E R Martin

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study
    Yi Ju Li
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    BMC Genet 6:S53. 2005
  2. pmc Accounting for linkage in family-based tests of association with missing parental genotypes
    Eden R Martin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 73:1016-26. 2003
  3. ncbi request reprint A novel method to identify gene-gene effects in nuclear families: the MDR-PDT
    E R Martin
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, DUMC 3445, Durham, NC 27710, USA
    Genet Epidemiol 30:111-23. 2006
  4. ncbi request reprint Genotype-based association test for general pedigrees: the genotype-PDT
    E R Martin
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genet Epidemiol 25:203-13. 2003
  5. ncbi request reprint An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder
    A E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Ann Hum Genet 70:281-92. 2006
  6. pmc SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    E R Martin
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA duke edu
    Am J Hum Genet 67:383-94. 2000
  7. pmc Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism
    D Q Ma
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 77:377-88. 2005
  8. ncbi request reprint Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease
    P I Lin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 67:64-8. 2006
  9. ncbi request reprint Apolipoprotein E controls the risk and age at onset of Parkinson disease
    Y J Li
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 62:2005-9. 2004
  10. ncbi request reprint Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder
    M M Menold
    Department of Medicine and the Center for Human Genetics, Duke University Medical Center, Durham NC 27710, USA
    J Neurogenet 15:245-59. 2001

Collaborators

Detail Information

Publications65

  1. pmc Application of a rank-based genetic association test to age-at-onset data from the Collaborative Study on the Genetics of Alcoholism study
    Yi Ju Li
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    BMC Genet 6:S53. 2005
    ..These two regions may harbor genes that regulate age at onset of ALDX1 and ALDX2. Future fine mapping of these two regions with densely spaced markers is warranted...
  2. pmc Accounting for linkage in family-based tests of association with missing parental genotypes
    Eden R Martin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 73:1016-26. 2003
    ..As an example, we compare the performance of the tests in a candidate-gene study in families with Parkinson disease...
  3. ncbi request reprint A novel method to identify gene-gene effects in nuclear families: the MDR-PDT
    E R Martin
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, DUMC 3445, Durham, NC 27710, USA
    Genet Epidemiol 30:111-23. 2006
    ..These results show the utility of the MDR-PDT for understanding the genetics of complex diseases...
  4. ncbi request reprint Genotype-based association test for general pedigrees: the genotype-PDT
    E R Martin
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genet Epidemiol 25:203-13. 2003
    ....
  5. ncbi request reprint An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder
    A E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Ann Hum Genet 70:281-92. 2006
    ..However, the consistency of results across analyses suggests that we have defined a useful framework for evaluating gene-gene interactions...
  6. pmc SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease
    E R Martin
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, 27710, USA duke edu
    Am J Hum Genet 67:383-94. 2000
    ....
  7. pmc Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism
    D Q Ma
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 77:377-88. 2005
    ..These results support the hypothesis that GABA receptor subunit genes are involved in autism, most likely via complex gene-gene interactions...
  8. ncbi request reprint Exploring the association of glyceraldehyde-3-phosphate dehydrogenase gene and Alzheimer disease
    P I Lin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 67:64-8. 2006
    ..A recent study reported the association between the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene on chromosome 12p and the risk of LOAD...
  9. ncbi request reprint Apolipoprotein E controls the risk and age at onset of Parkinson disease
    Y J Li
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 62:2005-9. 2004
    ..Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent...
  10. ncbi request reprint Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder
    M M Menold
    Department of Medicine and the Center for Human Genetics, Duke University Medical Center, Durham NC 27710, USA
    J Neurogenet 15:245-59. 2001
    ..02 and intron5_687T/C, p=0.03), suggesting that the GABRG3 gene or a gene nearby contributes to genetic risk in AutD...
