Research Topics
Species | K G MantonSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiationKenneth G Manton
Center for Demographic Studies Duke University 2117 Campus Drive Durham, NC 27708, USA
Curr Alzheimer Res 1:277-93. 2004..After reviewing human population evidence, we propose a model of neurodegeneration based upon the complexity of CNS functions...- SOD2 polymorphisms: unmasking the effect of polymorphism on splicingJing Shao
Department of Pathology, University of Washington, Seattle, Washington, USA
BMC Med Genet 8:7. 2007..The SOD2 gene encodes an antioxidant enzyme, mitochondrial superoxide dismutase. SOD2 polymorphisms are of interest because of their potential roles in the modulation of free radical-mediated macromolecular damage during aging... - Change in chronic disability from 1982 to 2004/2005 as measured by long-term changes in function and health in the U.S. elderly populationKenneth G Manton
Center for Demographic Studies, Duke University, Durham, NC 27708 0408, USA
Proc Natl Acad Sci U S A 103:18374-9. 2006..Changes in the rate and substance of disability declines seem consistent with the intentions of policy interventions in Medicare and Medicaid... - Fuzzy set analyses of genetic determinants of health and disability statusKenneth G Manton
Center for Demographic Studies, Duke University, 2117 Campus Drive, Durham, NC 27708, USA
Stat Methods Med Res 13:395-408. 2004..A number of interesting relations with APOE polymorphism were found where disability profiles were more predictive than specific diagnoses because they implicitly contained information on chronicity and severity of disease processes... - Forecasting the nursing home populationKenneth G Manton
Center for Demographic Studies, Duke University, Durham, North Carolina 27708-0408, USA
Med Care 41:21-4. 2003 - Demographic analysis and modeling of human populations exposed to ionizing radiationK G Manton
Duke University, Center for Demographic Studies, 2117 Campus Drive, Box 90408, Durham, NC 27708 0408, USA
Front Biosci 9:2144-52. 2004..We believe this will improve the ability of the model to identify health effects and reduce erroneous inferences... - Changes in the prevalence of chronic disability in the United States black and nonblack population above age 65 from 1982 to 1999K G Manton
Center for Demographic Studies, Duke University, Durham, NC 27708, USA
Proc Natl Acad Sci U S A 98:6354-9. 2001..26% per year, from 1989 to 1994 it was 0.38% per year, and from 1994 to 1999 it was 0.56% per year. In addition, disability declined by a greater percentage for blacks than for nonblacks over the 1989 to 1999 period... - Gender differences in the cross-sectional and cohort age dependence of cause-specific mortality: the United States, 1962 to 1995K G Manton
Duke University, Center for Demographic Studies, 2117 Campus Dr, Box 90408, Durham, NC 27708 0408, USA
J Gend Specif Med 3:47-54. 2000..Gender- and age-specific mortality rates were calculated to determine the role of behavioral and biologically based differences in health... - Declining prevalence of dementia in the U.S. elderly populationK C Manton
Duke University Center for Demographic Studies, Durham, NC, USA
Adv Gerontol 16:30-7. 2005..S. elderly population is the decline in vascular and mixed dementias, but not in Alzheimer's disease alone. Improved medical therapies and better education among the old appear to play important roles in this decline... - Dynamic paradigms for human mortality and agingK G Manton
Center for Demographic Studies, Duke University, Durham, North Carolina 27708 0408, USA
J Gerontol A Biol Sci Med Sci 54:B247-54. 1999..This article examines the theoretical basis for such models and the biological rationale of their parametric structure. Several examples are given... - The dynamics of dimensions of age-related disability 1982 to 1994 in the U.S. elderly populationK G Manton
Center for Demographic Studies, Duke University, USA
J Gerontol A Biol Sci Med Sci 53:B59-70. 1998..3%) implying a decline in age-related disability. Disability declines were correlated with reductions in select health conditions (e.g., dementia and circulatory disease) over the study period... - Changes in the age dependence of mortality and disability: cohort and other determinantsK G Manton
Center for Demographic Studies, Duke University, Durham, NC 27708 0088, USA
Demography 34:135-57. 1997..We find large changes in both mortality and disability in those cohorts, providing insights into what changes might have occurred and into what future changes might be expected... - Modeling the effects of biologically incorporated radionuclides and chronic low-dose ionizing radiation exposure on both cancer and chronic non-cancer diseasesK G Manton
