Research Topics
| MIGUEL A NICOLELISSummaryAffiliation: Duke University Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Learning to control a brain-machine interface for reaching and grasping by primatesJose M Carmena
Department of Neurobiology, Duke University, Durham, North Carolina, USA
PLoS Biol 1:E42. 2003..Learning to operate the BMIc was paralleled by functional reorganization in multiple cortical areas, suggesting that the dynamic properties of the BMIc were incorporated into motor and sensory cortical representations...- Computing with thalamocortical ensembles during different behavioural statesMiguel A L Nicolelis
Department of Neurology, Center for Neuroengineering, Box 3209, Room 327 Bryan Research Building, Duke University, Durham, NC 27710, USA
J Physiol 566:37-47. 2005.... 
Principles of neural ensemble physiology underlying the operation of brain-machine interfacesMiguel A L Nicolelis
Duke University Center for Neuroengineering and the Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
Nat Rev Neurosci 10:530-40. 2009..Further understanding of these principles is likely to have a key role in the future development of neuroprosthetics for restoring mobility in severely paralysed patients...
Thalamocortical [correction of Thalamcortical] optimization of tactile processing according to behavioral stateMiguel A L Nicolelis
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Neurosci 5:517-23. 2002....- Chronic, multisite, multielectrode recordings in macaque monkeysMiguel A L Nicolelis
Department of Neurobiology, Duke University, Durham, NC 27710, USA
Proc Natl Acad Sci U S A 100:11041-6. 2003..This method should benefit neurophysiological investigation of learning, perception, and sensorimotor integration in primates and the development of neuroprosthetic devices... - Multielectrode recordings: the next stepsMiguel A L Nicolelis
Department of Neurobiology, Box 3209, Duke University, Durham, North Carolina 27710, USA
Curr Opin Neurobiol 12:602-6. 2002..Current methods of multielectrode recording employ state of the art technologies; two potential new avenues of research will likely emerge from the further development of these experimental paradigms... - Dynamic shifting in thalamocortical processing during different behavioural statesMiguel A L Nicolelis
Department of Neurobiology and Duke Centre for Neuroengineering, Duke University Medical Center, Durham, NC 27710, USA
Philos Trans R Soc Lond B Biol Sci 357:1753-8. 2002.... - Brain-machine interfaces to restore motor function and probe neural circuitsMiguel A L Nicolelis
Department of Neurobiology, Box 3209, Bryan Research Building, Room 327E, 101 Research Drive, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Rev Neurosci 4:417-22. 2003 - Food reward in the absence of taste receptor signalingIvan E de Araujo
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 57:930-41. 2008..Our findings suggest that calorie-rich nutrients can directly influence brain reward circuits that control food intake independently of palatability or functional taste transduction... - Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunctionRui M Costa
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Neuron 52:359-69. 2006..Thus, dopamine-related disorders like Parkinson's disease may not stem from changes in the overall levels of cortical activity, but from dysfunctional activity coordination in corticostriatal circuits... - Cortical ensemble adaptation to represent velocity of an artificial actuator controlled by a brain-machine interfaceMikhail A Lebedev
Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
J Neurosci 25:4681-93. 2005..These results show that, during BMI control, cortical ensembles represent behaviorally significant motor parameters, even if these are not associated with movements of the animal's own limb... - Seeking the neural codeMiguel A L Nicolelis
Duke University, USA
Sci Am 295:70-7. 2006 - Optimizing a linear algorithm for real-time robotic control using chronic cortical ensemble recordings in monkeysJohan Wessberg
Duke University, USA
J Cogn Neurosci 16:1022-35. 2004.... - Behavioral and neural responses to gustatory stimuli delivered non-contingently through intra-oral cannulasErnesto S Soares
Department of Neurobiology, Duke University, Durham, NC, USA
Physiol Behav 92:629-42. 2007..We posit that these tuning changes arise, at least in part, from compounds released upon ingestion, and also from differences in areas of the oral cavity that are bathed as the animals ingest or reject the tastants... - Behavioral detection of tactile stimuli during 7-12 Hz cortical oscillations in awake ratsMichael C Wiest
Department of Neurobiology, Box 3209, Duke Medical Center, Durham, North Carolina 27710, USA
Nat Neurosci 6:913-4. 2003..They responded rapidly and reliably, suggesting that this brain rhythm represents normal physiological activity that does not preclude perception... - Dopaminergic control of sleep-wake statesKafui Dzirasa
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 26:10577-89. 2006..We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep... - Frontal and parietal cortical ensembles predict single-trial muscle activity during reaching movements in primatesDavid M Santucci
