Edward Levin

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Nicotine effects on learning in zebrafish: the role of dopaminergic systems
    Donnie Eddins
    Department of Psychiatry and Behavioral Sciences, Neurobehavioral Research Laboratory, Duke University Medical Center, P O Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 202:103-9. 2009
  2. ncbi request reprint Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: Significance for maternal stress and preterm labor
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA Nicholas School of the Environment, Duke University, Durham, NC, USA Electronic address
    Neurotoxicol Teratol 41:35-42. 2014
  3. pmc Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA Electronic address
    Eur J Pharmacol 718:167-72. 2013
  4. pmc Complex relationships of nicotinic receptor actions and cognitive functions
    Edward D Levin
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Box 104790 DUMC, Durham, NC 27710, USA Electronic address
    Biochem Pharmacol 86:1145-52. 2013
  5. pmc Improvement of attentional function with antagonism of nicotinic receptors in female rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences Duke University Medical Center, Durham, NC, USA
    Eur J Pharmacol 702:269-74. 2013
  6. ncbi request reprint α7-Nicotinic receptors and cognition
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Box No 104790, Duke University Medical Center, Durham, NC 27710, USA
    Curr Drug Targets 13:602-6. 2012
  7. ncbi request reprint Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:581-6. 2005
  8. ncbi request reprint Ketanserin attenuates nicotine-induced working memory improvement in rats
    Edward Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, United States
    Pharmacol Biochem Behav 82:289-92. 2005
  9. ncbi request reprint Timing of nicotine effects on learning in zebrafish
    Edward D Levin
    Neurobehavioral Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 184:547-52. 2006
  10. ncbi request reprint Persisting behavioral consequences of prenatal domoic acid exposure in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412 DUMC, Durham, NC, 27710, USA
    Neurotoxicol Teratol 27:719-25. 2005

Detail Information

Publications113 found, 100 shown here

  1. doi request reprint Nicotine effects on learning in zebrafish: the role of dopaminergic systems
    Donnie Eddins
    Department of Psychiatry and Behavioral Sciences, Neurobehavioral Research Laboratory, Duke University Medical Center, P O Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 202:103-9. 2009
    ..Nicotine improves cognitive function in a number of animal models including rats, mice, monkeys, and recently, zebrafish. The zebrafish model allows higher throughput and ease in discovering mechanisms of cognitive improvement...
  2. ncbi request reprint Prenatal dexamethasone augments the neurobehavioral teratology of chlorpyrifos: Significance for maternal stress and preterm labor
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA Nicholas School of the Environment, Duke University, Durham, NC, USA Electronic address
    Neurotoxicol Teratol 41:35-42. 2014
    ....
  3. pmc Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA Electronic address
    Eur J Pharmacol 718:167-72. 2013
    ....
  4. pmc Complex relationships of nicotinic receptor actions and cognitive functions
    Edward D Levin
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Box 104790 DUMC, Durham, NC 27710, USA Electronic address
    Biochem Pharmacol 86:1145-52. 2013
    ..The understanding of the functional neural bases of cognitive function is fundamental to the more effective development of nicotinic drugs for treating cognitive dysfunction. ..
  5. pmc Improvement of attentional function with antagonism of nicotinic receptors in female rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences Duke University Medical Center, Durham, NC, USA
    Eur J Pharmacol 702:269-74. 2013
    ..Development of drugs that provide a net decrease in nicotinic receptor activity either through antagonism or desensitization could be worth exploring for beneficial effects for treating cognitive impairments...
  6. ncbi request reprint α7-Nicotinic receptors and cognition
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Box No 104790, Duke University Medical Center, Durham, NC 27710, USA
    Curr Drug Targets 13:602-6. 2012
    ..These receptors are a promising target for development of therapeutic treatments for a variety of diseases of cognitive impairment including Alzheimer's disease, attention deficit hyperactivity disorder (ADHD) and schizophrenia...
