Joel Meyer

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology
    Maxwell C K Leung
    Nicholas School of the Environment, Duke University, Durham, North Carolina 27750, USA
    Toxicol Sci 106:5-28. 2008
  2. pmc Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity
    Andrey Alexeyenko
    Stockholm Bioinformatics Centre, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e10465. 2010
  3. pmc Assessing different mechanisms of toxicity in mountaintop removal/valley fill coal mining-affected watershed samples using Caenorhabditis elegans
    Elena A Turner
    Nicholas School of the Environment, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 8:e75329. 2013
  4. pmc Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans
    Amanda S Bess
    Duke University, Nicholas School of Environment, Integrated Toxicology and Environmental Health Program, LSRC, PO Box 90328, Durham, NC 27708, USA
    Nucleic Acids Res 40:7916-31. 2012
  5. pmc Mitochondria as a target of environmental toxicants
    Joel N Meyer
    Nicholas School of the Environment, Duke University, Durham, NC, USA
    Toxicol Sci 134:1-17. 2013
  6. pmc Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans
    Maxwell C K Leung
    Nicholas School of the Environment, Duke University, Durham, NC, USA
    BMC Pharmacol Toxicol 14:9. 2013
  7. pmc Involvement of autophagy and mitochondrial dynamics in determining the fate and effects of irreparable mitochondrial DNA damage
    Joel N Meyer
    Nicholas School of the Environment Duke University Durham, NC, USA
    Autophagy 8:1822-23. 2012
  8. doi request reprint Comparative biological effects and potency of 17α- and 17β-estradiol in fathead minnows
    N W Shappell
    Biosciences Research Laboratory, Red River Valley Agricultural Research Center, U S Department of Agriculture, 1605 Albrecht Boulevard, Fargo, ND 58105, USA
    Aquat Toxicol 100:1-8. 2010
  9. pmc QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology
    Joel N Meyer
    Nicholas School of the Environment, Duke University, Durham, Box 90328, NC 27708 0328, USA
    Ecotoxicology 19:804-11. 2010
  10. ncbi request reprint Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments
    Joel N Meyer
    Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, North Carolina 27708 0328, USA
    Toxicol Sci 68:69-81. 2002