Center for Demographic Studies, Duke University, Durham, NC 27708, USA
Radiats Biol Radioecol 46:675-86. 2006..They can combine data from multiple sources and from distinct levels of biological/population organization. The proposed models are intrinsically multivariate and non-linear and capture the dynamic aspects of health change... - Population models for the health effects of ionizing radiationI Akushevich
Center for Demographic Studies, Duke University, Durham, NC 27708, USA
Radiats Biol Radioecol 46:663-74. 2006..We also discuss the ways of how to generalize stochastic process and correlated frailty models for longitudinal and family analyses in radiation epidemiology... - The linkage of health status changes and disabilityK G Manton
Center for Demographic Studies, Duke University, Durham, NC 27706
Compr Gerontol A 1:16-24. 1987..Thus, in order to increase the average number of years that elderly persons can expect to live with less disability, or less severe forms of disability, new prevention strategies and techniques may have to be developed... - Active life expectancy estimates for the U.S. elderly population: a multidimensional continuous-mixture model of functional change applied to completed cohorts, 1982-1996K G Manton
Duke University, Center for Demographic Studies, Durham, NC 27708 0408, USA
Demography 37:253-65. 2000..At ages 65 and 85, comparisons with extant period estimates for 1990 show that our active life expectancy estimates are larger for both males and females than are extant period estimates based on coarse disability states... - Labor force participation and human capital increases in an aging population and implications for U.S. research investmentKenneth G Manton
Arts and Sciences, Duke University, Durham, NC 27708, USA
Proc Natl Acad Sci U S A 104:10802-7. 2007..We examine how disability declines and improved health may increase human capital at later ages and stimulate the growth of gross domestic product and national wealth... - NIH funding trajectories and their correlations with US health dynamics from 1950 to 2004Kenneth G Manton
Arts and Sciences, Duke University, Box 90408, 331 Trent Drive, Durham, NC 27708, USA
Proc Natl Acad Sci U S A 106:10981-6. 2009.... - Cohort changes in active life expectancy in the U.S. elderly population: experience from the 1982-2004 National Long-Term Care SurveyKenneth G Manton
Office of the Dean of Arts and Sciences, Campus Box 90408, Duke University, Trent Drive, Durham, NC 27708, USA
J Gerontol B Psychol Sci Soc Sci 63:S269-81. 2008..To understand declines in chronic disability prevalence in the U.S. elderly population, we examined cohort changes in active life expectancy, a health measure relating population disability and longevity dynamics... - Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sampleAlexander Kulminski
Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Trent Hall, Room 002, Durham, NC 27708, USA
Age Ageing 37:288-93. 2008..early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with disability... - Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older menAlexander M Kulminski
Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Trent Drive, Box 90408, Durham, NC 27708, USA
J Am Geriatr Soc 56:478-83. 2008.... - Medicare cost effects of recent U.S. disability trends in the elderly: future implicationsKenneth G Manton
Box 90408, Duke University, Durham, North Carolina
J Aging Health 19:359-81. 2007..The authors examine how trends in disability prevalence and in inflation-adjusted per capita, per annum Medicare costs, 1982 to 1999 and 1989 to 1999, affected total Medicare costs projected to 2004 and 2009... - Health-based population forecasting: effects of smoking on mortality and fertilityIgor Akushevich
Center for Demographic Studies, Duke University, Durham, NC 27708 0408, USA
Risk Anal 27:467-82. 2007..The generalization of the model to account for multiple risk factors (e.g., the simultaneous effects of alcohol consumption, obesity, and smoking) and effects on medical expenditures are discussed... - Recent declines in chronic disability in the elderly U.S. population: risk factors and future dynamicsKenneth G Manton
Arts and Sciences, Duke University, Durham, NC 27708, USA
Annu Rev Public Health 29:91-113. 2008..Concerns exist about whether disability declines will continue because of recent increases in obesity prevalence... - Endothelial progenitor cell therapy for atherosclerosis: the philosopher's stone for an aging population?Julia Kravchenko
