Joel N Meyer

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. Luz A, Godebo T, Bhatt D, Ilkayeva O, Maurer L, Hirschey M, et al. From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans. Toxicol Sci. 2016;152:349-62 pubmed publisher
  2. Meyer J, Chan S. Sources, mechanisms, and consequences of chemical-induced mitochondrial toxicity. Toxicology. 2017;391:2-4 pubmed publisher
  3. Shappell N, Hyndman K, Bartell S, Schoenfuss H. Comparative biological effects and potency of 17?- and 17?-estradiol in fathead minnows. Aquat Toxicol. 2010;100:1-8 pubmed publisher
  4. Rooney J, Luz A, González Hunt C, Bodhicharla R, Ryde I, Anbalagan C, et al. Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans. Exp Gerontol. 2014;56:69-76 pubmed publisher
    ..We discuss the relative pitfalls associated with using FUdR and germline deficient mutant strains as tools for the experimental elimination of progeny. ..
  5. Meyer J. QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology. Ecotoxicology. 2010;19:804-11 pubmed publisher
    ..I suggest that the QPCR assay is particularly powerful for some ecotoxicological studies. ..
  6. Luz A, Meyer J. Effects of reduced mitochondrial DNA content on secondary mitochondrial toxicant exposure in Caenorhabditis elegans. Mitochondrion. 2016;30:255-64 pubmed publisher
    ..These mixed results provide a first line of evidence suggesting that reduced mtDNA content may sensitize an individual to certain environmental exposures. ..
  7. request reprint
    Meyer J, Nacci D, Di Giulio R. Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments. Toxicol Sci. 2002;68:69-81 pubmed
    ..Additionally, we investigated the hypothesis that low CYP1A activity (measured as in ovo EROD activity) would correlate to increased survival in Elizabeth River sediment pore water; this hypothesis was not supported by our results...
  8. request reprint
    Meyer J, Di Giulio R. Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA. Mar Environ Res. 2002;54:621-6 pubmed
    ..Furthermore, the pattern of greater resistance to acute toxicity and P4501A-inducing activity in the first generation and less in subsequent generations is also observed upon exposure to PCB-126...
  9. Wyatt L, Luz A, Cao X, Maurer L, Blawas A, Aballay A, et al. Effects of methyl and inorganic mercury exposure on genome homeostasis and mitochondrial function in Caenorhabditis elegans. DNA Repair (Amst). 2017;52:31-48 pubmed publisher
    ..Overall, mercury exposure disrupted mitochondrial endpoints in a mercury-compound dependent fashion. ..

More Information

Publications12

  1. Luz A, Godebo T, Smith L, Leuthner T, Maurer L, Meyer J. Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. Toxicology. 2017;387:81-94 pubmed publisher
    ..It also suggests that individuals suffering from deficiencies in mitodynamic processes may be more susceptible to the mitochondrial toxicity of arsenic and other toxicants. ..
  2. Meyer J, Leuthner T, Luz A. Mitochondrial fusion, fission, and mitochondrial toxicity. Toxicology. 2017;391:42-53 pubmed publisher
  3. Luz A, Kassotis C, Stapleton H, Meyer J. The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARγ activation, in 3T3-L1 cells. Toxicology. 2018;393:150-159 pubmed publisher
    ..Exposures that disrupt mitochondrial function may have the potential to contribute to the rising incidence of metabolic syndrome, and thus more research is needed to understand the human health impact of pyraclostrobin exposure. ..