Lindsey Mork

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint The battle of the sexes
    B Capel
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mech Dev 92:89-103. 2000
  2. ncbi request reprint Frank Lillie's freemartin: illuminating the pathway to 21st century reproductive endocrinology
    Blanche Capel
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Zool A Comp Exp Biol 301:853-6. 2004
  3. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
  4. pmc Unmasking a role for sex chromosomes in gene silencing
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Genome Biol 11:134. 2010
  5. ncbi request reprint Sex in the 90s: SRY and the switch to the male pathway
    B Capel
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Physiol 60:497-523. 1998
  6. ncbi request reprint Migration of mesonephric cells into the mammalian gonad depends on Sry
    B Capel
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mech Dev 84:127-31. 1999
  7. pmc Germ cells are not required to establish the female pathway in mouse fetal gonads
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e47238. 2012
  8. doi request reprint Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 383:295-306. 2013
  9. pmc Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad
    Samantha A Jameson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Genet 8:e1002575. 2012
  10. ncbi request reprint Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta)
    Leo DiNapoli
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Zool B Mol Dev Evol 308:236-41. 2007

Collaborators

Detail Information

Publications44

  1. ncbi request reprint The battle of the sexes
    B Capel
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mech Dev 92:89-103. 2000
    ....
  2. ncbi request reprint Frank Lillie's freemartin: illuminating the pathway to 21st century reproductive endocrinology
    Blanche Capel
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Exp Zool A Comp Exp Biol 301:853-6. 2004
  3. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
    ..In principle, sex determination in other vertebrates may operate through any switch that introduces an imbalance between these two signaling pathways...
  4. pmc Unmasking a role for sex chromosomes in gene silencing
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Genome Biol 11:134. 2010
    ..Several sexually dimorphic phenotypes correlate with sex-chromosome dosage rather than with phenotypic sex. New research suggests that sex chromosome dimorphism helps to regulate gene silencing...
  5. ncbi request reprint Sex in the 90s: SRY and the switch to the male pathway
    B Capel
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Physiol 60:497-523. 1998
    ..Mechanisms of testis organogenesis triggered downstream of SRY include pathways of cell signaling controlling cell reorganization, cell proliferation, cell migration, and vascularization...
  6. ncbi request reprint Migration of mesonephric cells into the mammalian gonad depends on Sry
    B Capel
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mech Dev 84:127-31. 1999
    ..The induction of cell migration represents the earliest signaling pathway yet assigned to Sry...
  7. pmc Germ cells are not required to establish the female pathway in mouse fetal gonads
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e47238. 2012
    ..Since we do not find defects in the ovarian somatic program, the subsequent failure to form follicles at perinatal stages is likely attributable to the absence of germ cells rather than to defects in the somatic cells...
  8. doi request reprint Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 383:295-306. 2013
    ..This may explain the lack of complete sex reversal in such mutants at the sex-determining stage. ..
  9. pmc Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad
    Samantha A Jameson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Genet 8:e1002575. 2012
    ..More importantly, it yields new insights into the mechanisms by which different cell types in a single organ adopt their respective fates...
  10. ncbi request reprint Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta)
    Leo DiNapoli
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Zool B Mol Dev Evol 308:236-41. 2007
    ..We present evidence that normal morphological development of the fetal gonad occurs in both sexes in T. scripta after germ cell depletion, suggesting a conservation of developmental mechanisms across vertebrates...
  11. ncbi request reprint Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads
    Humphrey H C Yao
    Department of Cell Biology, Duke University, Durham NC 27710, USA
    Development 130:5895-902. 2003
    ..We suggest that at the stage when germ cells commit to meiosis, they reinforce ovarian fate by antagonizing the testis pathway...
  12. doi request reprint Gonad morphogenesis in vertebrates: divergent means to a convergent end
    Tony DeFalco
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Cell Dev Biol 25:457-82. 2009
    ..We also discuss the plasticity of the adult gonad and consider how different genetic and environmental conditions can induce transitions between testis and ovary morphology...
  13. pmc BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice
