N R MacIntyre

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Oxygen therapy and exercise response in lung disease
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 45:194-200; discussion 201-3. 2000
  2. ncbi request reprint Long-term oxygen therapy: conference summary
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 45:237-45. 2000
  3. ncbi request reprint Chronic obstructive pulmonary disease management: the evidence base
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, PO Box 3111, Durham, NC 27710, USA
    Respir Care 46:1294-303. 2001
  4. ncbi request reprint High-frequency jet ventilation
    N R MacIntyre
    Department of Pulmonary and Critical Care, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care Clin N Am 7:599-610. 2001
  5. ncbi request reprint Current issues in mechanical ventilation for respiratory failure
    Neil R MacIntyre
    Pulmonary and Critical Care Medicine, Duke University Medical Center, Room 7453 Duke Hospital, Box 3911 Medical Center, Durham, NC 27710, USA
    Chest 128:561S-567S. 2005
  6. doi request reprint The ventilator discontinuation process: an expanding evidence base
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Hospital, Durham, North Carolina 27710, USA
    Respir Care 58:1074-86. 2013
  7. ncbi request reprint Evidence-based assessments in the ventilator discontinuation process
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 57:1611-8. 2012
  8. doi request reprint Chronic critical illness: the growing challenge to health care
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 57:1021-7. 2012
  9. ncbi request reprint Pulmonary function testing: coding and billing issues
    Neil R MacIntyre
    Pulmonary Function Laboratory, Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
    Respir Care 48:786-90. 2003
  10. ncbi request reprint Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 52:416-21; discussion 421-2. 2007

Detail Information

Publications54

  1. ncbi request reprint Oxygen therapy and exercise response in lung disease
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 45:194-200; discussion 201-3. 2000
    ....
  2. ncbi request reprint Long-term oxygen therapy: conference summary
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 45:237-45. 2000
    ..These kinds of industry-profession collaborations benefit everyone. Finally, I'd like to extend my congratulations to all the speakers for jobs well done and to thank them for making my job as summarizer an enjoyable one...
  3. ncbi request reprint Chronic obstructive pulmonary disease management: the evidence base
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, PO Box 3111, Durham, NC 27710, USA
    Respir Care 46:1294-303. 2001
    ..Moreover, routine antibiotic use seems beneficial, and the role of noninvasive positive-pressure ventilation with patients suffering impending respiratory failure from acute COPD exacerbations is well supported by the literature...
  4. ncbi request reprint High-frequency jet ventilation
    N R MacIntyre
    Department of Pulmonary and Critical Care, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care Clin N Am 7:599-610. 2001
    ..g., selected neonates, adult airway surgical procedures) and to centers skilled in its use. Considerably more data are required before extensive application, especially in the adult, is warranted...
  5. ncbi request reprint Current issues in mechanical ventilation for respiratory failure
    Neil R MacIntyre
    Pulmonary and Critical Care Medicine, Duke University Medical Center, Room 7453 Duke Hospital, Box 3911 Medical Center, Durham, NC 27710, USA
    Chest 128:561S-567S. 2005
    ..These efforts involve the initiation of spontaneous-breathing trials, implementation of systematic weaning protocols, and optimization of individual patient interventions...
  6. doi request reprint The ventilator discontinuation process: an expanding evidence base
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Hospital, Durham, North Carolina 27710, USA
    Respir Care 58:1074-86. 2013
    ..Indeed, practice patterns are evolving in accordance with them. Nevertheless, there is still room for improvement, and further clinical studies, especially in the patient requiring PMV, are needed...
  7. ncbi request reprint Evidence-based assessments in the ventilator discontinuation process
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 57:1611-8. 2012
    ..Nevertheless, there is still room for improvement and need for further clinical studies, especially in the patient requiring prolonged mechanical ventilation...
  8. doi request reprint Chronic critical illness: the growing challenge to health care
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 57:1021-7. 2012
    ..Management of the CCI population requires a special combination of intensive care and rehabilitative skills...
