Joseph McClernon

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint The effects of foods, beverages, and other factors on cigarette palatability
    F Joseph McClernon
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27708, USA
    Nicotine Tob Res 9:505-10. 2007
  2. pmc Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study
    Jennifer N Felder
    Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7160, USA
    BMC Psychiatry 12:152. 2012
  3. ncbi request reprint Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study
    F Joseph McClernon
    Duke University Medical Center, NC 27708, USA
    Addict Biol 12:503-12. 2007
  4. ncbi request reprint DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Psychopharmacology (Berl) 194:433-41. 2007
  5. ncbi request reprint Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues
    Francis J McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Neuropsychopharmacology 33:2148-57. 2008
  6. ncbi request reprint Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary study
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC, 27708, USA
    Psychopharmacology (Berl) 197:95-105. 2008
  7. doi request reprint Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Cneter, Durham, NC 27708, USA
    Nicotine Tob Res 10:117-27. 2008
  8. pmc ADHD and smoking: from genes to brain to behavior
    FRANCIS JOSEPH MCCLERNON
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Ann N Y Acad Sci 1141:131-47. 2008
  9. pmc 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Psychopharmacology (Berl) 204:25-35. 2009
  10. pmc Smoking withdrawal symptoms are more severe among smokers with ADHD and independent of ADHD symptom change: results from a 12-day contingency-managed abstinence trial
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Nicotine Tob Res 13:784-92. 2011

