Anna Maria Masci

Summary

Affiliation: Duke Universiy
Location: Durham, NC , USA
Summary:
Biomedical ontology, cellular and molecular immunology.
Grants:
Ph.D. in Biothecnology
MS in Chemistry and Clinical Biochemistry

Publications

  1. ncbi HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling
    Anna Maria Masci
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 5 Via S Pansini, I 80131 Naples, Italy
    J Leukoc Biol 74:1117-24. 2003
  2. ncbi Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling
    Mario Galgani
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, , I-80131 Naples, Italy
    J Biol Chem 279:32507-14. 2004
  3. ncbi GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation
    Giuseppina Ruggiero
    Cattera di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Frederico II, Naples, Italy
    J Leukoc Biol 76:634-40. 2004
  4. ncbi Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis
    Cristiano Scotta
    Department of Cellular and Developmental Biology, La Sapienza University, Rome, 00185, Italy
    J Leukoc Biol 78:372-82. 2005
  5. ncbi Fatal immunodeficiency in a patient with thymoma and Good's syndrome
    Liliana Montella
    Medical Oncology Unit, S Giovanni di Dio Hospital, Frattaminore, Naples, Italy
    Tumori 91:361-3. 2005
  6. ncbi Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
    Maddalena Illario
    Department of Molecular and Cellular Biology and Pathology, Federico II University of Naples, Italy
    Blood 111:723-31. 2008
  7. ncbi An improved ontological representation of dendritic cells as a paradigm for all cell types
    Anna Maria Masci
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA
    BMC Bioinformatics 10:70. 2009
  8. ncbi Hematopoietic cell types: prototype for a revised cell ontology
    Alexander D Diehl
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Biomed Inform 44:75-9. 2011
  9. ncbi Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells
    L Vitiello
    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Italy
    Int J Immunopathol Pharmacol 23:307-16. 2010
  10. ncbi Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors
    Maria Letizia Giardino Torchia
    Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Naples, Italy
    PLoS ONE 5:e11052. 2010