  7. ncbi request reprint Nicotine and clozapine actions on pre-pulse inhibition deficits caused by N-methyl-D-aspartate (NMDA) glutamatergic receptor blockade
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:581-6. 2005
    ..Sensory modulation deficit, which is a syndrome of sensory over-responsiveness may also benefit from such combination therapy...
  8. ncbi request reprint Ketanserin attenuates nicotine-induced working memory improvement in rats
    Edward Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, United States
    Pharmacol Biochem Behav 82:289-92. 2005
    ..Given that many antipsychotic drugs have substantial 5-HT2 antagonist effects, these atypical antipsychotic drugs may reduce the cognitive improvements caused by nicotinic treatments...
  9. ncbi request reprint Timing of nicotine effects on learning in zebrafish
    Edward D Levin
    Neurobehavioral Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 184:547-52. 2006
    ..Recently, we have found that nicotine also improves memory in zebrafish. Nicotinic agonists are being developed as novel treatments for Alzheimer's disease and other cognitive impairments...
  10. ncbi request reprint Persisting behavioral consequences of prenatal domoic acid exposure in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412 DUMC, Durham, NC, 27710, USA
    Neurotoxicol Teratol 27:719-25. 2005
    ..This study demonstrates persisting neurobehavioral effects of acute prenatal exposure to domoic acid at doses that do not cause overt clinical signs of toxicity...
  11. pmc D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 98:210-4. 2011
    ..NMDA glutamate treatments may be particularly useful in helping lighter smokers successfully quit smoking, highlighting the need for diverse treatments for different types of smokers...
  12. doi request reprint Sazetidine-A, a selective alpha4beta2 nicotinic receptor desensitizing agent and partial agonist, reduces nicotine self-administration in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Box 104790, Duke University Medical Center Durham, NC 27710, USA
    J Pharmacol Exp Ther 332:933-9. 2010
    ..Saz-A, which is a selective alpha4beta2-desensitizing agent and partial agonist, effectively reduces nicotine self-administration. This type of treatment holds promise for a new therapy to aid smoking cessation...
  13. doi request reprint Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Box 104790, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Pharmacol 650:256-60. 2011
    ..H(1) antagonists may be a promising avenue to explore for new treatments to aid smoking cessation...
  14. pmc Early postnatal parathion exposure in rats causes sex-selective cognitive impairment and neurotransmitter defects which emerge in aging
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 208:319-27. 2010
    ..This study demonstrates the sex-selective, long-term behavioral alterations caused by otherwise nontoxic neonatal exposure to parathion, with effects increasingly expressed with aging...
  15. ncbi request reprint Extracellular superoxide dismutase (EC-SOD) quenches free radicals and attenuates age-related cognitive decline: opportunities for novel drug development in aging
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Curr Alzheimer Res 2:191-6. 2005
    ..Novel EC-SOD mimetics may be useful in attenuating aging-induced cognitive impairments and other aspects of physiological decline with aging...
  16. ncbi request reprint Fetal nicotinic overload, blunted sympathetic responsivity, and obesity
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Birth Defects Res A Clin Mol Teratol 73:481-4. 2005
  17. ncbi request reprint Olanzapine interactions with nicotine and mecamylamine in rats: effects on memory function
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 27:459-64. 2005
    ..Olanzapine caused a significant working memory impairment. Nicotine attenuated olanzapine-induced memory deficits. It may be the case that nicotinic co-treatment will be useful in addressing the cognitive impairment of schizophrenia...
  18. ncbi request reprint Genetic aspects of behavioral neurotoxicology
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States
    Neurotoxicology 30:741-53. 2009
    ..This symposium organized by Edward Levin and Annette Kirshner, brought together researchers from the laboratories of Michael Aschner, Douglas Ruden, ..
  19. ncbi request reprint Nicotinic effects on cognitive function: behavioral characterization, pharmacological specification, and anatomic localization
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 184:523-39. 2006
    ..Nicotine has been shown in a variety of studies in humans and experimental animals to improve cognitive function. Nicotinic treatments are being developed as therapeutic treatments for cognitive dysfunction...
