Paolo Mannelli

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: A very low dose naltrexone and buprenorphine open label trial
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States Electronic address
    Drug Alcohol Depend 138:83-8. 2014
  2. pmc The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Am J Drug Alcohol Abuse 38:200-5. 2012
  3. pmc Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Curr Drug Abuse Rev 5:52-63. 2012
  4. ncbi request reprint Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    J Clin Psychopharmacol 27:468-74. 2007
  5. ncbi request reprint Long-acting injectable naltrexone for the treatment of alcohol dependence
    Paolo Mannelli
    Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, NC 27705, USA
    Expert Rev Neurother 7:1265-77. 2007
  6. pmc Early outcomes following low dose naltrexone enhancement of opioid detoxification
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    Am J Addict 18:109-16. 2009
  7. pmc Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Addict Biol 14:204-13. 2009
  8. pmc Opioid use affects antioxidant activity and purine metabolism: preliminary results
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
    Hum Psychopharmacol 24:666-75. 2009
  9. ncbi request reprint Medical comorbidity and alcohol dependence
    Paolo Mannelli
    Duke University Medical Center, Durham, NC 27705, USA
    Curr Psychiatry Rep 9:217-24. 2007
  10. pmc Problem drinking and low-dose naltrexone-assisted opioid detoxification
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, North Carolina 27705, USA
    J Stud Alcohol Drugs 72:507-13. 2011

