Research Topics
Genomes and GenesSpecies | Paolo MannelliSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
The combination very low-dose naltrexone-clonidine in the management of opioid withdrawalPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Am J Drug Alcohol Abuse 38:200-5. 2012..Very low-dose naltrexone (VLNTX) has been shown to attenuate withdrawal intensity and noradrenaline release following opioid agonist taper, suggesting a combination with clonidine may result in improved safety and efficacy...- Buprenorphine-mediated transition from opioid agonist to antagonist treatment: state of the art and new perspectivesPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
Curr Drug Abuse Rev 5:52-63. 2012..Future studies should also test new pharmacological mechanisms to help reduce physical dependence, and identify individualized approaches, including the use of pharmacogenetics and long-acting opioid agonist and antagonist formulations... 
Long-acting injectable naltrexone for the treatment of alcohol dependencePaolo Mannelli
Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, NC 27705, USA
Expert Rev Neurother 7:1265-77. 2007..The clinical availability of extended-release naltrexone has the potential to enhance treatment outcomes for alcohol and other drug dependence disorders...- Early outcomes following low dose naltrexone enhancement of opioid detoxificationPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27705, USA
Am J Addict 18:109-16. 2009..Further studies are needed to test the utility of this approach in easing the transition from detoxification to various follow-up treatment modalities designed to address opioid dependence... - Very low dose naltrexone addition in opioid detoxification: a randomized, controlled trialPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
Addict Biol 14:204-13. 2009..Further studies should explore the use of VLNTX, combined with full and partial opioid agonist medications, in detoxification and long-term treatment of opioid dependence... - Medical comorbidity and alcohol dependencePaolo Mannelli
Duke University Medical Center, Durham, NC 27705, USA
Curr Psychiatry Rep 9:217-24. 2007.... - Effectiveness of low-dose naltrexone in the post-detoxification treatment of opioid dependencePaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27705, USA
J Clin Psychopharmacol 27:468-74. 2007..The present study evaluated whether the augmentation with low-dose NTX during the post-detoxification treatment of opioid dependence would improve outcomes... - Opioid use affects antioxidant activity and purine metabolism: preliminary resultsPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
Hum Psychopharmacol 24:666-75. 2009..Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant compounds and purine metabolism. We examined perturbations of neurotransmitter-related pathways in opioid dependence (OD)... - Problem drinking and low-dose naltrexone-assisted opioid detoxificationPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Suite 123, Durham, North Carolina 27705, USA
J Stud Alcohol Drugs 72:507-13. 2011..In a secondary analysis of these data, we sought to determine whether problem drinking affects detoxification outcomes and whether symptoms are influenced by VLNTX use... - Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controlsPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
Psychiatry Res 144:99-108. 2006.... 
Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependenceAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, United States
J Psychiatr Res 42:1213-9. 2008..However, little is known about the relationship between the 5-HTT and 5-HT receptors following cocaine exposure in humans...- Methylphenidate extended release (OROS MPH) for the treatment of antidepressant-related sexual dysfunction in patients with treatment-resistant depression: results from a 4-week, double-blind, placebo-controlled trialChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27705, USA
Clin Neuropharmacol 32:85-8. 2009..Adequately powered controlled trials are needed to fully evaluate the efficacy of OROS MPH in this area... - History of early abuse as a predictor of treatment response in patients with fibromyalgia: a post-hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled releaseChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
World J Biol Psychiatry 10:435-41. 2009.... - History of depressive and/or anxiety disorders as a predictor of treatment response: a post hoc analysis of a 12-week, randomized, double-blind, placebo-controlled trial of paroxetine controlled release in patients with fibromyalgiaChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27704, USA
Prog Neuropsychopharmacol Biol Psychiatry 33:996-1002. 2009..We investigated whether a history of depressive and/or anxiety disorders was associated with response to paroxetine controlled release (CR) in the treatment of fibromyalgia... - A double-blind, randomized, placebo-controlled trial of paroxetine controlled-release in irritable bowel syndromePrakash S Masand
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 1001 Winstead Dr, Suite 200, Cary, NC 27513, USA
Psychosomatics 50:78-86. 2009..Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that causes significant impairment in quality of life and accounts for $8 billion per year to the healthcare system and loss of productivity in the workplace... - Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic studyAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Psychopharmacology (Berl) 206:479-89. 2009..Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets... - Relationship of prolactin response to meta-chlorophenylpiperazine with severity of drug use in cocaine dependenceAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
