Jennifer S Li

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial
    Jennifer S Li
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27705, USA
    Circulation 117:553-9. 2008
  2. pmc Lessons learned from a pediatric clinical trial: the Pediatric Heart Network angiotensin-converting enzyme inhibition in mitral regurgitation study
    Jennifer S Li
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 161:233-40. 2011
  3. pmc Economic return of clinical trials performed under the pediatric exclusivity program
    Jennifer S Li
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA
    JAMA 297:480-8. 2007
  4. ncbi request reprint The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass
    Jennifer S Li
    Duke University Medical Center, Division of Pediatric Cardiology, Department of Pediatrics, Duke Clinical Research Institute, Box 3090, Durham, NC 27710, USA
    Expert Rev Cardiovasc Ther 4:649-54. 2006
  5. doi request reprint The efficacy and safety of the novel aldosterone antagonist eplerenone in children with hypertension: a randomized, double-blind, dose-response study
    Jennifer S Li
    Division of Pediatric Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr 157:282-7. 2010
  6. ncbi request reprint Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?
    Jennifer S Li
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Circulation 116:293-7. 2007
  7. pmc Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis
    J S Li
    Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, Maryland, USA
    Clin Pharmacol Ther 84:315-9. 2008
  8. pmc Pediatric cardiovascular drug trials, lessons learned
    Jennifer S Li
    Department of Pediatrics and Duke Clinical Research Institute, Durham, NC, USA
    J Cardiovasc Pharmacol 58:4-8. 2011
  9. doi request reprint Antiplatelet therapy in pediatric cardiovascular patients
    Jennifer S Li
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center and Duke Clinical Research Institute, PO Box 17969, Durham, NC 27705, USA
    Pediatr Cardiol 31:454-61. 2010
  10. pmc Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes
    Michelle C Wallace
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 91:1445-52. 2011

Detail Information

Publications81

  1. doi request reprint Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial
    Jennifer S Li
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center and Duke Clinical Research Institute, Durham, NC 27705, USA
    Circulation 117:553-9. 2008
    ....
  2. pmc Lessons learned from a pediatric clinical trial: the Pediatric Heart Network angiotensin-converting enzyme inhibition in mitral regurgitation study
    Jennifer S Li
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 161:233-40. 2011
    ..We hypothesized that angiotensin-converting enzyme inhibitor therapy would decrease the severity of mitral regurgitation and limit left ventricular volume overload in children following AVSD repair...
  3. pmc Economic return of clinical trials performed under the pediatric exclusivity program
    Jennifer S Li
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, NC 27705, USA
    JAMA 297:480-8. 2007
    ..This critique has been a substantial part of congressional debate on the program, which is due to expire in 2007...
  4. ncbi request reprint The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass
    Jennifer S Li
    Duke University Medical Center, Division of Pediatric Cardiology, Department of Pediatrics, Duke Clinical Research Institute, Box 3090, Durham, NC 27710, USA
    Expert Rev Cardiovasc Ther 4:649-54. 2006
    ..In addition, TP10 leads to early extubation in adult lung transplant recipients. TP10 is currently positioned for clinical development in a male-only indication of cardiac surgery on CPB...
  5. doi request reprint The efficacy and safety of the novel aldosterone antagonist eplerenone in children with hypertension: a randomized, double-blind, dose-response study
    Jennifer S Li
    Division of Pediatric Cardiology and Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Pediatr 157:282-7. 2010
    ..To determine the efficacy and safety of eplerenone therapy in children with hypertension...
  6. ncbi request reprint Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?
    Jennifer S Li
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Circulation 116:293-7. 2007
    ..Aspirin (ASA) often is used to prevent thrombosis in infants with congenital heart disease after placement of a systemic-to-pulmonary artery shunt, but its effect on outcomes is unknown...
  7. pmc Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis
    J S Li
    Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, Maryland, USA
    Clin Pharmacol Ther 84:315-9. 2008
    ..This study evaluated the results of six trials of ACE inhibitors in children, using meta-analytic techniques to estimate the effect of race on blood pressure response...