Research Grants

Detail Information

Publications52

  1. pmc Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: A very low dose naltrexone and buprenorphine open label trial
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States Electronic address
    Drug Alcohol Depend 138:83-8. 2014
    ..Here we present findings from an open label study that tested whether the transition from opioid addiction to XR-NTX can be safely and effectively performed in an outpatient setting using very low dose naltrexone and buprenorphine...
  2. pmc The combination very low-dose naltrexone-clonidine in the management of opioid withdrawal
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Am J Drug Alcohol Abuse 38:200-5. 2012
    ..Very low-dose naltrexone (VLNTX) has been shown to attenuate withdrawal intensity and noradrenaline release following opioid agonist taper, suggesting a combination with clonidine may result in improved safety and efficacy...
  3. pmc Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectives
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    Curr Drug Abuse Rev 5:52-63. 2012
    ..Future studies should also test new pharmacological mechanisms to help reduce physical dependence, and identify individualized approaches, including the use of pharmacogenetics and long-acting opioid agonist and antagonist formulations...
  4. ncbi request reprint Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependence
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
    J Clin Psychopharmacol 27:468-74. 2007
    ..The present study evaluated whether the augmentation with low-dose NTX during the post-detoxification treatment of opioid dependence would improve outcomes...
  5. ncbi request reprint Long-acting injectable naltrexone for the treatment of alcohol dependence
    Paolo Mannelli
    Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, NC 27705, USA
    Expert Rev Neurother 7:1265-77. 2007
    ..The clinical availability of extended-release naltrexone has the potential to enhance treatment outcomes for alcohol and other drug dependence disorders...
  6. pmc Early outcomes following low dose naltrexone enhancement of opioid detoxification
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
    Am J Addict 18:109-16. 2009
    ..Further studies are needed to test the utility of this approach in easing the transition from detoxification to various follow-up treatment modalities designed to address opioid dependence...
  7. pmc Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trial
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Addict Biol 14:204-13. 2009
    ..Further studies should explore the use of VLNTX, combined with full and partial opioid agonist medications, in detoxification and long-term treatment of opioid dependence...
  8. pmc Opioid use affects antioxidant activity and purine metabolism: preliminary results
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
    Hum Psychopharmacol 24:666-75. 2009
    ..Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant compounds and purine metabolism. We examined perturbations of neurotransmitter-related pathways in opioid dependence (OD)...
  9. ncbi request reprint Medical comorbidity and alcohol dependence
    Paolo Mannelli
    Duke University Medical Center, Durham, NC 27705, USA
    Curr Psychiatry Rep 9:217-24. 2007
    ....
  10. pmc Problem drinking and low-dose naltrexone-assisted opioid detoxification
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, North Carolina 27705, USA
    J Stud Alcohol Drugs 72:507-13. 2011
    ..In a secondary analysis of these data, we sought to determine whether problem drinking affects detoxification outcomes and whether symptoms are influenced by VLNTX use...
  11. ncbi request reprint Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Psychiatry Res 144:99-108. 2006
    ....
  12. ncbi request reprint Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, United States
    J Psychiatr Res 42:1213-9. 2008
    ..However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans...
  13. doi request reprint History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    World J Biol Psychiatry 10:435-41. 2009
    ....
  14. doi request reprint Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trial
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
    Clin Neuropharmacol 32:85-8. 2009
    ..Adequately powered controlled trials are needed to fully evaluate the efficacy of OROS MPH in this area...
  15. doi request reprint A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndrome
    Prakash S Masand
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 1001 Winstead Dr, Suite 200, Cary, NC 27513, USA
    Psychosomatics 50:78-86. 2009
    ..Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that causes significant impairment in quality of life and accounts for $8 billion per year to the healthcare system and loss of productivity in the workplace...
  16. doi request reprint Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 206:479-89. 2009
    ..Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets...
  17. doi request reprint History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgia
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27704, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:996-1002. 2009
    ..We investigated whether a history of depressive and/or anxiety disorders was associated with response to paroxetine controlled release (CR) in the treatment of fibromyalgia...
  18. ncbi request reprint Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Hum Psychopharmacol 21:367-75. 2006
    ..Serotonergic (5-HT) mechanisms appear to mediate central effects of cocaine. Therefore 5-HT disturbances could be associated with drug severity...
  19. pmc Comorbid substance use disorders with other Axis I and II mental disorders among treatment-seeking Asian Americans, Native Hawaiians/Pacific Islanders, and mixed-race people
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC, USA Electronic address
    J Psychiatr Res 47:1940-8. 2013
    ..In-depth research is needed to elucidate intraracial and interracial differences in treatment needs...
  20. ncbi request reprint A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    J Clin Psychopharmacol 26:653-6. 2006
    ..Combination of methylphenidate with antidepressants was well tolerated. Adequately powered, randomized, controlled trials are necessary to fully evaluate the efficacy of extended-release methylphenidate in TRD...
  21. pmc Prescription pain reliever abuse and dependence among adolescents: a nationally representative study
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC 27710, USA
    J Am Acad Child Adolesc Psychiatry 47:1020-9. 2008
    ....
  22. pmc Alcohol and drug use disorders among adults in emergency department settings in the United States
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Ann Emerg Med 60:172-80.e5. 2012
    ..We examine past-year substance use and substance use disorders (alcohol, 9 drug classes) among adult ED users. Prevalences of substance use and substance use disorders among ED nonusers are calculated for reference purposes...
  23. pmc Smoking and opioid detoxification: behavioral changes and response to treatment
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC
    Nicotine Tob Res 15:1705-13. 2013
    ..The relevance of tobacco use in opioid addiction (OA) has generated a demand for available and more effective interventions. Thus, further analysis of less explored nicotine-opioid clinical interactions is warranted...
  24. pmc Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adults
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Gen Hosp Psychiatry 35:74-82. 2013
    ..The objective was to identify a potential core set of brief screeners for the detection of individuals with a substance use disorder (SUD) in medical settings...
  25. ncbi request reprint Antagonist treatment of opioid withdrawal translational low dose approach
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    J Addict Dis 25:1-8. 2006
    ....
  26. pmc An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical features
    Chi Un Pae
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N C, and the Department of Psychiatry, College of Medicine, The Catholic University of Korea and Department of Psychiatry, Korea University, Seoul, South Korea
    Prim Care Companion J Clin Psychiatry 10:205-10. 2008