Detail Information

Publications35

  1. ncbi request reprint The effects of foods, beverages, and other factors on cigarette palatability
    F Joseph McClernon
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27708, USA
    Nicotine Tob Res 9:505-10. 2007
    ..Clinical implications and directions for future research are discussed...
  2. pmc Neural mechanisms of subclinical depressive symptoms in women: a pilot functional brain imaging study
    Jennifer N Felder
    Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599 7160, USA
    BMC Psychiatry 12:152. 2012
    ..The purpose of this study was to evaluate relations between subclinical levels of depressive symptoms and neural activation patterns during tasks previously shown to differentiate individuals with and without MDD...
  3. ncbi request reprint Selectively reduced responses to smoking cues in amygdala following extinction-based smoking cessation: results of a preliminary functional magnetic resonance imaging study
    F Joseph McClernon
    Duke University Medical Center, NC 27708, USA
    Addict Biol 12:503-12. 2007
    ....
  4. ncbi request reprint DRD4 VNTR polymorphism is associated with transient fMRI-BOLD responses to smoking cues
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Psychopharmacology (Berl) 194:433-41. 2007
    ..A dopamine receptor 4 variable number tandem repeat (DRD4 VNTR) polymorphism has been related to reactivity to smoking cues among smokers, but the effect of this genetic variation on brain responses to smoking cues has not been evaluated...
  5. ncbi request reprint Individual differences in nicotine dependence, withdrawal symptoms, and sex predict transient fMRI-BOLD responses to smoking cues
    Francis J McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Neuropsychopharmacology 33:2148-57. 2008
    ..These findings provide further evidence that reactivity to conditioned drug cues is multiply determined and suggest that smoking cessation treatments designed to reduce cue reactivity focus on each of these variables...
  6. ncbi request reprint Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary study
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC, 27708, USA
    Psychopharmacology (Berl) 197:95-105. 2008
    ..Individuals with attention deficit hyperactivity disorder (ADHD) smoke at higher rates than the general population; however, little is known about the mechanisms underlying this comorbidity...
  7. doi request reprint Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Cneter, Durham, NC 27708, USA
    Nicotine Tob Res 10:117-27. 2008
    ..We observed neither main effects nor interactions with CYP2A6, DAT, and SLC6A4 genes. These findings suggest that genotypes associated with catecholamine neurotransmission interact with ADHD symptoms to contribute to smoking risk...
  8. pmc ADHD and smoking: from genes to brain to behavior
    FRANCIS JOSEPH MCCLERNON
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Ann N Y Acad Sci 1141:131-47. 2008
    ..Finally, we discuss the implications of this model for prevention and clinical outcomes...
  9. pmc 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Psychopharmacology (Berl) 204:25-35. 2009
    ..Exposure to smoking-related cues can trigger relapse in smokers attempting to maintain abstinence...
  10. pmc Smoking withdrawal symptoms are more severe among smokers with ADHD and independent of ADHD symptom change: results from a 12-day contingency-managed abstinence trial
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Nicotine Tob Res 13:784-92. 2011
    ..The objective of this study was to characterize the differential effects of intermediate term smoking abstinence on self-reported withdrawal and ADHD symptoms in adult smokers with and without ADHD...
  11. ncbi request reprint Effects of transdermal nicotine on lateralized identification and memory interference
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 275 Civitan Bldg, Durham, NC 27710, USA
    Hum Psychopharmacol 18:339-43. 2003
    ..These findings are consistent with a model of the lateralized effects of nicotine on cognitive performance...
  12. ncbi request reprint The effects of controlled deep breathing on smoking withdrawal symptoms in dependent smokers
    F Joseph McClernon
    Department of Psychiatry, Nicotine Research Program, Duke University and Durham VA Medical Centers, 2200 W Main St, B 150, Durham, NC 27705, USA
    Addict Behav 29:765-72. 2004
    ..The results of this preliminary study suggest that controlled deep breathing may be useful for relieving symptoms of smoking withdrawal...
  13. ncbi request reprint Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 189:125-33. 2006
    ..Despite established links between nicotine dependence and depression, little research has examined the effects of nicotine on depression symptoms...
  14. ncbi request reprint Human functional neuroimaging in nicotine and tobacco research: basics, background, and beyond
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Nicotine Tob Res 6:941-59. 2004
    ..We address limitations of studies to date and identify opportunities for future research...
  15. pmc Abstinence-induced changes in self-report craving correlate with event-related FMRI responses to smoking cues
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Neuropsychopharmacology 30:1940-7. 2005
    ....
  16. pmc Association between trauma exposure and smoking in a population-based sample of young adults
    Miguel E Roberts
    Duke University Medical Center Durham Veterans Affairs Medical Center, Durham, North Carolina 27710, USA
    J Adolesc Health 42:266-74. 2008
    ..Contrary to current smoking trends in the general population, recent findings indicate continued high smoking rates in trauma-exposed samples...
  17. ncbi request reprint Cigarette smoking, ambulatory cardiovascular monitoring, and mood in Vietnam veterans with and without chronic posttraumatic stress disorder
    Jean C Beckham
    Duke University Medical Center, Department of Psychiatry, Durham, NC, USA
    Addict Behav 29:1579-93. 2004
    ..Findings suggest that the interrelationships among cardiovascular parameters, cigarette smoking, and PTSD deserve more research attention...
  18. pmc Interactions between genotype and depressive symptoms on obesity
    Bernard F Fuemmeler
    Duke University Medical Center, Durham, NC, USA
    Behav Genet 39:296-305. 2009
    ..48; 95% CI 0.26-0.89). No similar effect was observed among females. These findings highlight that the obesity-depression relationship may vary as a function of gender and genetic polymorphism, and suggest the need for further study...
  19. ncbi request reprint Effects of nicotine on novelty detection and memory recognition performance: double-blind, placebo-controlled studies of smokers and nonsmokers
    Brett Froeliger
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27708, USA
    Psychopharmacology (Berl) 205:625-33. 2009
    ..While nicotine replacement therapy improves attention during abstinence, it is unclear whether this is due to the alleviation of withdrawal-related deficits or inherent beneficial effects of nicotine...
  20. pmc Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptoms
    Scott H Kollins
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Nerv Ment Dis 197:442-9. 2009
    ..The risk of maternal smoking for the development of ADHD symptoms does not end during pregnancy. Research on the mechanisms underlying the observed associations is needed...
  21. pmc Adverse childhood events are associated with obesity and disordered eating: results from a U.S. population-based survey of young adults
    Bernard F Fuemmeler
    Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Trauma Stress 22:329-33. 2009
    ..This is the first study to note an association between childhood abuse with obesity and problematic weight management behaviors in a sample of young adults...
  22. pmc Monetary incentives promote smoking abstinence in adults with attention deficit hyperactivity disorder (ADHD)
    Scott H Kollins
    Duke ADHD Program, Department of Psychiatry, Duke University Medical Center, NC, USA
    Exp Clin Psychopharmacol 18:221-8. 2010
    ..Results suggest that monetary incentives may be a useful approach for promoting abstinence in adult smokers with ADHD, perhaps owing to altered reinforcement processes in these individuals...
  23. pmc Effects of smoking abstinence on reaction time variability in smokers with and without ADHD: an ex-Gaussian analysis
    Scott H Kollins
    Department of Psychiatry, Duke ADHD Program, 718 Rutherford Street, Durham, NC 27705, United States
    Drug Alcohol Depend 100:169-72. 2009
    ..These findings have implications for understanding the neuropsychopharmacology of nicotine and nicotine withdrawal...
  24. ncbi request reprint Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 184:523-39. 2006
    ..Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments for cognitive dysfunction...
  25. doi request reprint Ad lib smoking in post-traumatic stress disorder: an electronic diary study
    Jean C Beckham
    Durham Veterans Administration Medical Center, Durham, NC 27705, USA
    Nicotine Tob Res 10:1149-57. 2008
    ..These results are consistent with previous ambulatory findings regarding mood in smokers, and underscore that in smokers with PTSD, PTSD symptom variables as well as stress and anxiety are significantly associated with ad lib smoking...
  26. pmc Genes implicated in serotonergic and dopaminergic functioning predict BMI categories
    Bernard F Fuemmeler
    Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
    Obesity (Silver Spring) 16:348-55. 2008
    ..Interactions with gender and race/ethnicity were also examined...
  27. ncbi request reprint Mecamylamine moderates cue-induced emotional responses in smokers
    F Joseph McClernon
    Tobacco Neuroscience Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3516, Durham, NC 27710, United States
    Addict Behav 30:741-53. 2005
    ..A similar trend was observed for negative affect. These results suggest that mecamylamine can moderate smoking cue-induced emotional responses in smokers...
  28. ncbi request reprint Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adults
    Scott H Kollins
    Duke University Medical Center, Durham, NC, USA
    Arch Gen Psychiatry 62:1142-7. 2005
    ..Few studies, however, have examined ADHD symptoms in nonclinical samples to determine the extent to which the number of symptoms-independent of the full diagnosis-confer risk for smoking-related outcomes...
  29. ncbi request reprint Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthood
    Bernard F Fuemmeler
    Community and Family Medicine, University Medical Center, Duke University Medical Center, USA
    J Pediatr Psychol 32:1203-13. 2007
    ..To examine the association between retrospectively reported attention deficit hyperactivity disorder (ADHD) symptoms and progression to smoking and the association with nicotine dependence...
  30. pmc The effects of cigarette smoking on script-driven imagery in smokers with and without posttraumatic stress disorder
    Jean C Beckham
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Addict Behav 32:2900-15. 2007
    ..These results support that context and non-pharmacologic effects of smoking are important variables in smoking craving and mood, particularly in smokers with PTSD...
  31. doi request reprint Silver acetate interactions with nicotine and non-nicotine smoke components
    Jed E Rose
    Department of Psychiatry and Center for Nicotine and Smoking Cessation Research, Duke University, Durham, NC 27705, USA
    Exp Clin Psychopharmacol 18:462-9. 2010
    ..Further exploration is warranted of the use of silver-based preparations as a short-term adjunct to smoking cessation treatment...
  32. ncbi request reprint Hippocampal and striatal gray matter volume are associated with a smoking cessation treatment outcome: results of an exploratory voxel-based morphometric analysis
    Brett Froeliger
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC 27708, USA
    Psychopharmacology (Berl) 210:577-83. 2010
    ..However, associations between brain structure and smoking cessation treatment outcomes have not been reported...
  33. ncbi request reprint The effects of trauma recall on smoking topography in posttraumatic stress disorder and non-posttraumatic stress disorder trauma survivors
    F Joseph McClernon
    Duke University Medical Center, Durham, NC, USA
    Addict Behav 30:247-57. 2005
    ....
  34. pmc Increases in impulsivity following smoking abstinence are related to baseline nicotine intake and boredom susceptibility
    Jasmine Pettiford
    Duke University Medical Center, Durham, NC 27707, United States
    Addict Behav 32:2351-7. 2007
    ..These results suggest that smoking abstinence significantly increases errors of response inhibition and that the magnitude of this increase is related to trait impulsivity and nicotine intake variables...
  35. ncbi request reprint The effects of a low-carbohydrate ketogenic diet and a low-fat diet on mood, hunger, and other self-reported symptoms
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Suite 210 B Wing, 2200 West Main Street, Durham, NC 27705, USA
    Obesity (Silver Spring) 15:182-7. 2007
    ..To investigate the effects of weight loss diets on mood, food cravings, and other self-reported symptoms...

