D R McClay

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Evolutionary crossroads in developmental biology: sea urchins
    David R McClay
    Department of Biology, Duke University, Durham, NC 27708, USA
    Development 138:2639-48. 2011
  2. ncbi A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo
    D R McClay
    Department of Biology, DCMB Group, Box 91000, Duke University, Durham, NC 27708, USA
    Development 127:5113-22. 2000
  3. ncbi LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo
    D R Sherwood
    Developmental, Cell and Molecular Biology Group, Box 91000, Duke University, Durham, NC 27708, USA
    Development 126:1703-13. 1999
  4. ncbi Characterization of the role of cadherin in regulating cell adhesion during sea urchin development
    J R Miller
    Developmental, Cellular and Molecular Biology Group, Duke University, Durham, North Carolina 27708, USA
    Dev Biol 192:323-39. 1997
  5. ncbi Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo
    J R Miller
    Developmental, Cellular and Molecular Biology Group, Duke University, Durham, North Carolina 27708, USA
    Dev Biol 192:310-22. 1997
  6. ncbi Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo
    C Y Logan
    Developmental, Cellular and Molecular Biology Group and the Department of Zoology, Duke University, Durham, NC 27708, USA
    Development 126:345-57. 1999
  7. ncbi The role of Brachyury (T) during gastrulation movements in the sea urchin Lytechinus variegatus
    J M Gross
    Development, Cell and Molecular Biology Group, Duke University, Box 91000 LSRC, Durham, North Carolina 27710, USA
    Dev Biol 239:132-47. 2001
  8. ncbi A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis
    L M Angerer
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Development 127:1105-14. 2000
  9. ncbi LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo
    D R Sherwood
    Developmental, Cell and Molecular Biology Group, Box 91000, Duke University, Durham, NC 27708, USA
    Development 128:2221-32. 2001
  10. ncbi Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions
    C A Byrum
    Developmental, Cell, and Molecular Biology Group, Box 91000, Duke University, Durham, NC 27708, USA
    Dev Biol 300:194-218. 2006

Research Grants

  1. Sea Urchin Developmental Biology Conference XIV
    DAVID MC CLAY; Fiscal Year: 2002
  2. GERM LAYER SPECIFICATION
    DAVID MC CLAY; Fiscal Year: 2002
  3. EMBRYONIC CELL RECOGNITION--SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 2004
  4. NEURAL TUBE DEFECTS
    DAVID MC CLAY; Fiscal Year: 2005
  5. GERM LAYER SPECIFICATION
    DAVID MC CLAY; Fiscal Year: 2007
  6. TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGY
    DAVID MC CLAY; Fiscal Year: 2007
  7. EMBRYONIC CELL RECOGNITION--SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 2007
  8. EMBRYONIC CELL RECOGNITION: SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 1999
  9. EMBRYONIC CELL RECOGNITION: SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 1990
  10. EMBRYONIC CELL RECOGNITION: SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 1993