  9. ncbi request reprint Pulmonary function testing: coding and billing issues
    Neil R MacIntyre
    Pulmonary Function Laboratory, Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
    Respir Care 48:786-90. 2003
    ....
  10. ncbi request reprint Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 52:416-21; discussion 421-2. 2007
    ..Importantly, the clinical evidence that aerosolized antibiotics can treat established VAP is negative, and multiple consensus groups recommend against treating established VAP with aerosolized antibiotics...
  11. ncbi request reprint Respiratory mechanics in the patient who is weaning from the ventilator
    Neil R MacIntyre
    Respiratory Care Services, PO Box 3911, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 50:275-86; discussion 284-6. 2005
    ..Fifth, many of these management objectives can be effectively carried out with protocols executed by nonphysicians...
  12. ncbi request reprint Is there a role for screening spirometry?
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Respir Care 55:35-42. 2010
    ..The value of spirometry is increased when it is of good quality, is interpreted properly, and is used in high-risk populations as a case-finding rather than a screening tool...
  13. ncbi request reprint Ventilator-associated pneumonia: the role of ventilator management strategies
    Neil R MacIntyre
    Respiratory Care Services, PO Box 3911, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 50:766-72; discussion 772-3. 2005
    ..Finally, properly performed weaning protocols based on clinical evidence should reduce any iatrogenic delays in ventilator weaning and thereby minimize prolongation of unneeded mechanical ventilatory support...
  14. ncbi request reprint Mechanisms of functional loss in patients with chronic lung disease
    Neil R MacIntyre
    Respiratory Care Services, PO Box 3911, Duke University Medical Center, Durham NC 27710, USA
    Respir Care 53:1177-84. 2008
    ..Other less well understood factors include excessive dyspnea, impaired motivation, orthopedic issues, and psychiatric issues...
  15. pmc Acute exacerbations and respiratory failure in chronic obstructive pulmonary disease
    Neil MacIntyre
    Duke University Medical Center, Durham, NC 27710, USA
    Proc Am Thorac Soc 5:530-5. 2008
    ..Although mild episodes of AECOPD are generally reversible, more severe forms of respiratory failure are associated with a substantial mortality and a prolonged period of disability in survivors...
  16. ncbi request reprint Management of patients requiring prolonged mechanical ventilation: report of a NAMDRC consensus conference
    Neil R MacIntyre
    Duke University Medical Center, Durham, NC 27710, USA
    Chest 128:3937-54. 2005
    ..The document was reworked with input from all concerned until a final product with consensus recommendations on 12 specific issues was achieved...
  17. ncbi request reprint Corticosteroid therapy and chronic obstructive pulmonary disease
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 51:289-96. 2006
    ..Clinical evidence is particularly strong supporting the use of inhaled corticosteroids to prevent exacerbations and oral corticosteroids to reduce the duration and impact of exacerbations...
  18. ncbi request reprint Muscle dysfunction associated with chronic obstructive pulmonary disease
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 51:840-7; discussion 848-52. 2006
    ..Resistive breathing training is more controversial. Lung-volume-reduction surgery may help with the hyperinflation effects and improve gas exchange and respiratory-muscle function in selected patients...
  19. ncbi request reprint Ventilatory Management of ALI/ARDS
    Neil MacIntyre
    Division of Pulmonary, Allergy, and Critical Care, Duke University Medical Center, DUMC 3911, Durham, NC 27710, USA
    Semin Respir Crit Care Med 27:396-403. 2006
    ..This has resulted in significant improvements in outcomes. Future developments will need to further refine this lung protective concept...
  20. doi request reprint Is there a best way to set positive expiratory-end pressure for mechanical ventilatory support in acute lung injury?
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Box 3911, Room 1120, Erwin Road, Durham, NC 27710, USA
    Clin Chest Med 29:233-9, v. 2008
    ..Positive expiratory-end pressure is a widely used technique to maintain alveolar patency, but its beneficial effects must be balanced against its harmful effects...