Collaborators

Detail Information

Publications25

  1. ncbi HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling
    Anna Maria Masci
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 5 Via S Pansini, I 80131 Naples, Italy
    J Leukoc Biol 74:1117-24. 2003
    ..These findings reveal a novel mechanism by which HIVenv may modulate the processes of clonal expansion, homeostatic proliferation, and terminal differentiation of the naive T lymphocyte subset...
  2. ncbi Cyclic AMP modulates the functional plasticity of immature dendritic cells by inhibiting Src-like kinases through protein kinase A-mediated signaling
    Mario Galgani
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, , I-80131 Naples, Italy
    J Biol Chem 279:32507-14. 2004
    ..We propose that the cAMP-protein kinase A-dependent pathway regulates the functional plasticity of iDCs by gating the Toll-like receptor signaling at the level of Src-like kinases...
  3. ncbi GPI-defective monocytes from paroxysmal nocturnal hemoglobinuria patients show impaired in vitro dendritic cell differentiation
    Giuseppina Ruggiero
    Cattera di Immunologia, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita Frederico II, Naples, Italy
    J Leukoc Biol 76:634-40. 2004
    ..Finally, GPI-defective DCs showed a severe impairment in delivering accessory signals for T cell receptor-dependent T cell proliferation...
  4. ncbi Hypervariable region 1 variant acting as TCR antagonist affects hepatitis C virus-specific CD4+ T cell repertoire by favoring CD95-mediated apoptosis
    Cristiano Scotta
    Department of Cellular and Developmental Biology, La Sapienza University, Rome, 00185, Italy
    J Leukoc Biol 78:372-82. 2005
    ..These data support the hypothesis that in HCV infection, the generation of TCR antagonists may reshape the T cell repertoire, representing an efficacious immune evasion strategy of a highly mutant pathogen...
  5. ncbi Fatal immunodeficiency in a patient with thymoma and Good's syndrome
    Liliana Montella
    Medical Oncology Unit, S Giovanni di Dio Hospital, Frattaminore, Naples, Italy
    Tumori 91:361-3. 2005
    ..The authors present the clinical history of a thymoma patient affected by fatal immunodeficiency...
  6. ncbi Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells
    Maddalena Illario
    Department of Molecular and Cellular Biology and Pathology, Federico II University of Naples, Italy
    Blood 111:723-31. 2008
    ..These results reveal a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival...
  7. ncbi An improved ontological representation of dendritic cells as a paradigm for all cell types
    Anna Maria Masci
    Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA
    BMC Bioinformatics 10:70. 2009
    ..This approach limits the CL's utility for computation and for cross-species data integration...
  8. ncbi Hematopoietic cell types: prototype for a revised cell ontology
    Alexander D Diehl
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Biomed Inform 44:75-9. 2011
    ..The methods and improvements to the CL in this area represent a paradigm for improvement of the entire ontology over time...
  9. ncbi Thymoma-associated immunodeficiency: a syndrome characterized by severe alterations in NK, T and B-cells and progressive increase in naïve CD8+ T Cells
    L Vitiello
    Department of Cellular and Molecular Biology and Pathology, Federico II University of Naples, Italy
    Int J Immunopathol Pharmacol 23:307-16. 2010
    ..Furthermore, the accumulation of CD8+CD45RA+ T lymphocytes parallels these changes; this accumulation may have a role in determining the disease and can be used to monitor clinical stages of immunodeficiency in thymoma...
  10. ncbi Dendritic cells/natural killer cross-talk: a novel target for human immunodeficiency virus type-1 protease inhibitors
    Maria Letizia Giardino Torchia
    Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Naples, Italy
    PLoS ONE 5:e11052. 2010
    ..Here, we analyzed the ability of PIs to interfere with differentiation program of monocytes toward dendritic cell (DCs) lineage, a key process in the inflammatory response...
  11. ncbi Antibody-selected mimics of hepatitis C virus hypervariable region 1 activate both primary and memory Th lymphocytes
    Loredana Frasca
    Department of Cellular and Developmental Biology, La Sapienza University, Rome, Italy
    Hepatology 38:653-63. 2003
    ..In conclusion, these data lend strong support to using HVR1 mimotopes in vaccines designed to prevent replication of escape mutants...
  12. ncbi B-cell lymphopenia and hypogammaglobulinemia in thymoma patients
    L Montella
    Molecular and Clinical Oncology and Endocrinology Department, Faculty of Medicine, University Federico II, Via Pansini 5, 80131, Naples, Italy
    Ann Hematol 82:343-7. 2003
    ..Therefore, immunophenotype has to be monitored in follow-up of thymoma patients because it may reveal significant abnormalities...
  13. ncbi Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia
    Anna Maria Masci
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II University of Naples, Italy
    Blood 101:3106-8. 2003
    ..We propose that BV8 CD8(+) T cells may play a role in the pathogenesis of this immunodeficiency syndrome...
  14. ncbi Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation
    C Pignata
    Department of Pediatrics and Cellular and Molecular Biology and Pathology, Federico II University, Naples, Italy
    Blood 97:880-5. 2001
    ..Taken together, these findings suggest that bone marrow transplantation is ineffective in the long-term cure of this form of SCID...
  15. ncbi Modulation of CD45 tyrosine phosphatase activity by antigen
    F Lago Paz
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, , Naples, Italy
    Eur J Immunol 31:777-82. 2001
    ..Since the recruitment of CD4 is an initial step in the activation process, the inhibition of this pool of CD45 molecules would be crucial to prevent dephosphorylation of relevant substrates which promote the activation process...
  16. ncbi Logical development of the cell ontology
    Terrence F Meehan
    Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME, USA
    BMC Bioinformatics 12:6. 2011
    ..By making the information in the ontology computable, we can use automated reasoners to detect errors and assist with classification. Here we report on the generation of computable definitions for the hematopoietic cell types in the CL...