J P Mathew

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:880-7. 2009
  2. ncbi request reprint Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 107:577-84. 2007
  3. ncbi request reprint Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass
    Joseph P Mathew
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:294-9. 2005
  4. ncbi request reprint Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 35:2335-9. 2004
  5. ncbi request reprint A multicenter risk index for atrial fibrillation after cardiac surgery
    Joseph P Mathew
    Multicenter Study of Perioperative Ischemia Research Group and Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    JAMA 291:1720-9. 2004
  6. ncbi request reprint Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients
    Lian K Ti
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:211-3. 2003
  7. ncbi request reprint Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state
    J P Mathew
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Anesth 13:301-5. 2001
  8. ncbi request reprint Transesophageal echocardiography interpretation: a comparative analysis between cardiac anesthesiologists and primary echocardiographers
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 94:302-9, table of contents. 2002
  9. pmc Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery
    M V Podgoreanu
    Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 114:I275-81. 2006
  10. ncbi request reprint Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG
    G Burkhard Mackensen
    Division of Cardiothoracic Anesthesia and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 78:520-6. 2004

Research Grants

Detail Information

Publications82

  1. pmc Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:880-7. 2009
    ..Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass...
  2. ncbi request reprint Effects of extreme hemodilution during cardiac surgery on cognitive function in the elderly
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 107:577-84. 2007
    ....
  3. ncbi request reprint Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass
    Joseph P Mathew
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:294-9. 2005
    ....
  4. ncbi request reprint Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 35:2335-9. 2004
    ..We hypothesized that pexelizumab, a humanized scFv monoclonal antibody directed against the C5 complement component, would limit deficits in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass...
  5. ncbi request reprint A multicenter risk index for atrial fibrillation after cardiac surgery
    Joseph P Mathew
    Multicenter Study of Perioperative Ischemia Research Group and Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    JAMA 291:1720-9. 2004
    ..Atrial fibrillation is a common, but potentially preventable, complication following coronary artery bypass graft (CABG) surgery...
  6. ncbi request reprint Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients
    Lian K Ti
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:211-3. 2003
  7. ncbi request reprint Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state
    J P Mathew
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Anesth 13:301-5. 2001
    ..To evaluate the hypothesis that the bispectral index (BIS) is not affected by the hypothermia that is associated with cardiopulmonary bypass (CPB)...
  8. ncbi request reprint Transesophageal echocardiography interpretation: a comparative analysis between cardiac anesthesiologists and primary echocardiographers
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 94:302-9, table of contents. 2002
    ..Thus, the anesthesiologist and the intraoperative echocardiographer need not be mutually exclusive...
  9. pmc Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery
    M V Podgoreanu
    Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 114:I275-81. 2006
    ..We tested the hypothesis that candidate gene polymorphisms in inflammatory pathways contribute to risk of PMI after cardiac surgery...
  10. ncbi request reprint Preliminary report on the interaction of apolipoprotein E polymorphism with aortic atherosclerosis and acute nephropathy after CABG
    G Burkhard Mackensen
    Division of Cardiothoracic Anesthesia and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Ann Thorac Surg 78:520-6. 2004
    ..We hypothesized that patients with and without the epsilon4 allele (E4/non-E4) would have different associations between atheroma burden and postoperative renal dysfunction...
  11. ncbi request reprint Effect of apolipoprotein E genotype on cerebral autoregulation during cardiopulmonary bypass
    L K Ti
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 32:1514-9. 2001
    ....
  12. ncbi request reprint Report of the substudy assessing the impact of neurocognitive function on quality of life 5 years after cardiac surgery
    M F Newman
    Department of Anesthesiology, Division of Neurology, Duke University Medical Center, Durham, NC, USA
    Stroke 32:2874-81. 2001
    ..The purpose of our investigation was to determine the association between cognitive dysfunction and long-term quality of life after cardiac surgery...
  13. pmc Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury
    David L McDonagh
    Department of Anesthesiology and Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 112:852-9. 2010
    ..Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation...
  14. ncbi request reprint Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina
    J Am Coll Cardiol 49:1934-42. 2007
    ....
  15. ncbi request reprint Serum creatinine patterns in coronary bypass surgery patients with and without postoperative cognitive dysfunction
    Madhav Swaminathan
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 95:1-8, table of contents. 2002
    ..29; P = 0.46) was not significant. These data indicate that postcardiac surgery cognitive dysfunction, unlike stroke, is not associated with major increases in postoperative renal dysfunction...
