L B Marks

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Routine 3D treatment planning: opportunities, challenges, and hazards
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Oncology (Williston Park) 14:1191-201; discussion 1201, 1205-8. 2000
  2. ncbi request reprint A practical and easy method to locate the first three internal mammary lymph node-bearing areas
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 50:421-5. 2001
  3. ncbi request reprint Incorporation of functional status into dose-volume analysis
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 26:196-9. 1999
  4. ncbi request reprint The incidence and functional consequences of RT-associated cardiac perfusion defects
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 63:214-23. 2005
  5. ncbi request reprint Radiation-induced lung injury
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 13:333-45. 2003
  6. ncbi request reprint Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy: report of a prospective phase I dose escalation trial from the Carolina Conformal Therapy Consortium
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 22:4329-40. 2004
  7. ncbi request reprint The rationale and use of three-dimensional radiation treatment planning for lung cancer
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Chest 116:539S-545S. 1999
  8. ncbi request reprint Radiation-induced pulmonary injury: symptomatic versus subclinical endpoints
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Radiat Biol 76:469-75. 2000
  9. ncbi request reprint Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy: a preliminary report of a phase I dose escalation trial from the Carolina Conformal Therapy Consortium
    M A Socinski
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
    Oncologist 6:20-4. 2001
  10. ncbi request reprint Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation
    M S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 19:3758-65. 2001

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint Routine 3D treatment planning: opportunities, challenges, and hazards
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Oncology (Williston Park) 14:1191-201; discussion 1201, 1205-8. 2000
    ..These need to be addressed to maintain patient safety. Based on our experience with over 1,500 patients treated at Duke University, the benefits, challenges, and hazards of routine 3D treatment planning are discussed...
  2. ncbi request reprint A practical and easy method to locate the first three internal mammary lymph node-bearing areas
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 50:421-5. 2001
    ..To assess the distance from a clinically recognized anatomic landmark to the different costocondral interspaces in female patients to facilitate the design of radiation fields intended to include specific internal mammary nodal areas...
  3. ncbi request reprint Incorporation of functional status into dose-volume analysis
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 26:196-9. 1999
    ..The concept is illustrated by the use of SPECT imaging to assess the functional status of irradiated lung...
  4. ncbi request reprint The incidence and functional consequences of RT-associated cardiac perfusion defects
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 63:214-23. 2005
    ..We herein assess the temporal nature and volume dependence of RT-induced left ventricular perfusion defects and whether these perfusion defects are related to changes in cardiac wall motion or alterations in ejection fraction...
  5. ncbi request reprint Radiation-induced lung injury
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 13:333-45. 2003
    ..Sophisticated planning/delivery methods, such as intensity modulation, plus radioprotectors such as amifostine, hold promise to reduce the incidence of RT-induced lung injury...
  6. ncbi request reprint Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy: report of a prospective phase I dose escalation trial from the Carolina Conformal Therapy Consortium
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 22:4329-40. 2004
    ..6 Gy bid) for unresectable locally advanced lung cancer (IIB to IIIA/B) following induction carboplatin/paclitaxel (C/T) or carboplatin/vinorelbine (C/N)...
  7. ncbi request reprint The rationale and use of three-dimensional radiation treatment planning for lung cancer
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Chest 116:539S-545S. 1999
    ..Preliminary clinical studies suggest that this is a feasible approach worthy of additional study. The three-dimensional tools provide new opportunities to better understand radiation-induced changes in pulmonary function...
  8. ncbi request reprint Radiation-induced pulmonary injury: symptomatic versus subclinical endpoints
    L B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Radiat Biol 76:469-75. 2000
    ..To assess the relationship between radiation (RT)-induced pulmonary symptoms and subclinical changes in pulmonary functions tests (PFT) and radiographs...
  9. ncbi request reprint Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy: a preliminary report of a phase I dose escalation trial from the Carolina Conformal Therapy Consortium
    M A Socinski
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA
    Oncologist 6:20-4. 2001
    ..Key morbidity observed thus far has involved the esophagus. Further cohorts of patients will receive higher doses of conformal radiotherapy (in 6.4 Gy increments) until the maximum tolerated dose is reached...
  10. ncbi request reprint Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation
    M S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 19:3758-65. 2001
    ..Changes in plasma transforming growth factor beta (TGFbeta) levels during radiotherapy (RT) may identify patients at low risk for complications in whom higher doses of radiation could be safely delivered...
