CHRISTOPHER M O'CONNOR

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Impact of serial troponin release on outcomes in patients with acute heart failure: analysis from the PROTECT pilot study
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Circ Heart Fail 4:724-32. 2011
  2. pmc Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 5:63-71. 2012
  3. ncbi request reprint Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure
    Karen E Joynt
    Department of Medicine Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 93:783-5. 2004
  4. doi request reprint Mode of death and hospitalization from the Second Follow-up Serial Infusions of Nesiritide (FUSION II) trial and comparison of clinical events committee adjudicated versus investigator reported outcomes
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 108:1449-57. 2011
  5. doi request reprint Influence of global region on outcomes in heart failure β-blocker trials
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Division of Cardiology, Division of Clinical Pharmacology, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 58:915-22. 2011
  6. doi request reprint Effect of nesiritide in patients with acute decompensated heart failure
    C M O'Connor
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    N Engl J Med 365:32-43. 2011
  7. doi request reprint Covariate adjustment in heart failure randomized controlled clinical trials: a case analysis of the HF-ACTION trial
    CHRISTOPHER M O'CONNOR
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Heart Fail Clin 7:497-500. 2011
  8. ncbi request reprint Impact of nonfatal myocardial infarction on outcomes in patients with advanced heart failure and the effect of bucindolol therapy
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 95:558-64. 2005
  9. pmc Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, 2400 North Pratt Street, Box 3356, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 55:872-8. 2010
  10. pmc Antidepressant use, depression, and survival in patients with heart failure
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, 2400 N Pratt St, Box 3356, Durham, NC 27705, USA
    Arch Intern Med 168:2232-7. 2008

Research Grants

  1. ACTION - A CHF Trial Investigating Outcomes of Exercise
    CHRISTOPHER O CONNOR; Fiscal Year: 2007
  2. Heart Failure Clinical Research Network - RCC
    CHRISTOPHER O CONNOR; Fiscal Year: 2007

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. doi request reprint Impact of serial troponin release on outcomes in patients with acute heart failure: analysis from the PROTECT pilot study
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    Circ Heart Fail 4:724-32. 2011
    ..The degree and progression of cTnT release during hospitalization of patients with AHF is unclear. We evaluated the incidence of cTnT release during AHF hospitalization and the relationship of cTnT release with outcomes...
  2. pmc Factors related to morbidity and mortality in patients with chronic heart failure with systolic dysfunction: the HF-ACTION predictive risk score model
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 5:63-71. 2012
    ....
  3. ncbi request reprint Effect of angiotensin-converting enzyme inhibitors, beta blockers, statins, and aspirin on C-reactive protein levels in outpatients with heart failure
    Karen E Joynt
    Department of Medicine Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 93:783-5. 2004
    ..Baseline angiotensin-converting enzyme inhibitor plus beta-blocker use were associated with lower levels of CRP; no relation was found between CRP levels and aspirin or statin use...
  4. doi request reprint Mode of death and hospitalization from the Second Follow-up Serial Infusions of Nesiritide (FUSION II) trial and comparison of clinical events committee adjudicated versus investigator reported outcomes
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 108:1449-57. 2011
    ..40, McNemar p = 0.001) and 75% agreement (25% disagreement) between the investigators and the clinical events committee on cardiac classification for hospitalization (κ = 0.49, McNemar p <0.0001)...
  5. doi request reprint Influence of global region on outcomes in heart failure β-blocker trials
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Division of Cardiology, Division of Clinical Pharmacology, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 58:915-22. 2011
    ..We sought to describe the United States and the rest of the world (ROW) outcomes from the major β-blocker heart failure (HF) trials...
  6. doi request reprint Effect of nesiritide in patients with acute decompensated heart failure
    C M O'Connor
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    N Engl J Med 365:32-43. 2011
    ..Nesiritide is approved in the United States for early relief of dyspnea in patients with acute heart failure. Previous meta-analyses have raised questions regarding renal toxicity and the mortality associated with this agent...
  7. doi request reprint Covariate adjustment in heart failure randomized controlled clinical trials: a case analysis of the HF-ACTION trial
    CHRISTOPHER M O'CONNOR
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Heart Fail Clin 7:497-500. 2011
    ..This article reviews the HF-ACTION trial to better understand whether covariate adjustment should be prespecified as the primary end point in HF clinical trials...