  16. ncbi request reprint Glycosylated hemoglobin levels and outcome in non-diabetic cardiac surgery patients
    Christopher C C Hudson
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Can J Anaesth 57:565-72. 2010
    ..Therefore, in a cohort of non-diabetic patients, we tested the hypothesis that preoperative HbA1c is associated with early mortality risk after cardiac surgery...
  17. ncbi request reprint The association of patent foramen ovale and atrial fibrillation after coronary artery bypass graft surgery
    George Djaiani
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Anesth Analg 98:585-9, table of contents. 2004
    ..95; 1.007-3.778; P = 0.047), age (OR, 1.03; 1.015-1.053; P = 0.0004), and history of congestive heart failure (OR, 2.55; 1.671-3.900; P < 0.0001) were predictive of postoperative AF...
  18. ncbi request reprint Atrial fibrillation after cardiac surgery/cardiopulmonary bypass is associated with monocyte activation
    Manuel L Fontes
    Department of Anesthesiology, Yale School of Medicine, PO Box 208051, 333 Cedar St, New Haven, CT 06520 8051, USA
    Anesth Analg 101:17-23, table of contents. 2005
    ....
  19. ncbi request reprint Postcardiac surgery complications: association of acute renal dysfunction and atrial fibrillation
    Maher J Albahrani
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 96:637-43, table of contents. 2003
    ..This interaction suggests that a common etiology for these two complications may be more important in younger patients...
  20. ncbi request reprint Genetic factors contribute to bleeding after cardiac surgery
    I J Welsby
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thromb Haemost 3:1206-12. 2005
    ..Postoperative bleeding remains a common, serious problem for cardiac surgery patients, with striking inter-patient variability poorly explained by clinical, procedural, and biological markers...
  21. ncbi request reprint Predictors of inotrope use during separation from cardiopulmonary bypass
    Kenneth H McKinlay
    Division of Cardiothoracic Anesthesiology and Critical Care, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 18:404-8. 2004
    ..Design: Retrospective study of consecutive patients undergoing coronary artery bypass graft (CABG) surgery...
  22. ncbi request reprint Combined use of off-pump techniques and a sutureless proximal aortic anastomotic device reduces cerebral microemboli generation during coronary artery bypass grafting
    John E Scarborough
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 126:1561-7. 2003
    ....
  23. ncbi request reprint Cytokine secretion after cardiac surgery and its relationship to postoperative fever
    John D Mitchell
    Department of Anesthesiology and Critical Care Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Cytokine 38:37-42. 2007
    ..Of note is the previously undescribed bimodal pattern of cytokines' secretion after CABG. The association of fever with IL-6 levels suggests inflammatory mediation...
  24. ncbi request reprint Mannitol and dopamine in patients undergoing cardiopulmonary bypass: a randomized clinical trial
    Olivia V Carcoana
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520 8051, USA
    Anesth Analg 97:1222-9. 2003
    ..It is unclear whether this dopamine-related increase implies renal injury after CPB, and further investigations are required to examine the mechanism/clinical relevance of this observation...
  25. ncbi request reprint The rewarming rate and increased peak temperature alter neurocognitive outcome after cardiac surgery
    Alina M Grigore
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 94:4-10, table of contents. 2002
    ..Multivariable linear regression analysis, examining treatment group, diabetes, baseline cognitive function, and cross-clamp time revealed a significant association between change in cognitive function and rate of rewarming (P = 0.05)...
  26. ncbi request reprint Impact of mitral valve regurgitation evaluated by intraoperative transesophageal echocardiography on long-term outcomes after coronary artery bypass grafting
    Jacob N Schroder
    Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27703, USA
    Circulation 112:I293-8. 2005
    ..We sought to determine the long-term effect of uncorrected MR, measured by intraoperative transesophageal echocardiography (TEE), in CABG patients...
  27. ncbi request reprint Mitral flow propagation velocity identifies patients with abnormal diastolic function during coronary artery bypass graft surgery
    George N Djaiani
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 95:524-30, table of contents. 2002
    ..Vp <50 cm/s identifies abnormal D function in this patient population...
