Research Topics
| MOHAMED A contact NOORSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Simulating natural conditions in the laboratory: a re-examination of sexual isolation between sympatric and allopatric populations of Drosophila pseudoobscura and D. persimilisMohamed A F Noor
Department of Biological Sciences, Louisiana State University, Baton Rouge, 70803, USA
Behav Genet 36:322-7. 2006..Our results confirm the existence of a geographic pattern in sexual isolation in D. pseudoobscura, and we discuss differences in experimental designs in light of the biology of this species...- Gene transposition as a cause of hybrid sterility in DrosophilaJohn P Masly
Department of Biology, University of Rochester, Rochester, NY 14627, USA
Science 313:1448-50. 2006..simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution... 
Data sharing: how much doesn't get submitted to GenBank?Mohamed A F Noor
PLoS Biol 4:e228. 2006- What can you do with 0.1x genome coverage? A case study based on a genome survey of the scuttle fly Megaselia scalaris (Phoridae)David A Rasmussen
Department of Biology, Duke University, Durham, NC 27708, USA
BMC Genomics 10:382. 2009..Here, using a random pyrosequencing approach, we sequence the genome of the scuttle fly Megaselia scalaris and evaluate the utility of our low-coverage GSS approach... - Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3Nikolai P Kandul
Biology Department, Duke University, PO Box 90338, FFSC 4244, Durham, NC 27708, USA
BMC Genet 10:67. 2009..melanogaster. Although Bru-3's structure is expected to be conducive to AS, only two ASTs of this gene were previously described... - No evidence for learned mating discrimination in male Drosophila pseudoobscuraNikolai P Kandul
DCMB Group, Department of Biology, Box 91000, Duke University, Durham, NC 27708, USA
BMC Evol Biol 6:54. 2006..This ability of males to discriminate against heterospecific courtship may be advantageous in populations where two species co-occur if courtship or mating is costly... - Evolutionary genetics: jumping into a new speciesMohamed A F Noor
Duke University, Department of Biology, DCMB Group, Box 91000, Durham, North Carolina 27708, USA
Curr Biol 16:R890-2. 2006..A new study finds a dramatic increase in transposable element numbers in three new sunflower hybrid species, and may suggest a novel role for transposable elements in speciation... - A kingpin of academic inclusive fitness: the history and contributions of Bruce GrantMohamed A F Noor
DCMB Group/Biology, Duke University, Durham, North Carolina 27708, USA
Genetics 171:867-71. 2005 - Speciation genetics: evolving approachesMohamed A F Noor
DCMB Group Biology Department, Duke University, Box 91000, Durham, North Carolina 27708, USA
Nat Rev Genet 7:851-61. 2006.... - Connecting recombination, nucleotide diversity and species divergence in DrosophilaMohamed A F Noor
Biology Department, Duke University, Durham, North Carolina 27708, USA
Fly (Austin) 2:255-6. 2008.... - Divergence between the Drosophila pseudoobscura and D. persimilis genome sequences in relation to chromosomal inversionsMohamed A F Noor
Biology Department, Duke University, Durham, North Carolina 27708, USA
Genetics 177:1417-28. 2007..This reliance highlights the need for complementary genomic and population genetic approaches for tackling fundamental evolutionary questions such as speciation... - Patterns of evolution of genes disrupted in expression in Drosophila species hybridsMohamed A F Noor
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Genet Res 85:119-25. 2005..Alternative explanations are also considered... - Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces speciesMohamed A F Noor
Biology Department, Duke University, Durham, North Carolina, USA
Mol Biol Evol 25:2439-44. 2008..This study demonstrates that the association between interspecies nucleotide divergence and local recombination rates is not always a reliable indicator of recombination's mutagenicity... - A reversible color polyphenism in American peppered moth (Biston betularia cognataria) caterpillarsMohamed A F Noor
Biology Department, College of William and Mary in Virginia, Williamsburg, Virginia, United States of America
PLoS ONE 3:e3142. 2008..Given their broad host range, this directly induced color polyphenism likely provides the caterpillars with strong protection from bird predation... - Islands of speciation or mirages in the desert? Examining the role of restricted recombination in maintaining speciesM A F Noor
Biology Department, Duke University, Durham, NC 27708, USA
Heredity (Edinb) 103:439-44. 2009..We conclude by discussing strengths and weaknesses of various means for testing the role of restricted recombination in maintaining species... - Genome-wide patterns of expression in Drosophila pure species and hybrid males. II. Examination of multiple-species hybridizations, platforms, and life cycle stagesAmanda J Moehring
DCMB Group Biology, Duke University, USA
Mol Biol Evol 24:137-45. 2007..Further study of these misexpressed loci may allow us to identify precisely where disruptions in the spermatogenesis pathway occur... - Gene expression divergence and the origin of hybrid dysfunctionsDaniel Ortiz-Barrientos
