J M McClung

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Calpain-1 is required for hydrogen peroxide-induced myotube atrophy
    J M McClung
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Rm 25 Florida Gym, Gainesville, FL 32611, USA
    Am J Physiol Cell Physiol 296:C363-71. 2009
  2. pmc Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
    Crit Care Med 37:1373-9. 2009
  3. pmc p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting
    J M McClung
    Exercise Biochemistry Laboratory, University of Florida, Gainesville, Florida, USA
    Am J Physiol Cell Physiol 298:C542-9. 2010
  4. doi request reprint Redox regulation of diaphragm proteolysis during mechanical ventilation
    J M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1608-17. 2008
  5. pmc Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling
    J M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25 Florida Gym, Gainesville, FL 32611, USA
    J Physiol 585:203-15. 2007

Detail Information

Publications5

  1. pmc Calpain-1 is required for hydrogen peroxide-induced myotube atrophy
    J M McClung
    Dept of Applied Physiology and Kinesiology, Univ of Florida, Rm 25 Florida Gym, Gainesville, FL 32611, USA
    Am J Physiol Cell Physiol 296:C363-71. 2009
    ..Collectively, our data provide the first evidence for an absolute requirement for calpain-1 in the development of skeletal muscle myotube atrophy in response to oxidant-induced cellular stress...
  2. pmc Apocynin attenuates diaphragm oxidative stress and protease activation during prolonged mechanical ventilation
    Joseph M McClung
    Department of Applied Physiology and Kinesiology, Center for Exercise Science, University of Florida, Gainesville, FL, USA
    Crit Care Med 37:1373-9. 2009
    ..To investigate whether apocynin protects the diaphragm from wasting and oxidative stress during mechanical ventilation (MV)...
  3. pmc p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting
    J M McClung
    Exercise Biochemistry Laboratory, University of Florida, Gainesville, Florida, USA
    Am J Physiol Cell Physiol 298:C542-9. 2010
    ....
  4. doi request reprint Redox regulation of diaphragm proteolysis during mechanical ventilation
    J M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1608-17. 2008
    ..In summary, these data are consistent with the notion that the protective effect of antioxidants on the diaphragm during MV is due, at least in part, to decreasing myofilament protein substrate availability to the proteasome...
  5. pmc Antioxidant administration attenuates mechanical ventilation-induced rat diaphragm muscle atrophy independent of protein kinase B (PKB Akt) signalling
    J M McClung
    Department of Applied Physiology and Kinesiology, University of Florida, Room 25 Florida Gym, Gainesville, FL 32611, USA
    J Physiol 585:203-15. 2007
    ..Further, these results also indicate that differential regulation of diaphragmatic IGF-1-PI3K-Akt signalling exists during the early and late stages of MV...