MOHAMED A contact NOOR

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Simulating natural conditions in the laboratory: a re-examination of sexual isolation between sympatric and allopatric populations of Drosophila pseudoobscura and D. persimilis
    Mohamed A F Noor
    Department of Biological Sciences, Louisiana State University, Baton Rouge, 70803, USA
    Behav Genet 36:322-7. 2006
  2. ncbi request reprint Gene transposition as a cause of hybrid sterility in Drosophila
    John P Masly
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 313:1448-50. 2006
  3. pmc Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana
    Audrey S Chang
    Biology Department, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 5:e15377. 2010
  4. pmc How hot are drosophila hotspots? examining recombination rate variation and associations with nucleotide diversity, divergence, and maternal age in Drosophila pseudoobscura
    Brenda Manzano-Winkler
    Biology Department, Duke University, Durham, North Carolina, USA
    PLoS ONE 8:e71582. 2013
  5. pmc Gene expression disruptions of organism versus organ in Drosophila species hybrids
    Daniel J Catron
    Biology Department, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 3:e3009. 2008
  6. pmc The genomics of speciation in Drosophila: diversity, divergence, and introgression estimated using low-coverage genome sequencing
    Rob J Kulathinal
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    PLoS Genet 5:e1000550. 2009
  7. pmc Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2
    Sarah M Bennett
    Biology Department, Duke University, Durham, North Carolina, USA
    PLoS ONE 5:e11006. 2010
  8. pmc Data sharing: how much doesn't get submitted to GenBank?
    Mohamed A F Noor
    PLoS Biol 4:e228. 2006
  9. pmc What can you do with 0.1x genome coverage? A case study based on a genome survey of the scuttle fly Megaselia scalaris (Phoridae)
    David A Rasmussen
    Department of Biology, Duke University, Durham, NC 27708, USA
    BMC Genomics 10:382. 2009
  10. pmc Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3
    Nikolai P Kandul
    Biology Department, Duke University, PO Box 90338, FFSC 4244, Durham, NC 27708, USA
    BMC Genet 10:67. 2009

Detail Information

Publications50

  1. ncbi request reprint Simulating natural conditions in the laboratory: a re-examination of sexual isolation between sympatric and allopatric populations of Drosophila pseudoobscura and D. persimilis
    Mohamed A F Noor
    Department of Biological Sciences, Louisiana State University, Baton Rouge, 70803, USA
    Behav Genet 36:322-7. 2006
    ..Our results confirm the existence of a geographic pattern in sexual isolation in D. pseudoobscura, and we discuss differences in experimental designs in light of the biology of this species...
  2. ncbi request reprint Gene transposition as a cause of hybrid sterility in Drosophila
    John P Masly
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 313:1448-50. 2006
    ..simulans lineage. Because of this transposition, a fraction of hybrids completely lack JYAlpha and are sterile, representing reproductive isolation without sequence evolution...
  3. pmc Epistasis among Drosophila persimilis factors conferring hybrid male sterility with D. pseudoobscura bogotana
    Audrey S Chang
    Biology Department, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 5:e15377. 2010
    ..We further pinpoint the location of one locus that confers hybrid male sterility when homozygous, dubbed "mule-like", to roughly 250 kilobases...
  4. pmc How hot are drosophila hotspots? examining recombination rate variation and associations with nucleotide diversity, divergence, and maternal age in Drosophila pseudoobscura
    Brenda Manzano-Winkler
    Biology Department, Duke University, Durham, North Carolina, USA
    PLoS ONE 8:e71582. 2013
    ..Additionally, we found no correlation of average pairwise nucleotide diversity and divergence with recombination rate across the 20kb intervals, nor any effect of maternal age in weeks on recombination rate in our sample. ..
  5. pmc Gene expression disruptions of organism versus organ in Drosophila species hybrids
    Daniel J Catron
    Biology Department, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 3:e3009. 2008
    ....
