R B Nicklas

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint How cells get the right chromosomes
    R B Nicklas
    Department of Zoology, LSRC Building, Duke University, Box 91000, Durham, NC 27708 1000, USA
    Science 275:632-7. 1997
  2. ncbi request reprint Tension-sensitive kinetochore phosphorylation in vitro
    R B Nicklas
    Department of Zoology, Duke University, Durham, NC 27708, USA
    J Cell Sci 111:3189-96. 1998
  3. pmc The reduction of chromosome number in meiosis is determined by properties built into the chromosomes
    L V Paliulis
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    J Cell Biol 150:1223-32. 2000
  4. ncbi request reprint Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential
    R B Nicklas
    Department of Biology, Duke University, Durham, NC 27708 1000, USA
    J Cell Sci 114:4173-83. 2001
  5. pmc Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension
    J M King
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    J Cell Biol 151:739-48. 2000

Collaborators

Detail Information

Publications5

  1. ncbi request reprint How cells get the right chromosomes
    R B Nicklas
    Department of Zoology, LSRC Building, Duke University, Box 91000, Durham, NC 27708 1000, USA
    Science 275:632-7. 1997
    ..Errors are avoided by diverse uses of mechanical tension from mitotic forces. Tension stabilizes the proper chromosome configuration, controls a cell cycle checkpoint, and changes chromosome chemistry...
  2. ncbi request reprint Tension-sensitive kinetochore phosphorylation in vitro
    R B Nicklas
    Department of Zoology, Duke University, Durham, NC 27708, USA
    J Cell Sci 111:3189-96. 1998
    ..This suggests that the substrate's phosphorylatable groups are freely available to outside constituents, e.g. regulators, as well as to the kinetochore's own kinase and phosphatase...
  3. pmc The reduction of chromosome number in meiosis is determined by properties built into the chromosomes
    L V Paliulis
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    J Cell Biol 150:1223-32. 2000
    ..These results suggest that regulation of chromosome cohesion may be linked to differences in the arrangement of kinetochores in the two meiotic divisions...
  4. ncbi request reprint Checkpoint signals in grasshopper meiosis are sensitive to microtubule attachment, but tension is still essential
    R B Nicklas
    Department of Biology, Duke University, Durham, NC 27708 1000, USA
    J Cell Sci 114:4173-83. 2001
    ..This gives a reliable 'all clear' signal to the checkpoint, allowing the cell to progress to anaphase...
  5. pmc Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension
    J M King
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    J Cell Biol 151:739-48. 2000
    ..The possible functions of this dynein fraction are therefore limited to the initial attachment and movement of chromosomes and/or to a role in the mitotic checkpoint...