H Frederik Nijhout

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation
    Heather M Hines
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Genomics 13:288. 2012
  2. doi request reprint Developmental causes of allometry: new models and implications for phenotypic plasticity and evolution
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Integr Comp Biol 52:43-52. 2012
  3. pmc Homeostatic mechanisms in dopamine synthesis and release: a mathematical model
    Janet A Best
    Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA
    Theor Biol Med Model 6:21. 2009
  4. pmc Serotonin synthesis, release and reuptake in terminals: a mathematical model
    Janet Best
    Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA
    Theor Biol Med Model 7:34. 2010
  5. pmc Conflicting processes in the evolution of body size and development time
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Philos Trans R Soc Lond B Biol Sci 365:567-75. 2010
  6. pmc A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Nutr 139:784-91. 2009
  7. ncbi request reprint Polymorphic mimicry in Papilio dardanus: mosaic dominance, big effects, and origins
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 5:579-92. 2003
  8. doi request reprint Size matters (but so does time), and it's OK to be different
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Dev Cell 15:491-2. 2008
  9. pmc In silico experimentation with a model of hepatic mitochondrial folate metabolism
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 3:40. 2006
  10. ncbi request reprint A mathematical model of the folate cycle: new insights into folate homeostasis
    H Frederik Nijhout
    Departments of Biology and Mathematics, Duke University, Durham, NC 27708, USA
    J Biol Chem 279:55008-16. 2004

Collaborators

Detail Information

Publications62

  1. pmc Transcriptome analysis reveals novel patterning and pigmentation genes underlying Heliconius butterfly wing pattern variation
    Heather M Hines
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Genomics 13:288. 2012
    ..This included applying over 140 transcriptome microarrays to assay gene expression in dissected wing pattern elements across a range of developmental stages and wing pattern morphs of Heliconius erato...
  2. doi request reprint Developmental causes of allometry: new models and implications for phenotypic plasticity and evolution
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Integr Comp Biol 52:43-52. 2012
    ..Large evolutionary changes in allometry can be produced by small and simple changes in growth kinetics, and we show how understanding the development of traits can greatly simplify the interpretation of how they evolved...
  3. pmc Homeostatic mechanisms in dopamine synthesis and release: a mathematical model
    Janet A Best
    Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA
    Theor Biol Med Model 6:21. 2009
    ....
  4. pmc Serotonin synthesis, release and reuptake in terminals: a mathematical model
    Janet Best
    Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA
    Theor Biol Med Model 7:34. 2010
    ..The scientific issues are daunting but important for human health because of the use of selective serotonin reuptake inhibitors and other pharmacological agents to treat disorders in the serotonergic signaling system...
  5. pmc Conflicting processes in the evolution of body size and development time
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Philos Trans R Soc Lond B Biol Sci 365:567-75. 2010
    ..Therefore, simultaneous directional selection on body size and development time can be neither synergistic nor antagonistic but leads to conflicting selection on the underlying developmental parameters...
  6. pmc A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Nutr 139:784-91. 2009
    ..Our simulations showed that the primary function of SHMT was to increase the rate by which the glycine-serine balance was reequilibrated after a perturbation...
  7. ncbi request reprint Polymorphic mimicry in Papilio dardanus: mosaic dominance, big effects, and origins
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 5:579-92. 2003
    ....
  8. doi request reprint Size matters (but so does time), and it's OK to be different
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Dev Cell 15:491-2. 2008
    ..Under low-nutrition conditions, TOR suppresses ecdysone secretion--which otherwise terminates larval development--thereby prolonging growth and allowing larvae to still attain a near-normal body size...
  9. pmc In silico experimentation with a model of hepatic mitochondrial folate metabolism
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 3:40. 2006
    ....
  10. ncbi request reprint A mathematical model of the folate cycle: new insights into folate homeostasis
    H Frederik Nijhout
    Departments of Biology and Mathematics, Duke University, Durham, NC 27708, USA
    J Biol Chem 279:55008-16. 2004
    ..In the presence of folate binding and allosteric inhibition, the velocities show a remarkable constancy as total folate is decreased...
  11. ncbi request reprint A mathematical model for the regulation of juvenile hormone titers
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Insect Physiol 54:255-64. 2008
    ..These analyses suggest that there is a critical need to develop a better understanding of the in vivo role of synthesis, sequestration and degradation in JH titer regulation...
  12. pmc A quantitative analysis of the mechanism that controls body size in Manduca sexta
    H F Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Biol 5:16. 2006
    ..The processes that control the timing of ecdysone secretion in larvae of the moth Manduca sexta are sufficiently well understood that they can be described in a rigorous manner...