Hum Psychopharmacol 21:367-75. 2006..Serotonergic (5-HT) mechanisms appear to mediate central effects of cocaine. Therefore 5-HT disturbances could be associated with drug severity... - A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depressionAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
J Clin Psychopharmacol 26:653-6. 2006..Combination of methylphenidate with antidepressants was well tolerated. Adequately powered, randomized, controlled trials are necessary to fully evaluate the efficacy of extended-release methylphenidate in TRD... - Prescription pain reliever abuse and dependence among adolescents: a nationally representative studyLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, NC 27710, USA
J Am Acad Child Adolesc Psychiatry 47:1020-9. 2008.... - Alcohol and drug use disorders among adults in emergency department settings in the United StatesLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
Ann Emerg Med 60:172-80.e5. 2012..We examine past-year substance use and substance use disorders (alcohol, 9 drug classes) among adult ED users. Prevalences of substance use and substance use disorders among ED nonusers are calculated for reference purposes... - Antagonist treatment of opioid withdrawal translational low dose approachPaolo Mannelli
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
J Addict Dis 25:1-8. 2006.... - An open-label, rater-blinded, flexible-dose, 8-week trial of escitalopram in patients with major depressive disorder with atypical featuresChi Un Pae
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, N C, and the Department of Psychiatry, College of Medicine, The Catholic University of Korea and Department of Psychiatry, Korea University, Seoul, South Korea
Prim Care Companion J Clin Psychiatry 10:205-10. 2008..Adequately powered, randomized, double-blind, placebo-controlled trials are necessary to determine the efficacy of escitalopram in this disorder.Trial Registration: clinicaltrials.gov Identifier: NCT00610506... - Trends in nonheroin opioid abuse admissions: 1992-2004Kathleen S Peindl
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA
J Opioid Manag 3:215-23. 2007..This study examines trends for treatment admissions for nonheroin opioid abuse from 1992 to 2004... - A randomized, controlled, trial of controlled release paroxetine in fibromyalgiaAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27704, USA
Am J Med 120:448-54. 2007..We investigated the efficacy and tolerability of paroxetine controlled release, a selective serotonin reuptake inhibitor in fibromyalgia... - The high prevalence of substance use disorders among recent MDMA users compared with other drug users: Implications for interventionLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Box 3419, Durham, NC 27710, USA
Addict Behav 34:654-61. 2009.... - Hallucinogen use disorders among adult users of MDMA and other hallucinogensLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University, Durham, North Carolina 27710, USA
Am J Addict 17:354-63. 2008..Subthreshold hallucinogen dependence is relatively prevalent and represents a clinically important subgroup that warrants future research and consideration in a major diagnostic classification system... - Evaluating brief screeners to discriminate between drug use disorders in a sample of treatment-seeking adultsLi Tzy Wu
Department of Psychiatry and Behavioral Sciences, School of Medicine, Duke University Medical Center, Durham, NC 27710, USA Electronic address
Gen Hosp Psychiatry 35:74-82. 2013..The objective was to identify a potential core set of brief screeners for the detection of individuals with a substance use disorder (SUD) in medical settings... - Relationship of disinhibition and aggression to blunted prolactin response to meta-chlorophenylpiperazine in cocaine-dependent patientsAshwin A Patkar
Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27704, USA
Psychopharmacology (Berl) 185:123-32. 2006..Considerable evidence indicates that serotonergic (5-HT) mechanisms may mediate central effects of cocaine, and disinhibition and aggression... - Changes in tobacco smoking following treatment for cocaine dependenceAshwin A Patkar
Department of Psychiatry Behavioral Sciences, Duke University, Durham, North Carolina 27704, USA
Am J Drug Alcohol Abuse 32:135-48. 2006..There is no evidence that reduction in crack cocaine smoking following treatment is accompanied by an increase in tobacco smoking. It appears that concerns over tobacco being substituted for cocaine may be unfounded in this population... - Polymorphism in the serotonin transporter gene and response to treatment in African American cocaine and alcohol-abusing individualsPaolo Mannelli
Department of Psychiatry, Duke University Medical Center, Durham, NC 27704, USA
Addict Biol 10:261-8. 2005..Further investigations are required to determine the role of the 5-HTTLPR polymorphism in influencing treatment - outcome among substance abusers... - Reduction in methamphetamine induced sensitization and reinstatement after combined pergolide plus ondansetron treatment during withdrawalColin Davidson
Psychiatry, Box 3870, Duke University Medical Center, NC 27710, United States
Eur J Pharmacol 565:113-8. 2007..These data suggest that pergolide plus ondansetron treatment may be useful as a therapy to reduce relapse in methamphetamine abusers... - Recent advances in poststroke depressionHaresh M Tharwani