    Matthew S Cook
    Department of Cell Biology, Duke University, Durham, NC, USA
    Dev Biol 328:377-83. 2009
    ..We conclude that BAX-mediated apoptosis plays a role in early germ cell loss and protects from testicular teratoma formation on a mixed genetic background...
  14. pmc Four-dimensional analysis of vascularization during primary development of an organ, the gonad
    Douglas Coveney
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 105:7212-7. 2008
    ..This model of vascular development in an internal organ has a direct impact on the current dogma of vascular integration during organ development and presents important parallels with mechanisms of tumor vascularization...
  15. pmc Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice
    Lindsey Mork
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Biol Reprod 86:37. 2012
    ..These findings add complexity to the standard model of sex determination in which the Sertoli and granulosa cells of the adult testis and ovary directly stem from the supporting cell precursors of the bipotential gonad...
  16. pmc Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:2949-55. 2008
    ..The identification of beta-catenin as a key pro-ovarian and anti-testis signaling molecule will further our understanding of the mechanisms controlling sex determination and the molecular mechanisms that lead to sex-reversal...
  17. ncbi request reprint FGF9 promotes survival of germ cells in the fetal testis
    Leo DiNapoli
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 133:1519-27. 2006
    ..FGF9 is necessary for 11.5 dpc XY gonocyte survival and is the earliest reported factor with a sex-specific role in regulating germ cell survival...
  18. ncbi request reprint Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination
    Jennifer Schmahl
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 131:3627-36. 2004
    ..The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate...
  19. ncbi request reprint One tissue, two fates: molecular genetic events that underlie testis versus ovary development
    Jennifer Brennan
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 5:509-21. 2004
  20. pmc Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis
    Humphrey Hung Chang Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 16:1433-40. 2002
    ....
  21. pmc Mouse germ cell clusters form by aggregation as well as clonal divisions
    Lindsey Mork
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mech Dev 128:591-6. 2012
    ..We show that germ cell clusters in the fetal gonad arise through aggregation as well as cell division. Intercellular bridges, however, are likely restricted to cells of the same genotype...
  22. ncbi request reprint Cellular mechanisms of sex determination in the red-eared slider turtle, Trachemys scripta
    Humphrey H C Yao
    Department of Cell Biology, Duke University Medical Center, Box 3709, Nanaline Duke, Research Drive, Durham, NC 27710, USA
    Mech Dev 121:1393-401. 2004
    ..We conclude that typical testis architecture results from the maintenance and elaboration of primitive sex cords in T. scripta rather than the assembly of de novo structures as in mouse...
  23. ncbi request reprint Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad
    Jennifer Brennan
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 244:418-28. 2002
    ..This newly formed arterial system establishes a new pattern of blood flow in the XY gonad, which we speculate may have an important role in export of testosterone to masculinize the XY embryo...
  24. ncbi request reprint Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
    Humphrey H C Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Dev Dyn 230:210-5. 2004
    ..Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary...
  25. ncbi request reprint AMH induces mesonephric cell migration in XX gonads
    Andrea J Ross
    Department of Cell Biology, Duke University Medical Center, Box 3709, 340 Nanaline Duke, Research Dr, Durham, NC 27710, USA
    Mol Cell Endocrinol 211:1-7. 2003
    ..The factors involved in this process remain to be identified...
  26. ncbi request reprint Cell proliferation is necessary for the determination of male fate in the gonad
    Jennifer Schmahl
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Dev Biol 258:264-76. 2003
    ..We believe these studies suggest that proliferation is involved not only in the elaboration of organ pattern, but also in the choice between patterns (male and female) in the bipotential gonad...
  27. pmc Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam
    Hao Tang
    The Department of Cell Biology, Duke University Medical Center, Box 3471, Genome Science Research Building II, Room 4026, Research Drive, Durham, NC 27710, USA
    Dev Biol 318:73-81. 2008
    ..This suggests that either there is a function for the remaining N-terminal of GM114, or that there are alternative mechanisms in the mammalian system that control germ cell differentiation...
  28. pmc Oestrogen shuts the door on SOX9
    Lindsey Mork
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    BMC Biol 8:110. 2010
    ..See research article http://www.biomedcentral.com/1741-7007/8/113...