Center for Demographic Studies, Duke University, Durham, NC 27708, USA
Sci Aging Knowledge Environ 2005:pe18. 2005..67 versus 3.37 years; in males, an additional 5.94 versus 2.86 years, respectively)... - Newborn screening for severe combined immunodeficiency (SCID): a reviewHai Huang
Center for Demographic Studies, Duke University 2117 Campus Drive Box 90408 Durham, North Carolina 27708, USA
Front Biosci 10:1024-39. 2005..Screening newborns for SCID would allow early diagnosis and treatment -- as well as genetic counseling for the family... - Genome organization and three kinds of heritable changes: general description and stochastic factors (a review)Michael Golubovsky
Center for Demographic Studies, Duke University, 2117 Campus Drive, Durham, NC 27708, USA
Front Biosci 10:335-44. 2005..Together with epigenetic changes, they implement the operational genomic memory. This review discusses both the role of stochastic factors and the transient features of DNA components... - The immune system in aging: roles of cytokines, T cells and NK cellsHai Huang
Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
Front Biosci 10:192-215. 2005..In this review, age-related changes in inflammatory cytokines, T and NK cells, and the biology of IL-6 and TNF-alpha and their relevance to senescence are considered... - A three-generation approach in biodemography is based on the developmental profiles and the epigenetics of female gametesMichael Golubovsky
Center for Demographic Studies, Duke University, Durham, NC 27708, USA
Front Biosci 10:187-91. 2005..It is also important for evaluating the processes of senescence and the determinants of human disease... - The role of oxidative damage in mitochondria during aging: a reviewHai Huang
Center for Demographic Studies, Duke University, 2117 Campus Drive Box 90408, Durham, NC 27708, USA
Front Biosci 9:1100-17. 2004..While oxidative events in other cell organelles are likely to contribute to the pathobiology of aging, this review highlights alterations in mitochondrial function that, due to accumulated oxidative damage, occur with age... - Long-term economic growth stimulus of human capital preservation in the elderlyKenneth G Manton
Trinity College of Arts and Sciences, Duke University, Durham, NC 27708, USA
Proc Natl Acad Sci U S A 106:21080-5. 2009..Projections done for the time period used by the Congressional Budget Office in budget mark-ups (2010-2020) are presented in the supporting information... - Grade-of-membership sibpair linkage analysis maps IDDM11 to chromosome 14q24.3-q31E H Corder
The Center for Demographic Studies, Duke University, Durham, NC 27701 0408, USA
Ann Hum Genet 65:387-94. 2001..Genetic linkage of IDDM to the region was demonstrated by a 19% increase in the proportion of AA pairs over the haplotype groups: 'No', 42%; 'One', 49%; 'Two', 61%, p = 0.0005, representing a 43% relative increase... - Disability trends in gender and race groups of early retirement ages in the USAKonstantin G Arbeev
Max Planck Institut for Demographic Research, Rostock
Soz Praventivmed 49:142-51. 2004..CONCLUSIONS: Americans aged 65-69 years manifest a significant improvement in health over the 1980s-1990s but the dynamics differs in gender and race groups. Possible reasons for these differences are discussed... - Whether ionizing radiation is a risk factor for schizophrenia spectrum disorders?Konstantin N Loganovsky
Research Center for Radiation Medicine, Academy of Medical Sciences of Ukraine, Ukraine
World J Biol Psychiatry 6:212-30. 2005..Implementation of a study on schizophrenia spectrum disorders in Chernobyl accident victims is of significance for both clinical medicine and neuroscience... - Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR miceVladimir N Anisimov
N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
Exp Gerontol 38:449-61. 2003..For this reason, we conclude that the effect of melatonin as a geroprotector is dose-dependent... - The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic miceVladimir N Anisimov
Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
Int J Cancer 103:300-5. 2003..Adverse effect of melatonin on the life span in our study may be unique to the transgenic model used and may not be relevant to the suppressive effect of melatonin in delay of mammary cancer... - Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA miceVladimir N Anisimov
Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
Int J Cancer 111:475-9. 2004..The data demonstrate, for the first time, that exposure to constant illumination was followed by increases in the incidence of spontaneous lung carcinoma, leukemias and hepatocarcinoma in female CBA mice...