  8. pmc Pediatric cardiovascular drug trials, lessons learned
    Jennifer S Li
    Department of Pediatrics and Duke Clinical Research Institute, Durham, NC, USA
    J Cardiovasc Pharmacol 58:4-8. 2011
    ..These lessons learned may help to inform future pediatric clinical trial development...
  9. doi request reprint Antiplatelet therapy in pediatric cardiovascular patients
    Jennifer S Li
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center and Duke Clinical Research Institute, PO Box 17969, Durham, NC 27705, USA
    Pediatr Cardiol 31:454-61. 2010
    ..This review discusses aspects of antiplatelet therapy for pediatric patients...
  10. pmc Center variation in patient age and weight at Fontan operation and impact on postoperative outcomes
    Michelle C Wallace
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 91:1445-52. 2011
    ..We evaluated variation in age, weight, and weight-for-age z-score at Fontan across institutions, and the impact of these variables on postoperative morbidity and mortality...
  11. pmc The complex relationship between center volume and outcome in patients undergoing the Norwood operation
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1556-62. 2012
    ..We evaluated the impact of patient risk status on the relationship between center volume and outcome, and the extent to which differences in center volume account for between-center variation in outcome...
  12. pmc Perioperative methylprednisolone and outcome in neonates undergoing heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC, USA
    Pediatrics 129:e385-91. 2012
    ..We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates...
  13. pmc Comparative analysis of antifibrinolytic medications in pediatric heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA
    J Thorac Cardiovasc Surg 143:550-7. 2012
    ..We performed a comparative analysis in a large multicenter cohort...
  14. pmc Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database
    James C Fudge
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    Pediatrics 126:315-22. 2010
    ..We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery...
  15. pmc Safety and transparency of pediatric drug trials
    Daniel K Benjamin
    Department of Pediatrics, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA
    Arch Pediatr Adolesc Med 163:1080-6. 2009
    ....
  16. pmc Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis
    Annette K Ansong
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Early Hum Dev 85:S5-7. 2009
    ..Describe cerebrospinal fluid parameters in infants with culture-proven Group B streptococcal meningitis in the era of intrapartum antibiotic prophylaxis...
  17. pmc Association of center volume with mortality and complications in pediatric heart surgery
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Pediatrics 129:e370-6. 2012
    ..We examined this association in a large multicenter cohort...
  18. pmc Safety of aprotinin in congenital heart operations: results from a large multicenter database
    Sara K Pasquali
    Division of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina 27715, USA
    Ann Thorac Surg 90:14-21. 2010
    ..We evaluated the safety of aprotinin in a large multicenter cohort of children undergoing congenital heart operations...
  19. pmc Hospital variation in postoperative infection and outcome after congenital heart surgery
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
    Ann Thorac Surg 96:657-63. 2013
    ..However, the association of infection rates with hospital-level outcomes and resource utilization has not been well described. We evaluated this association across a multicenter cohort undergoing congenital heart surgery...
  20. pmc Relative impact of surgeon and center volume on early mortality after the Norwood operation
    Christoph P Hornik
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina 27715, USA
    Ann Thorac Surg 93:1992-7. 2012
    ..We evaluated the relative impact of surgeon and center volume on mortality in a large Norwood cohort...
  21. ncbi request reprint Racial differences are seen in blood pressure response to fosinopril in hypertensive children
    Sharad Menon
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 152:394-9. 2006
    ..It is well established that adult patients of different races show disparate response to angiotensin-converting enzyme (ACE) inhibitors, however no such studies have been performed in children...
  22. pmc Major infection after pediatric cardiac surgery: a risk estimation model
    Gregory M Barker
    Duke University Medical Center, Durham, North Carolina, USA
    Ann Thorac Surg 89:843-50. 2010
    ..In pediatric cardiac surgery, infection is a leading cause of morbidity and mortality. We created a model to predict risk of major infection in this population...
  23. pmc Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome
    Jason N Johnson
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    J Thorac Cardiovasc Surg 139:1205-10. 2010
    ..We describe center variation in delayed sternal closure after stage 1 palliation and associated outcomes...
  24. doi request reprint Cardiac surgery in infants with low birth weight is associated with increased mortality: analysis of the Society of Thoracic Surgeons Congenital Heart Database
    Christopher L Curzon
    Department of Pediatrics, Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 135:546-51. 2008
    ....