Collaborators

Detail Information

Publications12

  1. ncbi Evolutionary crossroads in developmental biology: sea urchins
    David R McClay
    Department of Biology, Duke University, Durham, NC 27708, USA
    Development 138:2639-48. 2011
    ....
  2. ncbi A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo
    D R McClay
    Department of Biology, DCMB Group, Box 91000, Duke University, Durham, NC 27708, USA
    Development 127:5113-22. 2000
    ..As Notch is maternally expressed in macromeres, additional components must be downstream of nuclear beta-catenin in macromeres for these cells to receive and transduce the micromere induction signal...
  3. ncbi LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo
    D R Sherwood
    Developmental, Cell and Molecular Biology Group, Box 91000, Duke University, Durham, NC 27708, USA
    Development 126:1703-13. 1999
    ..Taken together, these results offer compelling evidence that LvNotch signaling directly specifies the SMC fate, and that this signaling is critical for the differential specification of SMCs and endoderm in the sea urchin embryo...
  4. ncbi Characterization of the role of cadherin in regulating cell adhesion during sea urchin development
    J R Miller
    Developmental, Cellular and Molecular Biology Group, Duke University, Durham, North Carolina 27708, USA
    Dev Biol 192:323-39. 1997
    ....
  5. ncbi Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo
    J R Miller
    Developmental, Cellular and Molecular Biology Group, Duke University, Durham, North Carolina 27708, USA
    Dev Biol 192:310-22. 1997
    ..These data are consistent with a role for beta-catenin in regulating cell adhesion and adherens junction function during gastrulation in the sea urchin embryo...
  6. ncbi Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo
    C Y Logan
    Developmental, Cellular and Molecular Biology Group and the Department of Zoology, Duke University, Durham, NC 27708, USA
    Development 126:345-57. 1999
    ....
  7. ncbi The role of Brachyury (T) during gastrulation movements in the sea urchin Lytechinus variegatus
    J M Gross
    Development, Cell and Molecular Biology Group, Duke University, Box 91000 LSRC, Durham, North Carolina 27710, USA
    Dev Biol 239:132-47. 2001
    ....
  8. ncbi A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis
    L M Angerer
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Development 127:1105-14. 2000
    ..In addition, BMP2/4 levels influence the decision within ectoderm between epidermal and nonepidermal differentiation...
  9. ncbi LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo
    D R Sherwood
    Developmental, Cell and Molecular Biology Group, Box 91000, Duke University, Durham, NC 27708, USA
    Development 128:2221-32. 2001
    ....
  10. ncbi Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions
    C A Byrum
    Developmental, Cell, and Molecular Biology Group, Box 91000, Duke University, Durham, NC 27708, USA
    Dev Biol 300:194-218. 2006
    ..Finally, to assess roles of annotated phosphatases in endomesoderm formation, a literature review of phosphatase functions in model organisms was superimposed on sea urchin developmental pathways to predict areas of functional activity...
  11. ncbi Molecular cloning of the first metazoan beta-1,3 glucanase from eggs of the sea urchin Strongylocentrotus purpuratus
    E S Bachman
    Developmental Cell and Molecular Biology Group, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 93:6808-13. 1996
    ..A global phylogeny based on these regions strongly suggests that the glucanases are a very ancient family of genes. In particular, there is an especially deep split within genes taken from the bacterial genus Bacillus...
  12. ncbi PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos
    C A Bradham
    DCMB Group, Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Dev Dyn 229:713-21. 2004
    ..Our results are consistent with a model in which PI3K signaling is required, not for pattern sensing or interpretation but rather for the biomineralization process itself in the sea urchin embryo...

Research Grants35

  1. Sea Urchin Developmental Biology Conference XIV
    DAVID MC CLAY; Fiscal Year: 2002
    ..The concurrent sessions offer valuable opportunities for graduate students and postdocs to gain experience speaking at an international meeting, and the workshops introduce new approaches in these embryos. ..
  2. GERM LAYER SPECIFICATION
    DAVID MC CLAY; Fiscal Year: 2002
    ..abstract_text> ..
  3. EMBRYONIC CELL RECOGNITION--SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 2004
    ..4. A number of post-specification, pre-ingression changes have been observed in micromeres. In vitro and in vivo experiments will ask which of these are important for preparation of the EMT. ..
  4. NEURAL TUBE DEFECTS
    DAVID MC CLAY; Fiscal Year: 2005
    ..abstract_text> ..
  5. GERM LAYER SPECIFICATION
    DAVID MC CLAY; Fiscal Year: 2007
    ..This network eventually will enable us to explore how positional cues are produced and displayed for later morphogenetic patterning. ..
  6. TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGY
    DAVID MC CLAY; Fiscal Year: 2007
    ..Finally, an interactive environment and collaborations with clinical departments fosters the movement of the discovery process to treatments that will improve the human condition. ..
  7. EMBRYONIC CELL RECOGNITION--SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 2007
    ....
  8. EMBRYONIC CELL RECOGNITION: SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 1999
    ....
  9. EMBRYONIC CELL RECOGNITION: SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 1990
    ..These lineages will be studied further in order to establish the range of patterns present on the surface of embryonic cells that could be used as morphogenetic markers...
  10. EMBRYONIC CELL RECOGNITION: SPECIFICITY DETERMINANTS
    DAVID MC CLAY; Fiscal Year: 1993
    ..These interactions are both adhesive and involved in information transfer to establish embryonic pattern...
  11. EMBRYONIC CELL RECOGNITION--SPECIFICITY DETERMINANTS
    DAVID R MC CLAY; Fiscal Year: 2010
    ....