  8. ncbi request reprint Impact of nonfatal myocardial infarction on outcomes in patients with advanced heart failure and the effect of bucindolol therapy
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 95:558-64. 2005
    ..Beta-blocker therapy with bucindolol appears to attenuate the risk of nonfatal MI in this population...
  9. pmc Triage after hospitalization with advanced heart failure: the ESCAPE (Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness) risk model and discharge score
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, Duke University Medical Center, 2400 North Pratt Street, Box 3356, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 55:872-8. 2010
    ..Identifying high-risk heart failure (HF) patients at hospital discharge may allow more effective triage to management strategies...
  10. pmc Antidepressant use, depression, and survival in patients with heart failure
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, 2400 N Pratt St, Box 3356, Durham, NC 27705, USA
    Arch Intern Med 168:2232-7. 2008
    ..Because depression has also been shown to be associated with increased mortality in these patients, it remains unclear if this association is attributable to the use of antidepressants or to depression...
  11. ncbi request reprint Predictors of mortality after discharge in patients hospitalized with heart failure: an analysis from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 156:662-73. 2008
    ..We developed clinical models predictive of short-term clinical outcomes in a broad patient population discharged after hospitalization for HF...
  12. pmc Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 301:1439-50. 2009
    ..Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes...
  13. ncbi request reprint Inotropic drugs and neurohormonal antagonists in the treatment of HF in the elderly
    CHRISTOPHER M O'CONNOR
    Division of Clinical Pharmacology, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27710, USA
    Clin Geriatr Med 23:141-53. 2007
    ..The purpose of this article is to review recent studies on inotropic drugs and neurohormonal antagonists used in the treatment of patients who have HF, especially the elderly...
  14. ncbi request reprint Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST)
    C M O'Connor
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 138:78-86. 1999
    ..To evaluate clinical characteristics and outcomes of patients with advanced heart failure receiving intravenous continuous dobutamine in the FIRST Trial (Flolan International Randomized Survival Trial)...
  15. ncbi request reprint The new heart failure guidelines: strategies for implementation
    CHRISTOPHER M O'CONNOR
    Division of Clinical Pharmacology, Duke University Medical Center, Durham, NC 27705, USA
    Am Heart J 153:2-5. 2007
    ..Systematic processes are effective approaches to ensuring appropriate evidence-based therapies are prescribed in most patients...
  16. ncbi request reprint Clinical characteristics and long-term outcomes of patients with heart failure and preserved systolic function
    C M O'Connor
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina, USA
    Am J Cardiol 86:863-7. 2000
    ..Furthermore, several clinical and angiographic characteristics are predictive of long-term survival...
  17. doi request reprint Lessons learned from clinical trials in acute heart failure: phase 3 drug trials
    CHRISTOPHER M O'CONNOR
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Heart Fail Clin 7:451-6. 2011
    ..This article describes in detail these important aspects of conducting phase 3 clinical trials in an acute heart failure population...
  18. ncbi request reprint Tezosentan in patients with acute heart failure and acute coronary syndromes: design of the Randomized Intravenous Tezosentan study (RITZ-4)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center and Duke Clinical Research Institute, Durham, University of North Carolina, Chapel Hill, NC 27705, USA
    Am Heart J 144:583-8. 2002
    ..Tezosentan is a dual endothelin receptor antagonist, and it has improved cardiac output and reduced pulmonary and systemic vascular resistance in experimental animal models and in initial human acute decompensated heart failure studies...
  19. ncbi request reprint Tezosentan in patients with acute heart failure and acute coronary syndromes: design of the fourth Randomized Intravenous Tezosentan Study (RITZ-4)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 145:S58-9. 2003
  20. ncbi request reprint Comparison of two aspirin doses on ischemic stroke in post-myocardial infarction patients in the warfarin (Coumadin) Aspirin Reinfarction Study (CARS)
    C M O'Connor
    Department of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Cardiol 88:541-6. 2001
    ..The results of this secondary analysis suggest that aspirin 160 mg is more effective than aspirin 80 mg + warfarin 1 mg in preventing ischemic stroke in post-myocardial infarction patients...
  21. pmc Worsening depressive symptoms are associated with adverse clinical outcomes in patients with heart failure
    Andrew Sherwood
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 57:418-23. 2011
    ..The purpose of this study was to assess the impact of changes in symptoms of depression over a 1-year period on subsequent clinical outcomes in heart failure (HF) patients...