  25. pmc Differential case ascertainment in clinical registry versus administrative data and impact on outcomes assessment for pediatric cardiac operations
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
    Ann Thorac Surg 95:197-203. 2013
    ....
  26. ncbi request reprint Ambulatory electrocardiogram analysis in infants treated with recombinant human acid alpha-glucosidase enzyme replacement therapy for Pompe disease
    Amanda L Cook
    Division of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Med 8:313-7. 2006
    ..We evaluated 24-hour ambulatory electrocardiograms (ECGs) at baseline and during ERT in patients with infantile Pompe disease...
  27. pmc Corticosteroids and outcome in children undergoing congenital heart surgery: analysis of the Pediatric Health Information Systems database
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Circulation 122:2123-30. 2010
    ..Children undergoing congenital heart surgery often receive corticosteroids with the aim of reducing the inflammatory response after cardiopulmonary bypass; however, the value of this approach is unclear...
  28. pmc Pediatric antihypertensive trial failures: analysis of end points and dose range
    Daniel K Benjamin
    Office of Pediatric Therapeutics, US Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:834-40. 2008
    ..More importantly, our ability to combine data across trials allowed us to evaluate and potentially improve trial design...
  29. pmc Sildenafil exposure and hemodynamic effect after stage II single-ventricle surgery
    Kevin D Hill
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Crit Care Med 14:593-600. 2013
    ..To determine sildenafil exposure and hemodynamic effect in children after stage II single-ventricle surgery...
  30. pmc The economic returns of pediatric clinical trials of antihypertensive drugs
    Carissa M Baker-Smith
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Am Heart J 156:682-8. 2008
    ..We sought to determine the cost of performing pediatric exclusivity trials within a single therapeutic area and the subsequent economic return to industry sponsors...
  31. pmc Trends in endocarditis hospitalizations at US children's hospitals: impact of the 2007 American Heart Association Antibiotic Prophylaxis Guidelines
    Sara K Pasquali
    Division of Cardiology, Department of Pediatrics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 163:894-9. 2012
    ..The impact of these guidelines is unclear. We evaluated IE hospitalizations at US children's hospitals during this period...
  32. pmc Safety of placebo controls in pediatric hypertension trials
    P Brian Smith
    Food and Drug Administration, Rockville, MD, USA
    Hypertension 51:829-33. 2008
    ..Short-term exposure to placebo in pediatric trials of antihypertensive medications appears to be safe...
  33. pmc Complications after the Norwood operation: an analysis of The Society of Thoracic Surgeons Congenital Heart Surgery Database
    Christoph P Hornik
    Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA
    Ann Thorac Surg 92:1734-40. 2011
    ..Limited multicenter data exist regarding the prevalence of postoperative complications after the Norwood operation and their associated mortality risk...
  34. pmc Sildenafil exposure and hemodynamic effect after Fontan surgery
    Robert D Tunks
    1Department of Pediatrics, Duke University Medical Center, Durham, NC 2Duke Clinical Research Institute, Durham, NC 3Department of Pediatrics, University of North Carolina, Chapel Hill, NC
    Pediatr Crit Care Med 15:28-34. 2014
    ..Determine sildenafil exposure and hemodynamic effect in children after Fontan single-ventricle surgery...
  35. pmc Intervention for recoarctation in the single ventricle reconstruction trial: incidence, risk, and outcomes
    Kevin D Hill
    Clinical Research Institute, Duke University Medical Center, 2400 Pratt St, Durham, NC 27705, USA
    Circulation 128:954-61. 2013
    ..We sought to determine the incidence of recoarctation, risk factors, and outcomes in the SVR trial...
  36. pmc Platelet activity associated with concomitant use of clopidogrel and proton pump inhibitors in children with cardiovascular disease
    Sara K Pasquali
    Department of Pediatrics, Duke University Medical Center, Duke Clinical Research Institute, Durham, NC 27715, USA
    Congenit Heart Dis 5:552-5. 2010
    ..In adults with acute coronary syndrome, decreased platelet inhibition associated with concomitant use of clopidogrel and proton pump inhibitors (PPI) has been reported...