  11. ncbi request reprint Relating radiation-induced regional lung injury to changes in pulmonary function tests
    M Fan
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 51:311-7. 2001
    ..Additional studies to clarify the relationship between regional and global lung injury are needed...
  12. ncbi request reprint Can we predict radiation-induced changes in pulmonary function based on the sum of predicted regional dysfunction?
    M Fan
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 19:543-50. 2001
    ..To determine whether changes in whole-lung pulmonary function test (PFT) values are related to the sum of predicted radiation therapy (RT)-induced changes in regional lung perfusion...
  13. ncbi request reprint Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer: challenges and prospects
    M T Munley
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Lung Cancer 23:105-14. 1999
    ..The utilization of accurate nuclear medicine image reconstruction techniques and TCT may improve the treatment planning process...
  14. ncbi request reprint Radiation-induced pulmonary toxicity: a dose-volume histogram analysis in 201 patients with lung cancer
    M L Hernando
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 51:650-9. 2001
    ..CONCLUSIONS: Dosimetric factors were the best predictors of symptomatic RP after external beam RT for lung cancer. Multivariate models that also include clinical variables were slightly more predictive...
  15. ncbi request reprint A neural network to predict symptomatic lung injury
    M T Munley
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Phys Med Biol 44:2241-9. 1999
    ..813 +/- 0.06. The DVHR method had Az = 0.521 +/- 0.08. The network was also used to rank the significance of the input variables. Future studies will be conducted to improve network accuracy and to include functional imaging data...
  16. ncbi request reprint Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin: preliminary results
    P H Hardenbergh
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 49:1023-8. 2001
    ..Long-term follow-up is needed to assess whether these perfusion changes are transient or permanent and to determine if these findings are associated with changes in overall cardiac function and clinical outcome...
  17. pmc A genetic algorithm for variable selection in logistic regression analysis of radiotherapy treatment outcomes
    Olivier Gayou
    Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA
    Med Phys 35:5426-33. 2008
    ..In conclusion, genetic algorithms provide a reliable and fast way to select significant factors in logistic regression analysis of large clinical studies...
  18. ncbi request reprint Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast
    Lawrence J Solin
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer 103:1137-46. 2005
    ..The objective of the current study was to determine the long-term outcome after breast-conservation surgery followed by definitive breast irradiation for women with mammographically detected DCIS of the breast...
  19. ncbi request reprint High-dose, hyperfractionated, accelerated radiotherapy using a concurrent boost for the treatment of nonsmall cell lung cancer: unusual toxicity and promising early results
    S C King
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC USA
    Int J Radiat Oncol Biol Phys 36:593-9. 1996
    ....
  20. ncbi request reprint Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta
    X L Fu
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 50:899-908. 2001
    ..Thus, combining both physical and biologic risk factors may allow for better identification of patients at risk for the development of symptomatic radiation-induced lung injury...
  21. ncbi request reprint A new three-dimensional dose distribution reduction scheme for tubular organs
    S M Zhou
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 27:1727-31. 2000
    ..The DCH as a treatment planning tool can be easily implemented in a 3D planing system and is potentially useful for the study of the relationship between the complication risk and the longitudinal and circumferential dose distributions...
  22. ncbi request reprint Quantitative pulmonary single photon emission computed tomography for radiotherapy applications
    C Scarfone
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 26:1579-88. 1999
    ..SPECT has the potential to provide accurate estimates of lung activity distributions that, together with improved image quality, may be useful for the study and prediction of therapeutic response...
  23. pmc Stereotactic body radiotherapy for lesions of the spine and paraspinal regions
    John W Nelson
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 73:1369-75. 2009
    ..To describe our experience and clinical strategy for stereotactic body radiotherapy (SBRT) of spinal lesions...
  24. doi request reprint Regional lung density changes after radiation therapy for tumors in and around thorax
    Jinli Ma
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27599 7512, USA
    Int J Radiat Oncol Biol Phys 76:116-22. 2010
    ..To study the temporal nature of regional lung density changes and to assess whether the dose-dependent nature of these changes is associated with patient- and treatment-associated factors...
  25. pmc Variability of target and normal structure delineation for breast cancer radiotherapy: an RTOG Multi-Institutional and Multiobserver Study
    X Allen Li
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 73:944-51. 2009
    ....