Department of Neurobiology, Box 3209, Duke University Medical Center, 101 Research Drive, Room 327E, Durham, NC 27710, USA
Eur J Neurosci 22:1529-40. 2005..We propose that, in the future, recordings from multiple cortical areas and the extraction of muscle patterns from these recordings will help to restore limb mobility in paralysed patients... - Three-dimensional, automated, real-time video system for tracking limb motion in brain-machine interface studiesIan D Peikon
Department of Biomedical Engineering, Center for Neuroengineering, Duke University, Durham, NC 27710, USA
J Neurosci Methods 180:224-33. 2009..We propose that this system could also be extended to applications that include other classes of biological motion... - Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interfaceParag G Patil
Division of Neurosurgery, Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Neurosurgery 55:27-35; discussion 35-8. 2004.... - Neuronal activity in the primary somatosensory thalamocortical loop is modulated by reward contingency during tactile discriminationJanaina Pantoja
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 27:10608-20. 2007..Together, our results indicate that neuronal activity in the primary somatosensory thalamocortical loop is strongly modulated by reward contingency... - Licking-induced synchrony in the taste-reward circuit improves cue discrimination during learningRanier Gutierrez
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 30:287-303. 2010.... - Taste-guided decisions differentially engage neuronal ensembles across gustatory corticesChristopher J MacDonald
Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27708, USA
J Neurosci 29:11271-82. 2009..These results indicate that during a taste-guided decision task both primary and secondary gustatory cortices dynamically encode different types of information... - Depression at thalamocortical synapses: the key for cortical neuronal adaptation?Miguel A L Nicolelis
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 34:331-2. 2002..In this issue of Neuron, Chung et al. provide conclusive evidence that depression of thalamocortical synapses may play a significant role in the expression of neuronal adaptation in the rat somatosensory cortex... - Stable ensemble performance with single-neuron variability during reaching movements in primatesJose M Carmena
Department of Neurobiology, Center for Neuroengineering, Duke University, Durham, North Carolina 27710, USA
J Neurosci 25:10712-6. 2005.... - Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleepKafui Dzirasa
Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
PLoS ONE 4:e5238. 2009..Thus, we propose that persistent hyperdopaminergia, together with secondary alterations in other neuromodulatory systems, results in lower frequency activity in neural systems responsible for various cognitive processes... - The neural mechanisms of gustation: a distributed processing codeSidney A Simon
Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
Nat Rev Neurosci 7:890-901. 2006..On the basis of recent experimental data, we argue that these brain circuits make use of distributed ensemble codes that represent the sensory and post-ingestive properties of tastants... - Decoding of temporal intervals from cortical ensemble activityMikhail A Lebedev
Deptartment of Neurobiology, Duke Univiversity, Durham, North Carolina 27100, USA
J Neurophysiol 99:166-86. 2008..We suggest that decoding of temporal intervals from bilaterally recorded cortical ensembles could improve the performance of neural prostheses for restoration of motor function... - Neuronal ensemble bursting in the basal forebrain encodes salience irrespective of valenceShih Chieh Lin
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Neuron 59:138-49. 2008.... - Restoration of locomotive function in Parkinson's disease by spinal cord stimulation: mechanistic approachRomulo Fuentes
Department of Neurobiology, Duke Medical Center, 311 Research Drive, Durham, NC 27710, USA
Eur J Neurosci 32:1100-8. 2010.... - Spatiotemporal coupling between hippocampal acetylcholine release and theta oscillations in vivoHao Zhang
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 30:13431-40. 2010..These findings also suggest that phasic ACh is not required for theta initiation and may instead operate synergistically with theta oscillations to promote neural plasticity in the service of learning and memory... - Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchronyKafui Dzirasa
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 30:6387-97. 2010.... - Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of maniaKafui Dzirasa
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 30:16314-23. 2010.... - Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signalingKafui Dzirasa
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 29:8215-24. 2009.... - Acquiring local field potential information from amperometric neurochemical recordingsHao Zhang
Dept of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
J Neurosci Methods 179:191-200. 2009..As such, our findings provide the first demonstration that both LFP and local neurochemical information can be simultaneously acquired from electrochemical sensors alone... - Chronic in vivo multi-circuit neurophysiological recordings in miceKafui Dzirasa