  29. ncbi request reprint Cellular and molecular pathways regulating mammalian sex determination
    Christopher Tilmann
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 57:1-18. 2002
    ..Work is underway to identify genes controlling these processes. These genes will then be linked to Sry...
  30. doi request reprint Mixed signals: development of the testis
    Jonah Cool
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Semin Reprod Med 27:5-13. 2009
    ..In this article we focus on signals in the male gonad that first are responsible for the specification of Sertoli cells, and second for the specification and patterning of interstitial cells...
  31. ncbi request reprint The battle of the sexes: opposing pathways in sex determination
    Humphrey Hung Chang Yao
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Novartis Found Symp 244:187-98; discussion 198-206, 253-7. 2002
    ..Current experiments in the lab address the hypothesis that cord formation and germ cell entry into meiosis are competing pathways in gonad development...
  32. ncbi request reprint Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis
    Humphrey Hung Chang Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 246:356-65. 2002
    ....
  33. pmc Notch signaling maintains Leydig progenitor cells in the mouse testis
    Hao Tang
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:3745-53. 2008
    ....
  34. ncbi request reprint Pin1 regulates the timing of mammalian primordial germ cell proliferation
    Fawn W Atchison
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 130:3579-86. 2003
    ..These results indicate that Pin1 regulates the timing of PGC proliferation during mouse embryonic development...
  35. pmc Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:16558-63. 2007
    ..Using these two Cre lines, we provide the first genetic evidence that Fgfr2 plays distinct roles in proliferation and Sertoli cell differentiation during testis development...
  36. ncbi request reprint Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Dyn 235:2292-300. 2006
    ....
  37. pmc Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad
    Jennifer Brennan
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Genes Dev 17:800-10. 2003
    ..This work identifies PDGF signaling through the alpha receptor as an important event downstream of Sry in testis organogenesis and Leydig cell differentiation...
  38. ncbi request reprint A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation
    Douglas Coveney
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Gene Expr Patterns 7:82-92. 2007
    ....
  39. ncbi request reprint Optimized regimen for expression of heat-inducible Cre in mice
    Leo DiNapoli
    Duke University, Durham, NC 27710, USA
    Biotechniques 42:710, 712, 714. 2007
  40. pmc Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal
    Steven C Munger
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 23:2521-36. 2009
    ..Our results reveal the complex transcription architecture underlying sex determination, and provide a mechanism by which individuals may be sensitized for sex reversal...
  41. ncbi request reprint Signaling at the crossroads of gonad development
    Andrea J Ross
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Trends Endocrinol Metab 16:19-25. 2005
    ..Recently, several of the molecular signals that direct these processes have been identified. In addition, the pathways that suppress features of testis development in the XX gonad are being elucidated...
  42. pmc Blurring the edges in vertebrate sex determination
    Lindsey A Barske
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Genet Dev 18:499-505. 2008
    ..This system would be highly responsive to changes in the upstream primary signal and may provide a basis for the rapid evolution of and transitions between different methods of sex determination...
  43. doi request reprint Sexual development of the soma in the mouse
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Top Dev Biol 83:151-83. 2008
    ..However, recent evidence reveals expression differences between XX and XY brains prior to the time that hormones are circulating, suggesting that some influences on brain development may be autonomous to the cells of the brain...
  44. ncbi request reprint A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation
    Douglas Coveney
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Gene Expr Patterns 8:529-37. 2008
    ....

Research Grants22

  1. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. ..
  2. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. ..
  3. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ....
  4. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2009
    ....
  5. ORGAN SPECIFIC MECHANISMS OF VASCULAR DEVELOPMENT
    Blanche Capel; Fiscal Year: 2002
    ..Moreover, it serves as a general model of how the development of diverse vascular phenotypes is signaled and integrated with organogenesis throughout the embryo. ..
  6. Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1
    Blanche Capel; Fiscal Year: 2010
    ..Although DND1 is specific to germ cells, we anticipate that the regulatory mechanisms involved may be common to many pluripotent stem cell populations. ..