Research Topics
| Mark OnaitisSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Bayesian probit regression model for the diagnosis of pulmonary fibrosis: proof-of-principleEric B Meltzer
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
BMC Med Genomics 4:70. 2011..The accurate diagnosis of idiopathic pulmonary fibrosis (IPF) is a major clinical challenge. We developed a model to diagnose IPF by applying Bayesian probit regression (BPR) modelling to gene expression profiles of whole lung tissue...- A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinomaMark Onaitis
Department of Surgery, Duke University, Durham, North Carolina, USA
Ann Thorac Surg 91:1046-50; discussion 1050. 2011..By contrast, late progenitors are only able to produce alveolar cells. We sought to create a lung-specific progenitor cell signature for possible prognosis prediction in human lung cancer... 
Risk factors for atrial fibrillation after lung cancer surgery: analysis of the Society of Thoracic Surgeons general thoracic surgery databaseMark Onaitis
Department of Surgery, Duke University, DUMC Box 3305, Durham, NC 27710, USA
Ann Thorac Surg 90:368-74. 2010..Atrial fibrillation is responsible for significant morbidity after lung cancer surgery, and preoperative and perioperative risk factors are not well described...- Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastasesMark W Onaitis
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 87:1684-8. 2009..This study was undertaken to review a large series of resections of colorectal pulmonary metastases in the era of modern chemotherapy... 
CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapyMark W Onaitis
Department of Surgery, Duke University and Durham VA Medical Centers, Durham, NC 27710, USA
Surgery 134:300-5. 2003..sCD40L should be considered a crucial adjuvant in DC preparations for RNA-based DC vaccine therapies...- Utility of a simple algorithm to grade diastolic dysfunction and predict outcome after coronary artery bypass graft surgeryMadhav Swaminathan
Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 91:1844-50. 2011.... - Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgeryJoseph P Mathew
Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
Stroke 40:880-7. 2009..Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass... - Outcomes of video-assisted thoracoscopic decorticationBetty C Tong
Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 89:220-5. 2010..This study compared indications for and outcomes associated with VATSD and OD... - Pulmonary function tests do not predict pulmonary complications after thoracoscopic lobectomyMark F Berry
Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 89:1044-51; discussion 1051-2. 2010..Pulmonary function tests predict respiratory complications and mortality after lung resection through thoracotomy. We sought to determine the impact of pulmonary function tests upon complications after thoracoscopic lobectomy... - Ileal pouch-anal anastomosis for ulcerative colitis and familial adenomatous polyposis: historical development and current statusMark W Onaitis
Department of Surgery, Duke University, Durham, NC 27710, USA
Ann Surg 238:S42-8. 2003..Although research in this area will continue, the evolution of this operation has allowed it to become the gold standard for the treatment of ulcerative colitis and familial adenomatous polyposis... - Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicityMatthew F Kalady
Department of Surgery, Duke University Medical Center and Durham VA Medical Center, Durham, North Carolina 27710, USA
J Surg Res 116:24-31. 2004..This strategy should be considered in the future development of RNA-based DC vaccine strategies for the treatment of cancer... - Thoracoscopic lobectomy is a safe and versatile procedure: experience with 500 consecutive patientsMark W Onaitis
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Ann Surg 244:420-5. 2006..The outcomes after thoracoscopic lobectomy in patients with more complex pulmonary conditions are analyzed to determine safety, efficacy, and versatility... - Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitutionZeinab Abdel-Wahab
Department of Surgery, Duke University Medical Center, P O Box 2624 MSRB, Durham, NC 27710, USA
Cell Immunol 224:86-97. 2003..The ease with which such a mutation can be made in RNA presents another potential advantage of using RNA for immunotherapy. Our results support considering this strategy for enhancing the immunogenicity of DC-based RNA vaccines... - Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responsesZeinab Abdel-Wahab