  6. pmc The genomics of speciation in Drosophila: diversity, divergence, and introgression estimated using low-coverage genome sequencing
    Rob J Kulathinal
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA
    PLoS Genet 5:e1000550. 2009
    ..Our study serves as a proof-of-principle on how whole genome sequencing can be applied to formulate and test hypotheses about species formation in lesser-known non-model systems...
  7. pmc Slip-sliding away: serial changes and homoplasy in repeat number in the Drosophila yakuba homolog of human cancer susceptibility gene BRCA2
    Sarah M Bennett
    Biology Department, Duke University, Durham, North Carolina, USA
    PLoS ONE 5:e11006. 2010
    ..We conclude that the evolutionary history of dmbrca2 in D. yakuba and perhaps in other Drosophila species may be more complicated than can be inferred from examination of the published single genome sequences per species...
  8. pmc Data sharing: how much doesn't get submitted to GenBank?
    Mohamed A F Noor
    PLoS Biol 4:e228. 2006
  9. pmc What can you do with 0.1x genome coverage? A case study based on a genome survey of the scuttle fly Megaselia scalaris (Phoridae)
    David A Rasmussen
    Department of Biology, Duke University, Durham, NC 27708, USA
    BMC Genomics 10:382. 2009
    ..Here, using a random pyrosequencing approach, we sequence the genome of the scuttle fly Megaselia scalaris and evaluate the utility of our low-coverage GSS approach...
  10. pmc Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3
    Nikolai P Kandul
    Biology Department, Duke University, PO Box 90338, FFSC 4244, Durham, NC 27708, USA
    BMC Genet 10:67. 2009
    ..melanogaster. Although Bru-3's structure is expected to be conducive to AS, only two ASTs of this gene were previously described...
  11. pmc No evidence for learned mating discrimination in male Drosophila pseudoobscura
    Nikolai P Kandul
    DCMB Group, Department of Biology, Box 91000, Duke University, Durham, NC 27708, USA
    BMC Evol Biol 6:54. 2006
    ..This ability of males to discriminate against heterospecific courtship may be advantageous in populations where two species co-occur if courtship or mating is costly...
  12. ncbi request reprint Speciation genetics: evolving approaches
    Mohamed A F Noor
    DCMB Group Biology Department, Duke University, Box 91000, Durham, North Carolina 27708, USA
    Nat Rev Genet 7:851-61. 2006
    ....
  13. ncbi request reprint Patterns of evolution of genes disrupted in expression in Drosophila species hybrids
    Mohamed A F Noor
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Genet Res 85:119-25. 2005
    ..Alternative explanations are also considered...
  14. pmc A kingpin of academic inclusive fitness: the history and contributions of Bruce Grant
    Mohamed A F Noor
    DCMB Group Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 171:867-71. 2005
  15. pmc Divergence between the Drosophila pseudoobscura and D. persimilis genome sequences in relation to chromosomal inversions
    Mohamed A F Noor
    Biology Department, Duke University, Durham, North Carolina 27708, USA
    Genetics 177:1417-28. 2007
    ..This reliance highlights the need for complementary genomic and population genetic approaches for tackling fundamental evolutionary questions such as speciation...
  16. ncbi request reprint Evolutionary genetics: jumping into a new species
    Mohamed A F Noor
    Duke University, Department of Biology, DCMB Group, Box 91000, Durham, North Carolina 27708, USA
    Curr Biol 16:R890-2. 2006
    ..A new study finds a dramatic increase in transposable element numbers in three new sunflower hybrid species, and may suggest a novel role for transposable elements in speciation...
  17. pmc Mutagenesis from meiotic recombination is not a primary driver of sequence divergence between Saccharomyces species
    Mohamed A F Noor
    Biology Department, Duke University, Durham, North Carolina, USA
    Mol Biol Evol 25:2439-44. 2008
    ..This study demonstrates that the association between interspecies nucleotide divergence and local recombination rates is not always a reliable indicator of recombination's mutagenicity...
  18. pmc Connecting recombination, nucleotide diversity and species divergence in Drosophila
    Mohamed A F Noor
    Biology Department, Duke University, Durham, North Carolina 27708, USA
    Fly (Austin) 2:255-6. 2008
    ....