  26. ncbi request reprint 73.6 Gy and beyond: hyperfractionated, accelerated radiotherapy for non-small-cell lung cancer
    P D Maguire
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 19:705-11. 2001
    ..Late grade > or = 3 pulmonary toxicity occurred in 17%. Because of continued locoregional recurrences, we are currently using doses > or = 86 Gy...
  27. ncbi request reprint Multi-institutional review of repeat irradiation of chest wall and breast for recurrent breast cancer
    Andrew O Wahl
    Department of Radiation Oncology, Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Int J Radiat Oncol Biol Phys 70:477-84. 2008
    ..To review the toxicity and clinical outcomes for patients who underwent repeat chest wall or breast irradiation (RT) after local recurrence...
  28. doi request reprint Quantifying the dosimetric trade-offs when using intensity-modulated radiotherapy to treat concave targets containing normal tissues
    Adam S Reese
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Int J Radiat Oncol Biol Phys 73:585-93. 2009
    ....
  29. ncbi request reprint Predictors for pneumonitis during locoregional radiotherapy in high-risk patients with breast carcinoma treated with high-dose chemotherapy and stem-cell rescue
    Pehr A Lind
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Cancer 94:2821-9. 2002
    ..These patients are at risk of developing therapy-related pneumonitis (TRP) during or after radiotherapy (RT)...
  30. ncbi request reprint Functional imaging of normal tissues with nuclear medicine: applications in radiotherapy
    M T Munley
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 11:28-36. 2001
    ..This article reviews the studies performed in radiotherapy that used these modalities, and attempts to stimulate further interest in this topic...
  31. doi request reprint A methodology for selecting the beam arrangement to reduce the intensity-modulated radiation therapy (IMRT) dose to the SPECT-defined functioning lung
    S M McGuire
    Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Phys Med Biol 55:403-16. 2010
    ..1 +/- 3.6)%, respectively, compared to the SPECT Plan. Using fewer beams in IMRT planning may reduce the amount of functional lung that receives 5 and 13 Gy, a factor that has recently been associated with radiation pneumonitis...
  32. ncbi request reprint The physical parameters and molecular events associated with radiation-induced lung toxicity
    Z Vujaskovic
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 10:296-307. 2000
    ..This review discusses our current understanding of the physical and molecular factors contributing to RT-induced pulmonary injury...
  33. ncbi request reprint Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer
    Elizabeth S Evans
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Radiat Oncol Biol Phys 66:1125-34. 2006
    ....
  34. ncbi request reprint Body mass index predicts the incidence of radiation pneumonitis in breast cancer patients
    Aaron M Allen
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Cancer J 11:390-8. 2005
    ..We herein present a case control study assessing the impact of clinical and dose-volume metrics on the development of radiation pneumonitis in patients receiving sequential chemotherapy and local-regional radiotherapy...
  35. ncbi request reprint Routine use of approximately 60 Gy once-daily thoracic irradiation for patients with limited-stage small-cell lung cancer
    Keith L Miller
    Department of Radiation Oncology, Duke University Medical Center, and, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 56:355-9. 2003
    ..To review the outcome of patients with limited-stage small-cell lung cancer receiving daily thoracic irradiation (RT) to approximately 60 Gy...
  36. ncbi request reprint Dosimetric and clinical predictors for radiation-induced esophageal injury
    Sung Ja Ahn
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 61:335-47. 2005
    ..To evaluate the clinical and three-dimensional dosimetric parameters associated with esophageal injury after radiotherapy (RT) for non-small-cell lung cancer...
  37. doi request reprint Radiation dose-volume effects of optic nerves and chiasm
    Charles Mayo
    Department of Radiation Oncology, University of Massachusetts School of Medicine, Worcester, MA 01655, USA
    Int J Radiat Oncol Biol Phys 76:S28-35. 2010
    ..8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined...
  38. pmc Radiation dose-volume effects in the brain
    Yaacov Richard Lawrence
    Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Int J Radiat Oncol Biol Phys 76:S20-7. 2010
    ..Cognitive dysfunction in children is largely seen for whole brain doses of >or=18 Gy. No substantial evidence has shown that RT induces irreversible cognitive decline in adults within 4 years of RT...
  39. ncbi request reprint Myocardial perfusion changes in patients irradiated for left-sided breast cancer and correlation with coronary artery distribution
    Pehr A Lind
    Departmentsof Radiation Oncology, Duke University, Durham, NC, USA
    Int J Radiat Oncol Biol Phys 55:914-20. 2003
    ..To correlate SPECT changes with percent irradiated left ventricle (LV) volume and risk factors for coronary artery disease (CAD)...