Collaborators

Detail Information

Publications27

  1. pmc Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology
    Maxwell C K Leung
    Nicholas School of the Environment, Duke University, Durham, North Carolina 27750, USA
    Toxicol Sci 106:5-28. 2008
    ..elegans including genome-wide screening for molecular targets of toxicity and rapid toxicity assessment for new chemicals. We argue for an increased role for C. elegans in complementing other model systems in toxicological research...
  2. pmc Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity
    Andrey Alexeyenko
    Stockholm Bioinformatics Centre, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e10465. 2010
    ..For this purpose, we also computationally inferred a zebrafish (Danio rerio) interactome based on orthologs and interaction data from other eukaryotes...
  3. pmc Assessing different mechanisms of toxicity in mountaintop removal/valley fill coal mining-affected watershed samples using Caenorhabditis elegans
    Elena A Turner
    Nicholas School of the Environment, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 8:e75329. 2013
    ..Our results indicate that in general, the toxicity of streamwater to C. elegans was attributable to osmotic stress, while the toxicity of sediments resulted mostly from metals or metalloids. ..
  4. pmc Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans
    Amanda S Bess
    Duke University, Nicholas School of Environment, Integrated Toxicology and Environmental Health Program, LSRC, PO Box 90328, Durham, NC 27708, USA
    Nucleic Acids Res 40:7916-31. 2012
    ..Mutations in genes in these pathways exist in the human population, demonstrating the potential for important gene-environment interactions affecting mitochondrial health after genotoxin exposure...
  5. pmc Mitochondria as a target of environmental toxicants
    Joel N Meyer
    Nicholas School of the Environment, Duke University, Durham, NC, USA
    Toxicol Sci 134:1-17. 2013
    ..We conclude that the fields of environmental toxicology and environmental health should focus more strongly on mitochondria. ..
  6. pmc Effects of early life exposure to ultraviolet C radiation on mitochondrial DNA content, transcription, ATP production, and oxygen consumption in developing Caenorhabditis elegans
    Maxwell C K Leung
    Nicholas School of the Environment, Duke University, Durham, NC, USA
    BMC Pharmacol Toxicol 14:9. 2013
    ..The impacts of mtDNA damage incurred early in development are not well understood, especially in the case of types of mtDNA damage that are irreparable, such as ultraviolet C radiation (UVC)-induced photodimers...
  7. pmc Involvement of autophagy and mitochondrial dynamics in determining the fate and effects of irreparable mitochondrial DNA damage
    Joel N Meyer
    Nicholas School of the Environment Duke University Durham, NC, USA
    Autophagy 8:1822-23. 2012
    ..Reduced mitochondrial fission and autophagy caused no or small effects, while reduced mitochondrial fusion had dramatic effects...
  8. doi request reprint Comparative biological effects and potency of 17α- and 17β-estradiol in fathead minnows
    N W Shappell
    Biosciences Research Laboratory, Red River Valley Agricultural Research Center, U S Department of Agriculture, 1605 Albrecht Boulevard, Fargo, ND 58105, USA
    Aquat Toxicol 100:1-8. 2010
    ....
  9. pmc QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology
    Joel N Meyer
    Nicholas School of the Environment, Duke University, Durham, Box 90328, NC 27708 0328, USA
    Ecotoxicology 19:804-11. 2010
    ..I suggest that the QPCR assay is particularly powerful for some ecotoxicological studies...
  10. ncbi request reprint Cytochrome P4501A (CYP1A) in killifish (Fundulus heteroclitus): heritability of altered expression and relationship to survival in contaminated sediments
    Joel N Meyer
    Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, North Carolina 27708 0328, USA
    Toxicol Sci 68:69-81. 2002
    ..Additionally, we investigated the hypothesis that low CYP1A activity (measured as in ovo EROD activity) would correlate to increased survival in Elizabeth River sediment pore water; this hypothesis was not supported by our results...
  11. doi request reprint Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans
    Joel N Meyer
    Nicholas School of the Environment and Center for the Environmental Implications of NanoTechnology, Duke University, Durham, NC 27708 0328, United States
    Aquat Toxicol 100:140-50. 2010
    ..Finally, we describe a modified growth assay that permits differentiation between direct growth-inhibitory effects and indirect inhibition mediated by toxicity to the food source...
  12. pmc Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans
    Joel N Meyer
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Alexander Drive, Research Triangle Park, NC 27709, USA
    Genome Biol 8:R70. 2007
    ..We adapted a quantitative polymerase chain reaction assay to characterize repair of DNA damage induced by ultraviolet type C (UVC) radiation in C. elegans, and then tested whether DNA repair rates were affected by age in adults...
  13. ncbi request reprint Patterns of heritability of decreased EROD activity and resistance to PCB 126-induced teratogenesis in laboratory-reared offspring of killifish (Fundulus heteroclitus) from a creosote-contaminated site in the Elizabeth River, VA, USA
    Joel Meyer
    Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, NC 27708 0328, USA
    Mar Environ Res 54:621-6. 2002
    ..Furthermore, the pattern of greater resistance to acute toxicity and P4501A-inducing activity in the first generation and less in subsequent generations is also observed upon exposure to PCB-126...