  13. ncbi request reprint Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Epigenetics 1:81-7. 2006
    ..In silico experimentation allows us to evaluate the independent effects of various combinations of the long-range interactions, and thereby propose a plausible evolutionary scenario...
  14. ncbi request reprint The control of growth and differentiation of the wing imaginal disks of Manduca sexta
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27705, USA
    Dev Biol 302:569-76. 2007
    ..The dose-response to 20E reaches a plateau at about 0.1 microg/ml. Tracheal differentiation of the wing disks can be induced to initiate in vitro by a low concentration of 20E, whereas higher concentrations of 20E only stimulate growth...
  15. ncbi request reprint The control of growth
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Development 130:5863-7. 2003
    ....
  16. doi request reprint Dependence of morphometric allometries on the growth kinetics of body parts
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Theor Biol 288:35-43. 2011
    ....
  17. ncbi request reprint Elements of butterfly wing patterns
    H F Nijhout
    Department of Biology, Evolution, Ecology and Organismal Biology Group, Duke University, Durham, NC 27708 0338, USA
    J Exp Zool 291:213-25. 2001
    ..During pattern evolution, the same set of individual pattern elements is arranged in novel ways to produce species-specific patterns, including such adaptations as mimicry and camouflage...
  18. doi request reprint The cellular and physiological mechanism of wing-body scaling in Manduca sexta
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27705, USA
    Science 330:1693-5. 2010
    ..Thus, proportional growth is under hormonal control and indirectly regulated by the central nervous system...
  19. pmc Bombyxin is a growth factor for wing imaginal disks in Lepidoptera
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 99:15446-50. 2002
    ..It appears that the level of bombyxin in the hemolymph is modulated by the brain in response to variation in nutrition and is part of the mechanism that coordinates the growth of internal organs with overall somatic growth...
  20. ncbi request reprint Development and evolution of adaptive polyphenisms
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 5:9-18. 2003
    ....
  21. ncbi request reprint A mechanistic study of evolvability using the mitogen-activated protein kinase cascade
    H F Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 5:281-94. 2003
    ..This approach to the study of evolvability is generally applicable and complements the traditional approach through statistical genetics by providing a mechanistic understanding of the genetic interactions that produce the phenotype...
  22. ncbi request reprint The control of body size in insects
    H F Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Dev Biol 261:1-9. 2003
    ..The ways in which these higher-level regulatory mechanisms interact with cell- and molecular- level mechanisms are beginning to be elucidated...
  23. ncbi request reprint A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    J Nutr 136:2653-61. 2006
    ..These mathematical simulations of folate-mediated 1-carbon metabolism provide a cost-efficient approach to in silico experimentation that can complement and help guide laboratory studies...
  24. pmc A population model of folate-mediated one-carbon metabolism
    Tanya M Duncan
    Department of Biology, Duke University, Durham, NC 27708, USA
    Nutrients 5:2457-74. 2013
    ..We use this model to study how the concentrations of metabolites that can be measured in the plasma are related to their respective intracellular concentrations...
  25. pmc A mathematical model of glutathione metabolism
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    Theor Biol Med Model 5:8. 2008
    ..Deficits in glutathione have been implicated in aging and a host of diseases including Alzheimer's disease, Parkinson's disease, cardiovascular disease, cancer, Down syndrome and autism...
  26. pmc A switch in the control of growth of the wing imaginal disks of Manduca sexta
    Alexandra Tobler
    Department of Biology, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 5:e10723. 2010
    ..At the end of larval life feeding stops but the disks continue to grow, so at that time disk growth has become uncoupled from nutrition. We sought to determine at exactly what point in development this uncoupling occurs...
  27. pmc The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model
    Tanya M Duncan
    Department of Biology, Duke University, Durham, NC 27708, USA
    Mol Nutr Food Res 57:628-36. 2013
    ..It is assumed that plasma metabolite levels are proportional to their levels in tissues, but there is little information to support this assumption...
  28. ncbi request reprint Evolution of a polyphenism by genetic accommodation
    Yuichiro Suzuki
    Department of Biology, Duke University, Durham, NC 27708, USA
    Science 311:650-2. 2006
    ..Evidently, mechanisms that regulate developmental hormones can mask genetic variation and act as evolutionary capacitors, facilitating the origin of novel adaptive phenotypes...
  29. ncbi request reprint Rapid evolution of a polyphenic threshold
    Armin P Moczek
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 5:259-68. 2003
    ..We discuss the role of developmental control mechanisms in the origin of allometric diversification and explore potential evolutionary mechanisms that could drive scaling relationship evolution in nature...
  30. doi request reprint Constraint and developmental dissociation of phenotypic integration in a genetically accommodated trait
    Yuichiro Suzuki
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 10:690-9. 2008
    ..Thus, maladaptive correlated traits can be removed when multiple developmental modules exist, and the evolution of one or more of these modules is not constrained...