  21. ncbi request reprint Discontinuing mechanical ventilatory support
    Neil MacIntyre
    Duke University Medical Center, Durham, NC 27710, USA
    Chest 132:1049-56. 2007
    ..New evidence suggests that early tracheostomy placement may facilitate the ventilator withdrawal process in those patients requiring prolonged ventilatory support...
  22. ncbi request reprint Evidence-based ventilator weaning and discontinuation
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham NC 27710, USA
    Respir Care 49:830-6. 2004
    ..5. Ventilator-discontinuation and weaning protocols can be effectively carried out by nonphysician clinicians...
  23. ncbi request reprint Are there benefits or harm from pressure targeting during lung-protective ventilation?
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Hospital, Box 3911, Durham NC 27710, USA
    Respir Care 55:175-80; discussion 180-3. 2010
    ..Indeed, as is often the case in managing complex life-support devices, it is operator expertise rather than the device design features that most impacts patient outcomes...
  24. doi request reprint Is there a best way to set tidal volume for mechanical ventilatory support?
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Room 1120, Box 3911, Erwin Road, Durham, NC 27710, USA
    Clin Chest Med 29:225-31, v. 2008
    ..Clinical trials have shown that limiting maximal and tidal stretch improves outcomes, even if gas exchange is partially compromised. Thus, current strategies should focus on limiting tidal and maximal stretch as much as possible...
  25. ncbi request reprint Spirometry for the diagnosis and management of chronic obstructive pulmonary disease
    Neil R MacIntyre
    Duke University Hospital, Durham, NC 27710, USA
    Respir Care 54:1050-7. 2009
    ..This can be used to guide therapies and predict outcomes. Using spirometry to screen for obstructive lung disease, however, can be problematic, and the effect of screening on outcomes has yet to be demonstrated...
  26. ncbi request reprint Setting the frequency-tidal volume pattern
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 47:266-74; discussion 274-8. 2002
    ..Whether HFV will prove valuable in well-designed open lung strategies in the adult population still has to be determined...
  27. ncbi request reprint Chronic obstructive pulmonary disease: emerging medical therapies
    Neil R MacIntyre
    Respiratory Care Services, Department of Medicine, Duke University Medical Center, PO Box 3911, Durham NC 27710, USA
    Respir Care 49:64-9; discussion 69-71. 2004
    ..Of those tiotropium appears to be the closest to receiving clinical approval in the United States. The risk/benefit ratio and the cost-effectiveness of the other compounds are less clear and await additional study...
  28. doi request reprint Patient-ventilator interactions: optimizing conventional ventilation modes
    Neil R MacIntyre
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 56:73-84. 2011
    ..Clinicians need to know how to use these ventilation mode and monitor them properly, especially understanding the airway pressure and flow graphics. The clinical challenge is synchronizing ventilator gas delivery with patient effort...
  29. ncbi request reprint Aerosol delivery through an artificial airway
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 47:1279-88; discussion 1285-9. 2002
    ..Novel approaches, such as generating the aerosol within the airway, offer the opportunity to greatly increase deposition efficiency and focal drug targeting in intubated patients...
  30. ncbi request reprint Invasive mechanical ventilation in adults: conference summary
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 47:508-18. 2002
  31. ncbi request reprint Intratracheal catheters as drug delivery systems
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, PO Box 3911, Durham NC 27710
    Respir Care 46:193-7. 2001
    ..These catheters could be coupled with tracheal gas insufflation systems, not only to deliver therapeutic aerosols but also to create water aerosols to supply necessary humidification during tracheal gas insufflation...
  32. ncbi request reprint Respiratory controversies in the critical care setting. Conference summary
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, Duke Children s Hospital, Box 3046, Durham, NC 27710, USA
    Respir Care 52:636-44. 2007
    ..This Journal Conference queried the status quo to better enable clinicians to make informed decisions in the care of their critically ill patients...
