D J Madden

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Adult age differences in visual word identification: functional neuroanatomy by positron emission tomography
    David J Madden
    Duke University Medical Center, Durham, NC 27710, USA
    Brain Cogn 49:297-321. 2002
  2. pmc Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychol Rev 19:415-35. 2009
  3. pmc Age-related changes in selective attention and perceptual load during visual search
    David J Madden
    Center for the Study of Aging and Human Development and Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 18:54-67. 2003
  4. ncbi request reprint Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time
    David J Madden
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 21:1174-81. 2004
  5. pmc Age-related preservation of top-down attentional guidance during visual search
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA
    Psychol Aging 19:304-9. 2004
  6. pmc Aging and attentional guidance during visual search: functional neuroanatomy by positron emission tomography
    David J Madden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 17:24-43. 2002
  7. pmc Adult age differences in functional connectivity during executive control
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 52:643-57. 2010
  8. ncbi request reprint Adult age differences in visual search accuracy: attentional guidance and target detectability
    D J Madden
    Center for the Study of Aging and Human Development and Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 14:683-94. 1999
  9. ncbi request reprint Aging and recognition memory: changes in regional cerebral blood flow associated with components of reaction time distributions
    D J Madden
    Box 2980, Duke University Medical Center, Durham, NC 27710 USA
    J Cogn Neurosci 11:511-20. 1999
  10. pmc Age-related increase in top-down activation of visual features
    David J Madden
    Duke University Medical Center, Durham, NC 27710, USA
    Q J Exp Psychol (Hove) 60:644-51. 2007

Research Grants

  1. NEUROIMAGING OF AGE-RELATED COGNITIVE CHANGES
    David Madden; Fiscal Year: 2005
  2. NEUROIMAGING OF AGE RELATED COGNITIVE CHANGES
    David Madden; Fiscal Year: 2000
  3. NEUROIMAGING OF AGE-RELATED COGNITIVE CHANGES
    David Madden; Fiscal Year: 1993