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Genetica 129:71-81. 2007..Ultimately, we hope more functional genetic studies will complement our understanding of the genetic disruptions leading to hybrid dysfunctions and their role in the origin of species... - Multilocus test for introgression between the cactophilic species Drosophila mojavensis and Drosophila arizonaeBrian A Counterman
Levine Science Research Center, Developmental, Cell, and Molecular Biology Group, Box 91000, Duke University, Durham, North Carolina 27708, USA
Am Nat 168:682-96. 2006.... - Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilisCarlos A Machado
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 175:1289-306. 2007..persimilis and near one breakpoint, consistent with a scenario in which this inversion arose and was fixed in this species by natural selection... - The genetics of hybrid male sterility between the allopatric species pair Drosophila persimilis and D. pseudoobscura bogotana: dominant sterility alleles in collinear autosomal regionsAudrey S Chang
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Genetics 176:343-9. 2007..persimilis and D. pseudoobscura pseudoobscura. The autosomal loci identified in this study provide the basis for introgression mapping and, ultimately, for molecular cloning of interacting genes that contribute to F(1) hybrid sterility... - Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergenceRob J Kulathinal
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 105:10051-6. 2008..We propose that it is not cross-overs per se that are mutagenic, but rather repair of DNA double-strand break precursors via crossing over and gene conversion... - Failure to replicate two mate preference QTLs across multiple strains of Drosophila pseudoobscuraCallie V Barnwell
Biology Department, Duke University, Box 90338, Durham, NC 27708, USA
J Hered 99:653-6. 2008..pseudoobscura, although other explanations for the inconsistency are possible. These results underscore the need to examine multiple strains across a species when describing the genetic variation underlying behavioral traits... - Evolution of genes and genomes on the Drosophila phylogenyAndrew G Clark
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 450:203-18. 2007..These may prove to underlie differences in the ecology and behaviour of these diverse species... - A recombinational portrait of the Drosophila pseudoobscura genomeDaniel Ortiz-Barrientos
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Genet Res 87:23-31. 2006..Finally, the online Appendix presents 200 primer sequence pairs for molecular markers that can be used for mapping of quantitative trait loci, of which 125 are known to be polymorphic within or between species... - The evolution of conspecific sperm precedence in DrosophilaSheri M Dixon
Department of Biological Sciences, Life Sciences Building, Louisiana State University, Baton Rouge, LA 70803, USA
Mol Ecol 12:1179-84. 2003..These pairs of taxa are already separated by mating discrimination and/or hybrid sterility, so our observation suggests that conspecific sperm precedence does not always evolve before other barriers to gene exchange... - Variability on the dot chromosome in the Drosophila simulans cladeMohamed A F Noor
Department of Biological Sciences, Life Sciences Bldg, Louisiana State University, Baton Rouge, LA 70803, USA
Genetica 118:51-8. 2003..Overall, none of the data analyzed were consistent with recent introgression exclusively between D. simulans and D. mauritiana... - Genome-wide patterns of expression in Drosophila pure species and hybrid malesPawel Michalak
Department of Biological Sciences, Louisiana State University, USA
Mol Biol Evol 20:1070-6. 2003..Furthermore, genes that are expressed primarily or exclusively in males, including several involved in spermatogenesis, are disproportionately misexpressed in hybrids, suggesting a possible genetic cause for their sterility... - Evolutionary biology: Genes to make new speciesMohamed A F Noor
Nature 423:699-700. 2003 - Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilisMohamed A F Noor
Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
Genetics 165:1823-30. 2003..pseudoobscura lineage and that its underexpression in sterile hybrid males may cause an overproduction of TRAP100 protein, possibly yielding deleterious effects... - Using comparative genomic data to test for fast-X evolutionBrian A Counterman
Department of Biological Sciences, Louisiana State University, Life Sciences Building, Baton Rouge, Louisiana 70803, USA
Evolution Int J Org Evolution 58:656-60. 2004.... - A microsatellite linkage map of Drosophila mojavensisRegina Staten
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
BMC Genet 5:12. 2004..Drosophila mojavensis has been a model system for genetic studies of ecological adaptation and speciation. However, despite its use for over half a century, no linkage map has been produced for this species or its close relatives... - A test of the chromosomal rearrangement model of speciation in Drosophila pseudoobscuraKirsten M Brown
Department of Biological Sciences, Louisiana State University, Life Sciences Bldg, Baton Rouge, Louisiana 70803, USA
