Donna Niedzwiecki

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2
    Michael A Morse
    Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Box 3233, Durham, NC 27710, USA
    J Transl Med 5:42. 2007
  2. pmc Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: results from CALGB 9581
    Donna Niedzwiecki
    Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Hock Plaza, 2424 Erwin Rd, Room 8040, Durham, NC 27705, USA
    J Clin Oncol 29:3146-52. 2011
  3. ncbi request reprint Unrelated umbilical cord blood transplantation in adult patients
    Gwynn D Long
    Bone Marrow Transplantation Program, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Blood Marrow Transplant 9:772-80. 2003
  4. doi request reprint Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy
    Christopher A Crout
    Duke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA
    Cancer Invest 28:654-60. 2010
  5. ncbi request reprint Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution
    David A Rizzieri
    Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:690-7. 2007
  6. doi request reprint Immune reconstitution in children after unrelated cord blood transplantation
    Paul Szabolcs
    Department of Pediatrics, Pediatric Blood and Marrow Transplant Program, Department of Immunology, Duke University, Durham, North Carolina, USA
    Biol Blood Marrow Transplant 14:66-72. 2008
  7. pmc Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    Michael A Morse
    Department ofMedicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 112:610-8. 2008
  8. doi request reprint Multiagent chemotherapy for isolated colorectal liver metastases: a single-centered retrospective study
    Srinevas K Reddy
    Department of Surgery, Duke University Medical Center, Box 3247, Durham, NC 27710, USA
    J Gastrointest Surg 13:74-84. 2009
  9. pmc An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer
    Michael A Morse
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 120:3234-41. 2010
  10. pmc Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning
    Junya Kanda
    Adult Stem Cell Transplant Program, Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Biol Blood Marrow Transplant 17:867-74. 2011

