Research Topics
Genomes and GenesSpecies | Anna C NeedSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophreniaAnna C Need
Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
Am J Hum Genet 91:303-12. 2012....
Next generation disparities in human genomics: concerns and remediesAnna C Need
Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, NC 27708, USA
Trends Genet 25:489-94. 2009....- A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European AmericansAnna C Need
Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
Genome Biol 10:R7. 2009.... - Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsyErin L Heinzen
Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
Am J Hum Genet 91:293-302. 2012.... - A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTABAnna C Need
Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, 450 Research Drive, Box 91009, Durham, NC 27708, USA
Hum Mol Genet 18:4650-61. 2009..We discuss a possible role for rare variation in cognitive genomics... - A genome-wide investigation of SNPs and CNVs in schizophreniaAnna C Need
Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
PLoS Genet 5:e1000373. 2009..On balance, these data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens... - Common genetic variation and performance on standardized cognitive testsElizabeth T Cirulli
Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
Eur J Hum Genet 18:815-20. 2010.... - SVA: software for annotating and visualizing sequenced human genomesDongliang Ge
Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina 27708, USA
Bioinformatics 27:1998-2000. 2011..We illustrate the annotation features of SVA using two simple examples of sequenced genomes that harbor Mendelian mutations. Availability and implementation: Freely available on the web at http://www.svaproject.org... - Copy number variation of KIR genes influences HIV-1 controlKimberly Pelak
Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
PLoS Biol 9:e1001208. 2011.... - Using ERDS to infer copy-number variants in high-coverage genomesMingfu Zhu
Center for Human Genome Variation, Duke University, Durham, NC 27708, USA
Am J Hum Genet 91:408-21. 2012..These comparisons show that for genomes sequenced at high coverage, ERDS provides a computationally convenient method that calls CNVs as well as or better than any currently available method... - Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysisAnna C Need
Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
Eur J Hum Genet 17:946-57. 2009..On current evidence it is impossible to know which of these associations may be real, although in total they form a valuable resource that is immediately available to the scientific community... - WGAViewer: software for genomic annotation of whole genome association studiesDongliang Ge
Center for Population Genomics and Pharmacogenetics, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
Genome Res 18:640-3. 2008.... - Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasksNancy A Dennis
Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Hippocampus 21:980-9. 2011.... - Genome-wide scan of copy number variation in late-onset Alzheimer's diseaseErin L Heinzen
Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA
J Alzheimers Dis 19:69-77. 2010..In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation... - COMT val108/158 met genotype affects neural but not cognitive processing in healthy individualsNancy A Dennis
Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA
Cereb Cortex 20:672-83. 2010..Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output... - Failure to replicate effect of Kibra on human memory in two large cohorts of European originAnna C Need
Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA
Am J Med Genet B Neuropsychiatr Genet 147:667-8. 2008..These results suggest that Kibra does not have a strong and general effect on human memory... - Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromesErin L Heinzen
Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA
Am J Hum Genet 86:707-18. 2010..Collectively, these data implicate 16p13.11 and possibly other large deletions as risk factors for a wide range of epilepsy disorders, and they appear to point toward haploinsufficiency as a contributor to the pathogenicity of deletions... - A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instrumentsPatrick J Smith
Division of Medical Psychology, Duke University School of Medicine, Durham, NC 27710, USA
J Clin Exp Neuropsychol 35:319-28. 2013..Correlations between CANTAB subtests and traditional subtests were less consistent when age and education were controlled for. In conclusion, the CANTAB shows modest associations with traditional neuropsychological test measures... - Whole genome association studies in complex diseases: where do we stand?Anna C Need
Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
Dialogues Clin Neurosci 12:37-46. 2010..It is likely that the use of whole-genome sequencing to extend the study of rare variation in neuropsychiatry will greatly advance our understanding of neuropsychiatric genetics... 
Potential genetic causes of heterogeneity of treatment effectsDavid B Goldstein
Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27710, USA
Am J Med 120:S21-5. 2007..Increased understanding of a patient's genotype and its corresponding effect on drug response would be useful to the practicing clinician in choosing an effective drug and in optimizing the dose in a timely manner...- Clinical application of exome sequencing in undiagnosed genetic conditionsAnna C Need
Center for Human Genome Variation, Duke University School of Medicine, Box 91009, Durham, NC 27708, USA
J Med Genet 49:353-61. 2012.... - Priorities and standards in pharmacogenetic researchAnna C Need
Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, 103 Research Drive, DUMC Box 3471, Durham, North Carolina 27710, USA
Nat Genet 37:671-81. 2005..As the attention of researchers begins to shift toward more systematic pharmacogenetic investigations, we suggest some priorities and standards for pharmacogenetic research...