Evolution Int J Org Evolution 58:1856-60. 2004..p. pseudoobscura and D. persimilis, suggesting chromosomal rearrangements may facilitate species persistence despite hybridization... - Little qualitative RNA misexpression in sterile male F1 hybrids of Drosophila pseudoobscura and D. persimilisJane Reiland
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
BMC Evol Biol 2:16. 2002..Here, we study genome-wide patterns of expression in Drosophila pseudoobscura, D. persimilis, and their sterile F1 hybrid males using differential display... - Association of misexpression with sterility in hybrids of Drosophila simulansand D. mauritianaPawel Michalak
J Mol Evol 59:277-82. 2004.... - Evidence for a one-allele assortative mating locusDaniel Ortiz-Barrientos
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Science 310:1467. 2005..persimilis. This observation suggests that the type of genetic variation that is most conducive to controversial modes of speciation with gene flow, such as reinforcement or sympatric speciation, is present in nature... - The genetics of speciation by reinforcementDaniel Ortiz-Barrientos
Department of Biological Sciences, Louisiana State University, Baton Rouge, USA
PLoS Biol 2:e416. 2004.... - Likelihoods from summary statistics: recent divergence between speciesScotland C Leman
Institute of Statistics and Decision Sciences, Duke University, Durham, North Carolina 27708, USA
Genetics 171:1419-36. 2005..Our results for the complete data set also compare well with those obtained through Metropolis-Hastings sampling of fully resolved genealogies of entire nucleotide sequences... - Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolutionStephen Richards
Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston Texas 77030, USA
Genome Res 15:1-18. 2005..Overall, a pattern of repeat-mediated chromosomal rearrangement, and high coadaptation of both male genes and cis-regulatory sequences emerges as important themes of genome divergence between these species of Drosophila... - Recombination and the divergence of hybridizing speciesDaniel Ortiz-Barrientos
Department of Biological Sciences, 107 Life Sciences Building, Louisiana State University, Baton Rouge, LA 70803, USA
Genetica 116:167-78. 2002..Finally, we recommend recombination to be a focus of inquiry when studying the origins of biological diversity... - Variation in recombination rate may bias human genetic disease mapping studiesA Susannah Boyle
Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
Genetica 122:245-52. 2004..Future genetic mapping studies should be conscious of this potential complication by noting the regional recombination rate of regions implicated in diseases... - Fine-scale crossover rate heterogeneity in Drosophila pseudoobscuraElizabeth T Cirulli
J Mol Evol 64:129-35. 2007..These sequence features may contribute to broad-scale variation in crossover rate and, thus, shed light on features associated with crossover rate heterogeneity at a genome-wide scale... - Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical mapsStephen W Schaeffer
Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 179:1601-55. 2008..Despite the conservation of genes within homologous chromosome arms across species, the karyotypes of these species have changed through the fusion of chromosomal arms followed by subsequent rearrangement events... - Localization and characterization of X chromosome inversion breakpoints separating Drosophila mojavensis and Drosophila arizonaeElizabeth T Cirulli
University Program in Genetics and Genomics, Duke University, Durham, NC 27708, USA
J Hered 98:111-4. 2007..The localization of these inversion breakpoints will facilitate future genetic and molecular evolutionary studies in this species group, an emerging model system for ecological genetics... - Genetics of incipient speciation in Drosophila mojavensis. I. Male courtship song, mating success, and genotype x environment interactionsWilliam J Etges
Program in Ecology and Evolutionary Biology, Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, USA
Evolution 61:1106-19. 2007..Understanding the genetics of incipient speciation in D. mojavensis clearly depends on cactus-specific expression of traits associated with courtship behavior and sexual isolation... - Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association eventsCatherine Situma
Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA
Anal Biochem 363:35-45. 2007..The fru gene functions in the central nervous system, where it is necessary for sex determination and male courtship behavior, whereas the OdsH gene is involved in the regulation of transcription...
Research Grants
- Genetics of mate discrimination in Drosophila pseudoobscuraMOHAMED NOOR; Fiscal Year: 2007..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
- Genetics of speciation in Drosophila pseudoobscuraMOHAMED A NOOR; Fiscal Year: 2010..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
- Fine-scale recombination, variation, divergence, and codon bias in DrosophilaMOHAMED A contact NOOR; Fiscal Year: 2010....
- Fine-scale recombination, variation, divergence, and codon bias in DrosophilaMOHAMED NOOR; Fiscal Year: 2009....