  19. pmc A reversible color polyphenism in American peppered moth (Biston betularia cognataria) caterpillars
    Mohamed A F Noor
    Biology Department, College of William and Mary in Virginia, Williamsburg, Virginia, United States of America
    PLoS ONE 3:e3142. 2008
    ..Given their broad host range, this directly induced color polyphenism likely provides the caterpillars with strong protection from bird predation...
  20. pmc Islands of speciation or mirages in the desert? Examining the role of restricted recombination in maintaining species
    M A F Noor
    Biology Department, Duke University, Durham, NC 27708, USA
    Heredity (Edinb) 103:439-44. 2009
    ..We conclude by discussing strengths and weaknesses of various means for testing the role of restricted recombination in maintaining species...
  21. ncbi request reprint Multilocus test for introgression between the cactophilic species Drosophila mojavensis and Drosophila arizonae
    Brian A Counterman
    Levine Science Research Center, Developmental, Cell, and Molecular Biology Group, Box 91000, Duke University, Durham, North Carolina 27708, USA
    Am Nat 168:682-96. 2006
    ....
  22. pmc Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilis
    Carlos A Machado
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 175:1289-306. 2007
    ..persimilis and near one breakpoint, consistent with a scenario in which this inversion arose and was fixed in this species by natural selection...
  23. pmc Characterization of a male-predominant antisense transcript underexpressed in hybrids of Drosophila pseudoobscura and D. persimilis
    Mohamed A F Noor
    Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, USA
    Genetics 165:1823-30. 2003
    ..pseudoobscura lineage and that its underexpression in sterile hybrid males may cause an overproduction of TRAP100 protein, possibly yielding deleterious effects...
  24. pmc The genetics of hybrid male sterility between the allopatric species pair Drosophila persimilis and D. pseudoobscura bogotana: dominant sterility alleles in collinear autosomal regions
    Audrey S Chang
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 176:343-9. 2007
    ..persimilis and D. pseudoobscura pseudoobscura. The autosomal loci identified in this study provide the basis for introgression mapping and, ultimately, for molecular cloning of interacting genes that contribute to F(1) hybrid sterility...
  25. ncbi request reprint Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  26. pmc Failure to replicate two mate preference QTLs across multiple strains of Drosophila pseudoobscura
    Callie V Barnwell
    Biology Department, Duke University, Box 90338, Durham, NC 27708, USA
    J Hered 99:653-6. 2008
    ..pseudoobscura, although other explanations for the inconsistency are possible. These results underscore the need to examine multiple strains across a species when describing the genetic variation underlying behavioral traits...
  27. pmc Fine-scale mapping of recombination rate in Drosophila refines its correlation to diversity and divergence
    Rob J Kulathinal
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:10051-6. 2008
    ..We propose that it is not cross-overs per se that are mutagenic, but rather repair of DNA double-strand break precursors via crossing over and gene conversion...
  28. ncbi request reprint Gene expression divergence and the origin of hybrid dysfunctions
    Daniel Ortiz-Barrientos
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Genetica 129:71-81. 2007
    ..Ultimately, we hope more functional genetic studies will complement our understanding of the genetic disruptions leading to hybrid dysfunctions and their role in the origin of species...
  29. ncbi request reprint Association of misexpression with sterility in hybrids of Drosophila simulansand D. mauritiana
    Pawel Michalak
    J Mol Evol 59:277-82. 2004
    ....
  30. ncbi request reprint A test of the chromosomal rearrangement model of speciation in Drosophila pseudoobscura
    Kirsten M Brown
    Department of Biological Sciences, Louisiana State University, Life Sciences Bldg, Baton Rouge, Louisiana 70803, USA
    Evolution 58:1856-60. 2004
    ..p. pseudoobscura and D. persimilis, suggesting chromosomal rearrangements may facilitate species persistence despite hybridization...
