Jeanette McCarthy

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study
    Sunil Suchindran
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 6:e1000928. 2010
  2. pmc Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C
    Derek D Cyr
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e21854. 2011
  3. pmc Gene by sex interaction for measures of obesity in the framingham heart study
    Ashlee M Benjamin
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    J Obes 2011:329038. 2011
  4. pmc Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study
    Ornit Chiba-Falek
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    BMC Med Genet 11:9. 2010
  5. pmc Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin
    Jeanette J McCarthy
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27708, USA
    Gastroenterology 138:2307-14. 2010
  6. pmc Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction
    Jeanette J McCarthy
    Graduate School of Public Health, San Diego State University, San Diego, California 92182, USA
    J Clin Endocrinol Metab 94:1789-96. 2009
  7. doi request reprint A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    Hans L Tillmann
    Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Gastroenterology 139:1586-92, 1592.e1. 2010
  8. ncbi request reprint Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations
    Jeanette J McCarthy
    San Diego State University, San Diego, CA 92182 4162, USA
    Hum Hered 55:163-70. 2003
  9. ncbi request reprint Taking cardiovascular genetic association studies to the next level
    Geoffrey S Ginsburg
    Duke Institute for Genome Sciences and Policy, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 50:930-2. 2007
  10. pmc Metaprotein expression modeling for label-free quantitative proteomics
    Joseph E Lucas
    Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    BMC Bioinformatics 13:74. 2012

Research Grants

  1. Pharmacogenetics of lipid response to estrogen therapy
    Jeanette McCarthy; Fiscal Year: 2006
  2. Pharmacogenetics of lipid response to estrogen therapy
    Jeanette McCarthy; Fiscal Year: 2007
  3. Pharmacogenetics of lipid response to estrogen therapy
    Jeanette McCarthy; Fiscal Year: 2009