  40. pmc Radiation dose-volume effects in the esophagus
    Maria Werner-Wasik
    Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA 19107 5097, USA
    Int J Radiat Oncol Biol Phys 76:S86-93. 2010
    ..A variety of clinical and dosimetric parameters have been associated with acute and late toxicity. Suggestions for future studies are presented...
  41. ncbi request reprint "Anatomically-correct" dosimetric parameters may be better predictors for esophageal toxicity than are traditional CT-based metrics
    Daniel Kahn
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 62:645-51. 2005
    ..We herein assess the ability of a correction method, based on physiologic principles, to improve the predictive power of dosimetric parameters for radiation-induced esophageal injury...
  42. pmc Prospective assessment of dosimetric/physiologic-based models for predicting radiation pneumonitis
    Zafer Kocak
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 67:178-86. 2007
    ..We herein prospectively test the predictive abilities of these dosimetric/functional parameters on 2 cohorts of patients from Duke and The Netherlands Cancer Institute (NKI)...
  43. doi request reprint Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy
    Zhiheng Wang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    Int J Radiat Oncol Biol Phys 73:571-7. 2009
    ....
  44. pmc Radiation dose-volume effects in the lung
    Lawrence B Marks
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 76:S70-6. 2010
    ..The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects...
  45. pmc Radiation dose-volume effects of the urinary bladder
    Akila N Viswanathan
    Department of Radiation Oncology, Brigham and Women s Hospital, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 76:S116-22. 2010
    ..The data on partial-organ/nonuniform irradiation are suspect because the bladder motion is not accounted for, and many studies lack long enough follow-up data. Future studies are needed...
  46. doi request reprint Use of normal tissue complication probability models in the clinic
    Lawrence B Marks
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA
    Int J Radiat Oncol Biol Phys 76:S10-9. 2010
    ..A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included...
  47. ncbi request reprint Receiver operating characteristic curves to assess predictors of radiation-induced symptomatic lung injury
    Pehr A Lind
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 54:340-7. 2002
    ..To assess the utility of dosimetric/functional metrics as predictors of symptomatic radiation pneumonitis using receiver operating characteristic curves...
  48. doi request reprint Timing of local and distant failure in resected lung cancer: implications for reported rates of local failure
    Jessamy A Boyd
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Thorac Oncol 5:211-4. 2010
    ..e., local/regional) versus distant recurrence after surgery could potentially affect reported rates of local failure. We assessed this phenomenon in a large group of patients undergoing surgery for early-stage lung cancer...
  49. doi request reprint Current status of postoperative radiation for non-small-cell lung cancer
    Mert Saynak
    Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Semin Radiat Oncol 20:192-200. 2010
    ..Therefore, a reassessment of the utility of postoperative radiation therapy using limited fields and modern techniques is warranted...
  50. ncbi request reprint The impact of pre-radiotherapy surgery on radiation-induced lung injury
    Z Kocak
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Oncol (R Coll Radiol) 17:210-6. 2005
    ....
  51. ncbi request reprint Impact of consolidation radiotherapy in patients with advanced breast cancer treated with high-dose chemotherapy and autologous bone marrow rescue
    D L Carter
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    J Clin Oncol 17:887-93. 1999
    ..To examine the impact of consolidation radiotherapy (RT) after high-dose chemotherapy with autologous bone marrow rescue (HDC) in patients with advanced breast cancer...
  52. ncbi request reprint Integration of cone-beam CT in stereotactic body radiation therapy
    Fang Fang Yin
    Department of Radiation Oncology, Duke University Medical Center, Durham NC, USA
    Technol Cancer Res Treat 7:133-9. 2008
    ..Improved immobilization may enhance positioning accuracy. Typical total "in-room" times for the patients are approximately 1 hour. CBCT-guided SBRT is feasible and enhances setup accuracy using 3-D anatomical information...
  53. pmc A neural network model to predict lung radiation-induced pneumonitis
    Shifeng Chen
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 34:3420-7. 2007
    ..05). The network for prospective testing is publicly available via internet access...
  54. ncbi request reprint Cardiac toxicity following thoracic radiation
    Robert G Prosnitz
    Department of Radiation Oncology, Duke University, Box 3085 Duke University Medical Center, Durham, NC 27710, USA
    Semin Oncol 32:S71-80. 2005
    ..Further work is needed to quantify the frequency and severity of cardiac injury and develop preventative methods...
