Mark Newman

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Multicenter preoperative stroke risk index for patients undergoing coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group
    M F Newman
    Department of Anesthesiology, Duke Heart Center, Durham, NC, USA
    Circulation 94:II74-80. 1996
  2. ncbi Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial
    Mark F Newman
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 308:157-64. 2012
  3. ncbi Open heart surgery and cognitive decline
    Mark F Newman
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, NC 27710, USA
    Cleve Clin J Med 74:S52-5. 2007
  4. ncbi Central nervous system injury associated with cardiac surgery
    Mark F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 277110, USA
    Lancet 368:694-703. 2006
  5. ncbi Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery
    M F Newman
    Department of Anesthesiology, Division of Neurology, Duke University Medical Center, Durham, NC, USA
    Stroke 32:2874-81. 2001
  6. ncbi Apolipoprotein E polymorphisms and age at first coronary artery bypass graft
    M F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 92:824-9. 2001
  7. ncbi Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery
    M F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 344:395-402. 2001
  8. ncbi Effect of perfusion pressure on cerebral blood flow during normothermic cardiopulmonary bypass
    M F Newman
    Department of Anesthesiology, Duke Heart Center, Durham, NC, USA
    Circulation 94:II353-7. 1996
  9. ncbi Pharmacologic electroencephalographic suppression during cardiopulmonary bypass: a comparison of thiopental and isoflurane
    M F Newman
    Department of Anesthesiology, Duke Heart Center, Durham, North Carolina, USA
    Anesth Analg 86:246-51. 1998
  10. ncbi Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass
    L K Ti
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 32:1514-9. 2001

Research Grants

  1. AGING AND COGNITION AFTER CARDIAC SURGERY
    Mark Newman; Fiscal Year: 2003
  2. GENETICS, INFLAMMATION & POST-OP COGNITIVE DYSFUNCTION
    Mark Newman; Fiscal Year: 2003
  3. PeriOperative Interventional Neuroprotection Trial-POINT
    Mark Newman; Fiscal Year: 2006