  37. ncbi request reprint Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass
    Jennifer S Li
    Department of Pediatrics, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 147:173-80. 2004
    ..76, P = -.016), and with total (rho -0.56, P =.047) and net (rho -0.85, P =.0016) fluid and blood product administration/kg >24 hours after CPB...
  38. pmc Care models and associated outcomes in congenital heart surgery
    Danielle S Burstein
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Pediatrics 127:e1482-9. 2011
    ..The impact of this trend on patient outcomes is unclear. We evaluated postoperative outcomes associated with a CICU versus other ICU models...
  39. pmc Arrhythmias in patients receiving enzyme replacement therapy for infantile Pompe disease
    Roddy McDowell
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Med 10:758-62. 2008
    ..Because ectopy has been previously described in these patients, we sought to determine the prevalence and types of arrhythmias...
  40. pmc Variation in models of care delivery for children undergoing congenital heart surgery in the United States
    Danielle S Burstein
    Duke University Medical Center and Duke Clinical Research Institute, Durham, NC, USA
    World J Pediatr Congenit Heart Surg 1:8-14. 2010
    ..Further study is necessary to evaluate the implications of this variability on quality of care and patient outcomes. ..
  41. ncbi request reprint Oral antihypertensive trial design and analysis under the pediatric exclusivity provision
    Sara K Pasquali
    Pediatric Cardiovascular Program, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 144:608-14. 2002
    ..Guidelines were published outlining specific requirements for the design and analysis of trials to provide the requested information...
  42. pmc Center variation in hospital costs for patients undergoing congenital heart surgery
    Sara K Pasquali
    Divisions of Pediatric Cardiology and Cardiothoracic Surgery and the Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Circ Cardiovasc Qual Outcomes 4:306-12. 2011
    ..The purpose of this study was to evaluate variation between centers in total hospital costs for 4 congenital heart operations of varying complexity and associated factors...
  43. pmc Peer-reviewed publication of clinical trials completed for pediatric exclusivity
    Daniel K Benjamin
    Office of Pediatric Therapeutics, Office of the Commissioner, US Food and Drug Administration, Rockville, MD, USA
    JAMA 296:1266-73. 2006
    ..As a result, there have been over 100 product labeling changes. The publication status of studies completed for pediatric exclusivity has not been evaluated...
  44. pmc Racial and geographic disparities in timing of bidirectional Glenn and Fontan stages of single-ventricle palliation
    Angelo S Milazzo
    Pediatric Cardiovascular Program, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Natl Med Assoc 94:873-8. 2002
    ..In adults, race-based disparity in access to cardiovascular care has been documented. Racial differences in cardiac care for children have not been evaluated previously...
  45. pmc Celiac artery flow pattern in infants with single right ventricle following the Norwood procedure with a modified Blalock-Taussig or right ventricle to pulmonary artery shunt
    Jason N Johnson
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Pediatr Cardiol 32:479-86. 2011
    ..The celiac artery resistive index was higher in patients with the modified Blalock-Taussig shunt versus the right ventricle to pulmonary artery shunt but was not associated with measured gastrointestinal outcomes...
  46. pmc Safety monitoring of drugs receiving pediatric marketing exclusivity
    P Brian Smith
    MHS, Duke University Medical Center, Box 3179, Durham, NC 27710, USA
    Pediatrics 122:e628-33. 2008
    ..We sought to describe the Pediatric Advisory Committee's recommendations made in response to safety reviews informed by data from the Food and Drug Administration Adverse Event Reporting System in 67 drugs granted exclusivity...
  47. ncbi request reprint Is the extrapolated adult dose of fosinopril safe and effective in treating hypertensive children?
    Jennifer S Li
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Durham, NC 27710, USA
    Hypertension 44:289-93. 2004
    ..Because children appear to be more sensitive to lower doses of fosinopril than adults, starting doses for children should be < or =0.1 mg/kg...
  48. pmc Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation
    Kevin Watt
    Department of Pediatrics Duke University, Durham, NC, USA
    J Cardiovasc Pharmacol 58:126-32. 2011
    ..Research efforts should focus on evaluating the PK of drugs in patients on ECMO to avoid therapeutic failures or unnecessary toxicities...