  31. ncbi request reprint Developmental mechanisms of threshold evolution in a polyphenic beetle
    Armin P Moczek
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 4:252-64. 2002
    ..We discuss our findings in the context of the developmental regulatory mechanisms that underlie polyphenic development and use our results to explore the consequences of, and constraints on, polyphenism evolution in nature...
  32. ncbi request reprint Propagation of fluctuations in biochemical systems, I: linear SSC networks
    David F Anderson
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    Bull Math Biol 69:1791-813. 2007
    ..We also investigate the asymptotic behavior of the system as one reaction becomes fast relative to the others...
  33. pmc Mathematical model insights into arsenic detoxification
    Sean D Lawley
    Department of Mathematics, Duke University, 130 Science Drive, Durham, NC 27708, USA
    Theor Biol Med Model 8:31. 2011
    ....
  34. ncbi request reprint Pigmentation pattern formation in butterflies: experiments and models
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC 27708 0338, USA
    C R Biol 326:717-27. 2003
    ..We present some new results applied to pattern formation on the wing of the mimetic butterfly Papilio dardanus...
  35. doi request reprint Developmental constraints on the evolution of wing-body allometry in Manduca sexta
    Alexandra Tobler
    Department of Biology, Duke University, Durham, NC 27708, USA
    Evol Dev 12:592-600. 2010
    ..The available time period for growth of the wing imaginal disks poses a significant constraint on the proportional growth of wings, and thus on the evolution of large body size...
  36. ncbi request reprint Trade-offs during the development of primary and secondary sexual traits in a horned beetle
    Armin P Moczek
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Am Nat 163:184-91. 2004
    ..We use our findings to discuss the physiological causes and evolutionary consequences of resource allocation trade-offs...
  37. ncbi request reprint Geographic variation of caste structure among ant populations
    Andrew S Yang
    Department of Biology, Box 90338, Duke University, Durham, NC 27708 0338, USA
    Curr Biol 14:514-9. 2004
    ..morrisi colonies supports the predictions of adaptive demography theory and illustrates that developmental mechanisms can play a significant role in shaping the evolution of phenotype at the colony level...
  38. doi request reprint Development of polyploidy of scale-building cells in the wings of Manduca sexta
    Eugenia H Cho
    Department of Biology, Duke University, Durham, NC 27708, USA
    Arthropod Struct Dev 42:37-46. 2013
    ..We show that the inverse relationship fits the predictions of the compensation principle and does not fit constraints imposed by packing density, and we discuss mechanisms that could give rise to the inverse relationship...
  39. pmc Competition among body parts in the development and evolution of insect morphology
    H F Nijhout
    Department of Zoology Duke University Durham, NC 27708 0325, USA
    Proc Natl Acad Sci U S A 95:3685-9. 1998
    ....
  40. pmc Nonlinear developmental processes as sources of dominance
    M A Gilchrist
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 159:423-32. 2001
    ....
  41. ncbi request reprint Genetic basis of adaptive evolution of a polyphenism by genetic accommodation
    Y Suzuki
    Department of Biology, Duke University, Durham, NC, USA
    J Evol Biol 21:57-66. 2008
    ..The finding shows that the mechanism of genetic accommodation relies on genetic changes that are consistent with the current view of the genetic basis of adaptive evolution...
  42. ncbi request reprint The nature of robustness in development
    H F Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    Bioessays 24:553-63. 2002
    ..The nature of robustness and the ways in which robustness can evolve are discussed in the context of the problems that arise in the analysis of inherently nonlinear systems...
  43. pmc Supply-side constraints are insufficient to explain the ontogenetic scaling of metabolic rate in the tobacco Hornworm, Manduca sexta
    Viviane Callier
    Biology Department, Duke University, Durham, NC, USA
    PLoS ONE 7:e45455. 2012
    ....
  44. pmc Control of body size by oxygen supply reveals size-dependent and size-independent mechanisms of molting and metamorphosis
    Viviane Callier
    Department of Biology, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 108:14664-9. 2011
    ..We show that under these conditions, larvae do not use the critical weight mechanism, but instead use a size-independent mechanism that is independent of the brain...
  45. pmc Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 114:1547-52. 2006
    ..Most studies addressed these genes individually, often with different populations providing conflicting results...
  46. doi request reprint The biological significance of substrate inhibition: a mechanism with diverse functions
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    Bioessays 32:422-9. 2010
    ..Substrate inhibition of DNA methyltransferase serves to faithfully copy DNA methylation patterns when cells divide while preventing de novo methylation of methyl-free promoter regions...