  20. pmc Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Pharmacol 74:1182-91. 2007
    ..It is important to consider the interactions between nicotinic and antipsychotic drugs to develop the most efficacious treatment for cognitive improvement in people with schizophrenia...
  21. pmc Increased nicotine self-administration following prenatal exposure in female rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 85:669-74. 2006
    ..Our results further characterize the long-term liabilities of maternal smoking but also point to the potential liabilities of nicotine-based treatments for smoking cessation during pregnancy...
  22. ncbi request reprint Persistent neurobehavioral effects of early postnatal domoic acid exposure in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 28:673-80. 2006
    ..However, the sublethal persistent neurobehavioral toxicity appears to be less pervasive than reported effects following DA administered mid-gestation...
  23. pmc Nicotinic alpha7- or beta2-containing receptor knockout: effects on radial-arm maze learning and long-term nicotine consumption in mice
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Behav Brain Res 196:207-13. 2009
    ....
  24. ncbi request reprint Nicotinic-antipsychotic drug interactions and cognitive function
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    EXS 98:185-205. 2006
    ..Thus it appears that antipsychotic drugs with actions blocking 5HT2 receptors may limit the efficacy of nicotinic co-treatments for cognitive enhancement...
  25. ncbi request reprint The rationale for studying transmitter interactions to understand the neural bases of cognitive function
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center Durham, NC 27710, USA
    EXS 98:1-3. 2006
  26. pmc Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Pharmacol 600:93-7. 2008
    ..5-HT mechanisms play critical roles in the maintenance of nicotine self-administration. Better understanding of those roles may help lead to new 5-HT-based treatments for tobacco addiction...
  27. pmc Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:296-302. 2009
    ..Patients with hippocampal beta2-containing nicotinic receptor loss may be well treated with clozapine therapy, while those with frontal cortical beta2-containing receptor loss may have a potentiated memory impairment caused by clozapine...
  28. ncbi request reprint Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure
    Edward D Levin
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neurobiol Learn Mem 86:117-22. 2006
    ..This study showed that low doses of mecamylamine can effectively improve learning. A U-shaped dose-effect curve was documented. This suggests possible low-dose nicotinic antagonist lines of treatment for cognitive impairment...
  29. ncbi request reprint Metallothionein expression and neurocognitive function in mice
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Physiol Behav 87:513-8. 2006
    ..These results suggest that metallothioneins, through there roles in metal physiology or cellular protection, are involved in spatial learning and memory function...
  30. ncbi request reprint Effects of clozapine on memory function in the rat neonatal hippocampal lesion model of schizophrenia
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Neurobehavioral Research Laboratory, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:223-9. 2006
    ..These data show that clozapine can cause memory impairment and it potentiates rather than reverses hippocampal lesion-induced deficits. There are critical sex-related differences in these effects...
  31. pmc Clozapine treatment reverses dizocilpine-induced deficits of pre-pulse inhibition of tactile startle response
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 86:597-605. 2007
    ..This may be relevant to the action of clozapine in attenuating sensory gating deficits in schizophrenia and may point to new avenues of treatment for sensory modulation disorders in which there is excessive tactile response...
  32. ncbi request reprint Baclofen interactions with nicotine in rats: effects on memory
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 79:343-8. 2004
    ..This not only provides information concerning the neural bases of cognitive performance, it also lends insight into new combination treatments for memory impairment...
  33. ncbi request reprint Nicotinic involvement in memory function in zebrafish
    Edward D Levin
    Neurobehavioral Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Neurotoxicol Teratol 26:731-5. 2004
    ..This study shows that nicotine affects memory function in zebrafish much like in rats, mice, monkeys and humans. Now, zebrafish can be used to help understand the molecular mechanisms crucial to nicotine effects on memory...
