Christine E Marx

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Post-traumatic stress disorder in women: current concepts and treatments
    Marian I Butterfield
    Department of Psychiatry, Duke University and the Department of Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Curr Psychiatry Rep 4:474-86. 2002
  2. ncbi request reprint Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neuropsychopharmacology 31:1249-63. 2006
  3. ncbi request reprint Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 186:462-72. 2006
  4. ncbi request reprint The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease
    Christine E Marx
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina 27705, USA
    Biol Psychiatry 60:1287-94. 2006
  5. ncbi request reprint New developments in proteomics
    Mark W Massing
    Research Service of the Veteran Affairs Medical Center in Durham, North Carolina, USA
    N C Med J 68:119-22. 2007
  6. doi request reprint Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Int J Neuropsychopharmacol 11:547-52. 2008
  7. pmc Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neuropsychopharmacology 34:1885-903. 2009
  8. ncbi request reprint Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions
    Christine E Marx
    Duke University Medical Center, Durham NC, New York, NY, USA
    Pharmacol Biochem Behav 84:609-17. 2006
  9. ncbi request reprint Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?
    Christine E Marx
    Duke University Medical Center, Durham NC, USA
    Pharmacol Biochem Behav 84:598-608. 2006
  10. doi request reprint Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence
    C E Marx
    Duke University Medical Center, Durham, NC, USA
    Neuroscience 191:78-90. 2011