Collaborators

Detail Information

Publications19

  1. pmc Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study
    Sunil Suchindran
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 6:e1000928. 2010
    ..3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2) activity and mass...
  2. pmc Characterization of serum proteins associated with IL28B genotype among patients with chronic hepatitis C
    Derek D Cyr
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e21854. 2011
    ..To gain further insight into IL28B function we assessed the association of rs12979860 with expression of protein quantitative traits (pQTL analysis) generated using open-platform proteomics in serum from patients...
  3. pmc Gene by sex interaction for measures of obesity in the framingham heart study
    Ashlee M Benjamin
    Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    J Obes 2011:329038. 2011
    ..Primary effects in males were in the opposite direction from females and were replicated in Framingham Generation 3. Our data support a sex-influenced association between genetic variation at the LYPLAL1 locus and obesity-related traits...
  4. pmc Impact of gene variants on sex-specific regulation of human Scavenger receptor class B type 1 (SR-BI) expression in liver and association with lipid levels in a population-based study
    Ornit Chiba-Falek
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    BMC Med Genet 11:9. 2010
    ..However, the mechanism underlying this gene by sex interaction has not been explored...
  5. pmc Replicated association between an IL28B gene variant and a sustained response to pegylated interferon and ribavirin
    Jeanette J McCarthy
    Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27708, USA
    Gastroenterology 138:2307-14. 2010
    ..We investigated the association between the polymorphism rs12979860 and treatment response in a diverse cohort of chronic HCV patients...
  6. pmc Polymorphisms of the scavenger receptor class B member 1 are associated with insulin resistance with evidence of gene by sex interaction
    Jeanette J McCarthy
    Graduate School of Public Health, San Diego State University, San Diego, California 92182, USA
    J Clin Endocrinol Metab 94:1789-96. 2009
    ....
  7. doi request reprint A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice
    Hans L Tillmann
    Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Gastroenterology 139:1586-92, 1592.e1. 2010
    ..We analyzed the association between IL28B and the clinical presentation of acute hepatitis C virus (HCV) infection in a homogeneous population...
  8. ncbi request reprint Polymorphisms of the HDL receptor gene associated with HDL cholesterol levels in diabetic kindred from three populations
    Jeanette J McCarthy
    San Diego State University, San Diego, CA 92182 4162, USA
    Hum Hered 55:163-70. 2003
    ..We examined polymorphisms in the HDL receptor, SR-BI, for association with plasma HDL cholesterol levels...
  9. ncbi request reprint Taking cardiovascular genetic association studies to the next level
    Geoffrey S Ginsburg
    Duke Institute for Genome Sciences and Policy, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 50:930-2. 2007
    ..Consideration of these principles should provide insight into disease biology based on genetic findings and encourage their meaningful adoption into clinical practice...
  10. pmc Metaprotein expression modeling for label-free quantitative proteomics
    Joseph E Lucas
    Institute for Genome Sciences and Policy, Duke University, Durham, NC, USA
    BMC Bioinformatics 13:74. 2012
    ..Additionally, there may be systematic shifts in the sensitivity of the machine between experiments or even through time within the duration of a single experiment...
  11. pmc Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection
    Josephine H Li
    Institute for Genome Sciences and Policy, Durham, NC 27708, USA
    Hepatology 51:1904-11. 2010
    ..06), and apolipoprotein E (P = 0.01) were slightly lower in the rs12979860 CC genotype group, whereas levels of high-density lipoprotein cholesterol (P = 0.78) and apolipoprotein C-III (P = 0.74) did not vary by rs12979860 genotype...
  12. ncbi request reprint Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study
    Erin Richard
    School of Public Health, San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4162, USA
    Atherosclerosis 180:255-62. 2005
    ..We examined whether the association between SR-BI genotypes and HDL-C is modified by use of unopposed estrogen in community-dwelling postmenopausal Caucasian women...
  13. ncbi request reprint Advances in pharmacogenomic research and development
    Jeanette J McCarthy
    San Diego State University, 5500 Campanile Dr, San Diego, CA 92182 4162, USA
    Mol Biotechnol 25:275-82. 2003
    ....
  14. ncbi request reprint Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients
    Jeanette J McCarthy
    School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4162, USA
    Hum Genet 114:87-98. 2003
    ..039). Our results propose several new candidate genes for the metabolic syndrome and suggest that the genetic basis of this syndrome may be strongly modified by gender...
  15. ncbi request reprint Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome
    Jeanette J McCarthy
    School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182 4162, USA
    Nutr Metab Cardiovasc Dis 17:153-61. 2007
    ..Investigation of gene by sex interaction may help to elucidate underlying genetic susceptibilities and explain the sexual dimorphism of these complex traits...
  16. ncbi request reprint Replication of the association between the thrombospondin-4 A387P polymorphism and myocardial infarction
    Jennifer Wessel
    School of Public Health, San Diego State University, San Diego, Calif 92182 4162, USA
    Am Heart J 147:905-9. 2004
    ....
  17. ncbi request reprint Aspirin resistance and a single gene
    Brian K Jefferson
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Cardiol 95:805-8. 2005
    ..Aspirin resistance was significantly associated with genetic variation in the platelet surface adenosine 5-diphosphate receptor gene P2Y1...
  18. ncbi request reprint Coronary artery disease and the thrombospondin single nucleotide polymorphisms
    Olga I Stenina
    Joseph J Jacobs Center for Thrombosis and Vascular Biology and Department of Molecular Cardiology NB50, Cleveland Clinic Foundation Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Int J Biochem Cell Biol 36:1013-30. 2004
    ....
  19. ncbi request reprint Validity of reported genetic risk factors for acute coronary syndrome
    Jeanette J McCarthy
    JAMA 298:1758; author reply 1759. 2007

Research Grants4

  1. Pharmacogenetics of lipid response to estrogen therapy
    Jeanette McCarthy; Fiscal Year: 2006
    ..This may result in future clinically useful diagnostic tests that aid postmenopausal women in their decision whether to use estrogen therapy. ..
  2. Pharmacogenetics of lipid response to estrogen therapy
    Jeanette McCarthy; Fiscal Year: 2007
    ..This may result in future clinically useful diagnostic tests that aid postmenopausal women in their decision whether to use estrogen therapy. ..
  3. Pharmacogenetics of lipid response to estrogen therapy
    Jeanette McCarthy; Fiscal Year: 2009
    ..This may result in future clinically useful diagnostic tests that aid postmenopausal women in their decision whether to use estrogen therapy. ..