  22. ncbi request reprint Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 296:2217-26. 2006
    ..The association between systolic blood pressure (SBP) at admission, clinical characteristics, and outcomes in patients hospitalized for heart failure who have reduced or relatively preserved systolic function has not been well studied...
  23. pmc Markers of decongestion, dyspnea relief, and clinical outcomes among patients hospitalized with acute heart failure
    Robb D Kociol
    Duke Clinical Research Institute, Durham, NC, USA
    Circ Heart Fail 6:240-5. 2013
    ....
  24. ncbi request reprint Racial differences in the characteristics of patients admitted for acute decompensated heart failure and their relation to outcomes: results from the OPTIME-CHF trial
    Melvin R Echols
    Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Card Fail 12:684-8. 2006
    ..Recent data suggest that differences in response to therapy and survival exist between African Americans and Caucasians with heart failure. Whether these differences exist in acute decompensated heart failure (ADHF) is uncertain...
  25. ncbi request reprint Relationship between depressive symptoms and long-term mortality in patients with heart failure
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 154:102-8. 2007
    ..The study sought to assess the association of depressive symptoms and long-term mortality of patients with HF and to explore the prognostic predictability of the Beck Depression Inventory (BDI) scale for patients with HF...
  26. doi request reprint Dosing of beta-blocker therapy before, during, and after hospitalization for heart failure (from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure)
    Gregg C Fonarow
    Department of Medicine, UCLA Medical Center, Los Angeles, CA, USA
    Am J Cardiol 102:1524-9. 2008
    ..In the first 60 to 90 days after hospital discharge, little up-titration in beta-blocker dosing occurs. Further efforts are needed to help understand and overcome this beta-blocker titration gap...
  27. ncbi request reprint Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF Registry
    Gregg C Fonarow
    Ahmanson UCLA Cardiomyopathy Center, Department of Medicine, UCLA Medical Center, Los Angeles, California 90095 1679, USA
    J Am Coll Cardiol 50:768-77. 2007
    ..We sought to evaluate the characteristics, treatments, and outcomes of patients with preserved and reduced systolic function heart failure (HF)...
  28. doi request reprint Comparison of medical therapy dosing in outpatients cared for in cardiology practices with heart failure and reduced ejection fraction with and without device therapy: report from IMPROVE HF
    J Thomas Heywood
    Division of Cardiology, Scripps Clinic Torrey Pines, La Jolla, Calif 92037, USA
    Circ Heart Fail 3:596-605. 2010
    ..Few data exist to characterize the delivery of evidence-based medical therapy for outpatients with heart failure who have received implantable cardioverter-defibrillators or cardiac resynchronization therapy (CRT) for systolic dysfunction...
  29. ncbi request reprint Tezosentan in patients with acute heart failure and acute coronary syndromes: results of the Randomized Intravenous TeZosentan Study (RITZ-4)
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina 27705, USA
    J Am Coll Cardiol 41:1452-7. 2003
    ..We sought to determine the effect of tezosentan in patients with acute decompensated heart failure (HF) associated with acute coronary syndrome (ACS)...
  30. doi request reprint Predictors of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)
    William T Abraham
    Division of Cardiology, The Ohio State University, Columbus, Ohio, USA
    J Am Coll Cardiol 52:347-56. 2008
    ..The aim of this study was to develop a clinical model predictive of in-hospital mortality in a broad hospitalized heart failure (HF) patient population...
  31. ncbi request reprint Influence of a performance-improvement initiative on quality of care for patients hospitalized with heart failure: results of the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF)
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, 10833 LeConte Ave, Room 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Arch Intern Med 167:1493-502. 2007
    ..We sought to evaluate the effect of a national hospital-based initiative on quality of care in patients hospitalized with HF...
  32. ncbi request reprint Demographics, clinical characteristics, and outcomes of patients hospitalized for decompensated heart failure: observations from the IMPACT-HF registry
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Division of Cardiology, Duke University Medical Center and Clinical Research Institute, 2400 N Pratt Street, Durham, NC 27705, USA
    J Card Fail 11:200-5. 2005
    ....
  33. doi request reprint Ischemia change in stable coronary artery disease is an independent predictor of death and myocardial infarction
    Afshin Farzaneh-Far
    Section of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    JACC Cardiovasc Imaging 5:715-24. 2012
    ..The aim of this study was to evaluate the independent prognostic significance of ischemia change in stable coronary artery disease (CAD)...