  49. pmc Functional state following the Fontan procedure
    Ismee A Williams
    Department of Pediatrics, Division of Cardiology, Columbia University Medical Centre, New York, New York, USA
    Cardiol Young 19:320-30. 2009
    ..Despite improvements in outcomes after completion of the Fontan circulation, long-term functional state varies. We sought to identify pre- and postoperative characteristics associated with overall function...
  50. pmc Birth weight and prematurity in infants with single ventricle physiology: pediatric heart network infant single ventricle trial screened population
    Richard V Williams
    Department of Pediatrics, University of Utah, Salt Lake City, Utah, USA
    Congenit Heart Dis 5:96-103. 2010
    ....
  51. pmc Cardiovascular abnormalities in late-onset Pompe disease and response to enzyme replacement therapy
    Daniel Forsha
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27715, USA
    Genet Med 13:625-31. 2011
    ..We evaluated the prevalence of cardiovascular abnormalities and the efficacy and safety of enzyme replacement therapy in patients with late-onset Pompe disease...
  52. pmc Safety and efficacy of rivastigmine in adolescents with Down syndrome: a preliminary 20-week, open-label study
    James H Heller
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Child Adolesc Psychopharmacol 16:755-65. 2006
    ..These results underscore the need for larger, controlled studies employing a carefully constructed test battery capable of measuring the full scope of performance across multiple domains and a wide range of functional levels...
  53. pmc Use of cardiac magnetic resonance imaging to evaluate cardiac structure, function and fibrosis in children with infantile Pompe disease on enzyme replacement therapy
    Piers C A Barker
    Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Genet Metab 101:332-7. 2010
    ..We report the first use of CMR in a feasible protocol to quantify left ventricular (LV) mass, function, and the presence of myocardial fibrosis in the Pompe population...
  54. ncbi request reprint Cumulative radiation exposure and cancer risk estimation in children with heart disease
    Jason N Johnson
    From the Division of Pediatric Cardiology J N J, C P H, J S L, K D H and Division of Radiology T T Y, R E R, D P F, Department of Pediatrics, Duke University Medical Center, Durham, NC and Duke Clinical Research Institute, Durham, NC J S L, D K B, K D H
    Circulation 130:161-7. 2014
    ..We evaluated the cumulative effective dose of radiation from all radiation examinations to estimate the lifetime attributable risk of cancer in children with heart disease...
  55. pmc Status of the pediatric clinical trials enterprise: an analysis of the US ClinicalTrials.gov registry
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina, USA
    Pediatrics 130:e1269-77. 2012
    ..gov has enabled evaluation of the clinical trial enterprise as a whole, which was previously not possible. The purpose of this study was to create a snapshot of the pediatric clinical trial portfolio...
  56. ncbi request reprint Cardiac arrhythmias following anesthesia induction in infantile-onset Pompe disease: a case series
    Luke Y J Wang
    Division of Pediatric Anesthesiology, Duke Uinvesity Medical Center, Durham, NC 27710, USA
    Paediatr Anaesth 17:738-48. 2007
    ..Given this baseline cardiac physiology, coronary perfusion pressure becomes highly sensitive to abrupt changes in diastolic blood pressure (DBP)...
  57. ncbi request reprint Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia
    Anne Marie Valente
    Department of Pediatrics, Duke University, Box 3090, Durham, NC 27710, USA
    Pediatrics 115:e15-9. 2005
    ..The objective of this study was to determine prospectively the prevalence of IE among pediatric patients with SAB in a large tertiary care center...
  58. ncbi request reprint Electrocardiographic response to enzyme replacement therapy for Pompe disease
    Annette K Ansong
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA
    Genet Med 8:297-301. 2006
    ..We evaluated the effect of recombinant human GAA (rhGAA) enzyme replacement therapy (ERT) on these ECG parameters in patients with infantile-onset Pompe disease...