  33. ncbi request reprint Respiratory system simulations and modeling
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, North Carolina, USA
    Respir Care 49:401-8; discussion 408-9. 2004
    ....
  34. ncbi request reprint Intrabreath diffusing capacity of the lung in healthy individuals at rest and during exercise
    Yuh Chin T Huang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Chest 122:177-85. 2002
    ..Because DL distribution in the lung is inhomogeneous, and changes in the DL in diseased lungs may be regional, measuring regional DL, especially during exercise, may be more sensitive in detecting pulmonary vascular diseases...
  35. ncbi request reprint The "best" tidal volume for managing acute lung injury/acute respiratory distress syndrome
    Neil R MacIntyre
    Department of Pulmonary and Critical Care, Duke University Medical Center, Box 3911, Erwin Road, Durham, NC 27710, USA
    Respir Care Clin N Am 10:309-15, v. 2004
    ..Clinical trials have shown that limiting maximal and tidal stretch improves outcomes, even if gas exchange is partially compromised. Current strategies should focus on limiting tidal and maximal stretch as much as possible...
  36. ncbi request reprint Setting the positive expiratory-end pressure-FIO2 in acute lung injury/acute respiratory distress syndrome
    Neil R MacIntyre
    Department of Pulmonary and Critical Care, Duke University Medical Center, Box 3911, Erwin Road, Durham, NC 27710, USA
    Respir Care Clin N Am 10:301-8, v. 2004
    ..Mechanical approaches to achieve this balance are clinically difficult to do. Thus gas exchange algorithms with modest PaO2 goals are commonly used today. Recruitment maneuvers and long inspiratory time strategies may be useful adjuncts...
  37. ncbi request reprint Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation
    Li Yu Yang
    Department of Medicine, Duke University Medical Center, PO Box 3911, Durham, NC 27710, USA
    J Crit Care 22:252-7. 2007
    ..We hypothesized that a variable-flow, pressure-targeted breath would improve breathing effort versus a fixed flow-targeted breath...
  38. ncbi request reprint Aerosolized medications for altering lung surface active properties
    N R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, North Carolina 27710, USA
    Respir Care 45:676-83. 2000
    ..Other surface active materials exist and there are small studies showing benefit when large instilled doses of these materials are given. These materials, however, have never been studied as aerosols...
  39. ncbi request reprint Exercise outcomes after pulmonary rehabilitation depend on the initial mechanism of exercise limitation among non-oxygen-dependent COPD patients
    John F Plankeel
    Department of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC, USA
    Chest 127:110-6. 2005
    ..However, the degree of benefit from PR is variable. We hypothesized that the exercise response to PR varies depending on the initial factors that limit exercise...
  40. ncbi request reprint Inhaled corticosteroids in obstructive airway disease
    Ghee Chee Phua
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Duke University Medical Center, Durham NC 27710, USA
    Respir Care 52:852-8. 2007
    ..Newer inhaled corticosteroids with better pharmacologic properties are being developed and will probably be available in the near future...
  41. ncbi request reprint Analysis of an endotracheal intubation service provided by respiratory care practitioners
    J J Thalman
    Duke Medical Center, Durham, NC 27710
    Respir Care 38:469-73. 1993
    ..CONCLUSION: Respiratory Care Services can provide an effective intubation service. Cost savings were realized by centralizing equipment...
  42. ncbi request reprint Respiratory controversies in the critical care setting. Part I
    Ira M Cheifetz
    Division of Pediatric Critical Care Medicine, Duke Childrens Hospital, Durham, North Carolina
    Respir Care 52:406-7. 2007
  43. pmc Intersession variability in single-breath diffusing capacity in diabetics without overt lung disease
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    Am J Respir Crit Care Med 178:225-32. 2008
    ..However, little is known about the short-term intersession variability in DL(CO) in untrained subjects or how variability is affected by rigorous external quality control...