  34. pmc Galectin-3 in ambulatory patients with heart failure: results from the HF-ACTION study
    G Michael Felker
    Duke University Medical Center, Durham, NC 27710, USA
    Circ Heart Fail 5:72-8. 2012
    ..We evaluated the association between galectin-3 and long-term clinical outcomes in ambulatory heart failure patients enrolled in the HF-ACTION study...
  35. ncbi request reprint Usefulness of anemia as a predictor of death and rehospitalization in patients with decompensated heart failure
    G Michael Felker
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Am J Cardiol 92:625-8. 2003
    ..Lower baseline hemoglobin is associated with risk of short-term adverse clinical outcomes in this population, even after controlling for other baseline differences...
  36. ncbi request reprint Prognostic value of anxiety and depression in patients with chronic heart failure
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 110:3452-6. 2004
    ..In a secondary analysis of data collected for a published study of depression and prognosis in patients with CHF, we examined the relations among anxiety, depression, and prognosis...
  37. pmc The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure
    Tariq Ahmad
    Division of Cardiology, Duke University Medical Center, Durham, NC Duke Clinical Research Institute, Durham, NC
    Am Heart J 167:193-202.e1. 2014
    ..Whether exercise training leads to improvements in biomarkers and how such improvements relate to clinical outcomes are unclear...
  38. pmc Predictors of early dyspnoea relief in acute heart failure and the association with 30-day outcomes: findings from ASCEND-HF
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Eur J Heart Fail 15:456-64. 2013
    ..To examine the characteristics associated with early dyspnoea relief during acute heart failure (HF) hospitalization, and its association with 30-day outcomes...
  39. ncbi request reprint Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: the ESCAPE trial
    Cynthia Binanay
    Duke Clinical Research Institute, Durham, NC, USA
    JAMA 294:1625-33. 2005
    ..Pulmonary artery catheters (PACs) have been used to guide therapy in multiple settings, but recent studies have raised concerns that PACs may lead to increased mortality in hospitalized patients...
  40. ncbi request reprint Rationale and design of the pilot randomized study of nesiritide versus dobutamine in heart failure (PRESERVD-HF)
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University, Feinberg School of Medicine, Chicago, Ill 60611, USA
    Am Heart J 145:S55-7. 2003
  41. pmc Association of depression and survival in patients with chronic heart failure over 12 Years
    Julie Adams
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Psychosomatics 53:339-46. 2012
    ..To examine the relationship between depression and survival in patients with chronic heart failure (HF) over a 12-year follow-up period...
  42. pmc N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 158:S37-44. 2009
    ..To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure...
  43. ncbi request reprint Mortality risk associated with ejection fraction differs across resting nuclear perfusion findings
    Jamieson M Bourque
    Division of Cardiology, Department of Internal Medicine, Duke University Health System, Durham, NC, USA
    J Nucl Cardiol 14:165-73. 2007
    ..The purpose of this study was to determine whether the mortality risk associated with LVEF is the same across all values of SRS in a population undergoing evaluation for ischemic heart disease...
  44. doi request reprint Improving evidence-based care for heart failure in outpatient cardiology practices: primary results of the Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting (IMPROVE HF)
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Circulation 122:585-96. 2010
    ....
  45. pmc Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failure
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 158:S64-71. 2009
    ..We examined associations between patient-reported measures of health-related quality of life and clinical indicators of disease severity in a large, heterogeneous sample of patients with heart failure...
  46. ncbi request reprint Factors identified as precipitating hospital admissions for heart failure and clinical outcomes: findings from OPTIMIZE-HF
    Gregg C Fonarow
    Department of Medicine, UCLA University of California, Los Angeles Medical Center, Los Angeles, CA 90095 1679, USA
    Arch Intern Med 168:847-54. 2008
    ..This study evaluated the association between precipitating factors identified at the time of HF hospital admission and subsequent clinical outcomes...
  47. ncbi request reprint The Initiation Management Predischarge Process for Assessment of Carvedilol Therapy for Heart Failure (IMPACT-HF) Study: design and implications
    Wendy A Gattis
    Department of Medicine, Divisions of Clinical Pharmacology and Cardiology, Duke University Medical Center, Durham, North Carolina, USA
    Rev Cardiovasc Med 3:S48-54. 2002
    ..The trial data will determine if in-hospital initiation of beta-blocker therapy is effective at improving the long-term use of pharmacologic agents proven to reduce morbidity and mortality...