Detail Information

Publications25

  1. ncbi Multicenter preoperative stroke risk index for patients undergoing coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group
    M F Newman
    Department of Anesthesiology, Duke Heart Center, Durham, NC, USA
    Circulation 94:II74-80. 1996
    ..The goal of the present study was to develop a preoperative index predicting major perioperative neurological events in patients undergoing coronary artery bypass graft surgery...
  2. ncbi Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial
    Mark F Newman
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 308:157-64. 2012
    ....
  3. ncbi Open heart surgery and cognitive decline
    Mark F Newman
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, NC 27710, USA
    Cleve Clin J Med 74:S52-5. 2007
  4. ncbi Central nervous system injury associated with cardiac surgery
    Mark F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 277110, USA
    Lancet 368:694-703. 2006
    ..We describe these issues and the controversies that merit continued investigation...
  5. ncbi Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery
    M F Newman
    Department of Anesthesiology, Division of Neurology, Duke University Medical Center, Durham, NC, USA
    Stroke 32:2874-81. 2001
    ..The purpose of our investigation was to determine the association between cognitive dysfunction and long-term quality of life after cardiac surgery...
  6. ncbi Apolipoprotein E polymorphisms and age at first coronary artery bypass graft
    M F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 92:824-9. 2001
    ..Individuals with the apoE4 allele presented earlier for CABG, and the apoE4 allele is linked to age at first CABG...
  7. ncbi Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery
    M F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 344:395-402. 2001
    ..We sought to determine the course of cognitive change during the five years after CABG and the effect of perioperative decline on long-term cognitive function...
  8. ncbi Effect of perfusion pressure on cerebral blood flow during normothermic cardiopulmonary bypass
    M F Newman
    Department of Anesthesiology, Duke Heart Center, Durham, NC, USA
    Circulation 94:II353-7. 1996
    ..86 mL.100 g-1.min-1 change in cerebral blood flow (CBF) is predicted. The purpose of this study was to define the influence of mean arterial blood pressure (MAP) on CBF during normothermic CPB...
  9. ncbi Pharmacologic electroencephalographic suppression during cardiopulmonary bypass: a comparison of thiopental and isoflurane
    M F Newman
    Department of Anesthesiology, Duke Heart Center, Durham, North Carolina, USA
    Anesth Analg 86:246-51. 1998
    ..As others have noted, it seems that cerebral protection is more complex than a simple improvement in the balance of oxygen delivery and consumption...
  10. ncbi Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass
    L K Ti
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 32:1514-9. 2001
    ....
  11. ncbi Intraoperative systolic blood pressure variability predicts 30-day mortality in aortocoronary bypass surgery patients
    Solomon Aronson
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA parallel
    Anesthesiology 113:305-12. 2010
    ..We tested the hypothesis that intraoperative systolic blood pressure variability outside a targeted blood pressure range predicts 30-day mortality in patients undergoing cardiac surgery...
  12. ncbi The association of epsilon-aminocaproic acid with postoperative decrease in creatinine clearance in 1502 coronary bypass patients
    M Stafford-Smith
    Departments of Anesthesiology and Medicine Division of Nephrology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 91:1085-90. 2000
    ....
  13. ncbi Departures from the protocol during conduct of a clinical trial: a pattern from the data record consistent with a learning curve
    J M Taekman
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Qual Saf Health Care 19:405-10. 2010
    ....
  14. ncbi Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery
    M V Podgoreanu
    Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 114:I275-81. 2006
    ..We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk of PMI after cardiac surgery...
  15. ncbi Genetic factors contribute to bleeding after cardiac surgery
    I J Welsby
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thromb Haemost 3:1206-12. 2005
    ..Postoperative bleeding remains a common, serious problem for cardiac surgery patients, with striking inter-patient variability poorly explained by clinical, procedural, and biological markers...
  16. ncbi Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery
    A M Grigore
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 95:1110-9. 2001
    ..CONCLUSIONS: Hypothermic CPB does not provide additional central nervous system protection in adult cardiac surgical patients who were maintained at either 30 or 35 degrees C during CPB...
  17. ncbi Cardiopulmonary bypass induces neurologic and neurocognitive dysfunction in the rat
    G B Mackensen
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 95:1485-91. 2001
    ..CONCLUSIONS: CPB caused both neurologic and neurocognitive impairment in a rodent recovery model. This model could potentially facilitate the investigation of CPB-related injury mechanisms and possible neuroprotective interventions...
  18. ncbi Cerebral emboli and serum S100beta during cardiac operations
    H P Grocott
    Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 65:1645-9; discussion 1649-50. 1998
    ..The purpose of this investigation was to determine the correlation between cerebral microemboli and S100beta levels during cardiac operations...
  19. ncbi Cognitive decline after major noncardiac operations: a preliminary prospective study
    K P Grichnik
    Department of Anesthesia, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 68:1786-91. 1999
    ..Cardiac operations frequently are complicated by postoperative cognitive decline. Less common and less studied is postoperative cognitive decline after noncardiac surgery, so we determined its incidence, severity, and possible predictors...
  20. ncbi Neurological injury during cardiopulmonary bypass in the rat
    H P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Perfusion 16:75-81. 2001
    ..016). This rat model of CPB may allow for the study of CPB-associated neurological injury...
  21. ncbi Intraoperative physiologic variables and outcome in cardiac surgery: Part I. In-hospital mortality
    S E Hill
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 69:1070-5; discussion 1075-6. 2000
    ....
  22. ncbi Epsilon-aminocaproic acid administration and stroke following coronary artery bypass graft surgery
    E Bennett-Guerrero
    Department of Anesthesiology, The Mount Sinai Medical Center, New York, New York 10029 6574, USA
    Ann Thorac Surg 67:1283-7. 1999
    ..Anecdotal reports of thrombotic complications have led to speculation regarding this drug's safety. We investigated the association between epsilon-aminocaproic acid administration and postoperative stroke...
  23. ncbi Cerebral embolization during cardiac surgery: impact of aortic atheroma burden
    G B Mackensen
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Br J Anaesth 91:656-61. 2003
    ..Previously demonstrated associations between TCD-detectable cerebral emboli and adverse cerebral outcome may be related to the presence of significant aortic atheromatous disease...
  24. ncbi Report of a substudy on warm versus cold cardiopulmonary bypass: changes in creatinine clearance
    M Swaminathan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 72:1603-9. 2001
    ..87). CONCLUSIONS: We did not confirm an association between warm CPB and increased renal dysfunction after cardiac operations compared with hypothermic CPB...
  25. ncbi Predicting population coverage of T-cell epitope-based diagnostics and vaccines
    Huynh Hoa Bui
    La Jolla Institute for Allergy and Immunology, Division of Vaccine Discovery, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA
    BMC Bioinformatics 7:153. 2006
    ..Thus, without careful consideration, a vaccine or diagnostic with ethnically biased population coverage could result...

Research Grants12

  1. AGING AND COGNITION AFTER CARDIAC SURGERY
    Mark Newman; Fiscal Year: 2003
    ..The new information regarding cerebral protection would also have application in all ischemic brain syndromes including stroke. ..
  2. GENETICS, INFLAMMATION & POST-OP COGNITIVE DYSFUNCTION
    Mark Newman; Fiscal Year: 2003
    ..Such an association is an important first step in elucidating the mechanism underlying genetic susceptibility to ischemic insults, and designing interventional strategies to improve outcome. ..
  3. PeriOperative Interventional Neuroprotection Trial-POINT
    Mark Newman; Fiscal Year: 2006
    ..We propose that magnesium, through one of a number of potential mechanisms will allow us to alter susceptibility to neurocognitive dysfunction and thereby prevent this tragic consequence in the aging population. ..