Detail Information

Publications40

  1. pmc Adult age differences in visual word identification: functional neuroanatomy by positron emission tomography
    David J Madden
    Duke University Medical Center, Durham, NC 27710, USA
    Brain Cogn 49:297-321. 2002
    ....
  2. pmc Cerebral white matter integrity and cognitive aging: contributions from diffusion tensor imaging
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychol Rev 19:415-35. 2009
    ..With continued improvements in spatial resolution and integration with functional brain imaging, DTI holds considerable promise, both for theories of cognitive aging and for translational application...
  3. pmc Age-related changes in selective attention and perceptual load during visual search
    David J Madden
    Center for the Study of Aging and Human Development and Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 18:54-67. 2003
    ..Under more data-limited conditions (Experiment 3), an age-related decline in selective attention was evident, but the age difference was not attributable to capacity limitations as predicted by the perceptual load theory...
  4. ncbi request reprint Diffusion tensor imaging of adult age differences in cerebral white matter: relation to response time
    David J Madden
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 21:1174-81. 2004
    ....
  5. pmc Age-related preservation of top-down attentional guidance during visual search
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA
    Psychol Aging 19:304-9. 2004
    ..The authors conclude that under conditions that equate the physical structure of individual displays, top-down attentional guidance can be at least as effective for older adults as for younger adults...
  6. pmc Aging and attentional guidance during visual search: functional neuroanatomy by positron emission tomography
    David J Madden
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 17:24-43. 2002
    ....
  7. pmc Adult age differences in functional connectivity during executive control
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Neuroimage 52:643-57. 2010
    ..These findings highlight the functional connectivity of frontoparietal activation as a potential source of age-related decline in executive control...
  8. ncbi request reprint Adult age differences in visual search accuracy: attentional guidance and target detectability
    D J Madden
    Center for the Study of Aging and Human Development and Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 14:683-94. 1999
    ..A signal-detection model of the conjunction search data demonstrated that the age difference represented an age-related decline in target detectability...
  9. ncbi request reprint Aging and recognition memory: changes in regional cerebral blood flow associated with components of reaction time distributions
    D J Madden
    Box 2980, Duke University Medical Center, Durham, NC 27710 USA
    J Cogn Neurosci 11:511-20. 1999
    ..The data suggest that the attentional demands of this task are relatively greater for older adults and consequently lead to the recruitment of additional neural systems during task performance...
  10. pmc Age-related increase in top-down activation of visual features
    David J Madden
    Duke University Medical Center, Durham, NC 27710, USA
    Q J Exp Psychol (Hove) 60:644-51. 2007
    ..The age-related slowing was more pronounced in response to target colour variation, suggesting that older adults place relatively greater emphasis on the top-down activation of target features...
  11. pmc Adult age differences in the implicit and explicit components of top-down attentional guidance during visual search
    David J Madden
    Center for the Study of Aging and Human Development, Box 2980, Duke University Medical Center, Durham, NC 27710, USA
    Psychol Aging 20:317-29. 2005
    ..The results suggest that some forms of top-down attentional control are preserved as a function of adult age and may operate in a compensatory manner...
  12. ncbi request reprint Adult age differences in the functional neuroanatomy of verbal recognition memory
    D J Madden
    Center for the Study of Aging and Human Development, and Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Hum Brain Mapp 7:115-35. 1999
    ....
  13. pmc Adult age differences in the functional neuroanatomy of visual attention: a combined fMRI and DTI study
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Box 2980, Durham, NC 27710, USA
    Neurobiol Aging 28:459-76. 2007
    ....
  14. ncbi request reprint Interaction of hypertension and age in visual selective attention performance
    D J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    Health Psychol 17:76-83. 1998
    ....
  15. ncbi request reprint Adult age differences in the use of distractor homogeneity during visual search
    D J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 11:454-74. 1996
    ..The concept of a generalized, age-related slowing was able to account for many aspects of the data, although the degree of relative improvement associated with distractor homogeneity was greater for young adults than for older adults...
  16. ncbi request reprint Age-related changes in neural activity during visual target detection measured by fMRI
    David J Madden
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Cereb Cortex 14:143-55. 2004
    ..Older adults may place relatively greater emphasis on the attentional control of response regulation, in compensation for the age-related decline in visual processing efficiency...
  17. pmc A diffusion model analysis of adult age differences in episodic and semantic long-term memory retrieval
    Julia Spaniol
    Duke University Medical Center, Center for the Study of Aging and Human Development, Durham, NC, USA
    J Exp Psychol Learn Mem Cogn 32:101-17. 2006
    ..As predicted by the context-memory deficit hypothesis, there was no corresponding age-related decline in semantic drift rate...
  18. ncbi request reprint Age similarities in the inertial properties of attention
    L R Gottlob
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Percept Psychophys 61:740-55. 1999
    ..There were no age-related decrements in the allocation of visual attention...
  19. ncbi request reprint Time course of allocation of visual attention after equating for sensory differences: an age-related perspective
    L R Gottlob
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychol Aging 13:138-49. 1998
    ..The authors conclude that, in this spatial-cuing paradigm, an age-related change is evident in sensory processing but not in attentional allocation...
  20. pmc Effects of adult age and blood pressure on executive function and speed of processing
    Barbara Bucur
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA
    Exp Aging Res 36:153-68. 2010
    ..This result held even when the executive function scores were covaried for speed, demonstrating an independent, age-related effect of higher BP on executive function...
  21. ncbi request reprint Effects of exercise training on cardiorespiratory function in men and women older than 60 years of age
    J A Blumenthal
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710
    Am J Cardiol 67:633-9. 1991
    ..Maintenance of regular aerobic exercise for an extended time interval is associated with greater cardiovascular benefits among older adults than has been reported previously...
  22. pmc Age-related preservation of top-down control over distraction in visual search
    Matthew C Costello
    Duke University Medical Center, Durham, North Carolina, USA
    Exp Aging Res 36:249-72. 2010
    ..Furthermore, for both age groups, the distraction effect was manifested in a sustained manner across the reaction time distribution...