  11. ncbi request reprint Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease
    E R Martin
    Center for Human Genetics, Box 2903, Duke University Medical Center, Durham, NC 27710, USA
    JAMA 286:2245-50. 2001
    ..001) was detected between 4 of the 5 SNPs (SNPs 3, 9i, 9ii, and 11). CONCLUSIONS: This integrated approach of genetic linkage and positional association analyses implicates tau as a susceptibility gene for idiopathic PD...
  12. ncbi request reprint Life after the screen: making sense of many P-values
    S Schmidt
    Center for Human Genetics, Duke University Medical Center, Box 3468, Durham, North Carolina 27710, USA
    Genet Epidemiol 21:S546-51. 2001
    ..Genet Epidemiol, in press]. It appears that this approach is helpful for visualizing priority regions for follow-up analysis and reducing the number of false-positive linkage signals...
  13. ncbi request reprint Lack of association between UBQLN1 and Alzheimer disease
    M A Slifer
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 141:208-13. 2006
    ..Our results suggest that UBQLN1 variants do not increase risk for AD in these data...
  14. ncbi request reprint Analysis of the RELN gene as a genetic risk factor for autism
    D A Skaar
    Department of Medicine, Center for Human Genetics, IGSP, Duke University Medical Center, Durham, NC, USA
    Mol Psychiatry 10:563-71. 2005
    ..The most significant association identified from this combined data set was for the 5'-UTR repeat (PDT P-value=0.002). These analyses show the potential of RELN as an important contributor to genetic risk in autism...
  15. pmc A test for linkage and association in general pedigrees: the pedigree disequilibrium test
    E R Martin
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 67:146-54. 2000
    ..Thus, the PDT provides a general test of linkage disequilibrium that can be widely applied to different data structures...
  16. pmc Power calculations for likelihood ratio tests for offspring genotype risks, maternal effects, and parent-of-origin (POO) effects in the presence of missing parental genotypes when unaffected siblings are available
    E Rampersaud
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Genet Epidemiol 31:18-30. 2007
    ....
  17. ncbi request reprint Analysis of linkage disequilibrium in gamma-aminobutyric acid receptor subunit genes in autistic disorder
    E R Martin
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet 96:43-8. 2000
    ..This finding lends support for previous reports implicating the involvement of genes in this region with AD. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:43-48, 2000..
  18. ncbi request reprint Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease
    J M van der Walt
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Neurology 60:1189-91. 2003
    ..The authors did not find evidence for association with increased risk for PD between any individual NAT1 or NAT2 SNP or acetylation haplotype (N = 397 families, 1,580 individuals)...
  19. ncbi request reprint No association between the APOE gene and autism
    K L Raiford
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Med Genet B Neuropsychiatr Genet 125:57-60. 2004
    ....
  20. ncbi request reprint A Monte Carlo procedure for two-stage tests with correlated data
    E R Martin
    Section of Medical Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Genet Epidemiol 18:48-62. 2000
    ..We also discuss the use of a two-stage procedure when doing a genome scan for the data presented in the Genetic Analysis Workshop 9 study...
  21. ncbi request reprint Linkage and association analysis of chromosome 19q13 in multiple sclerosis
    M A Pericak-Vance
    Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Neurogenetics 3:195-201. 2001
    ..While consistent, this effect appears to be modest with a maximum lambda(s) = 1.47, probably representing no more than 10% of the overall genetic effect in MS...
  22. ncbi request reprint Analysis of association at single nucleotide polymorphisms in the APOE region
    E R Martin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genomics 63:7-12. 2000
    ..Our goal was to examine patterns of allelic association to begin to investigate the question of whether APOE could have been identified using SNPs. Our strongest evidence of association was at the 2 SNPs immediately flanking APOE...
  23. ncbi request reprint Articular hypermobility is a protective factor for hand osteoarthritis
    V B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 50:2178-83. 2004
    ..Very few studies have evaluated the association of articular hypermobility and radiographic osteoarthritis (OA) in humans. We assessed hypermobility and its relationship to radiographic hand OA in a family-based study...
