John R Lynch

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury
    John R Lynch
    The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 192:109-16. 2005
  2. ncbi request reprint Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
    Haichen Wang
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 206:59-69. 2007
  3. ncbi request reprint Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial
    John R Lynch
    Departments of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:2024-6. 2005
  4. ncbi request reprint Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage
    Haichen Wang
    Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neurocrit Care 5:71-8. 2006
  5. ncbi request reprint A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage
    Junling Gao
    Multidisciplinary Neuroprotection Laboratories, Durham, NC, USA
    Neurocrit Care 4:25-31. 2006
  6. ncbi request reprint APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    John R Lynch
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:48529-33. 2003
  7. ncbi request reprint Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway
    Brian E Mace
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurol Res 29:243-50. 2007
  8. ncbi request reprint Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model
    Stephen B Leinenweber
    Department of Pediatrics, Duke University Medical Center, Durham NC 27710, USA
    Eur J Pharmacol 531:126-32. 2006
  9. ncbi request reprint Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage
    Matthew J McGirt
    Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Duke University School of Medicine Duke University Medical Center, Durham, NC, USA
    Stroke 33:2950-6. 2002
  10. ncbi request reprint Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema
    John R Lynch
    Multidisciplinary Neuroprotection Laboratory, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 51:113-7. 2002

Collaborators

Detail Information

Publications20

  1. ncbi request reprint A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury
    John R Lynch
    The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 192:109-16. 2005
    ..The development of an apoE-based intervention represents a novel therapeutic strategy in the management of acute brain injury...
  2. ncbi request reprint Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
    Haichen Wang
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 206:59-69. 2007
    ..Furthermore, statin treatment improved cerebral hemodynamics following head injury. Thus, the administration of statins may represent a viable therapeutic strategy in the acute treatment of closed head injury...
  3. ncbi request reprint Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial
    John R Lynch
    Departments of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:2024-6. 2005
    ..Cerebral vasospasm remains a major source of morbidity after aneurysmal subarachnoid hemorrhage (SAH). We demonstrate that simvastatin reduces serum markers of brain injury and attenuates vasospasm after SAH...
  4. ncbi request reprint Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage
    Haichen Wang
    Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neurocrit Care 5:71-8. 2006
    ..In the current study, we test the hypothesis that levetiracetam, an anticonvulsant with favorable interaction and adverse event profiles, is neuroprotective in clinically relevant models of SAH and closed head injury (CHI)...
  5. ncbi request reprint A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage
    Junling Gao
    Multidisciplinary Neuroprotection Laboratories, Durham, NC, USA
    Neurocrit Care 4:25-31. 2006
    ..We then test the hypothesis that an apoE-derived therapeutic peptide reduces vasospasm and improves functional recovery after SAH...
  6. ncbi request reprint APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    John R Lynch
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:48529-33. 2003
    ....
  7. ncbi request reprint Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway
    Brian E Mace
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurol Res 29:243-50. 2007
    ..These results suggest that apoE modifies secondary neuronal injury caused by histamine release and are consistent with previous observations that apoE affects the CNS inflammatory response in an isoform-specific manner...
  8. ncbi request reprint Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model
    Stephen B Leinenweber
    Department of Pediatrics, Duke University Medical Center, Durham NC 27710, USA
    Eur J Pharmacol 531:126-32. 2006
    ..Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model...
  9. ncbi request reprint Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage
    Matthew J McGirt
    Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Duke University School of Medicine Duke University Medical Center, Durham, NC, USA
    Stroke 33:2950-6. 2002
    ..Simvastatin increases eNOS activity. We hypothesized that simvastatin would increase eNOS protein and ameliorate SAH-induced cerebral vasospasm...
  10. ncbi request reprint Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema
    John R Lynch
    Multidisciplinary Neuroprotection Laboratory, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 51:113-7. 2002
    ..Thus, modulation of the endogenous central nervous system inflammatory response may be one mechanism by which apolipoprotein E affects outcome following acute brain injury...
  11. ncbi request reprint Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage
    Matthew J McGirt
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosurg 98:1222-6. 2003
    ..The goal of this study was to assess whether clinical, radiographic, or serological variables could be used to identify patients at an increased risk for cerebral vasospasm...
  12. ncbi request reprint Novel diagnostic test for acute stroke
    John R Lynch
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 35:57-63. 2004
    ..The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of cerebral ischemia...
  13. ncbi request reprint Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat
    Hazem Elsersy
    The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, North Carolina, USA
    Anesthesiology 100:1160-6. 2004
    ..This study examined long-term outcome from severe forebrain ischemia in the rat, as a function of anesthetic given during the ischemic injury...
  14. ncbi request reprint Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Matthew J McGirt
    Multidisciplinary Neuroprotection Laboratory, Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
    Neurosurgery 51:1128-34; discussion 1134-5. 2002
    ..We hypothesized that serum von Willebrand factor (vWF) (a marker of endothelial cell death), MMP-9, and VEGF levels could serve as prognostic markers in predicting the occurrence of cerebral vasospasm...
  15. ncbi request reprint Accurate patient history contributes to differentiating diabetes insipidus: a case study
    DaiWai M Olson
    Duke University Hospital North, Durham, NC, USA
    J Neurosci Nurs 36:228-30. 2004
    ..Thus successful treatment required that nephrogenic and neurogenic DI be treated concomitantly...
  16. ncbi request reprint Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosurg 105:671-4. 2006
    ..The authors hypothesized that patients chronically treated with statins would have a decreased risk of symptomatic vasospasm after SAH...
  17. ncbi request reprint Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Neurosurg 51:320-8. 2004
  18. ncbi request reprint Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase
    Matthew J McGirt
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Clin Neurosurg 52:371-8. 2005
  19. ncbi request reprint Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Neurosurgery 54:1369-73; discussion 1373-4. 2004
    ..We examined the temporal relationship between serum BNP elevation, hyponatremia, and the onset of delayed ischemic neurological deficits and determined whether serum BNP levels correlated with the 2-week outcome after SAH...
  20. doi request reprint Interventional acute ischemic stroke therapy with intracranial self-expanding stent
    Osama O Zaidat
    Stroke 39:2392-5. 2008
    ..Newly available self-expanding intracranial atherosclerotic stents (SEIS), which can be deployed rapidly and safely, make acute stenting an option for treating AIS. We present the feasibility of this technique...