  48. ncbi request reprint Clinical and economic implications of the Multicenter Automatic Defibrillator Implantation Trial-II
    Sana M Al-Khatib
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Intern Med 142:593-600. 2005
    ..3 or less...
  49. ncbi request reprint Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial
    Wendy A Gattis
    Division of Cardiology, Duke University Medical Center and Duke Clinical Research Institute, Durham, North Carolina, USA
    J Am Coll Cardiol 43:1534-41. 2004
    ....
  50. ncbi request reprint Risk stratification after hospitalization for decompensated heart failure
    G Michael Felker
    Duke Clinical Research Institute, 2400 Pratt Street, Room 0311, Terrace Level, Durham, NC 27705, USA
    J Card Fail 10:460-6. 2004
    ..We used data from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study to develop a model that would predict outcomes in patients with decompensated HF...
  51. ncbi request reprint Prognosis of patients taking selective serotonin reuptake inhibitors before coronary artery bypass grafting
    Glen L Xiong
    Department of Internal Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 98:42-7. 2006
    ..26 to 1.70, p <0.0001, respectively). In conclusion, SSRI use before CABG was associated with a higher risk of long-term post-CABG mortality and rehospitalization. The explanation behind these findings requires further research...
  52. ncbi request reprint Effect of exercise training on ventricular function, dyssynchrony, resting myocardial perfusion, and clinical outcomes in patients with heart failure: a nuclear ancillary study of Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Tra
    Daniel R Bensimhon
    Moses Cone Hospital, Greensboro, NC, USA
    Am Heart J 154:46-53. 2007
    ....
  53. pmc Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION)
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 165:193-9. 2013
    ..The aim of this study was to investigate the clinical characteristics, exercise training response, β-blocker selectivity, and outcomes in patients with heart failure (HF) and chronic obstructive pulmonary disease (COPD)...
  54. doi request reprint Influence of beta-blocker continuation or withdrawal on outcomes in patients hospitalized with heart failure: findings from the OPTIMIZE-HF program
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, Los Angeles, California 90095 1679, USA
    J Am Coll Cardiol 52:190-9. 2008
    ..This study ascertains the relationship between continuation or withdrawal of beta-blocker therapy and clinical outcomes in patients hospitalized with systolic heart failure (HF)...
  55. ncbi request reprint Predicting significant coronary artery disease in patients with left ventricular dysfunction
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 152:340-7. 2006
    ..The objective of this study was to develop a model to assist clinicians in determining the likelihood of CAD before cardiac catheterization...
  56. ncbi request reprint The Pilot Randomized Study of Nesiritide Versus Dobutamine in Heart Failure (PRESERVD-HF)
    Mihai Gheorghiade
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Am J Cardiol 96:18G-25G. 2005
    ..Accordingly, therapies for AHFS that are aimed at improving hemodynamics may affect long-term prognosis by either injuring or salvaging myocardium...
  57. doi request reprint B-type natriuretic peptide assessment in ambulatory heart failure patients: insights from IMPROVE HF
    Andrew P Ambrosy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    J Cardiovasc Med (Hagerstown) 13:360-7. 2012
    ....
  58. ncbi request reprint Implications of elevated cardiac troponin T in ambulatory patients with heart failure: a prospective analysis
    Michael P Hudson
    Duke Clinical Research Institute, Durham, NC, USA
    Am Heart J 147:546-52. 2004
    ..We assessed whether elevated TnT levels are associated with the severity, etiology, and prognosis of HF in stable, ambulatory patients...
  59. doi request reprint Design and rationale of the PROTECT study: a placebo-controlled randomized study of the selective A1 adenosine receptor antagonist rolofylline for patients hospitalized with acute decompensated heart failure and volume overload to assess treatment effect
    Beth Davison Weatherley
    Momentum Research, Inc, Durham, NC
    J Card Fail 16:25-35. 2010
    ....
  60. pmc Long-term survival of patients with ischemic cardiomyopathy treated by coronary artery bypass grafting versus medical therapy
    Eric J Velazquez
    Division of Cardiovascular Medicine, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:523-30. 2012
    ....
  61. pmc Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    JAMA 301:1451-9. 2009
    ..Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent...
