MARY MARKERT

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Quantification of total T-cell receptor diversity by flow cytometry and spectratyping
    Stanca M Ciupe
    Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA
    BMC Immunol 14:35. 2013
  2. pmc First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Blood 117:688-96. 2011
  3. pmc Thymus transplantation
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 135:236-46. 2010
  4. doi request reprint Thymus transplantation in complete DiGeorge anomaly
    M Louise Markert
    Departments of Pediatrics and Immunology, Duke University Medical Center, Box 3068, Durham, NC, 27710, USA
    Immunol Res 44:61-70. 2009
  5. pmc Factors affecting success of thymus transplantation for complete DiGeorge anomaly
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 8:1729-36. 2008
  6. ncbi request reprint Use of allograft biopsies to assess thymopoiesis after thymus transplantation
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Research Park 4, Durham, NC 27710, USA
    J Immunol 180:6354-64. 2008
  7. pmc Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:4539-47. 2007
  8. ncbi request reprint Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome
    M Louise Markert
    Department of Pediatrics, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Blood 104:2574-81. 2004
  9. ncbi request reprint Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 102:1121-30. 2003
  10. ncbi request reprint Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    AIDS Res Hum Retroviruses 16:403-13. 2000

Detail Information

Publications15

  1. pmc Quantification of total T-cell receptor diversity by flow cytometry and spectratyping
    Stanca M Ciupe
    Department of Mathematics, Virginia Tech, 460 McBryde Hall, Blacksburg, VA 24060, USA
    BMC Immunol 14:35. 2013
    ..Flow cytometry can also be used to generate data about T-cell receptor BV gene usage, but its utility has not been compared to or tested in combination with spectratyping...
  2. pmc First use of thymus transplantation therapy for FOXN1 deficiency (nude/SCID): a report of 2 cases
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Blood 117:688-96. 2011
    ..Both subjects developed antigen-specific proliferative responses and have discontinued immunoglobulin replacement. In summary, thymus transplantation led to T-cell reconstitution and function in these FOXN1 deficient infants...
  3. pmc Thymus transplantation
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Clin Immunol 135:236-46. 2010
    ..The adverse events have been acceptable with thyroid disease being the most common. Research continues on mechanisms underlying immune reconstitution after thymus transplantation...
  4. doi request reprint Thymus transplantation in complete DiGeorge anomaly
    M Louise Markert
    Departments of Pediatrics and Immunology, Duke University Medical Center, Box 3068, Durham, NC, 27710, USA
    Immunol Res 44:61-70. 2009
    ..Immunosuppression is necessary to control the oligoclonal T cells. The results of thymus transplantation are reported for a series of 50 patients, of whom 36 survive. The survivors develop naïve T cells and a diverse T cell repertoire...
  5. pmc Factors affecting success of thymus transplantation for complete DiGeorge anomaly
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Am J Transplant 8:1729-36. 2008
    ..Although subtle immune effects may yet be associated with some of the factors tested, it is remarkable that consistently good immune outcomes result despite variation in dose, HLA matching and use of immunosuppression...
  6. ncbi request reprint Use of allograft biopsies to assess thymopoiesis after thymus transplantation
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Research Park 4, Durham, NC 27710, USA
    J Immunol 180:6354-64. 2008
    ..In summary, combining biopsy and autopsy data, allogeneic thymus tissues showed thymopoiesis in 24 of 29 (86%) evaluable transplants. The results of these biopsies led to improved care of these complex patients...
  7. pmc Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 109:4539-47. 2007
    ..In summary, diagnosis of complete DiGeorge anomaly is challenging because of the variability of presentation. Thymus transplantation was well tolerated and resulted in stable immunoreconstitution in these infants...
  8. ncbi request reprint Postnatal thymus transplantation with immunosuppression as treatment for DiGeorge syndrome
    M Louise Markert
    Department of Pediatrics, Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA
    Blood 104:2574-81. 2004
    ....
  9. ncbi request reprint Thymus transplantation in complete DiGeorge syndrome: immunologic and safety evaluations in 12 patients
    M Louise Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Blood 102:1121-30. 2003
    ..Thymic transplantation is efficacious, well tolerated, and should be considered as treatment for infants with complete DiGeorge syndrome...
  10. ncbi request reprint Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    AIDS Res Hum Retroviruses 16:403-13. 2000
    ..There was no clear difference in restoration of T cell function in the transplant recipients compared with the controls. Increases in TRECs after initiation of HAART may correlate with improved immune function...
  11. ncbi request reprint Transplantation of thymus tissue in complete DiGeorge syndrome
    M L Markert
    Department of Pediatrics, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 341:1180-9. 1999
    ..The DiGeorge syndrome is a congenital disorder that affects the heart, parathyroid glands, and thymus. In complete DiGeorge syndrome, patients have severely reduced T-cell function...
  12. ncbi request reprint Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 158:998-1005. 1997
    ....
  13. ncbi request reprint Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    AIDS Res Hum Retroviruses 17:1635-43. 2001
    ..Thymopoiesis in adult AIDS patients may contribute to immune reconstitution even after prolonged CD4+ T lymphopenia...
  14. ncbi request reprint The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection
    B F Haynes
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 18:529-60. 2000
    ....
  15. ncbi request reprint Purine nucleoside phosphorylase deficiency
    M L Markert
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710
    Immunodefic Rev 3:45-81. 1991
    ..In light of the poor prognosis for PNP deficiency, bone marrow transplantation should be considered for all patients. In the future, improved forms of therapy such as gene therapy may become available...

Research Grants21

  1. THYMIC TRANSPLANTATION IN COMPLETE DIGEORGE SYNDROME
    MARY LOUISE MARKERT; Fiscal Year: 2010
    ....
  2. THYMIC TRANSPLANTATION IN COMPLETE DIGEORGE SYNDROME
    MARY MARKERT; Fiscal Year: 2007
    ..We will also study expression of 4 genes important in thymus organogenesis. These four aims will provide a foundation of understanding of mechanisms involved in T cell development after thymus transplantation. ..
  3. Dynamics of TCR Repertoire Following Thymus Transplant
    MARY MARKERT; Fiscal Year: 2007
    ..These findings will have application to thymus and bone marrow transplantation for immunodeficiency and cancer. ..
  4. Dose Study of thymus Transplantation
    MARY MARKERT; Fiscal Year: 2007
    ..Abstract Not Provided. ..
  5. Phase I Serum-free cultured thymus transplantation in DiGeorge anomaly, IND9836,
    MARY MARKERT; Fiscal Year: 2009
    ..The focus of these experiments is the development of thymopoiesis and normal presentation of promiscuously expressed antigens in the thymus. ..
  6. THYMIC TRANSPLANTATION IN COMPLETE DIGEORGE SYNDROME
    MARY MARKERT; Fiscal Year: 2003
    ..These research studies done in parallel with the clinical trial of thymus and bone marrow transplantation in DiGeorge patients will greatly enhance our understanding of the role of the thymus in T, NK-T and B cell development. ..
  7. Parathyroid and Thymus Transplants in DiGeorge Syndrome
    MARY MARKERT; Fiscal Year: 2005
    ..Indirect allorecognition as a mechanism of graft rejection will be assessed by ELISpot. The third aim will assess safety and tolerability. ..