Research Topics
| Donna NiedzwieckiSummaryAffiliation: Duke University Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2Michael A Morse
Department of Medicine, Division of Medical Oncology, Duke University Medical Center, Box 3233, Durham, NC 27710, USA
J Transl Med 5:42. 2007..We proposed to address these concerns by using cancer vaccines to stimulate HER2 intracellular domain (ICD)-specific T cell and antibody responses...- Documenting the natural history of patients with resected stage II adenocarcinoma of the colon after random assignment to adjuvant treatment with edrecolomab or observation: results from CALGB 9581Donna Niedzwiecki
Cancer and Leukemia Group B Statistical Center, Duke University Medical Center, Hock Plaza, 2424 Erwin Rd, Room 8040, Durham, NC 27705, USA
J Clin Oncol 29:3146-52. 2011..This study also prospectively studied patient- and tumor-specific markers of treatment outcome... 
Unrelated umbilical cord blood transplantation in adult patientsGwynn D Long
Bone Marrow Transplantation Program, Duke University Medical Center, Durham, North Carolina 27710, USA
Biol Blood Marrow Transplant 9:772-80. 2003..Infection was the primary cause of death. These results suggest that unrelated umbilical cord blood transplantation is a viable option for adult patients and should be explored in patients with earlier-stage disease...
Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapyChristopher A Crout
Duke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA
Cancer Invest 28:654-60. 2010..High responses were noted, though durable remissions were few, indicating non-traditional chemotherapy options are important to investigate in this illness...- Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitutionDavid A Rizzieri
Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Durham, NC 27710, USA
J Clin Oncol 25:690-7. 2007..To allow a donor to be found for nearly all patients, we have used a nonmyeloablative conditioning regimen in conjunction with stem cells from a related donor with one fully mismatched HLA haplotype... - Immune reconstitution in children after unrelated cord blood transplantationPaul Szabolcs
Department of Pediatrics, Pediatric Blood and Marrow Transplant Program, Department of Immunology, Duke University, Durham, North Carolina, USA
Biol Blood Marrow Transplant 14:66-72. 2008..However, there is also realistic hope that clinical translation of new immunotherapy strategies could enhance immune competence after UCBT either by having an impact on the thymic-independent early period or by fostering thymic recovery... - Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccinesMichael A Morse
Department ofMedicine, Duke University Medical Center, Durham, NC 27710, USA
Blood 112:610-8. 2008.... - Multiagent chemotherapy for isolated colorectal liver metastases: a single-centered retrospective studySrinevas K Reddy
Department of Surgery, Duke University Medical Center, Box 3247, Durham, NC 27710, USA
J Gastrointest Surg 13:74-84. 2009..The objective of this retrospective study was to determine the effect of multiagent chemotherapy on long-term survival after resection of CLM... - An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancerMichael A Morse
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 120:3234-41. 2010..These data suggest that VRP-based vectors can overcome the presence of neutralizing antibodies to break tolerance to self antigen and may be clinically useful for immunotherapy in the setting of tumor-induced immunosuppression... - Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioningJunya Kanda
Adult Stem Cell Transplant Program, Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
Biol Blood Marrow Transplant 17:867-74. 2011..This study supports the use of TBI 1350 cGy/Flu as an alternative to conventional myeloablative conditioning for dual UCB transplantation... - Comparison of radiologists and technologists in the performance of air-contrast barium enemasWilliam M Thompson
Department of Radiology, Duke University Medical Center, Erwin Rd, Box 3808, Durham, NC 27710, USA
AJR Am J Roentgenol 187:706-9. 2006..Training technologists to perform ACBE may help to alleviate the radiology staffing shortage in the United States... - Causes of errors in polyp detection at air-contrast barium enema examinationWilliam M Thompson
Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710, USA
Radiology 239:139-48. 2006..To retrospectively determine the cause of errors in air-contrast barium enema (ACBE) examination for detection of polyps 6 mm or larger... - Intensive chemotherapy with and without cranial radiation for Burkitt leukemia and lymphoma: final results of Cancer and Leukemia Group B Study 9251David A Rizzieri
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer 100:1438-48. 2004..The objective of the current study was to evaluate the efficacy of intensive chemotherapy with and without cranial radiation for central nervous system (CNS) prophylaxis in adults with Burkitt leukemia or lymphoma... - Low-dose weekly paclitaxel for recurrent or refractory aggressive non-Hodgkin lymphomaDavid A Rizzieri
Division of Medical Oncology and Transplantation, Duke University Medical Center, and the Duke Oncology Network, Duke University, Durham, North Carolina 27710, USA
Cancer 100:2408-14. 2004..The current study tested this hypothesis by using low-dose, weekly paclitaxel in patients with recurrent or refractory NHL... - Enumerating antigen-specific T-cell responses in peripheral blood: a comparison of peptide MHC Tetramer, ELISpot, and intracellular cytokine analysisAmy C Hobeika
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
J Immunother (1997) 28:63-72. 2005..These assays will better define the quantity and quality of protective immune responses to viral disease and offer insight into the requirements for protective anti-cancer immunity... - Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34Robert W Storms
Department of Medicine, Division of Cellular Therapy, Duke University Medical Center, Box 3361, Durham, NC 27710, USA
Blood 106:95-102. 2005..The differential expression of ALDH may provide a means to explore normal and malignant processes associated with myeloid and lymphoid development... - Phase I study of immunization with dendritic cells modified with fowlpox encoding carcinoembryonic antigen and costimulatory moleculesMichael A Morse
Duke University Medical Center, Durham, North Carolina 27710, USA
Clin Cancer Res 11:3017-24. 2005..To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor antigen... - Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activityDavid A Rizzieri
Department of Medicine, Division of Oncology and Stem Cell Transplantation, Duke University Medical Center, Durham, NC 27710, USA
Leuk Lymphoma 46:1455-62. 2005..Further, stromal changes correlate with disease response over the course of the patient's disease. This new finding may have implications for the timing of anti-stromally directed therapies... - Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancerZhen Su
Genitourinary Cancer Immunotherapy Program, Division of Urology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 174:3798-807. 2005..Our findings provide a rationale for further development of hTERT-transfected DC vaccines in the treatment of prostate and other cancers... - Prospective comparison of patient experience with colon imaging testsHayden B Bosworth
Center for Health Services Research in Primary Care, Durham VA Medical Center, Durham, NC, USA
Am J Med 119:791-9. 2006..This finding has important implications for physicians considering different colon imaging tests... - Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cellsZhen Su
Cancer Immunotherapy Program, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Cancer Res 63:2127-33. 2003..8 months. These data provide a scientific rationale for continued clinical investigation of this polyvalent vaccine strategy in the treatment of metastatic renal cell carcinoma and, potentially, other cancers... - Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccineTakuya Osada
Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Clin Cancer Res 15:2789-96. 2009.... - Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumorsAxel Heiser
Cancer Immunotherapy Program, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Clin Invest 109:409-17. 2002....