  62. doi request reprint Day of admission and clinical outcomes for patients hospitalized for heart failure: findings from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients With Heart Failure (OPTIMIZE-HF)
    Gregg C Fonarow
    Department of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095 1679, USA
    Circ Heart Fail 1:50-7. 2008
    ..This study examined the relationship between the day of the week patients are hospitalized for HF and death rate, length of stay (LOS), and rehospitalization rate...
  63. pmc Long-term outcomes and costs of ventricular assist devices among Medicare beneficiaries
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 300:2398-406. 2008
    ..In 2003, Medicare expanded coverage of ventricular assist devices as destination, or permanent, therapy for end-stage heart failure. Little is known about the long-term outcomes and costs associated with these devices...
  64. ncbi request reprint Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Galter 10 240, 201 E Huron Street, Chicago, IL 60611, USA
    Eur Heart J 28:980-8. 2007
    ..The predictive value of hyponatraemia has not been evaluated in unselected patients hospitalized with heart failure...
  65. ncbi request reprint Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis
    Kirkwood F Adams
    Department of Medicine and Radiology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27517, USA
    J Am Coll Cardiol 46:497-504. 2005
    ..The purpose of this study was to investigate the relationship of serum digoxin concentration (SDC) and outcomes in women with heart failure (HF)...
  66. doi request reprint Atrial fibrillation or flutter on initial electrocardiogram is associated with worse outcomes in patients admitted for worsening heart failure with reduced ejection fraction: findings from the EVEREST Trial
    Robert J Mentz
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 164:884-92.e2. 2012
    ..However, the clinical profile and outcomes of patients following hospitalization for HF with AF/AFL on initial electrocardiogram (ECG) has not been well studied...
  67. ncbi request reprint The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment
    Gad Cotter
    Momentum Research, Inc, Durham, North Carolina, USA
    J Card Fail 14:631-40. 2008
    ..Although not powered around any specific hypothesis, this pilot study was designed to identify an efficacious dose while refining inclusion criteria and end points...
  68. ncbi request reprint Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure
    Benjamin H Trichon
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Am J Cardiol 91:538-43. 2003
    ..MR is common in patients with LV systolic dysfunction and heart failure. After adjusting for other clinical variables, the presence of MR independently predicted worsened survival...
  69. doi request reprint Factors associated with improvement in ejection fraction in clinical practice among patients with heart failure: findings from IMPROVE HF
    Jane E Wilcox
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am Heart J 163:49-56.e2. 2012
    ..This study evaluated changes in LVEF and associated factors in outpatients with systolic HF or post-myocardial infarction with reduced LVEF during 24 months of follow-up...
  70. ncbi request reprint A smoker's paradox in patients hospitalized for heart failure: findings from OPTIMIZE-HF
    Gregg C Fonarow
    Department of Medicine, UCLA Medical Center, Los Angeles, CA, USA
    Eur Heart J 29:1983-91. 2008
    ..This study aimed to ascertain the relationship between smoking and clinical outcomes in patients hospitalized with heart failure (HF)...
  71. ncbi request reprint Anemia in patients with heart failure and preserved systolic function
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 151:457-62. 2006
    ..Although heart failure in the setting of preserved systolic function (PSF) is an important clinical problem, the relationship between anemia and outcomes in patients with PSF has not been carefully evaluated...
  72. pmc Admission, discharge, or change in B-type natriuretic peptide and long-term outcomes: data from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF) linked to Medicare claims
    Robb D Kociol
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 4:628-36. 2011
    ..It is unknown if admission, discharge, or change from admission to discharge BNP measure is the most important predictor of long-term outcomes...
  73. doi request reprint Early worsening heart failure in patients admitted with acute heart failure--a new outcome measure associated with long-term prognosis?
    Beth Davison Weatherley
    Momentum Research Inc, Durham, NC, USA
    Fundam Clin Pharmacol 23:633-9. 2009
    ..7-6.3). Early WHF is a common adverse event in patients admitted with AHF, and is associated with AHF severity and excessive 6-month mortality. WHF should be considered as a clinically important endpoint in AHF studies...
  74. ncbi request reprint Usefulness of an elevated troponin-I in predicting clinical events in patients admitted with acute heart failure and acute coronary syndrome (from the RITZ-4 trial)
    Wendy A Gattis
    Duke Clinical Research Institute, Duke University Medical Center, 2400 N Pratt Street, Box 17969, Durham, NC 27710, USA
    Am J Cardiol 93:1436-7, A10. 2004
    ..One hundred ninety-two patients were enrolled in this study. Patients with baseline cTnI values were included in this analysis, and the relation between cTnI and the composite clinical primary end point of RITZ-4 was evaluated...