  24. pmc X-APL: an improved family-based test of association in the presence of linkage for the X chromosome
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA
    Am J Hum Genet 80:59-68. 2007
    ..To show its utility and to discuss interpretation in real-data analysis, we also applied the X-APL to candidate-gene data in a sample of families with Parkinson disease...
  25. ncbi request reprint Interpretation of simultaneous linkage and family-based association tests in genome screens
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27710, USA
    Genet Epidemiol 31:134-42. 2007
    ..We concluded that when linkage and association tests are applied in the same data, the type I error rate of neither test will be affected and that power can be increased by applying tests conditionally...
  26. ncbi request reprint NOS2A and the modulating effect of cigarette smoking in Parkinson's disease
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 60:366-73. 2006
    ..NOS2A is a candidate gene for Parkinson's disease (PD) that potentially interacts with cigarette smoking. We examined NOS2A for association with PD risk and age at onset (AAO) and for interaction with smoking...
  27. ncbi request reprint The APL test: extension to general nuclear families and haplotypes and examination of its robustness
    Ren Hua Chung
    Bioinformatics Research Center, North Carolina State University, Raleigh, N C, USA
    Hum Hered 61:189-99. 2006
    ..Furthermore, the robustness of APL in practice has not been examined. Here we present a generalization of the APL model and examination of its robustness under a variety of non-standard scenarios...
  28. pmc Investigation of autism and GABA receptor subunit genes in multiple ethnic groups
    Ann L Collins
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Neurogenetics 7:167-74. 2006
    ..0253). These results confirmed our earlier findings, indicating GABRA4 and GABRB1 as genes contributing to autism susceptibility, extending the effect to multiple ethnic groups and suggesting seizures as a stratifying phenotype...
  29. ncbi request reprint Family-based case-control study of MAOA and MAOB polymorphisms in Parkinson disease
    Sun J Kang
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mov Disord 21:2175-80. 2006
    ..02). No significant association was found in the male subset. Our results add to the evidence of involvement of MAOB in PD and suggest that the effect may be stronger in women...
  30. pmc No gene is an island: the flip-flop phenomenon
    Ping I Lin
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Am J Hum Genet 80:531-8. 2007
    ....
  31. doi request reprint Disease associations and family-based tests
    Warren J Ewens
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Protoc Hum Genet . 2003
    ..The unit includes the Sib TDT (S-TDT) method, which allows application of the principle of the TDT to sibships without parental data. This extension of TDT is potentially valuable for studying late onset diseases...
  32. pmc Pesticide exposure and risk of Parkinson's disease: a family-based case-control study
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Neurol 8:6. 2008
    ..Pesticides and correlated lifestyle factors (e.g., exposure to well-water and farming) are repeatedly reported risk factors for Parkinson's disease (PD), but few family-based studies have examined these relationships...
  33. doi request reprint X-LRT: a likelihood approach to estimate genetic risks and test association with X-linked markers using a case-parents design
    Li Zhang
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
    Genet Epidemiol 32:370-80. 2008
    ..In addition, estimation of disease-related marker relative risks provides a measure of the magnitude of X-linked genetic effects on complex disorders...
  34. doi request reprint A multiple testing correction method for genetic association studies using correlated single nucleotide polymorphisms
    Xiaoyi Gao
    Center for Genetic Epidemiology and Statistical Genetics, Miami Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Genet Epidemiol 32:361-9. 2008
    ..The efficiency and accuracy of the proposed method make it an attractive choice for multiple testing adjustment when there is high intermarker LD in the SNP data set...
  35. pmc Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
    Gaofeng Wang
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 82:283-9. 2008
    ..We propose this is likely to be a common mechanism of genetic modulation of individual susceptibility to complex disease...
  36. pmc Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis
    Tricia A Thornton-Wells
    Biobehavioral Intervention Training Program, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University Institute for Imaging Science, Vanderbilt University, Nashville, Tennessee 37203, USA
    Genet Epidemiol 32:187-203. 2008
    ..Further studies are needed to replicate these statistical findings and to elucidate possible biological interaction mechanisms between LRRTM3 and these genes...
