Sean M O'Brien

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint An empirically based tool for analyzing mortality associated with congenital heart surgery
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Thorac Cardiovasc Surg 138:1139-53. 2009
  2. doi request reprint Statistical issues in the analysis and interpretation of outcomes for congenital cardiac surgery
    Sean M O'Brien
    Department of Biostatistics and Bioinformatics and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Cardiol Young 18:145-51. 2008
  3. doi request reprint Impact of case volume on hospital performance assessment
    Sean M O'Brien
    Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA
    Arch Intern Med 168:1277-84. 2008
  4. ncbi request reprint Accuracy of the aristotle basic complexity score for classifying the mortality and morbidity potential of congenital heart surgery operations
    Sean M O'Brien
    Duke University Medical Center, Durham, North Carolina, USA
    Ann Thorac Surg 84:2027-37; discussion 2027-37. 2007
  5. ncbi request reprint Exploring the behavior of hospital composite performance measures: an example from coronary artery bypass surgery
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 116:2969-75. 2007
  6. pmc The complex relationship between center volume and outcome in patients undergoing the Norwood operation
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1556-62. 2012
  7. pmc Comparative analysis of antifibrinolytic medications in pediatric heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
    J Thorac Cardiovasc Surg 143:550-7. 2012
  8. pmc Perioperative methylprednisolone and outcome in neonates undergoing heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA
    Pediatrics 129:e385-91. 2012
  9. pmc Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes
    Michelle C Wallace
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 91:1445-52. 2011
  10. ncbi request reprint Quality measurement in adult cardiac surgery: part 2--Statistical considerations in composite measure scoring and provider rating
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Ann Thorac Surg 83:S13-26. 2007

Detail Information

Publications38

  1. doi request reprint An empirically based tool for analyzing mortality associated with congenital heart surgery
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Thorac Cardiovasc Surg 138:1139-53. 2009
    ..Our goal was to create an objective, empirically based index that can be used to identify the statistically estimated risk of in-hospital mortality by procedure and to group procedures into risk categories...
  2. doi request reprint Statistical issues in the analysis and interpretation of outcomes for congenital cardiac surgery
    Sean M O'Brien
    Department of Biostatistics and Bioinformatics and Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Cardiol Young 18:145-51. 2008
    ..Concepts are illustrated using artificial data from two hypothetical hospitals, as well as real data from a multi-institution registry...
  3. doi request reprint Impact of case volume on hospital performance assessment
    Sean M O'Brien
    Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA
    Arch Intern Med 168:1277-84. 2008
    ..Process performance measures are increasingly used to assess and reward hospital quality. The impact of small hospital case volumes on such measures is not clear...
  4. ncbi request reprint Accuracy of the aristotle basic complexity score for classifying the mortality and morbidity potential of congenital heart surgery operations
    Sean M O'Brien
    Duke University Medical Center, Durham, North Carolina, USA
    Ann Thorac Surg 84:2027-37; discussion 2027-37. 2007
    ..This collaborative study combined two multiinstitution databases to assess how well the ABC score predicts the actual morbidity and mortality potential of 131 congenital heart surgery procedures...
  5. ncbi request reprint Exploring the behavior of hospital composite performance measures: an example from coronary artery bypass surgery
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 116:2969-75. 2007
    ..Although the HQID composite calculation is straightforward and easily understood, its method of combining process and outcome measures has not been validated...
  6. pmc The complex relationship between center volume and outcome in patients undergoing the Norwood operation
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1556-62. 2012
    ..We evaluated the impact of patient risk status on the relationship between center volume and outcome, and the extent to which differences in center volume account for between-center variation in outcome...
  7. pmc Comparative analysis of antifibrinolytic medications in pediatric heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
    J Thorac Cardiovasc Surg 143:550-7. 2012
    ..We performed a comparative analysis in a large multicenter cohort...
  8. pmc Perioperative methylprednisolone and outcome in neonates undergoing heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA
    Pediatrics 129:e385-91. 2012
    ..We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates...
  9. pmc Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes
    Michelle C Wallace
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 91:1445-52. 2011
    ..We evaluated variation in age, weight, and weight-for-age z-score at Fontan across institutions, and the impact of these variables on postoperative morbidity and mortality...