  14. pmc The long amplicon quantitative PCR for DNA damage assay as a sensitive method of assessing DNA damage in the environmental model, Atlantic killifish (Fundulus heteroclitus)
    Dawoon Jung
    Nicholas School of the Environment, Duke University, Durham, NC 27708, USA
    Comp Biochem Physiol C Toxicol Pharmacol 149:182-6. 2009
    ..Therefore, we argue that this assay will be a valuable tool in assessing DNA damage in ecotoxicological studies...
  15. ncbi request reprint Analysis of CpG methylation in the killifish CYP1A promoter
    Alicia R Timme-Laragy
    Nicholas School of the Environment and Earth Sciences Integrated Toxicology Program, Box 90328, Duke University, Durham, NC, USA
    Comp Biochem Physiol C Toxicol Pharmacol 141:406-11. 2005
    ..In fish from both the contaminated and the reference site, cytosine methylation was not detectable at any of the 34 CpG sites examined, including 3 that are part of putative xenobiotic response elements...
  16. ncbi request reprint Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells
    Janine H Santos
    Laboratory of Molecular Genetics, National Institute of Environmental Health Science, NIH, Research Triangle Park, NC, USA
    Methods Mol Biol 314:183-99. 2006
    ..In addition, we give a detailed protocol for the QPCR assay that helps facilitate its successful deployment in any molecular biology laboratory...
  17. ncbi request reprint Antioxidant defenses in killifish (Fundulus heteroclitus) exposed to contaminated sediments and model prooxidants: short-term and heritable responses
    Joel N Meyer
    Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, NC 27708 0328, USA
    Aquat Toxicol 65:377-95. 2003
    ..The responses of specific antioxidant parameters, including sex-specific responses in the cases of glutathione concentrations and GR activity, are also discussed...
  18. pmc The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number
    Senyene E Hunter
    Nicholas School of the Environment, Duke University, Durham, NC 27708 0328, USA
    Methods 51:444-51. 2010
    ..Finally, we illustrate the use of the assay by measuring repair of ultraviolet C radiation-induced DNA damage in the nuclear but not mitochondrial genomes of a zebrafish cell culture...
  19. pmc Nucleotide excision repair genes are expressed at low levels and are not detectably inducible in Caenorhabditis elegans somatic tissues, but their function is required for normal adult life after UVC exposure
    Windy A Boyd
    Biomolecular Screening Branch, National Toxicology Program, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA
    Mutat Res 683:57-67. 2010
    ..Finally, we describe a refinement of our DNA damage assay that allows damage measurement in single nematodes...
  20. ncbi request reprint Differential display of hepatic mRNA from killifish (Fundulus heteroclitus) inhabiting a Superfund estuary
    Joel N Meyer
    Nicholas School of the Environment and Earth Sciences, and Integrated Toxicology Program, Duke University, Durham, NC 27708 0328, USA
    Aquat Toxicol 73:327-41. 2005
    ..In addition, the results indicate that the effect of contaminated sediment exposure on the expression of a large proportion of the differentially expressed mRNAs was dependent on the sex of the fish...
  21. ncbi request reprint Expression and inducibility of aryl hydrocarbon receptor pathway genes in wild-caught killifish (Fundulus heteroclitus) with different contaminant-exposure histories
    Joel N Meyer
    Nicholas School of the Environment and Earth Sciences and Integrated Toxicology Program, Duke University, Durham, North Carolina 27708 0328, USA
    Environ Toxicol Chem 22:2337-43. 2003
    ....
  22. ncbi request reprint Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Natinoal Institutes of Health, 111, Alexander Drive, MD D3 01, Research Triangle Park, NC 27709, USA
    Aging Cell 3:399-411. 2004
    ..These results suggest that mitochondrial telomerase sensitizes cells to oxidative stress, which can lead to apoptotic cell death, and imply a novel function of telomerase in mitochondrial DNA transactions...
  23. ncbi request reprint Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination
    Sherine S L Chan
    Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 48:190-200. 2007
    ..Our data suggest that AZT/3TC combination treatment produces greater mtDNA damage than either agent individually, and that female mice are more sensitive than males to AZT/3TC-induced mtDNA damage...
  24. ncbi request reprint Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis
    Janine Hertzog Santos
    Laboratory of Molecular Genetics, National Institute of Environmental and Health Sciences NIH, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Hum Mol Genet 15:1757-68. 2006
    ....
  25. pmc Altered gene expression and DNA damage in peripheral blood cells from Friedreich's ataxia patients: cellular model of pathology
    Astrid C Haugen
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    PLoS Genet 6:e1000812. 2010
    ..Furthermore, the identification of potential biomarkers, including the DNA damage found in peripheral blood, may have predictive value in future clinical trials...
  26. pmc Nonadditive effects of PAHs on Early Vertebrate Development: mechanisms and implications for risk assessment
    Sonya M Billiard
    Health Canada, Health Products and Food Branch, Bureau of Chemical Safety, Ottawa, Ontario K1A0L2, Canada
    Toxicol Sci 105:5-23. 2008
    ..Throughout, we place particular emphasis on research on the early life stages of fish, which has proven to be a sensitive and rapid developmental model to elucidate effects of hydrocarbon mixtures...