  55. ncbi request reprint Self-consistent tumor control probability and normal tissue complication probability models based on generalized EUD
    Su Min Zhou
    Radiation Oncology Department, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 34:2807-15. 2007
    ..Finally, numerical fits of our models to some experimental data are also presented...
  56. ncbi request reprint Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment
    Robert G Prosnitz
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 110:1840-50. 2007
    ..Previously, the authors identified cardiac perfusion defects in approximately 50% to 60% of patients 0.5 to 2 years post-RT. In the current study, they assessed the persistence of these defects 3 to 6 years post-RT...
  57. ncbi request reprint Challenges in the clinical application of advanced technologies to reduce radiation-associated normal tissue injury
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:4-12. 2007
  58. doi request reprint Teaching the anatomy of oncology: evaluating the impact of a dedicated oncoanatomy course
    Junzo P Chino
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 79:853-9. 2011
    ..We developed an anatomy-focused educational program for radiation oncology residents integrating cadaver dissection into the didactic review of diagnostic, surgical, radiologic, and treatment planning, and herein assess its efficacy...
  59. pmc Predicting lung radiotherapy-induced pneumonitis using a model combining parametric Lyman probit with nonparametric decision trees
    Shiva K Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 68:1212-21. 2007
    ..To develop and test a model to predict for lung radiation-induced Grade 2+ pneumonitis...
  60. pmc Investigation of the support vector machine algorithm to predict lung radiation-induced pneumonitis
    Shifeng Chen
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 34:3808-14. 2007
    ..The model SVM(all) is publicly available via internet access...
  61. ncbi request reprint The impact of advanced technologies on treatment deviations in radiation treatment delivery
    Lawrence B Marks
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:1579-86. 2007
    ..To assess the impact of new technologies on deviation rates in radiation therapy (RT)...
  62. ncbi request reprint Cone-beam CT localization of internal target volumes for stereotactic body radiotherapy of lung lesions
    Zhiheng Wang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:1618-24. 2007
    ..The technique is illustrated by using both phantom and patient cases...
  63. pmc Comparing digital tomosynthesis to cone-beam CT for position verification in patients undergoing partial breast irradiation
    Junan Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 73:952-7. 2009
    ....
  64. doi request reprint Intensity-modulated radiotherapy for resected mesothelioma: the Duke experience
    Edward F Miles
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 71:1143-50. 2008
    ..To assess the safety and efficacy of intensity-modulated radiotherapy (IMRT) after extrapleural pneumonectomy for malignant pleural mesothelioma...
  65. doi request reprint Preoperative chemotherapy versus preoperative chemoradiotherapy for stage III (N2) non-small-cell lung cancer
    Kristin Higgins
    Department of Radiation Oncology, Duke University of Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 75:1462-7. 2009
    ..To compare preoperative chemotherapy (ChT) and preoperative chemoradiotherapy (ChT-RT) in operable Stage III non-small-cell lung cancer...
  66. doi request reprint Radiation-induced reductions in regional lung perfusion: 0.1-12 year data from a prospective clinical study
    Junan Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 76:425-32. 2010
    ..To assess the time and regional dependence of radiation therapy (RT)-induced reductions in regional lung perfusion 0.1-12 years post-RT, as measured by single photon emission computed tomography (SPECT) lung perfusion...
  67. pmc Combining multiple models to generate consensus: application to radiation-induced pneumonitis prediction
    Shiva K Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 35:5098-109. 2008
    ..2, lung volume receiving >20-30 Gy; (4) female sex; and (5) squamous cell histology. To facilitate ease of interpretation and prospective use, the fused outcome results for the patients were fitted to a logistic probability function...
  68. doi request reprint The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 18:240-3. 2008
    ....
  69. pmc Using patient data similarities to predict radiation pneumonitis via a self-organizing map
    Shifeng Chen
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Phys Med Biol 53:203-16. 2008
    ..The SOM model developed here may not be extrapolated to treatment techniques outside that used in our database, such as several-field lung intensity modulated radiation therapy or gated radiation therapy...
  70. ncbi request reprint Point: Hyperthermia with radiation for chest wall recurrences
    Ellen L Jones
    Duke University Medical Center, Durham, NC 27710, USA
    J Natl Compr Canc Netw 5:339-44. 2007
    ..g., local/ regional recurrence after prior radiation), a reasonable option to consider is radiation with hyperthermia as a radiation sensitizer. This article reviews the rationale and supporting literature for this recommendation...