Detail Information

Publications25

  1. ncbi request reprint Post-traumatic stress disorder in women: current concepts and treatments
    Marian I Butterfield
    Department of Psychiatry, Duke University and the Department of Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Curr Psychiatry Rep 4:474-86. 2002
    ..Selective serotonin reuptake inhibitors are the current first-line pharmacotherapy. Efficacious psychosocial interventions include exposure therapy and cognitive processing therapy...
  2. ncbi request reprint Neuroactive steroids are altered in schizophrenia and bipolar disorder: relevance to pathophysiology and therapeutics
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neuropsychopharmacology 31:1249-63. 2006
    ..Neuroactive steroids may therefore be candidate modulators of the pathophysiology of schizophrenia and bipolar disorder, and relevant to the treatment of these disorders...
  3. ncbi request reprint Neuroactive steroids, negative affect, and nicotine dependence severity in male smokers
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, and Durham Veterans Affairs Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 186:462-72. 2006
    ..These molecules may be relevant to tobacco addiction and affective symptoms...
  4. ncbi request reprint The neurosteroid allopregnanolone is reduced in prefrontal cortex in Alzheimer's disease
    Christine E Marx
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina 27705, USA
    Biol Psychiatry 60:1287-94. 2006
    ..We therefore investigated prefrontal cortex (PFC) NS levels in AD...
  5. ncbi request reprint New developments in proteomics
    Mark W Massing
    Research Service of the Veteran Affairs Medical Center in Durham, North Carolina, USA
    N C Med J 68:119-22. 2007
  6. doi request reprint Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Int J Neuropsychopharmacol 11:547-52. 2008
    ..Knockout of Bcl-2 significantly increases pregnenolone levels in mice (p<0.01), while allopregnanolone levels are unaltered. NS induction may be relevant to mechanisms contributing to lithium therapeutic efficacy and neuroprotection...
  7. pmc Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Neuropsychopharmacology 34:1885-903. 2009
    ..Mean BACS and MCCB composite scores were correlated (r(s)=0.74, p<0.0001). Pregnenolone may be a promising therapeutic agent for negative symptoms and merits further investigation for cognitive symptoms in schizophrenia...
  8. ncbi request reprint Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: implications for therapeutic actions
    Christine E Marx
    Duke University Medical Center, Durham NC, New York, NY, USA
    Pharmacol Biochem Behav 84:609-17. 2006
    ..Since pregnenolone decreases have been linked to depression, it is possible that olanzapine- and fluoxetine-induced pregnenolone elevations may contribute to the antidepressant actions of these agents...
  9. ncbi request reprint Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: candidate mechanism for superior efficacy?
    Christine E Marx
    Duke University Medical Center, Durham NC, USA
    Pharmacol Biochem Behav 84:598-608. 2006
    ..987). Olanzapine also elevates pregnenolone levels, but to a lesser degree than clozapine. Pregnenolone induction may contribute to the clinical actions of clozapine and olanzapine...
  10. doi request reprint Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence
    C E Marx
    Duke University Medical Center, Durham, NC, USA
    Neuroscience 191:78-90. 2011
    ..This article is part of a Special Issue entitled: Neuroactive Steroids: Focus on Human Brain...
  11. ncbi request reprint Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents
    Christine E Marx
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    Neuropsychopharmacology 28:1-13. 2003
    ..Alterations in this neuroactive steroid may result in the modulation of GABAergic and dopaminergic neurotransmission, potentially contributing to antipsychotic efficacy...
  12. pmc Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer's disease compared to cognitively intact control subjects
    Jennifer C Naylor
    VA Mid Atlantic Mental Illness, Research and Clinical Center MIRECC, Durham, NC, USA
    Biochim Biophys Acta 1801:951-9. 2010
    ..In addition, the APOE4 allele is associated with reduced allopregnanolone levels. Neurosteroids may be relevant to the neurobiology and therapeutics of AD...
  13. pmc Cerebrospinal fluid dehydroepiandrosterone levels are correlated with brain dehydroepiandrosterone levels, elevated in Alzheimer's disease, and related to neuropathological disease stage
    Jennifer C Naylor
    Durham Veterans Affairs Medical Center, 508 Fulton Street, MHSL 116A, Durham, North Carolina 27705, USA
    J Clin Endocrinol Metab 93:3173-8. 2008
    ..We therefore determined DHEA and pregnenolone levels in AD patients (n = 25) and cognitively intact control subjects (n = 16) in both CSF and temporal cortex...
  14. doi request reprint An open-label pilot study of aripiprazole for male and female veterans with chronic post-traumatic stress disorder who respond suboptimally to antidepressants
    Nagy A Youssef
    VA Mid Atlantic Mental Illness, Research and Clinical Center, Durham Veterans Affairs Medical Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    Int Clin Psychopharmacol 27:191-6. 2012
    ..These promising initial results merit further investigation in a larger, randomized-controlled trial...
  15. pmc Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001
    Jason D Kilts
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Pain Med 11:1469-76. 2010
    ..We thus hypothesized that endogenous allopregnanolone and other neurosteroid levels may be negatively correlated with self-reported pain symptoms in humans...
  16. pmc A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans
    Jennifer C Naylor
    VA Mid Atlantic Mental Illness, Research and Clinical Center, Durham, NC, USA
    Psychiatry Res 206:318-20. 2013
    ..Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD...
  17. doi request reprint Adverse impact of coercive treatments on psychiatric inpatients' satisfaction with care
    Jennifer L Strauss
    Center for Health Services Research in Primary Care, VISN 6 MIRECC, Bldg 6, 508 Fulton Street, Durham, NC, 27705, USA
    Community Ment Health J 49:457-65. 2013
    ..Albeit preliminary, these results document associations between patients' satisfaction ratings and their subjective experiences of coercion during both current and prior hospitalizations. ..
  18. doi request reprint Is military sexual trauma associated with trading sex among women veterans seeking outpatient mental health care?
    Jennifer L Strauss
    Health Services Research and Development, Durham VA Medical Center, Durham, North Carolina 27705, USA
    J Trauma Dissociation 12:290-304. 2011
    ..Results extend previously observed associations between sexual trauma and trading sex in civilian cohorts and underscore the pernicious influence of sexual victimization across the lifespan...
  19. ncbi request reprint Interpersonal trauma, war zone exposure, and posttraumatic stress disorder among veterans with schizophrenia
    Patrick S Calhoun
    VA Mid Atlantic Region Mental Illness Research, Education and Clinical Center 116B, 508 Fulton Street, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Schizophr Res 91:210-6. 2007
    ..Results suggest that PTSD is highly prevalent and under-diagnosed among veterans with schizophrenia. Increased assessment of trauma and PTSD in this population is warranted...
  20. doi request reprint Antipsychotic drugs: comparison in animal models of efficacy, neurotransmitter regulation, and neuroprotection
    Jeffrey A Lieberman
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, 1051 Riverside Dr, Unit 4, New York, NY 10032, USA
    Pharmacol Rev 60:358-403. 2008
    ....
  21. pmc Neurosteroid modulation of GABAergic neurotransmission in the central amygdala: a role for NMDA receptors
    Chunsheng Wang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, NC 27705, USA
    Neurosci Lett 415:118-23. 2007
    ..These ALLO effects on GABAergic transmission in the central amygdala may play a role in mediating its anxiolytic actions...
  22. ncbi request reprint Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol
    Amira Pierucci-Lagha
    Department of Psychiatry, Alcohol Research Center, University of Connecticut School of Medicine, Farmington, CT 06030, and Department of Psychiatry and Behavioral Sciences, Durham VA Medical Center, NC 27705, USA
    Psychopharmacology (Berl) 186:451-61. 2006
    ..This study examined the effects of alcohol on plasma steroid hormone concentrations on the hypothesis that the endocrine effects mediate some of the subjective effects of alcohol...
  23. ncbi request reprint Neuroactive steroids and suicidality in posttraumatic stress disorder
    Marian I Butterfield
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    Am J Psychiatry 162:380-2. 2005
    ..Since high rates of suicidality accompany PTSD, the authors investigated neuroactive steroid levels and correlations to suicide attempts in veterans with this disorder...
  24. ncbi request reprint Is obstructive sleep apnea associated with ADHD?
    Nagy A Youssef
    VA Mid Atlantic Mental Illness Research Education and Clinical Center, Durham VA Medical Center, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Ann Clin Psychiatry 23:213-24. 2011
    ..Because this may have important public health implications, we reviewed the literature regarding this association, with a focus on interventional studies examining the effect of OSA treatment on change in ADHD symptoms...
  25. doi request reprint Access to medical care among persons with psychotic and major affective disorders
    Daniel W Bradford
    Psychosocial Rehabilitation and Recovery Center, Durham VA Medical Center, MHSL 116D Hillandale 2, 508 Fulton St, Durham, NC 27705, USA
    Psychiatr Serv 59:847-52. 2008
    ..This study therefore examined access and barriers to medical care among persons with serious mental illness...