  75. ncbi request reprint Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 153:201-11. 2007
    ..Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial...
  76. ncbi request reprint Improving the use of evidence-based heart failure therapies in the outpatient setting: the IMPROVE HF performance improvement registry
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, Los Angeles, CA 90095 1679, USA
    Am Heart J 154:12-38. 2007
    ..Deidentified clinical data from the medical records of a planned 43,000 patients from 160 US cardiology practices will be included in this study...
  77. pmc Effect of peripheral arterial disease on functional and clinical outcomes in patients with heart failure (from HF-ACTION)
    W Schuyler Jones
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 108:380-4. 2011
    ..62, p = 0.011). Patients with PAD and HF had deceased baseline exercise capacity and decreased response to exercise training. In conclusion, PAD is an independent predictor of all-cause death or hospitalization in patients with HF...
  78. ncbi request reprint The primary and secondary prevention of coronary artery disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Richard C Becker
    Duke Cardiovascular Thrombosis Center, Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, USA
    Chest 133:776S-814S. 2008
    ..For primary prevention in patients with moderate risk for a coronary event, we recommend aspirin, 75-100 mg/d, over either no antithrombotic therapy or vitamin K antagonist (Grade 1A)...
  79. ncbi request reprint Importance of echocardiography in patients with severe nonischemic heart failure: the second Prospective Randomized Amlodipine Survival Evaluation (PRAISE-2) echocardiographic study
    Christopher H Cabell
    Duke University School of Medicine, Durham, NC, USA
    Am Heart J 147:151-7. 2004
    ....
  80. pmc Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Tr
    Allen E Atchley
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 158:S53-63. 2009
    ..This article addresses the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) gated SPECT imaging (gSPECT) substudy baseline results...
  81. ncbi request reprint Clinical outcomes in patients on beta-blocker therapy admitted with worsening chronic heart failure
    Wendy A Gattis
    Duke University Medical Center Duke Clinical Research Institute, Division of Cardiology, Durham, North Carolina 27705, USA
    Am J Cardiol 91:169-74. 2003
    ..These results also suggest that caution should be taken when withdrawing beta blockade in this population...
  82. doi request reprint Heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Circ Heart Fail 1:98-106. 2008
    ..IMPROVE HF is a prospective cohort study designed to characterize current management of patients with chronic HF and ejection fraction < or =35% in a national registry of 167 US outpatient cardiology practices...
  83. pmc Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am Heart J 163:20-6. 2012
    ..Depression is a risk factor of MSIMI. The REMIT trial investigates whether selective serotonin reuptake inhibitor (SSRI) treatment can improve MSIMI. The rationale and outline of the study are described...
  84. doi request reprint Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program
    CHRISTOPHER M O'CONNOR
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 159:841-849.e1. 2010
    ..To the best of our knowledge, there has been no systematic analysis of the causes of death and rehospitalization in this patient population...
  85. ncbi request reprint Clinical characteristics and referral pattern of patients with left ventricular dysfunction and significant coronary artery disease undergoing radionuclide imaging
    Jamieson M Bourque
    Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Nucl Cardiol 11:118-25. 2004
    ..All of these differences must be incorporated into proper outcomes examinations. We sought to identify the nuclear perfusion imaging referral pattern for patients with left ventricular (LV) dysfunction and significant CAD...
  86. pmc Relation between dose of loop diuretics and outcomes in a heart failure population: results of the ESCAPE trial
    Vic Hasselblad
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Eur J Heart Fail 9:1064-9. 2007
    ..We examined the relation of maximal in-hospital diuretic dose to weight loss, changes in renal function, and mortality in hospitalised heart failure (HF) patients...
  87. doi request reprint Association of weight change with subsequent outcomes in patients hospitalized with acute decompensated heart failure
    Rajendra H Mehta
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 103:76-81. 2009
    ..e., death and/or rehospitalization) in patients with HF in the design of treatment strategies for novel therapeutic agents in randomized controlled clinical trials...
  88. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  89. pmc Relationship of technetium-99m tetrofosmin-gated rest single-photon emission computed tomography myocardial perfusion imaging to death and hospitalization in heart failure patients: results from the nuclear ancillary study of the HF-ACTION trial
    Allen E Atchley
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 161:1038-45. 2011
    ....