  31. pmc A microsatellite linkage map of Drosophila mojavensis
    Regina Staten
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    BMC Genet 5:12. 2004
    ..Drosophila mojavensis has been a model system for genetic studies of ecological adaptation and speciation. However, despite its use for over half a century, no linkage map has been produced for this species or its close relatives...
  32. ncbi request reprint Using comparative genomic data to test for fast-X evolution
    Brian A Counterman
    Department of Biological Sciences, Louisiana State University, Life Sciences Building, Baton Rouge, Louisiana 70803, USA
    Evolution 58:656-60. 2004
    ....
  33. ncbi request reprint Evolutionary biology: Genes to make new species
    Mohamed A F Noor
    Nature 423:699-700. 2003
  34. ncbi request reprint Genome-wide patterns of expression in Drosophila pure species and hybrid males
    Pawel Michalak
    Department of Biological Sciences, Louisiana State University, USA
    Mol Biol Evol 20:1070-6. 2003
    ..Furthermore, genes that are expressed primarily or exclusively in males, including several involved in spermatogenesis, are disproportionately misexpressed in hybrids, suggesting a possible genetic cause for their sterility...
  35. ncbi request reprint Variability on the dot chromosome in the Drosophila simulans clade
    Mohamed A F Noor
    Department of Biological Sciences, Life Sciences Bldg, Louisiana State University, Baton Rouge, LA 70803, USA
    Genetica 118:51-8. 2003
    ..Overall, none of the data analyzed were consistent with recent introgression exclusively between D. simulans and D. mauritiana...
  36. ncbi request reprint The evolution of conspecific sperm precedence in Drosophila
    Sheri M Dixon
    Department of Biological Sciences, Life Sciences Building, Louisiana State University, Baton Rouge, LA 70803, USA
    Mol Ecol 12:1179-84. 2003
    ..These pairs of taxa are already separated by mating discrimination and/or hybrid sterility, so our observation suggests that conspecific sperm precedence does not always evolve before other barriers to gene exchange...
  37. pmc Little qualitative RNA misexpression in sterile male F1 hybrids of Drosophila pseudoobscura and D. persimilis
    Jane Reiland
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    BMC Evol Biol 2:16. 2002
    ..Here, we study genome-wide patterns of expression in Drosophila pseudoobscura, D. persimilis, and their sterile F1 hybrid males using differential display...
  38. pmc The genetics of speciation by reinforcement
    Daniel Ortiz-Barrientos
    Department of Biological Sciences, Louisiana State University, Baton Rouge, USA
    PLoS Biol 2:e416. 2004
    ....
  39. ncbi request reprint A recombinational portrait of the Drosophila pseudoobscura genome
    Daniel Ortiz-Barrientos
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Genet Res 87:23-31. 2006
    ..Finally, the online Appendix presents 200 primer sequence pairs for molecular markers that can be used for mapping of quantitative trait loci, of which 125 are known to be polymorphic within or between species...
  40. pmc Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution
    Stephen Richards
    Human Genome Sequencing Center and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston Texas 77030, USA
    Genome Res 15:1-18. 2005
    ..Overall, a pattern of repeat-mediated chromosomal rearrangement, and high coadaptation of both male genes and cis-regulatory sequences emerges as important themes of genome divergence between these species of Drosophila...
  41. pmc Likelihoods from summary statistics: recent divergence between species
    Scotland C Leman
    Institute of Statistics and Decision Sciences, Duke University, Durham, North Carolina 27708, USA
    Genetics 171:1419-36. 2005
    ..Our results for the complete data set also compare well with those obtained through Metropolis-Hastings sampling of fully resolved genealogies of entire nucleotide sequences...
  42. ncbi request reprint Evidence for a one-allele assortative mating locus
    Daniel Ortiz-Barrientos
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Science 310:1467. 2005
    ..persimilis. This observation suggests that the type of genetic variation that is most conducive to controversial modes of speciation with gene flow, such as reinforcement or sympatric speciation, is present in nature...
