Anna C Need

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia
    Anna C Need
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    Am J Hum Genet 91:303-12. 2012
  2. ncbi request reprint Next generation disparities in human genomics: concerns and remedies
    Anna C Need
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, NC 27708, USA
    Trends Genet 25:489-94. 2009
  3. pmc A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Genome Biol 10:R7. 2009
  4. pmc Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy
    Erin L Heinzen
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    Am J Hum Genet 91:293-302. 2012
  5. pmc A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, 450 Research Drive, Box 91009, Durham, NC 27708, USA
    Hum Mol Genet 18:4650-61. 2009
  6. pmc The characterization of twenty sequenced human genomes
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS Genet 6:e1001111. 2010
  7. pmc A genome-wide investigation of SNPs and CNVs in schizophrenia
    Anna C Need
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000373. 2009
  8. pmc Common genetic variation and performance on standardized cognitive tests
    Elizabeth T Cirulli
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    Eur J Hum Genet 18:815-20. 2010
  9. pmc SVA: software for annotating and visualizing sequenced human genomes
    Dongliang Ge
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina 27708, USA
    Bioinformatics 27:1998-2000. 2011
  10. pmc Copy number variation of KIR genes influences HIV-1 control
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    PLoS Biol 9:e1001208. 2011

Detail Information

Publications24

  1. pmc Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia
    Anna C Need
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    Am J Hum Genet 91:303-12. 2012
    ....
  2. ncbi request reprint Next generation disparities in human genomics: concerns and remedies
    Anna C Need
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, NC 27708, USA
    Trends Genet 25:489-94. 2009
    ....
  3. pmc A genome-wide genetic signature of Jewish ancestry perfectly separates individuals with and without full Jewish ancestry in a large random sample of European Americans
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Genome Biol 10:R7. 2009
    ....
  4. pmc Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy
    Erin L Heinzen
    Center for Human Genome Variation, Duke University School of Medicine, Durham, NC 27708, USA
    Am J Hum Genet 91:293-302. 2012
    ....
  5. pmc A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, 450 Research Drive, Box 91009, Durham, NC 27708, USA
    Hum Mol Genet 18:4650-61. 2009
    ..We discuss a possible role for rare variation in cognitive genomics...
  6. pmc The characterization of twenty sequenced human genomes
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS Genet 6:e1001111. 2010
    ..Finally, we find that, on average, each genome carries 165 homozygous protein-truncating or stop loss variants in genes representing a diverse set of pathways...
  7. pmc A genome-wide investigation of SNPs and CNVs in schizophrenia
    Anna C Need
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000373. 2009
    ..On balance, these data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens...
  8. pmc Common genetic variation and performance on standardized cognitive tests
    Elizabeth T Cirulli
    Center for Human Genome Variation, Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    Eur J Hum Genet 18:815-20. 2010
    ....
  9. pmc SVA: software for annotating and visualizing sequenced human genomes
    Dongliang Ge
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina 27708, USA
    Bioinformatics 27:1998-2000. 2011
    ..We illustrate the annotation features of SVA using two simple examples of sequenced genomes that harbor Mendelian mutations...
  10. pmc Copy number variation of KIR genes influences HIV-1 control
    Kimberly Pelak
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    PLoS Biol 9:e1001208. 2011
    ....
  11. pmc Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis
    Anna C Need
    Center for Human Genome Variation, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Eur J Hum Genet 17:946-57. 2009
    ..On current evidence it is impossible to know which of these associations may be real, although in total they form a valuable resource that is immediately available to the scientific community...
  12. pmc Using ERDS to infer copy-number variants in high-coverage genomes
    Mingfu Zhu
    Center for Human Genome Variation, Duke University, Durham, NC 27708, USA
    Am J Hum Genet 91:408-21. 2012
    ..These comparisons show that for genomes sequenced at high coverage, ERDS provides a computationally convenient method that calls CNVs as well as or better than any currently available method...
  13. pmc WGAViewer: software for genomic annotation of whole genome association studies
    Dongliang Ge
    Center for Population Genomics and Pharmacogenetics, Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA
    Genome Res 18:640-3. 2008
    ....
  14. pmc Brain-derived neurotrophic factor val66met polymorphism and hippocampal activation during episodic encoding and retrieval tasks
    Nancy A Dennis
    Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Hippocampus 21:980-9. 2011
    ....
  15. doi request reprint A comparison of the Cambridge Automated Neuropsychological Test Battery (CANTAB) with "traditional" neuropsychological testing instruments
    Patrick J Smith
    Division of Medical Psychology, Duke University School of Medicine, Durham, NC 27710, USA
    J Clin Exp Neuropsychol 35:319-28. 2013
    ..Correlations between CANTAB subtests and traditional subtests were less consistent when age and education were controlled for. In conclusion, the CANTAB shows modest associations with traditional neuropsychological test measures...
  16. pmc Genome-wide scan of copy number variation in late-onset Alzheimer's disease
    Erin L Heinzen
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA
    J Alzheimers Dis 19:69-77. 2010
    ..In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation...
  17. pmc COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals
    Nancy A Dennis
    Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA
    Cereb Cortex 20:672-83. 2010
    ..Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output...
  18. ncbi request reprint Failure to replicate effect of Kibra on human memory in two large cohorts of European origin
    Anna C Need
    Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 147:667-8. 2008
    ..These results suggest that Kibra does not have a strong and general effect on human memory...
  19. pmc Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes
    Erin L Heinzen
    Center for Human Genome Variation, School of Medicine, Duke University, Durham, NC 27708, USA
    Am J Hum Genet 86:707-18. 2010
    ..Collectively, these data implicate 16p13.11 and possibly other large deletions as risk factors for a wide range of epilepsy disorders, and they appear to point toward haploinsufficiency as a contributor to the pathogenicity of deletions...
  20. ncbi request reprint One gene, many neuropsychiatric disorders: lessons from Mendelian diseases
    Xiaolin Zhu
    Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina, USA
    Nat Neurosci 17:773-81. 2014
    ..Ultimately, we conclude that functional approaches will be critical for explaining the causes of nonspecific risk factors discovered by human genetic studies of neuropsychiatric disorders. ..
  21. pmc Whole genome association studies in complex diseases: where do we stand?
    Anna C Need
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina 27708, USA
    Dialogues Clin Neurosci 12:37-46. 2010
    ..It is likely that the use of whole-genome sequencing to extend the study of rare variation in neuropsychiatry will greatly advance our understanding of neuropsychiatric genetics...
  22. ncbi request reprint Potential genetic causes of heterogeneity of treatment effects
    David B Goldstein
    Center for Population Genomics and Pharmacogenetics, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27710, USA
    Am J Med 120:S21-5. 2007
    ..Increased understanding of a patient's genotype and its corresponding effect on drug response would be useful to the practicing clinician in choosing an effective drug and in optimizing the dose in a timely manner...
  23. pmc Clinical application of exome sequencing in undiagnosed genetic conditions
    Anna C Need
    Center for Human Genome Variation, Duke University School of Medicine, Box 91009, Durham, NC 27708, USA
    J Med Genet 49:353-61. 2012
    ....
  24. ncbi request reprint Priorities and standards in pharmacogenetic research
    Anna C Need
    Institute for Genome Sciences and Policy, Center for Population Genomics and Pharmacogenetics, Duke University, 103 Research Drive, DUMC Box 3471, Durham, North Carolina 27710, USA
    Nat Genet 37:671-81. 2005
    ..As the attention of researchers begins to shift toward more systematic pharmacogenetic investigations, we suggest some priorities and standards for pharmacogenetic research...