  28. ncbi request reprint Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial
    P Murali Doraiswamy
    Department of Psychiatry, Center for the Study of Aging, and Duke Heart Center, Duke University Medical Center, Durham, North Carolina, USA
    Psychopharmacol Bull 40:54-62. 2007
    ..To study the effect of donepezil in treating patients with cognitive decline following coronary artery bypass graft (CABG) surgery...
  29. ncbi request reprint Spontaneous echocardiographic contrast indicating successful endoleak management
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 104:1037-9. 2007
  30. ncbi request reprint Preoperative low molecular weight heparin reduces heparin responsiveness during cardiac surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Can J Anaesth 54:107-13. 2007
    ..The current study examines the effect of preoperative LMWH therapy on subsequent heparin responsiveness during cardiac surgery...
  31. ncbi request reprint Central nervous system injury associated with cardiac surgery
    Mark F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 277110, USA
    Lancet 368:694-703. 2006
    ..We describe these issues and the controversies that merit continued investigation...
  32. ncbi request reprint The "sandblasting" effect of aortic cannula on arch atheroma during cardiopulmonary bypass
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 104:1350-1. 2007
  33. ncbi request reprint Intraoperative hyperglycemia and cognitive decline after CABG
    Ferenc Puskas
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 84:1467-73. 2007
    ..The factors influencing its incidence and severity are not completely known. We hypothesized that hyperglycemia, which is known to exacerbate other forms of cerebral injury, may exacerbate NCD after cardiac operations...
  34. ncbi request reprint Neurocognitive dysfunction following cardiac surgery
    Frederick W Lombard
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Semin Cardiothorac Vasc Anesth 14:102-10. 2010
    ..This article reviews the current literature on the etiology of POCD following cardiac surgery, discusses strategies to reduce patient risk, and provides some insight into some controversies that merit continued investigation...
  35. doi request reprint Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injury
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 89:1098-104. 2010
    ..Although some early recovery is common, its effect on long-term outcomes is unclear. We tested the hypothesis that early renal recovery after CSA-AKI is independently associated with improved long-term survival...
  36. ncbi request reprint The relationship of plasma transfusion from female and male donors with outcome after cardiac surgery
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 140:1353-60. 2010
    ..We examined whether plasma donor gender is related to postcardiac surgery pulmonary dysfunction and death or prolonged hospitalization...
  37. pmc Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 24:427-33. 2010
    ..The authors tested the hypothesis that genetic polymorphisms of inflammatory mediators and cellular adhesion molecules are associated with bleeding after cardiac surgery...
  38. pmc Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion
    Aslan T Turer
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Box 31297, Erwin Rd, Durham, NC 27710, USA
    Circulation 119:1736-46. 2009
    ..Furthermore, the effect of preexisting ventricular state on ischemia-induced metabolic derangements has not been established...
  39. pmc Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:953-9. 2008
    ..To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery...
  40. doi request reprint Guidelines for the performance of a comprehensive intraoperative epiaortic ultrasonographic examination: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists; endorsed by the Society of Thoracic S
    Kathryn E Glas
    Department of Anesthesiology, Emory University, Atlanta, GA, USA
    Anesth Analg 106:1376-84. 2008
  41. ncbi request reprint The effect of aprotinin on outcome after coronary-artery bypass grafting
    Andrew D Shaw
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27516, USA
    N Engl J Med 358:784-93. 2008
    ..Aprotinin has recently been associated with adverse outcomes in patients undergoing cardiac surgery. We reviewed our experience with this agent in patients undergoing cardiac surgery at Duke University Medical Center...
  42. ncbi request reprint Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events
    Madhav Swaminathan
    Duke University Medical Center, Department of Anesthesiology, Box 3094, Durham, North Carolina 27710, USA
    Anesthesiology 107:739-45. 2007
    ..Therefore, the authors hypothesized that deterioration in intraoperative left ventricular regional wall motion immediately after CABG surgery is associated with a higher risk of adverse cardiac events...
  43. pmc Pulse pressure and long-term survival after coronary artery bypass graft surgery
    Nikolay M Nikolov
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 110:335-40. 2010
    ..We therefore assessed long-term survival in patients with increased PP at the time of presentation for CABG surgery...
  44. ncbi request reprint ABO blood group and bleeding after coronary artery bypass graft surgery
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Blood Coagul Fibrinolysis 18:781-5. 2007
    ..In conclusion, although we identified clinical and procedural factors that were independently associated with bleeding, blood group was not one of these factors...