  59. ncbi request reprint Clinical trials in children with Down syndrome: issues from a cognitive research perspective
    James H Heller
    Department of Surgery, Duke University Medical Center DUMC, Box 3528, 244 Bell Building, Durham, NC 27710, USA
    Am J Med Genet C Semin Med Genet 142:187-95. 2006
    ..It is hoped that this article will raise awareness of the unmet need for clinical research in the cognitive and adaptive function of individuals with DS, especially children with DS...
  60. doi request reprint Oropharyngeal dysphagia in infants and children with infantile Pompe disease
    Harrison N Jones
    Division of Speech Pathology and Audiology, Department of Surgery, Duke University, 155 Baker House, Trent Drive, DUMC 3887, Durham, NC 27710, USA
    Dysphagia 25:277-83. 2010
    ..9% of subjects, including penetration in five (38.46%) and silent aspiration in an additional five (38.46%). No relationship in the relative involvement of swallowing, gross motor function, and cardiac disease appeared to be present...
  61. pmc Globalization of pediatric research: analysis of clinical trials completed for pediatric exclusivity
    Sara K Pasquali
    Duke University Medical Center, Department of Pediatrics, Division of Cardiology, PO Box 17969, Durham, NC 27715, USA
    Pediatrics 126:e687-92. 2010
    ..We evaluated the setting of published studies conducted under the US Pediatric Exclusivity Provision, which provides economic incentives to pharmaceutical companies to conduct drug studies with children...
  62. doi request reprint Major complications associated with transcatheter atrial septal occluder implantation: a review of the medical literature and the manufacturer and user facility device experience (MAUDE) database
    Jeffrey W Delaney
    Duke University Medical Center, Division of Pediatric Cardiology, Durham, NC 27710, USA
    Congenit Heart Dis 2:256-64. 2007
    ..To summarize major complications and outcome for patients receiving percutaneous closure of atrial septal communications...
  63. pmc Echocardiographic manifestations of Glycogen Storage Disease III: increase in wall thickness and left ventricular mass over time
    Shawyntee M Vertilus
    Divisions of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genet Med 12:413-23. 2010
    ..Some patients develop increased left ventricular thickness by echocardiography, but the rate of increase and its significance remain unclear...
  64. doi request reprint Global longitudinal cardiac strain and strain rate for assessment of fetal cardiac function: novel experience with velocity vector imaging
    Piers C A Barker
    Duke Children s Heart Program, Duke University Medical Center, Durham, North Carolina, USA
    Echocardiography 26:28-36. 2009
    ..This report describes the novel measurement of global strain, strain rate, and velocity using Velocity Vector Imaging (VVI) in a group of fetuses with and without heart disease...
  65. ncbi request reprint Clinical auscultation skills in pediatric residents
    P R Gaskin
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Pediatrics 105:1184-7. 2000
    ..The aim of this study is to determine the level of clinical auscultation skills in pediatric residents at Duke University Medical Center...
  66. ncbi request reprint Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis
    J S Li
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Clin Infect Dis 30:633-8. 2000
    ..aureus should be considered a major criterion, regardless of whether the infection is nosocomially acquired or whether a removable source of infection is present. Positive Q-fever serology should be changed to a major criterion...
  67. pmc Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials
    C M Baker-Smith
    Department of Pediatrics, Duke University, Durham, North Carolina, USA
    Clin Pharmacol Ther 87:668-71. 2010
    ..The incidence of cough in children receiving ACEis (reported cough, 3.2%) was similar to that in children receiving ARBs (reported cough, 1.8%) (P = 0.34). Reports of cough were lower in children than in adults...
  68. doi request reprint A rare coronary collateral in pulmonary atresia and intact septum with coronary sinusoids
    Daniel Forsha
    Division of Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    World J Pediatr Congenit Heart Surg 3:255-9. 2012
    ..The clinical course in this infant included extracorporeal life support and coil occlusion of the collateral in order to manage multiple ischemic events. ..
  69. ncbi request reprint A meta-analysis of medical versus surgical therapy for Candida endocarditis
    William J Steinbach
    Division of Infectious Diseases, Department of Pediatrics, Duke University, Durham, NC 27710, USA
    J Infect 51:230-47. 2005
    ..The optimal management of Candida infective endocarditis (IE) is unknown...
  70. ncbi request reprint Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters?