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
J Neurosci Methods 195:36-46. 2011..Thus, our approach provides a powerful tool that will aid in dissecting the central brain network changes that underlie the complex behavioral deficits displayed by various genetically modified mice... - Spinal cord stimulation restores locomotion in animal models of Parkinson's diseaseRomulo Fuentes
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Science 323:1578-82. 2009..We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future... - A fully implantable 96-channel neural data acquisition systemMICHAEL RIZK
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
J Neural Eng 6:026002. 2009..This demonstration of a high channel-count fully implanted neural data acquisition system is a critical step in the development of a clinically viable brain-machine interface... - Fast modulation of prefrontal cortex activity by basal forebrain noncholinergic neuronal ensemblesShih Chieh Lin
Department of Neurobiology, Duke University Medical Center, 101 Research Drive, Box 3209, Durham, NC 27710, USA
J Neurophysiol 96:3209-19. 2006.... - Neural ensemble coding of satiety statesIvan E de Araujo
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
Neuron 51:483-94. 2006..This distributed population code might constitute a neural mechanism underlying meal initiation under different metabolic states... - Long-lasting novelty-induced neuronal reverberation during slow-wave sleep in multiple forebrain areasSidarta Ribeiro
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina, USA
PLoS Biol 2:E24. 2004.... - Reduction of single-neuron firing uncertainty by cortical ensembles during motor skill learningDana Cohen
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:3574-82. 2004.... - Transmission latencies in a telemetry-linked brain-machine interfaceChad A Bossetti
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
IEEE Trans Biomed Eng 51:919-24. 2004..A comparison of neuron firing rate and resulting latencies shows that high latencies result from neuron bursting. These results will impact the design of transcutaneous telemetry in a BMI... - Layer-specific somatosensory cortical activation during active tactile discriminationDavid J Krupa
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Science 304:1989-92. 2004..Instead, these results suggest that top-down influences during active discrimination may alter the overall functional nature of SI as well as layer-specific mechanisms of tactile processing... - Differential corticostriatal plasticity during fast and slow motor skill learning in miceRui M Costa
Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA
Curr Biol 14:1124-34. 2004..However, the nature and dynamics of the plastic changes in each of these brain structures during the different phases of motor learning remain unclear... - Heterogeneous integration of bilateral whisker signals by neurons in primary somatosensory cortex of awake ratsMichael C Wiest
Department of Neurobiology, Duke University Medical Center, 101 Research Drive, Durham, NC 27710, USA
J Neurophysiol 93:2966-73. 2005.... - Global forebrain dynamics predict rat behavioral states and their transitionsDamien Gervasoni
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 24:11137-47. 2004.... - Gustatory effects of capsaicin that are independent of TRPV1 receptorsRui M Costa
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
Chem Senses 30:i198-200. 2005 - Two multichannel integrated circuits for neural recording and signal processingIyad Obeid
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
IEEE Trans Biomed Eng 50:255-8. 2003..Those on Device B had mean gains of 53.4 and 47.4 dB with a high-pass filter pole at 211 Hz and an equivalent input noise of 4.4 microV(rms). Both devices were tested in vivo with electrode arrays implanted in the somatosensory cortex... - Brain-machine interfaces: past, present and futureMikhail A Lebedev
Department of Neurobiology and Center for Neuroengineering, Duke University, Durham, NC 27710, USA
Trends Neurosci 29:536-46. 2006..By reaching these milestones, future BMIs will be able to drive and control revolutionary prostheses that feel and act like the human arm... - A multichannel telemetry system for single unit neural recordingsIyad Obeid
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
J Neurosci Methods 133:33-8. 2004..The device was successfully used to record signals from awake, chronically implanted macaque and owl monkeys... - Rapid taste responses in the gustatory cortex during lickingJennifer R Stapleton
Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
J Neurosci 26:4126-38. 2006.... - A low power multichannel analog front end for portable neural signal recordingsIyad Obeid
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
J Neurosci Methods 133:27-32. 2004..The described circuit is light weight and low power and is used as a component of a wearable multichannel neural telemetry system... - Reverberation, storage, and postsynaptic propagation of memories during sleepSidarta Ribeiro
Department of Neurobiology, Duke University Medical Center, Duke University, Durham, North Carolina 27710, USA
Learn Mem 11:686-96. 2004.... - Orbitofrontal ensemble activity monitors licking and distinguishes among natural rewardsRanier Gutierrez