  37. pmc Increased efficiency of case-control association analysis by using allele-sharing and covariate information
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 65:154-65. 2008
    ....
  38. ncbi request reprint Investigation of potential gene-gene interactions between APOE and RELN contributing to autism risk
    Allison E Ashley-Koch
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Snyderman Genomic Sciences Building, Durham, NC 27710, USA
    Psychiatr Genet 17:221-6. 2007
    ..RELN shares a common biological pathway with APOE, and Persico et al. have observed transmission distortion of the APOE-2 allele in autism families...
  39. ncbi request reprint Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease
    Xueying Liang
    Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, USA
    Hum Mutat 28:1065-73. 2007
    ..However, the candidate gene and linkage analysis results did not converge, suggesting that there is more extensive heterogeneity on chromosome 10 than previously appreciated...
  40. ncbi request reprint Methods for interaction analyses using family-based case-control data: conditional logistic regression versus generalized estimating equations
    Dana B Hancock
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Genet Epidemiol 31:883-93. 2007
    ..g., population stratification) and the interpretation of its OR estimates...
  41. ncbi request reprint Smoking, caffeine, and nonsteroidal anti-inflammatory drugs in families with Parkinson disease
    Dana B Hancock
    Center for Human Genetics and Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Arch Neurol 64:576-80. 2007
    ..To assess associations between Parkinson disease (PD) and putatively protective factors-smoking, caffeine (coffee, tea, and soft drinks), and nonsteroidal anti-inflammatory drugs (aspirin, ibuprofen, and naproxen)...
  42. ncbi request reprint Interpreting analyses of continuous covariates in affected sibling pair linkage studies
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 31:541-52. 2007
    ..They suggest that the side-by-side evaluation of OSA and QTL results may provide important information about the relationship of measured covariates with either disease risk or linkage heterogeneity...
  43. doi request reprint Disease associations and family-based tests
    Warren J Ewens
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Curr Protoc Hum Genet . 2008
    ..The unit includes the Sib TDT (S-TDT) method, which allows application of the principle of the TDT to sibships without parental data, and several related tests...
  44. ncbi request reprint Parsing the genetic heterogeneity of chromosome 12q susceptibility genes for Alzheimer disease by family-based association analysis
    Ping I Lin
    Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    Neurogenetics 7:157-65. 2006
    ..0026). These results suggest that subset and covariate analyses may be one approach to help identify novel susceptibility genes on chromosome 12q for LOAD...
  45. pmc Fibroblast growth factor 20 polymorphisms and haplotypes strongly influence risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 74:1121-7. 2004
    ..0003), whereas a second haplotype (A-G-G-G-C) was found to be negatively associated with risk of PD (P=.0009). Our results strongly support FGF20 as a risk factor for PD...
  46. pmc Adjusting for covariates on a slippery slope: linkage analysis of change over time
    Evadnie Rampersaud
    Section of Medical Genetics, Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA
    BMC Genet 4:S50. 2003
    ....
  47. ncbi request reprint Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
    ..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
  48. ncbi request reprint The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 347:143-6. 2003
    ..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association...
  49. ncbi request reprint Association study of Parkin gene polymorphisms with idiopathic Parkinson disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC
    Arch Neurol 60:975-80. 2003
    ..However, previous case-control studies have reported conflicting results regarding the role of more common Parkin polymorphisms as susceptibility alleles for idiopathic PD...
  50. ncbi request reprint Parkin mutations and susceptibility alleles in late-onset Parkinson's disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 53:624-9. 2003
    ..These findings suggest that mutations in Parkin contribute to the common form of PD and that heterozygous mutations, especially those lying in exon 7, act as susceptibility alleles for late-onset form of Parkinson disease...