    ..Adequately powered, randomized, double-blind, placebo-controlled trials are necessary to determine the efficacy of escitalopram in this disorder.Trial Registration: clinicaltrials.gov Identifier: NCT00610506...
  27. ncbi request reprint A randomized, controlled, trial of controlled release paroxetine in fibromyalgia
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
    Am J Med 120:448-54. 2007
    ..We investigated the efficacy and tolerability of paroxetine controlled release, a selective serotonin reuptake inhibitor in fibromyalgia...
  28. pmc The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for intervention
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
    Addict Behav 34:654-61. 2009
    ....
  29. pmc Hallucinogen use disorders among adult users of MDMA and other hallucinogens
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, North Carolina 27710, USA
    Am J Addict 17:354-63. 2008
    ..Subthreshold hallucinogen dependence is relatively prevalent and represents a clinically important subgroup that warrants future research and consideration in a major diagnostic classification system...
  30. ncbi request reprint Trends in nonheroin opioid abuse admissions: 1992-2004
    Kathleen S Peindl
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA
    J Opioid Manag 3:215-23. 2007
    ..This study examines trends for treatment admissions for nonheroin opioid abuse from 1992 to 2004...
  31. ncbi request reprint Changes in tobacco smoking following treatment for cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry Behavioral Sciences, Duke University, Durham, North Carolina 27704, USA
    Am J Drug Alcohol Abuse 32:135-48. 2006
    ..There is no evidence that reduction in crack cocaine smoking following treatment is accompanied by an increase in tobacco smoking. It appears that concerns over tobacco being substituted for cocaine may be unfounded in this population...
  32. ncbi request reprint Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patients
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27704, USA
    Psychopharmacology (Berl) 185:123-32. 2006
    ..Considerable evidence indicates that serotonergic (5-HT) mechanisms may mediate central effects of cocaine, and disinhibition and aggression...
  33. ncbi request reprint Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individuals
    Paolo Mannelli
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27704, USA
    Addict Biol 10:261-8. 2005
    ..Further investigations are required to determine the role of the 5-HTTLPR polymorphism in influencing treatment - outcome among substance abusers...
  34. ncbi request reprint Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patients
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Am J Addict 14:43-53. 2005
    ..Tobacco smoking was not related to changes in cocaine use. Also, marijuana smoking does not appear to be associated with a reduction in tobacco or cocaine use...
  35. ncbi request reprint Recent advances in poststroke depression
    Haresh M Tharwani
    Duke Psychiatry Specialty Clinic, Cary, NC 27518, USA
    Curr Psychiatry Rep 9:225-31. 2007
    ..More research is needed to understand the pathophysiology of depression after stroke. There also is a need for more randomized clinical trials to better treat patients with this condition...
  36. ncbi request reprint Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawal
    Colin Davidson
    Psychiatry, Box 3870, Duke University Medical Center, NC 27710, United States
    Eur J Pharmacol 565:113-8. 2007
    ..These data suggest that pergolide plus ondansetron treatment may be useful as a therapy to reduce relapse in methamphetamine abusers...
  37. pmc Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategy
    Tong H Lee
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, United States
    Drug Alcohol Depend 124:11-8. 2012
    ....
  38. pmc An integrated alcohol abuse and medical treatment model for patients with hepatitis C
    Rae Jean Proeschold-Bell
    Duke Global Health Institute, Center for Health Policy and Inequalities Research, Duke University, 2812 Erwin Rd, 403, Durham, NC 27705, USA
    Dig Dis Sci 57:1083-91. 2012
    ..Patients with chronic hepatitis C virus (HCV) infection have high rates of alcohol consumption, which is associated with progression of fibrosis and lower response rates to HCV treatment...
  39. ncbi request reprint Polypharmacy in pregnant women with major psychiatric illness: a pilot study
    Kathleen S Peindl
    Department of Psychiatry, Duke University, Durham, NC 27705, USA
    J Psychiatr Pract 13:385-92. 2007
    ..6 medications per woman. The present descriptive study examined patterns of medication use across pregnancy in a low socioeconomic status population of women who had a psychiatric illness as a primary diagnosis...
  40. pmc Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study
    Li Tzy Wu
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC, USA Electronic address
    J Psychiatr Res 50:26-35. 2014
    ..Behavioral health indicators (major depressive episode, arrest history, nicotine dependence, alcohol disorder) were associated with CU and CUD. In conclusion, CUD disproportionally affects nonwhite groups and youth. ..
  41. ncbi request reprint Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patients
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Addict Dis 23:93-109. 2004
    ..Clinicians should be cautious about forecasting treatment-outcomes for addicted patients based on their primary substances of abuse...
  42. ncbi request reprint Use of very low-dose naltrexone during opiate detoxification
    Paolo Mannelli
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Addict Dis 22:63-70. 2003
    ....
  43. ncbi request reprint The distribution of cocaine in mice differs by age and strain
    Lois E McCarthy
    Farber Institute for Neurosciences, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Neurotoxicol Teratol 26:839-48. 2004
    ..Furthermore, potentially important strain differences between CD-1 and C57BL/6 mice were noted in cocaine levels following acute and chronic cocaine administration, and in locomotor activity following acute cocaine administration...
  44. ncbi request reprint Chronic very low dose naltrexone administration attenuates opioid withdrawal expression
    Paolo Mannelli
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biol Psychiatry 56:261-8. 2004
    ..We examined whether administering extremely small quantities of opiate antagonists in the presence of opiate agonist drugs reduces withdrawal expression...
  45. ncbi request reprint Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patients
    Ashwin A Patkar
    Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107, USA
    J Addict Dis 23:109-22. 2004
    ..Combining these behavioral measures with other clinical predictors may help in early identification of 'poor responders' who may benefit from additional or alternative treatment approaches...
  46. ncbi request reprint High- and low-structure treatments for substance dependence: role of learned helplessness
    Charles C Thornton
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvannia 19107, USA
    Am J Drug Alcohol Abuse 29:567-84. 2003
    ..A matching approach that assigns patients to high- and low-structure treatments based on pretreatment levels of LH might improve treatment outcomes for substance-dependent patients...
  47. ncbi request reprint Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependence
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
    Psychopharmacology (Berl) 176:74-81. 2004
    ..Therefore, serum PRL may have a potential role as a biological marker of drug severity and treatment outcome in cocaine dependence...
  48. ncbi request reprint A functional prodynorphin promoter polymorphism and opioid dependence
    Riju Ray
    Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
    Psychiatr Genet 15:295-8. 2005
    ..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls...
  49. ncbi request reprint Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence
    Rachel J Smith
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005
    ..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
  50. ncbi request reprint Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteers
    Ashwin A Patkar
    Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Psychiatr Genet 14:25-32. 2004
    ....

Research Grants1

  1. Place of low-dose naltrexone in opiate detoxification
    Paolo Mannelli; Fiscal Year: 2004
    ..abstract_text> ..