Department of Neurobiology, Duke University Medical Center, Bryan Research Bldg, Durham, NC 27710, USA
J Neurophysiol 95:119-33. 2006..These results provide a new role for the OFC in influencing licking clusters and anticipating specific rewards... - Taste-specific neuronal ensembles in the gustatory cortex of awake ratsDonald B Katz
Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
J Neurosci 22:1850-7. 2002..These data suggest that taste-specific GC assemblies may transiently form and coevolve on a behaviorally appropriate timescale, contributing to rats' ability to discriminate tastants... - Gustatory processing is dynamic and distributedDonald B Katz
Volen Center for Complex Systems, Department of Psychology, Brandeis University, MS 062, Waltham, MA 02454 9110, USA
Curr Opin Neurobiol 12:448-54. 2002..We propose that the specifics of gustatory responses grow not only out of information ascending from taste receptor cells, but also from the cycling of information around a massively interconnected system... - Interval timing and the encoding of signal duration by ensembles of cortical and striatal neuronsMatthew S Matell
Department of Psychological and Brain Sciences, Duke University, USA
Behav Neurosci 117:760-73. 2003..Results suggest that striatal and cortical neurons encode specific durations in their firing rate and thereby serve as components of a neural circuit used to represent duration... - Unscented Kalman filter for brain-machine interfacesZheng Li
Department of Computer Science, Duke University, Durham, North Carolina, United States of America
PLoS ONE 4:e6243. 2009..The 10th order unscented Kalman filter outperformed the standard Kalman filter and the Wiener filter in both off-line reconstruction of movement trajectories and real-time, closed-loop BMI operation... - Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptorsGeorgia M Alexander
Department of Neurobiology, Duke University, Durham, NC 27710, USA
Neuron 63:27-39. 2009..These results demonstrate a powerful chemical-genetic tool for remotely controlling the activity of discrete populations of neurons in vivo... - Integration of bilateral whisker stimuli in rats: role of the whisker barrel corticesMarshall G Shuler
Department of Neuroscience, 190 Thayer Street, HHMI Brown University, Providence, RI 02912, USA
Cereb Cortex 12:86-97. 2002..The findings presented here indicate that rats can solve a task that requires the conjoint detection of left and right whisker-mediated distance information and implicate the SIws as central to this ability... - Processing of tactile information by the hippocampusAntonio Pereira
Departamento de Fisiologia, Universidade Federal do Para, PA 66075 900, Belem, Brazil
Proc Natl Acad Sci U S A 104:18286-91. 2007..Taken together, our results show that tactile information associated with fine whisker discrimination is readily available to the hippocampus for dynamic updating of spatial maps... - Controlling robots with the mindMiguel A L Nicolelis
Sci Am 287:46-53. 2002 - Interpreting spatial and temporal neural activity through a recurrent neural network brain-machine interfaceJustin C Sanchez
Department of Pediatrics Division of Neurology, University of Florida, Gainesville, FL 32611, USA
IEEE Trans Neural Syst Rehabil Eng 13:213-9. 2005..Next, using the trained model weights, we derive a temporal sensitivity measure to asses how the model utilized the sampled cortices and neurons in real-time during BMI testing... - Continuous shared control for stabilizing reaching and grasping with brain-machine interfacesHyun K Kim
Touch Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA
IEEE Trans Biomed Eng 53:1164-73. 2006..Such a marked performance improvement in this test case suggests that some level of machine autonomy will be an important component of successful BMI systems in general... - Ascertaining the importance of neurons to develop better brain-machine interfacesJustin C Sanchez
Department of Biomedical Engineering, University of Florida, Room EB 454, Gainesville, FL 32611, USA
IEEE Trans Biomed Eng 51:943-53. 2004.... - The muscle activation method: an approach to impedance control of brain-machine interfaces through a musculoskeletal model of the armHyun K Kim
Mechatronics and Manufacturing Technology Center, Samsung Electronics, Suwon, Korea
IEEE Trans Biomed Eng 54:1520-9. 2007..Furthermore, it successfully predicted limb interactions with novel force fields, which is a new and significant capability lacking in other algorithms...
Research Grants
- Corticofugal Modulation of Tactile Sensory ProcessingMiguel Nicolelis; Fiscal Year: 2005..abstract_text> ..
- Method for In-Vivo Assessment of Neuronal DysfunctionMiguel Nicolelis; Fiscal Year: 2007....
- Trigeminal System Plasticity During Active ExplorationMiguel Nicolelis; Fiscal Year: 2007....
- GNE 2007: Global NeuroEngineering 2007Miguel Nicolelis; Fiscal Year: 2007....
- Trigeminal System Plasticity During Active ExplorationMiguel A L Nicolelis; Fiscal Year: 2010..abstract_text> ..
- TRIGEMINAL SYSTEM PLASTICITY DURING FACIAL ANESTHESIAMiguel Nicolelis; Fiscal Year: 2002....
- Dorsal Column Stimulation as a New Therapy for Motor DisordersMiguel A L Nicolelis; Fiscal Year: 2010....