  51. pmc Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
    Joelle M van der Walt
    Department of Medicine, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 72:804-11. 2003
    ..45; 95% CI 0.22-0.93; P=.03). Our results suggest that ND3 is an important factor in PD susceptibility among white individuals and could help explain the role of complex I in PD expression...
  52. ncbi request reprint Association of ulcerative colitis with the inflammatory bowel disease susceptibility locus IBD2 in non-Jewish Caucasians and evidence of genetic heterogeneity among racial and ethnic populations with Crohn disease
    Sonja M S Uthoff
    Price Institute of Surgical Research, Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Am J Med Genet 113:242-9. 2002
    ..These data indicate that there may be significant genetic heterogeneity between different ethnic and racial IBD populations or may simply reflect differences in marker allele frequencies among populations...
  53. ncbi request reprint Multiple susceptibility loci for multiple sclerosis
    Jonathan L Haines
    Program in Human Genetics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Hum Mol Genet 11:2251-6. 2002
    ..These regions can now be targeted for detailed study to identify the underlying MS susceptibility genes...
  54. ncbi request reprint Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    Joelle M van der Walt
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 365:28-32. 2004
    ..We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE...
  55. ncbi request reprint Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease
    Kristin K Nicodemus
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurogenetics 5:201-8. 2004
    ..In conclusion, SNPs +5361, or a SNP in strong linkage disequilibrium, may confer some additional risk for developing AD beyond the risk due to APOE-4; however, the effect independent of APOE-4 is likely to be small...
  56. ncbi request reprint Linkage analysis with gene-environment interaction: model illustration and performance of ordered subset analysis
    Silke Schmidt
    Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Epidemiol 30:409-22. 2006
    ....
  57. ncbi request reprint Lack of association between autism and SLC25A12
    Raquel Rabionet
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, 595 LaSalle St, Durham, NC 27710, USA
    Am J Psychiatry 163:929-31. 2006
    ..This study aimed to test for association in SLC25A12 in an independent data set of 327 families with autistic offspring...
  58. ncbi request reprint Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring
    Andrew S Allen
    Department of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina 27710, USA
    Genet Epidemiol 30:248-58. 2006
    ..The power and efficacy of the approach is illustrated through a series of simulation experiments in which the approach is compared to existing methods...
  59. pmc Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing
    Abee L Boyles
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Hered 59:220-7. 2005
    ..Describe the inflation in nonparametric multipoint LOD scores due to inter-marker linkage disequilibrium (LD) across many markers with varied allele frequencies...
  60. ncbi request reprint Maternal lineages and Alzheimer disease risk in the Old Order Amish
    Joelle M van der Walt
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genet 118:115-22. 2005
    ..Therefore, we suggest that the genetic effect responsible for AD dementia in the affected Amish pedigrees is unlikely to be of mitochondrial origin and may be caused by nuclear genetic factors...
  61. ncbi request reprint The ubiquilin 1 gene and Alzheimer's disease
    Michael A Slifer
    N Engl J Med 352:2752-3; author reply 2752-3. 2005
  62. pmc Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases
    Yi Ju Li
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Neurobiol Aging 27:1087-93. 2006
    ..These findings suggest the presence of genetic heterogeneity for GSTO1h's effect on AAO, and support GSTO1h's role in modifying AAO in these two disorders...
  63. ncbi request reprint Analysis of the autism chromosome 2 linkage region: GAD1 and other candidate genes
    Raquel Rabionet
    Department of Medicine, Center for Human Genetics, 595 LaSalle St, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 372:209-14. 2004
    ....
  64. ncbi request reprint Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype
    Sofia A Oliveira
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Neurogenetics 5:147-55. 2004
    ..02). These results define the genes and regulatory regions included in this region of LD, containing an important susceptibility allele contributing to increased risk of neurodegeneration...
  65. pmc Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis
    Silke Schmidt
    Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:708-17. 2002
    ..03), whereas a higher proportion of APOE-2 carriers exhibit a mild disease course (P=.02)...