  45. ncbi request reprint Intraoperative systolic blood pressure variability predicts 30-day mortality in aortocoronary bypass surgery patients
    Solomon Aronson
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA parallel
    Anesthesiology 113:305-12. 2010
    ..We tested the hypothesis that intraoperative systolic blood pressure variability outside a targeted blood pressure range predicts 30-day mortality in patients undergoing cardiac surgery...
  46. ncbi request reprint Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Box 3094, DUMC, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 68:369-75. 2006
    ..We sought to determine the impact of this postoperative cognitive dysfunction on quality of life (QOL) and to characterize the dysfunction from the patient's perspective...
  47. doi request reprint Increasing healthcare resource utilization after coronary artery bypass graft surgery in the United States
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Circ Cardiovasc Qual Outcomes 2:305-12. 2009
    ..Our objective was to determine patterns of discharge disposition after CABG surgery in the United States...
  48. ncbi request reprint Quantitative echocardiographic assessment of regional wall motion and left ventricular asynchrony with color kinesis in cardiac surgery patients
    Mihai V Podgoreanu
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Duke University Medical Center Duke Heart Center, Durham, North Carolina 27710, USA
    Anesth Analg 96:1294-300, table of contents. 2003
    ..By diagnosing tardokinesis, common among cardiac surgical patients even with normal standard ejection phase indices, quantitative CK may improve the intraoperative detection of regional ischemic changes...
  49. ncbi request reprint Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery
    John V Booth
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 145:1108-13. 2003
    ..Magnesium is an important regulator of vascular tone, reperfusion injury, and thrombosis. Therefore, we decided to investigate the relationship between serum magnesium levels and major adverse cardiac events (MACE) after CABG...
  50. ncbi request reprint Neurologic outcomes after coronary artery bypass grafting with and without cardiopulmonary bypass
    John E Scarborough
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Semin Thorac Cardiovasc Surg 15:52-62. 2003
    ..Other technical innovations, such as the use of sutureless and clampless aortic anastomotic devices, also may be able to further minimize the neurologic complications associated with CABG...
  51. ncbi request reprint An assessment of two different methods of left ventricular ejection time measurement by transesophageal echocardiography
    Madhav Swaminathan
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 97:642-7. 2003
    ..M-mode may be an acceptable alternative to the Doppler method, especially when transvalvular velocity gradients cannot be readily obtained. M-mode is a simple, yet often underused, method of evaluating LVET during TEE...
  52. ncbi request reprint Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury
    Christine S Rinder
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06520 8051, USA
    Ann Thorac Surg 75:899-905. 2003
    ..We hypothesized that components of the inflammatory response to CPB may similarly contribute to post-CPB acute renal injury...
  53. ncbi request reprint Depression as a risk factor for mortality after coronary artery bypass surgery
    James A Blumenthal
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Lancet 362:604-9. 2003
    ..We sought to assess whether depression is associated with an increased risk of mortality...
  54. ncbi request reprint The importance of intraoperative transesophageal echocardiography in endovascular repair of thoracic aortic aneurysms
    Madhav Swaminathan
    Departments of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 97:1566-72. 2003
    ..The anesthesiologist is ideally positioned to provide the endovascular team with vital information regarding stent positioning, endoleaks, and cardiac performance with a single imaging modality...
  55. ncbi request reprint Aortic atheroma burden and cognitive dysfunction after coronary artery bypass graft surgery
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 78:1556-62. 2004
    ..Atherosclerotic disease of the aorta is a known risk factor for stroke after cardiac surgery, but its relationship to NCD is unclear. This study investigates the relationship between aortic atherosclerotic disease and NCD after CABG...
  56. ncbi request reprint Genetic polymorphisms and the risk of stroke after cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:1854-8. 2005
    ..Therefore, we tested the hypothesis that specific genetic polymorphisms are associated with an increased risk of stroke after cardiac surgery...
  57. ncbi request reprint Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery
    Mark Stafford-Smith
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Kidney Dis 45:519-30. 2005
    ..Therefore, we tested the hypothesis that selected gene variants are associated with acute renal injury, reflected by a serum creatinine level increase after cardiac surgery...