  71. ncbi request reprint Relationship between the generalized equivalent uniform dose formulation and the Poisson statistics-based tumor control probability model
    Su Min Zhou
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 31:2606-9. 2004
    ....
  72. ncbi request reprint A practical approach to pulmonary risk assessment in the radiotherapy of lung cancer
    Keith L Miller
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Semin Radiat Oncol 14:298-307. 2004
    ..We present a proposed approach to the evaluation, risk assessment, and follow-up of patients treated with thoracic radiotherapy for lung cancer...
  73. ncbi request reprint Predicting radiotherapy-induced cardiac perfusion defects
    Shiva K Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 32:19-27. 2005
    ..In conclusion, the nonparametric LDA model appears to be a more accurate predictor of radiotherapy-induced left ventricular perfusion defects than commonly used parametric models...
  74. ncbi request reprint Penalized likelihood fluence optimization with evolutionary components for intensity modulated radiation therapy treatment planning
    Alan H Baydush
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 31:2335-43. 2004
    ....
  75. ncbi request reprint Incorporation of functional imaging data in the evaluation of dose distributions using the generalized concept of equivalent uniform dose
    Moyed M Miften
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Phys Med Biol 49:1711-21. 2004
    ..In conclusion, incorporating functional data in the calculation of EUD is important in evaluating the biological merit of treatment plans...
  76. ncbi request reprint A preliminary study of the role of modulated electron beams in intensity modulated radiotherapy, using automated beam orientation and modality selection
    Shiva K Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 59:602-17. 2004
    ..To apply this algorithm to study the utility of modulated electron beams in the context of IMRT planning...
  77. ncbi request reprint Normal-tissue toxicities of thoracic radiation therapy: esophagus, lung, and spinal cord as organs at risk
    Maria Werner-Wasik
    Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, 111 South 11th Street, Philadelphia, PA 19107, USA
    Hematol Oncol Clin North Am 18:131-60, x-xi. 2004
    ....
  78. ncbi request reprint Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data
    John P Kirkpatrick
    Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3085, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 58:641-54. 2004
    ....
  79. ncbi request reprint Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 56:988-95. 2003
    ..To report the incidence of late complications in long-term survivors of very-high-dose thoracic radiotherapy (RT) treated on a prospective clinical trial...
  80. ncbi request reprint Patterns of failure after resection of non-small-cell lung cancer: implications for postoperative radiation therapy volumes
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 65:1097-105. 2006
    ..To analyze local-regional patterns of failure after surgical resection of non-small-cell lung cancer (NSCLC)...
  81. ncbi request reprint The time course of radiation therapy-induced reductions in regional perfusion: a prospective study with >5 years of follow-up
    Roxanne T Woel
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 52:58-67. 2002
    ..To assess the time-dependence of radiation therapy (RT)-induced reductions in regional lung perfusion, as measured by single photon emission computed tomography (SPECT) lung perfusion scans...
  82. ncbi request reprint Breast conservation rates-barriers between tertiary care and community practice
    Carol A Hahn
    Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 55:1196-9. 2003
    ..We evaluated the influence on BCT rates of opening a radiotherapy (RT) clinic at a community hospital in North Carolina. Before opening, RT was available 5 miles away at a tertiary care center...
  83. ncbi request reprint Influence of dose calculation model on treatment plan evaluation in conformal radiotherapy: a three-case study
    Moyed M Miften
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Med Dosim 27:51-7. 2002
    ..The CRT plans show the importance of accurate modeling of the effect of tissue inhomogeneities on dose distributions in the target and critical structures for lung and head-and-neck treatments...
  84. ncbi request reprint Local recurrence following initial resection of NSCLC: salvage is possible with radiation therapy
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer J 12:283-8. 2006
    ..This retrospective study evaluates the utility of salvage radiation therapy in this setting...
  85. ncbi request reprint Is there an increased risk of local recurrence under the heart block in patients with left-sided breast cancer?
    Katelyn A Raj
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer J 12:309-17. 2006
    ..Shaping the field with a heart block reduces cardiac exposure but may under-dose the breast and/or chest wall. We compared the incidence and location of local recurrences in patients irradiated with and without a heart block...