Duke Psychiatry Specialty Clinic, Cary, NC 27518, USA
Curr Psychiatry Rep 9:225-31. 2007..More research is needed to understand the pathophysiology of depression after stroke. There also is a need for more randomized clinical trials to better treat patients with this condition... - Medical symptoms associated with tobacco smoking with and without marijuana abuse among crack cocaine-dependent patientsAshwin A Patkar
Department of Psychiatry and Human Behavior, Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Am J Addict 14:43-53. 2005..Tobacco smoking was not related to changes in cocaine use. Also, marijuana smoking does not appear to be associated with a reduction in tobacco or cocaine use... - Pharmacologically-mediated reactivation and reconsolidation blockade of the psychostimulant-abuse circuit: a novel treatment strategyTong H Lee
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, United States
Drug Alcohol Depend 124:11-8. 2012.... - An integrated alcohol abuse and medical treatment model for patients with hepatitis CRae Jean Proeschold-Bell
Duke Global Health Institute, Center for Health Policy and Inequalities Research, Duke University, 2812 Erwin Rd, 403, Durham, NC 27705, USA
Dig Dis Sci 57:1083-91. 2012..Patients with chronic hepatitis C virus (HCV) infection have high rates of alcohol consumption, which is associated with progression of fibrosis and lower response rates to HCV treatment... - Polypharmacy in pregnant women with major psychiatric illness: a pilot studyKathleen S Peindl
Department of Psychiatry, Duke University, Durham, NC 27705, USA
J Psychiatr Pract 13:385-92. 2007..6 medications per woman. The present descriptive study examined patterns of medication use across pregnancy in a low socioeconomic status population of women who had a psychiatric illness as a primary diagnosis... - The distribution of cocaine in mice differs by age and strainLois E McCarthy
Farber Institute for Neurosciences, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
Neurotoxicol Teratol 26:839-48. 2004..Furthermore, potentially important strain differences between CD-1 and C57BL/6 mice were noted in cocaine levels following acute and chronic cocaine administration, and in locomotor activity following acute cocaine administration... - Use of very low-dose naltrexone during opiate detoxificationPaolo Mannelli
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Addict Dis 22:63-70. 2003.... - High- and low-structure treatments for substance dependence: role of learned helplessnessCharles C Thornton
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvannia 19107, USA
Am J Drug Alcohol Abuse 29:567-84. 2003..A matching approach that assigns patients to high- and low-structure treatments based on pretreatment levels of LH might improve treatment outcomes for substance-dependent patients... - Relationship of serum prolactin with severity of drug use and treatment outcome in cocaine dependenceAshwin A Patkar
Department of Psychiatry and Human Behavior, Jefferson Medical College and Thomas Jefferson University Hospital, 33 South 9th Street, Suite 210E, Philadelphia, PA 19107, USA
Psychopharmacology (Berl) 176:74-81. 2004..Therefore, serum PRL may have a potential role as a biological marker of drug severity and treatment outcome in cocaine dependence... - Pre-treatment measures of impulsivity, aggression and sensation seeking are associated with treatment outcome for African-American cocaine-dependent patientsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, 833 Chestnut Street East, Suite 210E, Philadelphia, PA 19107, USA
J Addict Dis 23:109-22. 2004..Combining these behavioral measures with other clinical predictors may help in early identification of 'poor responders' who may benefit from additional or alternative treatment approaches... - Comparison of pretreatment characteristics and treatment outcomes for alcohol-, cocaine-, and multisubstance-dependent patientsAshwin A Patkar
Division of Substance Abuse Programs, Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, PA 19107, USA
J Addict Dis 23:93-109. 2004..Clinicians should be cautious about forecasting treatment-outcomes for addicted patients based on their primary substances of abuse... - Chronic very low dose naltrexone administration attenuates opioid withdrawal expressionPaolo Mannelli
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Biol Psychiatry 56:261-8. 2004..CONCLUSIONS: Reduction of withdrawal upon chronic very low naltrexone administration may be due in part to decreased activation of brainstem noradrenergic neurons in morphine dependent rats... - Relationship between serotonin transporter gene polymorphisms and platelet serotonin transporter sites among African-American cocaine-dependent individuals and healthy volunteersAshwin A Patkar
Department of Psychiatry and Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Psychiatr Genet 14:25-32. 2004.... - A functional prodynorphin promoter polymorphism and opioid dependenceRiju Ray
Department of Pharmacology, University of Pennsylvania, Philadelphia, 19104, USA
Psychiatr Genet 15:295-8. 2005..We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls... - Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependenceRachel J Smith
Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Med Genet B Neuropsychiatr Genet 133:105-9. 2005..The results indicate that polymorphisms in the novel splice variant are not associated with opioid dependence, but are in LD with other polymorphisms in OPRM1...
Research Grants
- Place of low-dose naltrexone in opiate detoxificationPaolo Mannelli; Fiscal Year: 2004..abstract_text> ..