  58. ncbi request reprint Unexpected transesophageal echocardiographic finding after septal myectomy
    Madhav Swaminathan
    Division of Cardiothoracic Anesthesia and Critical Care, Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 16:384-5. 2002
  59. ncbi request reprint Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes
    Mihai V Podgoreanu
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 130:330-9. 2005
    ..By using microarray technology, this study examines myocardial gene expression responses to cardiopulmonary bypass in the absence of cardioplegic arrest and ischemia-reperfusion injury...
  60. doi request reprint Storage age of transfused platelets and outcomes after cardiac surgery
    Ian J Welsby
    Department of Anesthesiology, Duke University Medical Center, and the Duke Clinical Research Institute, Durham, North Carolina 27710, USA
    Transfusion 50:2311-7. 2010
    ..The relationship between duration of platelet (PLT) storage, currently limited to 5days, and surgical outcomes has not been established. We tested the hypothesis that PLT storage age was associated with adverse outcomes...
  61. ncbi request reprint Cerebral embolization during cardiac surgery: impact of aortic atheroma burden
    G B Mackensen
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Box 3094, Duke University Medical Center, Durham, NC 27710, USA
    Br J Anaesth 91:656-61. 2003
    ..In this study, we sought to determine the relationship between cerebral microemboli and aortic atheroma burden in patients undergoing cardiac surgery...
  62. ncbi request reprint Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA
    Ann Thorac Surg 81:1644-9. 2006
    ..We examined transcerebral platelet activation gradients using simultaneous measurements in arterial and jugular venous blood and then compared gradients with post-CPB-associated neurocognitive injury...
  63. ncbi request reprint The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery
    Timothy O Stanley
    Departments of Anesthesiology, Psychiatry and Behavioral Sciences, Medicine Neurology, and Surgery, Duke University Medical Center, Durham, North Carolina
    Anesth Analg 94:290-5, table of contents. 2002
    ..Atrial fibrillation was associated with poorer cognitive function 6 wk after surgery. Although the mechanism of this association is yet to be determined, prevention of atrial fibrillation may result in improved neurocognitive function...
  64. pmc Changes in neurocognitive functioning following lung transplantation
    B M Hoffman
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 12:2519-25. 2012
    ..07). Lung transplantation, like cardiac revascularization procedures, appears to be associated with cognitive decline in a subset of older patients, which could impact daily functioning posttransplant...
  65. ncbi request reprint A randomized controlled trial of the Arctic Sun Temperature Management System versus conventional methods for preventing hypothermia during off-pump cardiac surgery
    Hilary P Grocott
    Department of Anesthesiology and Surgery, Duke University Medical Center, Durham, North Carolina
    Anesth Analg 98:298-302, table of contents. 2004
    ..Importantly, this was achieved in the absence of any other temperature modulating techniques, including the use of IV fluid warming or increases in the ambient operating room temperature...
  66. ncbi request reprint Malpositioned left ventricular assist device cannula: diagnosis and management with transesophageal echocardiography guidance
    Alina Nicoara
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesth Analg 105:1574-6. 2007
  67. ncbi request reprint Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells
    Scott A Hagen
    Pediatric Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 98:343-8. 2003
    ..This is important because GRKs regulate the function of G protein-coupled receptors involved in inflammation...
  68. ncbi request reprint Age increases expression and receptor-mediated activation of G alpha i in human atria
    Jason D Kilts
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cardiovasc Pharmacol 42:662-70. 2003
    ..Because beta2ARs in human atria mediate contractility through cAMP-mediated phosphorylation of phospholamban, we conclude that an age-induced increase in Galphai may have a role in depressing cardiac function in aged human atria...
  69. ncbi request reprint Prevention of cerebral hyperthermia during cardiac surgery by limiting on-bypass rewarming in combination with post-bypass body surface warming: a feasibility study
    Shahar Bar-Yosef
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Anesth Analg 99:641-6, table of contents. 2004
    ..7 degrees C +/- 0.5 degrees C; P = 0.024). We conclude that limiting rewarming during CPB, when used in combination with surface warming, can prevent cerebral hyperthermia while minimizing the risk of postoperative hypothermia[corrected]...
  70. ncbi request reprint Preliminary evaluation of the Arctic Sun temperature-controlling system during off-pump coronary artery bypass surgery
    Timothy O Stanley
    Department of Anesthesiology, Division of Cardiac Anesthesiology and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 75:1140-4. 2003
    ..The purpose of this study was to determine the efficacy of a new thermoregulatory device, the Arctic Sun temperature-controlling circulating fluid adhesive pad system, in preventing hypothermia during OPCAB surgery...