  90. ncbi request reprint The association between depression and chronic kidney disease and mortality among patients hospitalized with congestive heart failure
    S Susan Hedayati
    Department of Medicine, Division of Nephrology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 44:207-15. 2004
    ..The point prevalence of depression and its relationship to poor outcomes among patients with chronic kidney disease (CKD) has not been fully characterized...
  91. ncbi request reprint Heart failure etiology and response to milrinone in decompensated heart failure: results from the OPTIME-CHF study
    G Michael Felker
    Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Cardiol 41:997-1003. 2003
    ..The goal of this study was to assess the interaction between heart failure (HF) etiology and response to milrinone in decompensated HF...
  92. pmc High mortality without ESCAPE: the registry of heart failure patients receiving pulmonary artery catheters without randomization
    Larry A Allen
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    J Card Fail 14:661-9. 2008
    ..The external validity of these findings is debated...
  93. ncbi request reprint Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial
    Michael S Cuffe
    Northwestern University Medical School, Division of Cardiology, 201 E Huron St, Galter 10 240, Chicago, IL 60611, USA
    JAMA 287:1541-7. 2002
    ..Although intravenous inotropic therapy usually produces beneficial hemodynamic effects and is labeled for use in the care of such patients, the effect of such therapy on intermediate-term clinical outcomes is uncertain...
  94. ncbi request reprint Overview of current noninodilator therapies for acute heart failure syndromes
    Wendy Gattis Stough
    Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 96:41G-6G. 2005
    ....
  95. ncbi request reprint Clinical effectiveness of implantable cardioverter-defibrillators among medicare beneficiaries with heart failure
    Adrian F Hernandez
    Duke Clinical Research Institute, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
    Circ Heart Fail 3:7-13. 2010
    ..The clinical effectiveness of implantable cardioverter-defibrillators (ICDs) in older patients with heart failure has not been established, and older patients have been underrepresented in previous studies...
  96. ncbi request reprint Rapid clinical assessment of patients with acute heart failure: first blood pressure and oxygen saturation--is that all we need?
    Olga Milo-Cotter
    Momentum Research Inc, 3100 Tower Blvd, Suite 802, Durham, NC 27707, USA
    Cardiology 114:75-82. 2009
    ..Low oxygen saturation (SaO2) and systolic blood pressure (SBP) are signs of impending respiratory and circulatory failure that can be obtained quickly in patients with AHF...
  97. doi request reprint Associations between outpatient heart failure process-of-care measures and mortality
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, Los Angeles, CA 90095 1679, USA
    Circulation 123:1601-10. 2011
    ..However, this association has not been evaluated for current and emerging outpatient HF measures...
  98. pmc Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 56:692-9. 2010
    ..The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo...
  99. ncbi request reprint Dissociation between hemodynamic changes and symptom improvement in patients with advanced congestive heart failure
    Monica R Shah
    Duke Clinical Research Institute, P O Box 17969, Durham, NC 27715, USA
    Eur J Heart Fail 4:297-304. 2002
    ..Changes in hemodynamic measures often serve as surrogate end points in efficacy trials for advanced heart failure, although there are few objective data to support this practice...
  100. doi request reprint Troponin elevation in heart failure prevalence, mechanisms, and clinical implications
    Robb D Kociol
    Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    J Am Coll Cardiol 56:1071-8. 2010
    ..Ultimately, this information might allow physicians to guide therapy, choose appropriate therapeutics, and improve HF outcomes...
  101. pmc STICH (Surgical Treatment for Ischemic Heart Failure) trial enrollment
    Robert H Jones
    Division of Cardiothoracic Surgery Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Cardiol 56:490-8. 2010
    ..The aim of this study was to assess the influence of enrolling site location and enrollment performance on the generalizability of STICH (Surgical Treatment for Ischemic Heart Failure) trial results...

Research Grants4

  1. ACTION - A CHF Trial Investigating Outcomes of Exercise
    CHRISTOPHER O CONNOR; Fiscal Year: 2007
    ..The trial will take place over 5 years with an initial 6 months for planning, training, and implementation; 3 years of enrollment; 1 year of follow-up; and 6 months for close out, analysis, and presentation. ..
  2. Heart Failure Clinical Research Network - RCC
    CHRISTOPHER O CONNOR; Fiscal Year: 2007
    ..The successful accomplishment of these aims will be a significant contribution to both the Heart Failure Network and the overall care of patients with heart failure. (End of Abstract) ..