  10. ncbi request reprint Quality measurement in adult cardiac surgery: part 2--Statistical considerations in composite measure scoring and provider rating
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Ann Thorac Surg 83:S13-26. 2007
  11. pmc Postoperative inotrope and vasopressor use following CABG: outcome data from the CAPS-care study
    Judson B Williams
    Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    J Card Surg 26:572-8. 2011
    ..Limited clinical data exist to guide practice patterns and evidence-based use of inotropes and vasopressors following coronary artery bypass grafting (CABG)...
  12. pmc Association of center volume with mortality and complications in pediatric heart surgery
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Pediatrics 129:e370-6. 2012
    ..We examined this association in a large multicenter cohort...
  13. pmc Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome
    Jason N Johnson
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    J Thorac Cardiovasc Surg 139:1205-10. 2010
    ..We describe center variation in delayed sternal closure after stage 1 palliation and associated outcomes...
  14. pmc Relative impact of surgeon and center volume on early mortality after the Norwood operation
    Christoph P Hornik
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1992-7. 2012
    ..We evaluated the relative impact of surgeon and center volume on mortality in a large Norwood cohort...
  15. doi request reprint Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database
    James C Fudge
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    Pediatrics 126:315-22. 2010
    ..We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery...
  16. pmc Major infection after pediatric cardiac surgery: a risk estimation model
    Gregory M Barker
    Duke University Medical Center, Durham, North Carolina, USA
    Ann Thorac Surg 89:843-50. 2010
    ..In pediatric cardiac surgery, infection is a leading cause of morbidity and mortality. We created a model to predict risk of major infection in this population...
  17. doi request reprint The Society of Thoracic Surgeons 2008 cardiac surgery risk models: part 2--isolated valve surgery
    Sean M O'Brien
    Duke Clinical Research Institute, Durham, North Carolina, USA
    Ann Thorac Surg 88:S23-42. 2009
    ..Expanding upon existing valve models, the new STS models include several nonfatal complications in addition to mortality...
  18. ncbi request reprint Long-term survival after aortic valve replacement among high-risk elderly patients in the United States: insights from the Society of Thoracic Surgeons Adult Cardiac Surgery Database, 1991 to 2007
    J Matthew Brennan
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Circulation 126:1621-9. 2012
    ....
  19. doi request reprint Reoperation for bleeding in patients undergoing coronary artery bypass surgery: incidence, risk factors, time trends, and outcomes
    Rajendra H Mehta
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 2:583-90. 2009
    ..Reoperation for bleeding represents an important complication in patients undergoing coronary artery bypass surgery (CABG). Yet, few studies have characterized risk factors and patient outcomes of this event...
  20. doi request reprint Clinical characteristics and in-hospital outcomes of patients with cardiogenic shock undergoing coronary artery bypass surgery: insights from the Society of Thoracic Surgeons National Cardiac Database
    Rajendra H Mehta
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 117:876-85. 2008
    ..There exist few studies that characterize contemporary clinical features and outcomes or risk factors for operative mortality in cardiogenic shock (CS) patients undergoing coronary artery bypass grafting (CABG)...
  21. doi request reprint Evaluation of failure to rescue as a quality metric in pediatric heart surgery: an analysis of the STS Congenital Heart Surgery Database
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27715, USA
    Ann Thorac Surg 94:573-9; discussion 579-80. 2012
    ..It is unknown whether this holds true in pediatric heart surgery. We characterized the relationship between complications, FTR, and mortality in this population...
  22. doi request reprint Variation in perioperative vasoactive therapy in cardiovascular surgical care: data from the Society of Thoracic Surgeons
    Adrian F Hernandez
    Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 158:47-52. 2009
    ..The appropriate use of vasoactive cardiovascular drugs in high-risk coronary artery bypass grafting (CABG) patients has not been well characterized...
  23. pmc Association between endoscopic vs open vein-graft harvesting and mortality, wound complications, and cardiovascular events in patients undergoing CABG surgery
    Judson B Williams
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 308:475-84. 2012
    ..The safety and durability of endoscopic vein graft harvest in coronary artery bypass graft (CABG) surgery has recently been called into question...
  24. ncbi request reprint A decade of short-term outcomes in post cardiac surgery ventricular assist device implantation: data from the Society of Thoracic Surgeons' National Cardiac Database
    Adrian F Hernandez
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    Circulation 116:606-12. 2007
    ..We examined a large national clinical database to assess trends in the incidence of post-cardiac surgery shock requiring VAD implantation, survival rates, and risk factors for mortality...