  44. ncbi request reprint A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation
    Mitchell M Levy
    Brown University School of Medicine, Division of Pulmonary and Critical Care Medicine, Rhode Island Hospital, 593 Eddy St, Main 7, Providence, RI, 02903, USA
    Chest 127:928-35. 2005
    ..To characterize and compare transfusion practices in a broad sample of patients receiving mechanical ventilation (MV) and not receiving MV in the ICU...
  45. ncbi request reprint Life-threatening asthma: pathophysiology and management
    Njira L Lugogo
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 53:726-35; discussion 735-9. 2008
    ..The early identification and appropriate management of acute asthma is critical in decreasing asthma morbidity and mortality. This paper reviews current pharmacologic and nonpharmacologic management of severe acute asthma...
  46. ncbi request reprint Cognitive and psychological outcomes of exercise in a 1-year follow-up study of patients with chronic obstructive pulmonary disease
    Charles F Emery
    Department of Psychology, Ohio State University, Columbus, OH 43210, USA
    Health Psychol 22:598-604. 2003
    ..Continued exercise among patients with COPD is associated with maintenance of physical, cognitive, and psychological functioning...
  47. ncbi request reprint The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States
    Howard L Corwin
    Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Crit Care Med 32:39-52. 2004
    ..To quantify the incidence of anemia and red blood cell (RBC) transfusion practice in critically ill patients and to examine the relationship of anemia and RBC transfusion to clinical outcomes...
  48. ncbi request reprint Respiratory controversies in the critical care setting. Does airway pressure release ventilation offer important new advantages in mechanical ventilator support?
    Timothy R Myers
    Asthma Center, Division of Pediatric Pulmonology, Rainbow Babies and Children s Hospital, Case Western Reserve University, Cleveland, OH 44106, USA
    Respir Care 52:452-8; discussion 458-60. 2007
    ..The few clinical trials to date indicate that APRV provides adequate gas exchange, but none of the data indicate that APRV confers better clinical outcomes than other ventilation strategies...
  49. ncbi request reprint Marital adjustment among patients with chronic obstructive pulmonary disease who are participating in pulmonary rehabilitation
    Jamile A Ashmore
    Departments of Psychology and Internal Medicine, Ohio State University, 1885 Neil Avenue, Columbus, OH 43210, USA
    Heart Lung 34:270-8. 2005
    ..Marital adjustment has been associated with morbidity and mortality across various chronic diseases but has been largely ignored among patients with chronic obstructive pulmonary disease (COPD)...
  50. doi request reprint Ventilator advisory system employing load and tolerance strategy recommends appropriate pressure support ventilation settings: multisite validation study
    Michael J Banner
    Department of Anesthesiology, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Chest 133:697-703. 2008
    ..To validate these recommendations, we performed a multisite study comparing the advisory system recommendations to experienced physician decisions...
  51. ncbi request reprint The American Association for Respiratory Care and the National Lung Health Education Program: assuring quality in spirometry
    Neil R MacIntyre
    Respir Care 49:587-8. 2004
  52. ncbi request reprint Standardization of the single-breath diffusing capacity in a multicenter clinical trial
    Robert A Wise
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Chest 132:1191-7. 2007
    ..The safety assessment of inhalable insulin required the standardization of measurement of single-breath DLCO in multicenter clinical trials to optimize test precision...
  53. ncbi request reprint Bringing scientific evidence to the ventilator weaning and discontinuation process: evidence-based practice guidelines
    Neil R MacIntyre
    Respir Care 47:29-30. 2002
  54. ncbi request reprint Intrabreath analysis of carbon monoxide uptake during exercise in patients at risk for lung injury
    Yuh Chin T Huang
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Respir Med 100:1226-33. 2006
    ..We conclude that exercise assessments of DL at low lung volumes and gas mixing properties may be sensitive indicators of lung injury...