Jennifer S Li

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..Aspirin (ASA) often is used to prevent thrombosis in infants with congenital heart disease after placement of a systemic-to-pulmonary artery shunt, but its effect on outcomes is unknown...

..This review discusses aspects of antiplatelet therapy for pediatric patients...

..To determine the efficacy and safety of eplerenone therapy in children with hypertension...

..This critique has been a substantial part of congressional debate on the program, which is due to expire in 2007...

..These lessons learned may help to inform future pediatric clinical trial development...

..Progress in the treatment of children with cardiovascular disease will depend on the future of multicenter collaborative clinical trials. The lessons learned from this study may contribute to improvements in this research...

..In addition, TP10 leads to early extubation in adult lung transplant recipients. TP10 is currently positioned for clinical development in a male-only indication of cardiac surgery on CPB...

..This study evaluated the results of six trials of ACE inhibitors in children, using meta-analytic techniques to estimate the effect of race on blood pressure response...

..We evaluated variation in age, weight, and weight-for-age z-score at Fontan across institutions, and the impact of these variables on postoperative morbidity and mortality...

..We evaluated the impact of patient risk status on the relationship between center volume and outcome, and the extent to which differences in center volume account for between-center variation in outcome...

..We evaluated outcomes across methylprednisolone regimens versus no steroids in a large cohort of neonates...

..We performed a comparative analysis in a large multicenter cohort...

..We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery...

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..Describe cerebrospinal fluid parameters in infants with culture-proven Group B streptococcal meningitis in the era of intrapartum antibiotic prophylaxis...

..We examined this association in a large multicenter cohort...

..We evaluated the safety of aprotinin in a large multicenter cohort of children undergoing congenital heart operations...

..We evaluated the relative impact of surgeon and center volume on mortality in a large Norwood cohort...

..It is well established that adult patients of different races show disparate response to angiotensin-converting enzyme (ACE) inhibitors, however no such studies have been performed in children...

..In pediatric cardiac surgery, infection is a leading cause of morbidity and mortality. We created a model to predict risk of major infection in this population...

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..We describe center variation in delayed sternal closure after stage 1 palliation and associated outcomes...

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..Periods of highest risk may be early in the course of ERT when there is a substantial decrease in left ventricular mass and an initial decrease in ejection fraction...

..Children undergoing congenital heart surgery often receive corticosteroids with the aim of reducing the inflammatory response after cardiopulmonary bypass; however, the value of this approach is unclear...

..More importantly, our ability to combine data across trials allowed us to evaluate and potentially improve trial design...

..We sought to determine the cost of performing pediatric exclusivity trials within a single therapeutic area and the subsequent economic return to industry sponsors...

..The impact of these guidelines is unclear. We evaluated IE hospitalizations at US children's hospitals during this period...

..Short-term exposure to placebo in pediatric trials of antihypertensive medications appears to be safe...

..Limited multicenter data exist regarding the prevalence of postoperative complications after the Norwood operation and their associated mortality risk...

..The impact of this trend on patient outcomes is unclear. We evaluated postoperative outcomes associated with a CICU versus other ICU models...

..In adults with acute coronary syndrome, decreased platelet inhibition associated with concomitant use of clopidogrel and proton pump inhibitors (PPI) has been reported...

..In the infant, TP10 appears to decrease CPB-induced complement activation and protect vascular function. These results support a phase III trial of TP10 in infants requiring CPB...

..Because ectopy has been previously described in these patients, we sought to determine the prevalence and types of arrhythmias...

..New legislation may stimulate study of drugs without remaining patent life, but data on safety, long-term outcomes, and the youngest pediatric age groups are also needed for a full understanding of all issues pertinent to pediatric use...

..The celiac artery resistive index was higher in patients with the modified Blalock-Taussig shunt versus the right ventricle to pulmonary artery shunt but was not associated with measured gastrointestinal outcomes...

..The purpose of this study was to evaluate variation between centers in total hospital costs for 4 congenital heart operations of varying complexity and associated factors...

..As a result, there have been over 100 product labeling changes. The publication status of studies completed for pediatric exclusivity has not been evaluated...

..Because children appear to be more sensitive to lower doses of fosinopril than adults, starting doses for children should be < or =0.1 mg/kg...

