Oncology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Arch Surg 140:1115-20. 2005
    ..Analysis of multiple clinical and pathological factors in patients undergoing therapeutic hyperthermic isolated limb perfusion for extremity melanoma can identify variables with prognostic significance...
  24. ncbi request reprint Immunotherapy of surgical malignancies
    Michael A Morse
    Duke University Medical Center, Durham, North Carolina, USA
    Curr Probl Surg 41:15-132. 2004
  25. pmc Evidence that SOX2 overexpression is oncogenic in the lung
    Yun Lu
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 5:e11022. 2010
    ..SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung...
  26. ncbi request reprint Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells
    Matthew F Kalady
    Department of General Surgery, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, USA
    J Gastrointest Surg 8:175-81; discussion 181-2. 2004
    ..These data suggest that total tumor RNA-pulsed dendritic cells may have potential as an adjuvant immunotherapy for patients with pancreatic cancer...
  27. ncbi request reprint Carcinoid and chylous ascites: an unusual association
    Alan P Kypson
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gastrointest Surg 6:781-3. 2002
    ..Chylous ascites caused by carcinoid tumors is extremely rare. While carcinoid tumors usually have an indolent course, their association with chylous ascites is a harbinger of a poor outcome...
  28. ncbi request reprint Smoking cessation and the success of lung cancer surgery
    Loretta Erhunmwunsee
    Duke University Medical Center, Durham, NC 27710, USA
    Curr Oncol Rep 11:269-74. 2009
    ..Thus, smoking not only leads to lung cancer but also lowers the survival of those who undergo treatment of their cancer...
  29. ncbi request reprint Pancreatic duct strictures: identifying risk of malignancy
    Matthew F Kalady
    Department of Surgery, Duke University Medical Center, Box 3118, Durham, NC 27710, USA
    Ann Surg Oncol 11:581-8. 2004
    ..This study aimed to define PDS characteristics that predict malignancy and would thus invoke further diagnostic evaluation or aggressive treatment...