  25. doi request reprint Cardiac surgery in infants with low birth weight is associated with increased mortality: analysis of the Society of Thoracic Surgeons Congenital Heart Database
    Christopher L Curzon
    Department of Pediatrics, Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 135:546-51. 2008
    ....
  26. pmc Contemporary results for proximal aortic replacement in North America
    Judson B Williams
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Am Coll Cardiol 60:1156-62. 2012
    ..The purpose of this study was to characterize operative outcomes for ascending aorta and arch replacement on a national scale and to develop risk models for mortality and major morbidity...
  27. pmc Complications after the Norwood operation: an analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database
    Christoph P Hornik
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
    Ann Thorac Surg 92:1734-40. 2011
    ..Limited multicenter data exist regarding the prevalence of postoperative complications after the Norwood operation and their associated mortality risk...
  28. doi request reprint Association between physician billing and cardiac stress testing patterns following coronary revascularization
    Bimal R Shah
    Duke Clinical Research Institute and Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina 27705, USA
    JAMA 306:1993-2000. 2011
    ..The degree to which financial factors may influence use of cardiac stress imaging procedures is unknown...
  29. pmc Care models and associated outcomes in congenital heart surgery
    Danielle S Burstein
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Pediatrics 127:e1482-9. 2011
    ..The impact of this trend on patient outcomes is unclear. We evaluated postoperative outcomes associated with a CICU versus other ICU models...
  30. pmc Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 160:1099-104. 2010
    ....
  31. doi request reprint Comparison of composite measure methodologies for rewarding quality of care: an analysis from the American Heart Association's Get With The Guidelines program
    Zubin J Eapen
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC
    Circ Cardiovasc Qual Outcomes 4:610-8. 2011
    ..We sought to conduct an observational analysis to determine the influence of the opportunity-based and all-or-none composite performance measures on hospital rankings...
  32. ncbi request reprint Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery
    Rajendra H Mehta
    Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 114:2208-16; quiz 2208. 2006
    ..Estimation of an individual patient's risk for postoperative dialysis can support informed clinical decision making and patient counseling...
  33. doi request reprint Variation in use of blood transfusion in coronary artery bypass graft surgery
    Elliott Bennett-Guerrero
    Division of Perioperative Clinical Research, Duke Clinical Research Institute, Duke University Medical Center, PO Box 3094, Durham, NC 27710, USA
    JAMA 304:1568-75. 2010
    ..Perioperative blood transfusions are costly and have safety concerns. As a result, there have been multiple initiatives to reduce transfusion use. However, the degree to which perioperative transfusion rates vary among hospitals is unknown...
  34. ncbi request reprint Contemporary performance of surgical ventricular restoration procedures: data from the Society of Thoracic Surgeons' National Cardiac Database
    Adrian F Hernandez
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Am Heart J 152:494-9. 2006
    ..We sought to characterize the performance of SVR nationally and describe the acute risks of mortality and major morbidity plus predictors of adverse outcomes...
  35. pmc Relationship of the time interval between cardiac catheterization and elective coronary artery bypass surgery with postprocedural acute kidney injury
    Rajendra H Mehta
    Duke Clinical Research Institute, Box 17969, Durham, NC 27715, USA
    Circulation 124:S149-55. 2011
    ..However, these studies, because of the small number of patients, were unable to adequately account for patient case-mix and included both those undergoing elective surgery and those undergoing urgent surgery...
  36. ncbi request reprint Clinical predictors of major infections after cardiac surgery
    Vance G Fowler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 112:I358-65. 2005
    ....
  37. doi request reprint Patterns of cardiac stress testing after revascularization in community practice
    Bimal R Shah
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA
    J Am Coll Cardiol 56:1328-34. 2010
    ..The purpose of this study was to determine the pattern of cardiac stress testing after coronary revascularization in community practice...
  38. doi request reprint Do physicians' attitudes toward implantable cardioverter defibrillator therapy vary by patient age, gender, or race?
    Sana M Al-Khatib
    Duke Cardiovascular Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Durham, NC, USA
    Ann Noninvasive Electrocardiol 16:77-84. 2011
    ..We assessed whether physicians' recommendation for ICD therapy varies as a function of patient age, gender, race, and physician's specialty...