  47. ncbi request reprint A mathematical model of the methionine cycle
    Michael C Reed
    Department of Mathematics, Duke University, Durham, NC 27708, USA
    J Theor Biol 226:33-43. 2004
    ..We conduct computational "experiments" that give understanding of the regulatory behavior of the methionine cycle under normal conditions and the behavior in the presence of genetic variation and dietary deficiencies...
  48. ncbi request reprint Evolution of novel abdominal appendages in a sepsid fly from histoblasts, not imaginal discs
    Julia H Bowsher
    Department of Biology, Box 90338, Duke University, Durham, NC 27708, USA
    Evol Dev 9:347-54. 2007
    ..The recruitment of histoblasts to produce appendages has not been documented before, and implies a developmental and evolutionary potential for histoblasts that was previously unknown...
  49. pmc The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model
    Rotem Ben-Shachar
    Program in Computational Biology and Bioinformatics, Duke University, Durham, NC, USA
    Theor Biol Med Model 9:55. 2012
    ..The standard treatment for overdose is N-acetyl-cysteine (NAC), which is given to stimulate the production of glutathione...
  50. doi request reprint Predicting the response to simultaneous selection: genetic architecture and physiological constraints
    Goggy Davidowitz
    Department of Entomology, University of Arizona, 1140 E South Campus Drive, Forbes 410, Tucson, Arizona 85721, USA
    Evolution 66:2916-28. 2012
    ....
  51. pmc The developmental and physiological basis of body size evolution in an insect
    G Davidowitz
    Department of Biology, Duke University, Durham, NC 27708, USA
    Proc Biol Sci 268:1589-93. 2001
    ..Changes in these three developmental processes completely account for the observed evolutionary change in body size...
  52. ncbi request reprint Genes on the wing
    H F Nijhout
    Zoology Department, Duke University, Durham, NC 27708 0325
    Science 265:44-5. 1994
  53. doi request reprint The development of wing shape in Lepidoptera: mitotic density, not orientation, is the primary determinant of shape
    H Frederik Nijhout
    Department of Biology, Duke University, Durham, NC, 27708, USA
    Evol Dev 16:68-77. 2014
    ..Evolution of wing shape comes about by changes in the progression of spatial patterns of cell division. ..
  54. pmc Singularity in polarization: rewiring yeast cells to make two buds
    Audrey S Howell
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 139:731-43. 2009
    ..Slowing competition in normal cells also allowed occasional formation of two buds, suggesting that singularity is enforced by rapid competition between Cdc42 clusters...
  55. pmc The role of low levels of juvenile hormone esterase in the metamorphosis of Manduca sexta
    M H Browder
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Insect Sci 1:11. 2001
    ..Therefore, although the normal timing of the onset of wandering does not require peak levels of JHE, it requires low to moderate levels of JHE to be present until larvae reach a weight of about 8.0 g...
  56. ncbi request reprint Metaphors and the role of genes in development
    H F Nijhout
    Department of Zoology, Duke University, Durham, North Carolina 27706
    Bioessays 12:441-6. 1990
    ..The consequences of adopting this alternative view of development are discussed...
  57. ncbi request reprint On the association between genes and complex traits
    H F Nijhout
    Department of Biology, Duke University, Durham, NC 27708, USA
    J Investig Dermatol Symp Proc 8:162-3. 2003
  58. ncbi request reprint Critical weight in the development of insect body size
    Goggy Davidowitz
    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
    Evol Dev 5:188-97. 2003
    ..Thus, the determinants of body size and the determinants of plasticity of body size do not need to be identical...
  59. pmc Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria
    Damien Leduc
    Inserm Avenir Group, Institut de Génétique et de Microbiologie, CNRS UMR8621, F 91405 Orsay, France
    J Bacteriol 189:8537-45. 2007
    ..In addition, our observations suggest that the presence of flavin-dependent thymidylate synthase X provides growth benefits under conditions in which the level of reduced folate derivatives is compromised...
  60. ncbi request reprint Size and shape: the developmental regulation of static allometry in insects
    Alexander W Shingleton
    Department of Zoology, Michigan State University, 203 Natural Science, East Lansing, MI 48910, USA
    Bioessays 29:536-48. 2007
    ..This model serves as the foundation for a research program that will result in a deeper understanding of the relationship between growth and form, a question that has fascinated biologists for centuries...
  61. ncbi request reprint The robustness of the transcriptional response to alterations in morphogenetic gradients
    Reiner A Veitia
    Université Denis Diderot Paris VII and INSERM U709 Université Paris V, France
    Bioessays 28:282-9. 2006
    ..Our results highlight how non-linearities can be a source of robustness and the crucial role of the inhibitor in the generation of a sharp and robust response...
  62. ncbi request reprint Mathematical modeling: epidemiology meets systems biology
    Cornelia M Ulrich
    Cancer Epidemiol Biomarkers Prev 15:827-9. 2006