  86. ncbi request reprint Somnolence syndrome after focal radiation therapy to the pineal region: case report and review of the literature
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    J Neurooncol 78:153-6. 2006
    ..Prednisone was prescribed and within 1 week her symptoms had largely resolved. This is the first report of the somnolence syndrome after focal radiation therapy. The possible etiology of the somnolence syndrome is discussed...
  87. ncbi request reprint Using FDG-PET activity as a surrogate for tumor cell density and its effect on equivalent uniform dose calculation
    Su Min Zhou
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 31:2577-83. 2004
    ..e., whether including or not including the possible tumor cell density heterogeneity within tumor can be significant with large tumor volumes. Further research is needed to assess the usefulness of the fEUD concept in radiation treatment...
  88. ncbi request reprint Integral dose conservation in radiotherapy
    Adam S Reese
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 36:734-40. 2009
    ..This implies that there are limitations in the extent to which a critical structure can be spared based on the location and geometry of the critical structure relative to the target...
  89. ncbi request reprint Optimization of a 90Sr/90Y radiation source train stepping for intravascular brachytherapy
    Moyed M Miften
    Department of Radiation Oncology, Duke University Medical Cente, Durham, North Carolina 27710, USA
    Med Phys 29:2891-6. 2002
    ..The work presented in this paper provides a model to address the finite length of RST in IVB treatments. While the results presented are specific to the 90Sr/90Y RST, the methods should apply to other finite length RSTs...
  90. doi request reprint Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer 115:5218-27. 2009
    ..The objective of the current study was to evaluate the actuarial risk of local failure (LF) after surgery for stage I to II nonsmall cell lung cancer (NSCLC) and assess surgical and pathologic factors affecting this risk...
  91. ncbi request reprint Estimating the magnitude and field-size dependence of radiotherapy-induced mortality and tumor control after postoperative radiotherapy for non-small-cell lung cancer: calculations from clinical trials
    Edward F Miles
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 68:1047-52. 2007
    ....
  92. ncbi request reprint Comparing radical prostatectomy and brachytherapy for localized prostate cancer
    Brian P Quaranta
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 18:1289-302; discussion 1302-4, 1309. 2004
    ..Although radical prostatectomy and/or brachytherapy may play a role in the care of high-risk patients in the future, external-beam radiation therapy in combination with androgen deprivation has the best track record to date...
  93. pmc Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation
    Jeffrey J Meyer
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Radiat Oncol 1:48. 2006
    ....
  94. ncbi request reprint A methodology for using SPECT to reduce intensity-modulated radiation therapy (IMRT) dose to functioning lung
    Sarah M McGuire
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 66:1543-52. 2006
    ..We present a methodology for achieving this aim and test it in intensity-modulated radiotherapy (IMRT) treatment-planning...
  95. ncbi request reprint Assessing the ability of the antiangiogenic and anticytokine agent thalidomide to modulate radiation-induced lung injury
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 66:477-82. 2006
    ..The purpose of this study was to determine the maximal tolerated dose of thalidomide when used in combination with vinorelbine plus thoracic radiotherapy...
  96. ncbi request reprint Late effects of breast radiotherapy in young women
    Katelyn A Raj
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Breast Dis 23:53-65. 2005
    ..In this article we review late cardiac complications associated with tangential breast RT and the risk of developing a secondary breast cancer after mantle RT for Hodgkin's disease...
  97. doi request reprint Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction
    Carol A Hahn
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 73:1082-7. 2009
    ..A prospective study was performed to formally relate dose-dependent radiologically defined changes in normal brain induced by radiotherapy (RT) to neurocognitive dysfunction in subjects with primary brain tumors...
  98. doi request reprint Prone positioning causes the heart to be displaced anteriorly within the thorax: implications for breast cancer treatment
    Junzo P Chino
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 70:916-20. 2008
    ..We herein quantitatively compare the intrathoracic location of the heart in the prone and supine positions in patients treated for breast cancer...
  99. ncbi request reprint A dose-volume-based tool for evaluating and ranking IMRT treatment plans
    Moyed M Miften
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Appl Clin Med Phys 5:1-14. 2004
    ....
  100. ncbi request reprint Postoperative radiation therapy for lung cancer: where do we stand?
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 22:301-10; discussion 310, 314-5, 319. 2008
    ..Clinicians must therefore counsel patients regarding the risk of disease recurrence after surgery, the potential but unproven benefit of postoperative radiation therapy, and the possibility of treatment-related complications...
  101. ncbi request reprint Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions
    S K Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Med Phys 31:1452-61. 2004
    ....