  23. pmc Age-related decline of visual processing components in change detection
    Matthew C Costello
    Center for the Study of Aging and Human Development and Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Psychol Aging 25:356-68. 2010
    ..PsycINFO Database Record (c) 2010 APA, all rights reserved)...
  24. pmc Determination of multiple sclerosis plaque size with diffusion-tensor MR Imaging: comparison study with healthy volunteers
    Susan M Kealey
    Departments of Radiology and Psychiatry and Behavioral Science, Duke University Medical Center, Erwin Rd, Box 3808, Durham, NC 27710, USA
    Radiology 236:615-20. 2005
    ....
  25. pmc Toward discovery science of human brain function
    Bharat B Biswal
    Department of Radiology, New Jersey Medical School, Newark, NJ 07103, USA
    Proc Natl Acad Sci U S A 107:4734-9. 2010
    ..To initiate discovery science of brain function, the 1000 Functional Connectomes Project dataset is freely accessible at www.nitrc.org/projects/fcon_1000/...
  26. ncbi request reprint Lexical and sublexical components of age-related changes in neural activation during visual word identification
    Wythe L Whiting
    Duke University Medical Center, Durham, NC 27710, USA
    J Cogn Neurosci 15:475-87. 2003
    ..We conclude that aging affects the neural mechanisms supporting word identification performance although behavioral measures of this ability are generally constant as a function of age...
  27. pmc Assessing the effects of age on long white matter tracts using diffusion tensor tractography
    Simon W Davis
    Center for Cognitive Neuroscience, Duke University, PO Box 90999, LSRC Bldg, Room B254, Durham, NC 27708, USA
    Neuroimage 46:530-41. 2009
    ..Taken together, the results help to clarify how age-related white matter decline impairs cognitive performance...
  28. pmc Effects of aging on the neural correlates of successful item and source memory encoding
    Nancy A Dennis
    Center for Cognitive Neuroscience, Levine Science Research Center, Duke University, Durham, NC 27708, USA
    J Exp Psychol Learn Mem Cogn 34:791-808. 2008
    ..The functional connectivity findings are consistent with a posterior-anterior shift with aging previously reported in several cognitive domains and linked to functional compensation...
  29. pmc Cerebral white matter integrity mediates adult age differences in cognitive performance
    David J Madden
    Duke University Medical Center, Durham, NC 27710, USA
    J Cogn Neurosci 21:289-302. 2009
    ..This result is the first demonstration that the integrity of specific white matter tracts is a mediator of age-related changes in cognitive performance...
  30. pmc Age-related differences in the processing of redundant visual dimensions
    Barbara Bucur
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Psychol Aging 20:435-46. 2005
    ..These findings indicate that the coactive processing of redundant visual dimensions is spared in healthy older adults and that for both groups, attention must be focused on both dimensions for coactivation to occur...
  31. pmc Searching from the top down: ageing and attentional guidance during singleton detection
    Wythe L Whiting
    Duke University, Medical Center, Durham, NC, USA
    Q J Exp Psychol A 58:72-97. 2005
    ....
  32. ncbi request reprint Age differences in the strategic allocation of visual attention
    L R Gottlob
    Duke University Medical Center, Durham, North Carolina, USA
    J Gerontol B Psychol Sci Soc Sci 54:P165-72. 1999
    ..Results are consistent with age-related cognitive slowing, but also suggest a difference in strategy according to the availability of visual information...
  33. pmc Age-related slowing of memory retrieval: contributions of perceptual speed and cerebral white matter integrity
    Barbara Bucur
    Center for the Study of Aging and Human Development, Duke University Medical Center, USA
    Neurobiol Aging 29:1070-9. 2008
    ..These findings suggest that white matter integrity in prefrontal regions is one mechanism underlying the relation between individual differences in perceptual speed and episodic retrieval...
  34. pmc Measurement of spontaneous signal fluctuations in fMRI: adult age differences in intrinsic functional connectivity
    Nan kuei Chen
    Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC 27710, USA
    Brain Struct Funct 213:571-85. 2009
    ..The developed FC analysis illustrates the value of identifying connectivity by combining structural, functional, and behavioral data...
  35. ncbi request reprint Role of aerobic fitness and aging on cerebral white matter integrity
    Bonita L Marks
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina, USA
    Ann N Y Acad Sci 1097:171-4. 2007
    ..There are only a few studies, however, investigating potential mechanisms for the improvements in aerobic fitness. Our study suggests that greater aerobic fitness may be related to greater WM integrity in select brain regions...
  36. pmc Processing speed and memory mediate age-related differences in decision making
    Debra E Henninger
    Center for the Study of Aging and Human Development, Duke University Medical Center, NC, USA
    Psychol Aging 25:262-70. 2010
    ..The authors conclude that the reduction in decision quality and associated changes in risk preferences commonly ascribed to aging are instead mediated by age-related changes in underlying cognitive capacities...
  37. ncbi request reprint Differential age effects in semantic and episodic memory
    Philip A Allen
    The University of Akron, Ohio 44325 4301, USA
    J Gerontol B Psychol Sci Soc Sci 57:P173-86. 2002
    ..These data are consistent with a theoretical framework in which there are age-related dissociations between peripheral and central processes across semantic and episodic memory...
  38. pmc Overriding age differences in attentional capture with top-down processing
    Wythe L Whiting
    Department of Psychology, Washington and Lee University, Lexington, VA 24450, USA
    Psychol Aging 22:223-32. 2007
    ..The authors suggest that older adults' ability to use top-down information during search to avoid or attend to cues may be resource-limited...
  39. pmc Effects of healthy aging on hippocampal and rhinal memory functions: an event-related fMRI study
    Sander M Daselaar
    Univeristy of Amsterdam, Animal Physiology and Cognitive Neuroscience section Swammerdam Institute of Life Sciences, University of Amsterdam, Nieuwe Achtergracht 166, Amsterdam, The Netherlands
    Cereb Cortex 16:1771-82. 2006
    ..This finding has important clinical implications because early Alzheimer's disease impairs both hippocampus and rhinal cortex...
  40. ncbi request reprint Differential age effects for case and hue mixing in visual word recognition
    Philip A Allen
    Department of Psychology, The University of Akron, Ohio 44325 4301, USA
    Psychol Aging 17:622-35. 2002
    ..Younger adults showed the predicted results, but older adults did not. These results suggest that holistic central processes are maintained, but that older adults exhibited an analytic decrement..

Research Grants13

  1. NEUROIMAGING OF AGE-RELATED COGNITIVE CHANGES
    David Madden; Fiscal Year: 2005
    ..The findings will be relevant to the development of functional neuroimaging techniques that can aid in the diagnosis of significant and abnormal cognitive impairment. ..
  2. NEUROIMAGING OF AGE RELATED COGNITIVE CHANGES
    David Madden; Fiscal Year: 2000
    ..For each subject, the PET images will be registered to MRI. The project is designed to provide new data regarding the age-related changes in neural functioning that occur independently of the presence of significant disease. ..
  3. NEUROIMAGING OF AGE-RELATED COGNITIVE CHANGES
    David Madden; Fiscal Year: 1993
    ....