..We sought to describe the Pediatric Advisory Committee's recommendations made in response to safety reviews informed by data from the Food and Drug Administration Adverse Event Reporting System in 67 drugs granted exclusivity...

..In adults, race-based disparity in access to cardiovascular care has been documented. Racial differences in cardiac care for children have not been evaluated previously...

..Research efforts should focus on evaluating the PK of drugs in patients on ECMO to avoid therapeutic failures or unnecessary toxicities...

..We report the first use of CMR in a feasible protocol to quantify left ventricular (LV) mass, function, and the presence of myocardial fibrosis in the Pompe population...

..We evaluated the prevalence of cardiovascular abnormalities and the efficacy and safety of enzyme replacement therapy in patients with late-onset Pompe disease...

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..Despite improvements in outcomes after completion of the Fontan circulation, long-term functional state varies. We sought to identify pre- and postoperative characteristics associated with overall function...

..These results underscore the need for larger, controlled studies employing a carefully constructed test battery capable of measuring the full scope of performance across multiple domains and a wide range of functional levels...

..9% of subjects, including penetration in five (38.46%) and silent aspiration in an additional five (38.46%). No relationship in the relative involvement of swallowing, gross motor function, and cardiac disease appeared to be present...

..To summarize major complications and outcome for patients receiving percutaneous closure of atrial septal communications...

..Given this baseline cardiac physiology, coronary perfusion pressure becomes highly sensitive to abrupt changes in diastolic blood pressure (DBP)...

..It is hoped that this article will raise awareness of the unmet need for clinical research in the cognitive and adaptive function of individuals with DS, especially children with DS...

..We evaluated the setting of published studies conducted under the US Pediatric Exclusivity Provision, which provides economic incentives to pharmaceutical companies to conduct drug studies with children...

..The objective of this study was to determine prospectively the prevalence of IE among pediatric patients with SAB in a large tertiary care center...

..Some patients develop increased left ventricular thickness by echocardiography, but the rate of increase and its significance remain unclear...

..These results suggest that these ECG parameters may be useful markers of the severity of cardiac disease and the response to ERT treatment in patients with infantile Pompe disease...

..This report describes the novel measurement of global strain, strain rate, and velocity using Velocity Vector Imaging (VVI) in a group of fetuses with and without heart disease...

..The incidence of cough in children receiving ACEis (reported cough, 3.2%) was similar to that in children receiving ARBs (reported cough, 1.8%) (P = 0.34). Reports of cough were lower in children than in adults...

..The aim of this study is to determine the level of clinical auscultation skills in pediatric residents at Duke University Medical Center...

..aureus should be considered a major criterion, regardless of whether the infection is nosocomially acquired or whether a removable source of infection is present. Positive Q-fever serology should be changed to a major criterion...

..Abnormal cerebrospinal fluid (CSF) parameters are often used to predict neonatal meningitis and determine length and type of antibiotic therapy in neonates with a positive blood culture and negative CSF culture...

..The effect of CRIM status on outcome appears to be mediated by antibody responses to the exogenous protein...

..The optimal management of Candida infective endocarditis (IE) is unknown...

..Those with intramural or single coronary arteries have significant added mortality that has persisted over time...

..Device closure of ASD results in substantial hospital-related cost savings that will be an important consideration once new devices are approved for clinical use...

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..In 300 studies, a normal diagnosis obviated further evaluation. A single ISDN line is adequate for transmission of pediatric echocardiograms and it allows for remote management of patients with CHD...

..The aim of this study was to describe exercise performance during the first 2 decades of life in Fontan survivors by a cross-sectional study and to identify factors that influence exercise performance...

..Studies have suggested that primary corticosteroid therapy might be beneficial and that adverse events are infrequent with short-term use...

..Our objective was to determine the relationship between functional outcome and abnormalities of heart rate and rhythm after the Fontan operation...

..Recent studies in an FBN1-targeted mouse model of MFS with aortic disease similar to that seen in humans showed that treatment with losartan normalized aortic root growth and aortic wall architecture...

..After the Fontan procedure, patients are at risk for suboptimal health status related to their complex healthcare experience, physiological limitations, medical complications, and guarded long-term prognosis...