  71. ncbi request reprint Prevalence of risk factors, and not gender per se, determines short- and long-term survival after coronary artery bypass surgery
    Colleen Gorman Koch
    Cleveland Clinic Foundation, OH, USA
    J Cardiothorac Vasc Anesth 17:585-93. 2003
    ..Studies that have compared postoperative survival in women and men beyond hospital discharge report disparate results with regard to the independent effect of gender per se on ultimate survival...
  72. doi request reprint Pulse pressure and risk of adverse outcome in coronary bypass surgery
    Manuel L Fontes
    Weill Medical College of Cornell University, Ischemia Research and Education Foundation 1111 Bayhill Dr, Suite 480, San Bruno, CA 94066, USA
    Anesth Analg 107:1122-9. 2008
    ..The relationship of PP and acute perioperative vascular outcome among patients having coronary artery bypass graft (CABG) surgery is less well known...
  73. ncbi request reprint Guidelines for performing a comprehensive epicardial echocardiography examination: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists
    Scott T Reeves
    Medical University of South Carolina, Charleston, South Carolina, USA
    J Am Soc Echocardiogr 20:427-37. 2007
  74. ncbi request reprint Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology
    Stroke 34:508-13. 2003
    ..We therefore sought to determine the association of decreased EndoCAb and the incidence of postoperative cognitive decline...
  75. ncbi request reprint Platelet PlA2 polymorphism and platelet activation are associated with increased troponin I release after cardiopulmonary bypass
    Christine S Rinder
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8051, USA
    Anesthesiology 97:1118-22. 2002
    ....
  76. doi request reprint Intraoperative transesophageal echocardiography diagnosis of residual tumor fragment after surgical removal of renal cell carcinoma
    Susan M Martinelli
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Anesth Analg 106:1633-5. 2008
  77. ncbi request reprint Case report: optimizing intraoperative detection of pulmonary embolism using contrast-enhanced echocardiography
    Igor Izrailtyan
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Can J Anaesth 53:711-5. 2006
    ..However, the sensitivity of intraoperative TEE to detect thromboemboli is reported to be below 50%. In this report, we describe the use of contrast-enhanced TEE (CE-TEE) to improve the visualization of PE...
  78. ncbi request reprint Guidelines for performing a comprehensive epicardial echocardiography examination: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists
    Scott T Reeves
    Medical University of South Carolina, USA
    Anesth Analg 105:22-8. 2007
  79. ncbi request reprint Brief report: The declining incidence of cerebral hyperthermia during cardiac surgery: a seven-year experience in 6,334 patients
    William B Corkey
    Department of Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Can J Anaesth 52:626-9. 2005
    ..As a result, we hypothesized that the maximum temperature reached during cardiac surgery has decreased at our institution over time...
  80. ncbi request reprint American Society of Echocardiography/Society of Cardiovascular Anesthesiologists recommendations and guidelines for continuous quality improvement in perioperative echocardiography
    Joseph P Mathew
    Duke University Medical Center, Durham, North Carolina, USA
    J Am Soc Echocardiogr 19:1303-13. 2006
  81. ncbi request reprint Prophylaxis against postoperative atrial fibrillation: current progress and future directions
    Mihai V Podgoreanu
    JAMA 294:3140-2. 2005
  82. ncbi request reprint Guidelines for the performance of a comprehensive intraoperative epiaortic ultrasonographic examination: recommendations of the American Society of Echocardiography and the Society of Cardiovascular Anesthesiologists; endorsed by the Society of Thoracic S
    Kathryn E Glas
    Department of Anesthesiology, Emory University, Atlanta, Georgia
    J Am Soc Echocardiogr 20:1227-35. 2007

Research Grants2

  1. Lidocaine for Neuroprotection During Cardiac Surgery
    Joseph Mathew; Fiscal Year: 2009
    ..The use of lidocaine therapy holds great promise for improving cognitive function and as a consequence, quality of life and functional independence for the large number of our increasingly elderly patients. ..
  2. Lidocaine for Neuroprotection During Cardiac Surgery
    Joseph P Mathew; Fiscal Year: 2010
    ..The use of lidocaine therapy holds great promise for improving cognitive function and as a consequence, quality of life and functional independence for the large number of our increasingly elderly patients. ..