Department of Surgery, Duke University, Durham, NC 27710, USA
J Surg Res 124:264-73. 2005..These results demonstrate the possibility of enhancing the immunogenicity of the native MART-1 and other RNA derived from weakly immunogenic tumors in DC-based immunotherapy... - A comprehensive evaluation for aspiration after esophagectomy reduces the incidence of postoperative pneumoniaMark F Berry
Division of Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Thorac Cardiovasc Surg 140:1266-71. 2010..This study assesses the effect of using a comprehensive swallowing evaluation before starting oral feedings on aspiration detection and pneumonia occurrence after esophagectomy... - Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injuryDavid L McDonagh
Department of Anesthesiology and Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Anesthesiology 112:852-9. 2010..Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation... - Risk factors for morbidity after lobectomy for lung cancer in elderly patientsMark F Berry
Department of Surgery, Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 88:1093-9. 2009..Studies evaluating risk factors for complications after lobectomy in elderly patients have not adequately analyzed the effect of using minimally invasive approaches... - The Kraske procedure: a critical analysis of a surgical approach for mid-rectal lesionsMark Onaitis
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Surg Oncol 94:194-202. 2006..However, it does carry a moderate complication rate and thus should be utilized selectively in managing patients with mid-rectal tumors not amenable to other treatment options... - Thoracoscopic lobectomy: a safe and effective strategy for patients with stage I lung cancerLarkin J Daniels
Division of Cardiothoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Ann Thorac Surg 74:860-4. 2002..Long-term follow-up is required to determine if recurrence rate and 5-year survival are comparable with thoracotomy for lobectomy... - Enhanced dendritic cell antigen presentation in RNA-based immunotherapyMatthew F Kalady
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Surg Res 105:17-24. 2002..This combination of strategies may be used to enhance immune responses to RNA-based dendritic cell vaccines... - Thoracoscopic lobectomy is associated with lower morbidity compared with thoracotomyNestor R Villamizar
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Thorac Cardiovasc Surg 138:419-25. 2009..The incidence of postoperative complications has not been thoroughly assessed. This study analyzes morbidity after lobectomy to compare the thoracoscopic approach and thoracotomy... - Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor responseThomas A Aloia
Division of Surgical Oncology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Arch Surg 140:1115-20. 2005.... - Immunotherapy of surgical malignanciesMichael A Morse
Duke University Medical Center, Durham, North Carolina, USA
Curr Probl Surg 41:15-132. 2004 - Smoking cessation and the success of lung cancer surgeryLoretta Erhunmwunsee
Duke University Medical Center, Durham, NC 27710, USA
Curr Oncol Rep 11:269-74. 2009..Thus, smoking not only leads to lung cancer but also lowers the survival of those who undergo treatment of their cancer... - Evidence that SOX2 overexpression is oncogenic in the lungYun Lu
Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
PLoS ONE 5:e11022. 2010..SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung... - Pancreatic duct strictures: identifying risk of malignancyMatthew F Kalady
Department of Surgery, Duke University Medical Center, Box 3118, Durham, NC 27710, USA
Ann Surg Oncol 11:581-8. 2004..05 with irregular branches). CONCLUSIONS: This study demonstrates that certain characteristics of PDS can predict the subset of patients who have an increased risk of cancer... - Carcinoid and chylous ascites: an unusual associationAlan P Kypson
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Gastrointest Surg 6:781-3. 2002..Chylous ascites caused by carcinoid tumors is extremely rare. While carcinoid tumors usually have an indolent course, their association with chylous ascites is a harbinger of a poor outcome... - Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cellsMatthew F Kalady
Department of General Surgery, Duke University and Durham VA Medical Centers, Durham, North Carolina 27710, USA
J Gastrointest Surg 8:175-81; discussion 181-2. 2004..These data suggest that total tumor RNA-pulsed dendritic cells may have potential as an adjuvant immunotherapy for patients with pancreatic cancer...