Research Grants11

  1. Drug Cue Reactivity in Smokers: An fMRI Investigation
    Francis McClernon; Fiscal Year: 2002
    ..The results of this study will enhance our understanding of the neurobiological basis of tobacco dependence, inform treatment development, and generate additional hypotheses and research plans. ..
  2. Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction
    FRANCIS JOSEPH MCCLERNON; Fiscal Year: 2010
    ..These include both sensory (taste, aroma) and behavioral (puffing, handling) factors. A better understanding of how these factors affect the brain can lead to new and more effective treatments to help smokers quit. ..
  3. Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine Dependence
    FRANCIS JOSEPH MCCLERNON; Fiscal Year: 2010
    ..The proposed research will lead to a better understanding of the neural and genetic basis of comorbid ADHD and nicotine dependence and inform the development of new treatments. ..
  4. Brain Substrates of Extinction-Based Treatment for Nicotine Dependence
    Francis McClernon; Fiscal Year: 2009
    ..The proposed research will lead to a better understanding of the neural basis of EBT which will lead to further refinement of this promising new treatment. ..
  5. Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction
    Francis McClernon; Fiscal Year: 2009
    ..These include both sensory (taste, aroma) and behavioral (puffing, handling) factors. A better understanding of how these factors affect the brain can lead to new and more effective treatments to help smokers quit. ..
  6. Neuropharmacology of Response Inhibition in Comorbid ADHD and Nicotine Dependence
    Francis McClernon; Fiscal Year: 2009
    ..The proposed research will lead to a better understanding of the neural and genetic basis of comorbid ADHD and nicotine dependence and inform the development of new treatments. ..
  7. Neuroimaging Attentional Impairment During Abstinence
    Francis McClernon; Fiscal Year: 2006
    Candidate: F. Joseph McClernon, Ph.D., is a Research Associate in the Department of Psychiatry and Behavioral Sciences at Duke University Medical Center (DUMC)...
  8. Brain Substrates of Extinction-Based Treatment for Nicotine Dependence
    FRANCIS JOSEPH MCCLERNON; Fiscal Year: 2010
    ..The proposed research will lead to a better understanding of the neural basis of EBT which will lead to further refinement of this promising new treatment. ..