  43. ncbi request reprint Genome-wide patterns of expression in Drosophila pure species and hybrid males. II. Examination of multiple-species hybridizations, platforms, and life cycle stages
    Amanda J Moehring
    DCMB Group Biology, Duke University, USA
    Mol Biol Evol 24:137-45. 2007
    ..Further study of these misexpressed loci may allow us to identify precisely where disruptions in the spermatogenesis pathway occur...
  44. ncbi request reprint Recombination and the divergence of hybridizing species
    Daniel Ortiz-Barrientos
    Department of Biological Sciences, 107 Life Sciences Building, Louisiana State University, Baton Rouge, LA 70803, USA
    Genetica 116:167-78. 2002
    ..Finally, we recommend recombination to be a focus of inquiry when studying the origins of biological diversity...
  45. ncbi request reprint Fine-scale crossover rate heterogeneity in Drosophila pseudoobscura
    Elizabeth T Cirulli
    J Mol Evol 64:129-35. 2007
    ..These sequence features may contribute to broad-scale variation in crossover rate and, thus, shed light on features associated with crossover rate heterogeneity at a genome-wide scale...
  46. ncbi request reprint Localization and characterization of X chromosome inversion breakpoints separating Drosophila mojavensis and Drosophila arizonae
    Elizabeth T Cirulli
    University Program in Genetics and Genomics, Duke University, Durham, NC 27708, USA
    J Hered 98:111-4. 2007
    ..The localization of these inversion breakpoints will facilitate future genetic and molecular evolutionary studies in this species group, an emerging model system for ecological genetics...
  47. ncbi request reprint Variation in recombination rate may bias human genetic disease mapping studies
    A Susannah Boyle
    Department of Biological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    Genetica 122:245-52. 2004
    ..Future genetic mapping studies should be conscious of this potential complication by noting the regional recombination rate of regions implicated in diseases...
  48. pmc Immobilized molecular beacons: a new strategy using UV-activated poly(methyl methacrylate) surfaces to provide large fluorescence sensitivities for reporting on molecular association events
    Catherine Situma
    Department of Chemistry, Louisiana State University, Baton Rouge, LA 70803, USA
    Anal Biochem 363:35-45. 2007
    ..The fru gene functions in the central nervous system, where it is necessary for sex determination and male courtship behavior, whereas the OdsH gene is involved in the regulation of transcription...
  49. ncbi request reprint Genetics of incipient speciation in Drosophila mojavensis. I. Male courtship song, mating success, and genotype x environment interactions
    William J Etges
    Program in Ecology and Evolutionary Biology, Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Evolution 61:1106-19. 2007
    ..Understanding the genetics of incipient speciation in D. mojavensis clearly depends on cactus-specific expression of traits associated with courtship behavior and sexual isolation...
  50. pmc Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps
    Stephen W Schaeffer
    Department of Biology and Institute of Molecular Evolutionary Genetics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 179:1601-55. 2008
    ..Despite the conservation of genes within homologous chromosome arms across species, the karyotypes of these species have changed through the fusion of chromosomal arms followed by subsequent rearrangement events...

Research Grants7

  1. Genetics of mate discrimination in Drosophila pseudoobscura
    MOHAMED NOOR; Fiscal Year: 2007
    ..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
  2. Fine-scale recombination, variation, divergence, and codon bias in Drosophila
    MOHAMED NOOR; Fiscal Year: 2009
    ....
  3. Genetics of mate discrimination in Drosophila pseudoobscura
    MOHAMED NOOR; Fiscal Year: 2009
    ..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
  4. Genetics of speciation in Drosophila pseudoobscura
    MOHAMED A NOOR; Fiscal Year: 2010
    ..It will also advance the area of behavioral genetics and the genetics of complex traits using a model system, with potential implications for developing hypotheses regarding human behaviors and traits. ..
  5. Fine-scale recombination, variation, divergence, and codon bias in Drosophila
    MOHAMED A contact NOOR; Fiscal Year: 2010
    ....
  6. Fine-scale recombination, variation, divergence, and codon bias in Drosophila
    MOHAMED NOOR; Fiscal Year: 2009
    ....