    Harmony P Garges
    Pediatrics, Duke University, Durham, North Carolina, USA
    Pediatrics 117:1094-100. 2006
    ..Abnormal cerebrospinal fluid (CSF) parameters are often used to predict neonatal meningitis and determine length and type of antibiotic therapy in neonates with a positive blood culture and negative CSF culture...
  71. pmc Cross-reactive immunologic material status affects treatment outcomes in Pompe disease infants
    Priya S Kishnani
    Department of Pediatrics, Division of Medical Genetics, Duke University Medical Center, Box 103856 DUMC, 4th Floor GSRBI, 595 LaSalle Street, Durham, NC 27710, USA
    Mol Genet Metab 99:26-33. 2010
    ..The effect of CRIM status on outcome appears to be mediated by antibody responses to the exogenous protein...
  72. ncbi request reprint Coronary artery pattern and outcome of arterial switch operation for transposition of the great arteries: a meta-analysis
    Sara K Pasquali
    Pediatric Cardiovascular Program, Duke University Medical Center, Durham, NC 27710, USA
    Circulation 106:2575-80. 2002
    ..This meta-analysis assesses the effect of coronary anatomy on post-ASO mortality, both overall and adjusted for time...
  73. ncbi request reprint Cost implications of closure of atrial septal defect
    Sherri S Baker
    Division of Pediatric Cardiology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Catheter Cardiovasc Interv 55:83-7. 2002
    ..Device closure of ASD results in substantial hospital-related cost savings that will be an important consideration once new devices are approved for clinical use...
  74. pmc Linking clinical registry data with administrative data using indirect identifiers: implementation and validation in the congenital heart surgery population
    Sara K Pasquali
    Department of Pediatrics, Duke University School of Medicine, Durham, NC Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Am Heart J 160:1099-104. 2010
    ....
  75. ncbi request reprint Measures of cardiac repolarization and body position in infants
    Sherri S Baker
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Pediatr (Phila) 42:67-70. 2003
    ....
  76. ncbi request reprint Real-time transmission of pediatric echocardiograms using a single ISDN line
    Angelo S Milazzo
    Pediatric Cardiovascular Program, Duke University Medical Center, Box 3090, Durham, NC 27710, USA
    Comput Biol Med 32:379-88. 2002
    ..In 300 studies, a normal diagnosis obviated further evaluation. A single ISDN line is adequate for transmission of pediatric echocardiograms and it allows for remote management of patients with CHD...
  77. doi request reprint A cross-sectional study of exercise performance during the first 2 decades of life after the Fontan operation
    Stephen M Paridon
    The University of Pennsylvania, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 52:99-107. 2008
    ..The aim of this study was to describe exercise performance during the first 2 decades of life in Fontan survivors by a cross-sectional study and to identify factors that influence exercise performance...
  78. pmc Functional status, heart rate, and rhythm abnormalities in 521 Fontan patients 6 to 18 years of age
    Andrew D Blaufox
    Medical University of South Carolina, Charleston, SC, USA
    J Thorac Cardiovasc Surg 136:100-7, 107.e1. 2008
    ..Our objective was to determine the relationship between functional outcome and abnormalities of heart rate and rhythm after the Fontan operation...
  79. ncbi request reprint Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure
    Brian W McCrindle
    University of Toronto, Hospital for Sick Children, Toronto, Canada
    Circulation 113:1123-9. 2006
    ..After the Fontan procedure, patients are at risk for suboptimal health status related to their complex healthcare experience, physiological limitations, medical complications, and guarded long-term prognosis...
  80. pmc Rationale and design of a randomized clinical trial of beta-blocker therapy (atenolol) versus angiotensin II receptor blocker therapy (losartan) in individuals with Marfan syndrome
    Ronald V Lacro
    Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Am Heart J 154:624-31. 2007
    ..Recent studies in an FBN1-targeted mouse model of MFS with aortic disease similar to that seen in humans showed that treatment with losartan normalized aortic root growth and aortic wall architecture...
  81. ncbi request reprint Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease
    Jane W Newburger
    Department of Cardiology, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 356:663-75. 2007
    ..Studies have suggested that primary corticosteroid therapy might be beneficial and that adverse events are infrequent with short-term use...