Collaborators

Detail Information

Publications25

  1. pmc Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2
    Michael A Morse
    Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Box 3233, Durham, NC 27710, USA
    J Transl Med 5:42. 2007
    ..We proposed to address these concerns by using cancer vaccines to stimulate HER2 intracellular domain (ICD)-specific T cell and antibody responses...
  2. pmc Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: results from CALGB 9581
    Donna Niedzwiecki
    Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Hock Plaza, 2424 Erwin Rd, Room 8040, Durham, NC 27705, USA
    J Clin Oncol 29:3146-52. 2011
    ..This study also prospectively studied patient- and tumor-specific markers of treatment outcome...
  3. ncbi request reprint Unrelated umbilical cord blood transplantation in adult patients
    Gwynn D Long
    Bone Marrow Transplantation Program, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Blood Marrow Transplant 9:772-80. 2003
    ..Infection was the primary cause of death. These results suggest that unrelated umbilical cord blood transplantation is a viable option for adult patients and should be explored in patients with earlier-stage disease...
  4. doi request reprint Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy
    Christopher A Crout
    Duke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA
    Cancer Invest 28:654-60. 2010
    ..High responses were noted, though durable remissions were few, indicating non-traditional chemotherapy options are important to investigate in this illness...
  5. ncbi request reprint Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution
    David A Rizzieri
    Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:690-7. 2007
    ..To allow a donor to be found for nearly all patients, we have used a nonmyeloablative conditioning regimen in conjunction with stem cells from a related donor with one fully mismatched HLA haplotype...
  6. doi request reprint Immune reconstitution in children after unrelated cord blood transplantation
    Paul Szabolcs
    Department of Pediatrics, Pediatric Blood and Marrow Transplant Program, Department of Immunology, Duke University, Durham, North Carolina, USA
    Biol Blood Marrow Transplant 14:66-72. 2008
    ..However, there is also realistic hope that clinical translation of new immunotherapy strategies could enhance immune competence after UCBT either by having an impact on the thymic-independent early period or by fostering thymic recovery...
  7. pmc Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    Michael A Morse
    Department ofMedicine, Duke University Medical Center, Durham, NC 27710, USA
    Blood 112:610-8. 2008
    ....
  8. doi request reprint Multiagent chemotherapy for isolated colorectal liver metastases: a single-centered retrospective study
    Srinevas K Reddy
    Department of Surgery, Duke University Medical Center, Box 3247, Durham, NC 27710, USA
    J Gastrointest Surg 13:74-84. 2009
    ..The objective of this retrospective study was to determine the effect of multiagent chemotherapy on long-term survival after resection of CLM...
  9. pmc An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer
    Michael A Morse
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 120:3234-41. 2010
    ..These data suggest that VRP-based vectors can overcome the presence of neutralizing antibodies to break tolerance to self antigen and may be clinically useful for immunotherapy in the setting of tumor-induced immunosuppression...
  10. pmc Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning
    Junya Kanda
    Adult Stem Cell Transplant Program, Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Biol Blood Marrow Transplant 17:867-74. 2011
    ..This study supports the use of TBI 1350 cGy/Flu as an alternative to conventional myeloablative conditioning for dual UCB transplantation...
  11. ncbi request reprint Comparison of radiologists and technologists in the performance of air-contrast barium enemas
    William M Thompson
    Department of Radiology, Duke University Medical Center, Erwin Rd, Box 3808, Durham, NC 27710, USA
    AJR Am J Roentgenol 187:706-9. 2006
    ..The purpose of this study was to determine whether the rate of polyp detection and the quality of air-contrast barium enema (ACBE) procedures performed by technologists differ from those performed by radiologists...
  12. ncbi request reprint Causes of errors in polyp detection at air-contrast barium enema examination
    William M Thompson
    Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
    Radiology 239:139-48. 2006
    ..To retrospectively determine the cause of errors in air-contrast barium enema (ACBE) examination for detection of polyps 6 mm or larger...
  13. ncbi request reprint Intensive chemotherapy with and without cranial radiation for Burkitt leukemia and lymphoma: final results of Cancer and Leukemia Group B Study 9251
    David A Rizzieri
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 100:1438-48. 2004
    ..The objective of the current study was to evaluate the efficacy of intensive chemotherapy with and without cranial radiation for central nervous system (CNS) prophylaxis in adults with Burkitt leukemia or lymphoma...
  14. ncbi request reprint Low-dose weekly paclitaxel for recurrent or refractory aggressive non-Hodgkin lymphoma
    David A Rizzieri
    Division of Medical Oncology and Transplantation, Duke University Medical Center, and the Duke Oncology Network, Duke University, Durham, North Carolina 27710, USA
    Cancer 100:2408-14. 2004
    ..The current study tested this hypothesis by using low-dose, weekly paclitaxel in patients with recurrent or refractory NHL...
  15. ncbi request reprint Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysis
    Amy C Hobeika
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Immunother 28:63-72. 2005
    ..These assays will better define the quantity and quality of protective immune responses to viral disease and offer insight into the requirements for protective anti-cancer immunity...
  16. pmc Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34
    Robert W Storms
    Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Box 3361, Durham, NC 27710, USA
    Blood 106:95-102. 2005
    ..The differential expression of ALDH may provide a means to explore normal and malignant processes associated with myeloid and lymphoid development...
  17. ncbi request reprint Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory molecules
    Michael A Morse
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cancer Res 11:3017-24. 2005
    ..To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor antigen...
  18. ncbi request reprint Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity
    David A Rizzieri
    Department of Medicine, Division of Oncology and Stem Cell Transplantation, Duke University Medical Center, Durham, NC 27710, USA
    Leuk Lymphoma 46:1455-62. 2005
    ..Further, stromal changes correlate with disease response over the course of the patient's disease. This new finding may have implications for the timing of anti-stromally directed therapies...
  19. ncbi request reprint Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer
    Zhen Su
    Genitourinary Cancer Immunotherapy Program, Division of Urology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 174:3798-807. 2005
    ..Our findings provide a rationale for further development of hTERT-transfected DC vaccines in the treatment of prostate and other cancers...
  20. ncbi request reprint Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells
    Zhen Su
    Cancer Immunotherapy Program, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer Res 63:2127-33. 2003
    ..8 months. These data provide a scientific rationale for continued clinical investigation of this polyvalent vaccine strategy in the treatment of metastatic renal cell carcinoma and, potentially, other cancers...
  21. ncbi request reprint Prospective comparison of patient experience with colon imaging tests
    Hayden B Bosworth
    Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
    Am J Med 119:791-9. 2006
    ..We examined differences in patient experience with colon imaging tests and whether they varied with gender, age, and race...
  22. pmc Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine
    Takuya Osada
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Clin Cancer Res 15:2789-96. 2009
    ....
  23. doi request reprint Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803
    Robert S Warren
    Authors Affiliations Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California Department of Biostatistics and Bioinformatics, Alliance Statistics and Data Center, Duke University Medical Center, Durham, North Carolina Dana Farber Cancer Institute Dana Farber Cancer Institute, Brigham and Women s Hospital, Boston, Massachusetts The Ohio State University, Columbus, Ohio National Cancer Institute, Bethesda, Maryland and Memorial Sloan Kettering Cancer Center, New York, New York
    Clin Cancer Res 19:5777-87. 2013
    ..We investigated whether mutations in the DNA-binding domain of TP53 are associated with survival in stage III colon cancer...
  24. pmc Predictive and prognostic analysis of PIK3CA mutation in stage III colon cancer intergroup trial
    Shuji Ogino
    Affiliations of authors Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA SO, XL, YI, MY, NJM, KN, RJM, JAM, CSF Department of Pathology SO, Channing Division of Network Medicine, Department of Medicine DS, CSF, and Department of Surgery MMB, Brigham and Women s Hospital and Harvard Medical School, Boston, MA SO Department of Epidemiology SO, DS and Department of Biostatistics DS, Harvard School of Public Health, Boston, MA Alliance Statistics and Data Center, Duke University Medical Center, Durham, NC DN Memorial Sloan Kettering Cancer Center, New York, NY LBS Hôpital du Sacré Coeur de Montréal, Montreal, Canada RW Loyola University Stritch School of Medicine, Maywood, IL AH current Edward Cancer Center, Naperville, IL AH Northwestern University, Chicago, IL ABB Toledo Community Hospital Oncology Program, Toledo, OH RBM Division of Medical Oncology, Germany
    J Natl Cancer Inst 105:1789-98. 2013
    ..Somatic mutations in PIK3CA (phosphatidylinositol-4,5-bisphosphonate 3-kinase [PI3K], catalytic subunit alpha gene) activate the PI3K-AKT signaling pathway and contribute to pathogenesis of various malignancies, including colorectal cancer...
  25. pmc Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors
    Axel Heiser
    Cancer Immunotherapy Program, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Clin Invest 109:409-17. 2002
    ....