  34. ncbi request reprint Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center Durham, Neurobehavioral Research Laboratory, Durham, NC 27710, USA
    Neurotoxicol Teratol 26:719-23. 2004
    ..The molecular mechanisms by which early developmental CPF exposure produces these behavioral impairments expressed in adulthood can now be studied in the zebrafish model...
  35. ncbi request reprint Development of nicotinic drug therapy for cognitive disorders
    E D Levin
    Department of Psychiatry and Behavioral Sciences, Neurobehavioral Research Laboratory, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Pharmacol 393:141-6. 2000
    ....
  36. ncbi request reprint Prenatal chlorpyrifos exposure in rats causes persistent behavioral alterations
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 24:733-41. 2002
    ..Additional defects may be revealed by similar strategies that subject the animals to acute challenges, thus, uncovering the adaptive mechanisms that maintain basal performance...
  37. ncbi request reprint Nicotinic receptor subtypes and cognitive function
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Neurobehavioral Research Laboratory, Box 3412, Durham, North Carolina 27710, USA
    J Neurobiol 53:633-40. 2002
    ..These studies of the neural nicotinic mechanisms underlying cognitive function are key for opening avenues for development of safe and effective nicotinic treatments for cognitive dysfunction...
  38. ncbi request reprint Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice
    Edward D Levin
    Dept of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27710, USA
    Behav Genet 32:119-25. 2002
    ..05). Enhancement of EC-SOD activity appears to improve learning and memory performance, specifically in aging mice. EC-SOD mimetic treatment during the course of aging may hold promise for aging-induced cognitive impairment...
  39. ncbi request reprint Hippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory
    E D Levin
    Department of Psychiatry and Behavioral Sciences, P O Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 109:757-65. 2002
    ..These results support the involvement of alpha 4 beta 2 and alpha 7 nicotinic receptors in the ventral hippocampus as being critical for memory function...
  40. pmc A rat model of the cognitive impairment from Pfiesteria piscicida exposure
    E D Levin
    Integrated Toxicology Program, Department of Psychiatry, Duke University Medical Center and Nicholas School of the Environment, Duke University, Durham, North Carolina 27710, USA
    Environ Health Perspect 109:757-63. 2001
    ....
  41. ncbi request reprint Persistent behavioral consequences of neonatal chlorpyrifos exposure in rats
    E D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 130:83-9. 2001
    ..Additional defects may be revealed by similar strategies that subject the animals to acute challenges, thus uncovering the adaptive mechanisms that maintain basal performance...
  42. ncbi request reprint Effects of chronic nicotine and methylphenidate in adults with attention deficit/hyperactivity disorder
    E D Levin
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Exp Clin Psychopharmacol 9:83-90. 2001
    ..Lorr, & L. F. Droppleman, 1981). This small study (40 participants) provided evidence that nicotine treatment can reduce severity of attentional deficit symptoms and produce improvement on an objective computerized attention task...
  43. ncbi request reprint The nicotinic antagonist mecamylamine preferentially inhibits cocaine vs. food self-administration in rats
    E D Levin
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Physiol Behav 71:565-70. 2000
    ..Nicotinic antagonistic treatment may be a useful new approach to treat cocaine addiction...
  44. ncbi request reprint Molecular overexpression of extracellular superoxide dismutase increases the dependency of learning and memory performance on motivational state
    E D Levin
    Department of Psychiatry, Nicholas School of the Environment Duke University, Durham, NC, USA
    Behav Genet 30:95-100. 2000
    ....
  45. ncbi request reprint Rapid neurobehavioral analysis of Pfiesteria piscicida effects in juvenile and adult rats
    E D Levin
    Department of Psychiatry, Duke University Medical Center, Duke University, Durham, NC 27710, USA
    Neurotoxicol Teratol 22:533-40. 2000
    ....
  46. ncbi request reprint AR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats
    E D Levin
    Psychiatry Department, Duke University Medical Center, Durham, North Carolina 27710, USA
    Behav Pharmacol 10:675-80. 1999
    ....
  47. ncbi request reprint Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 25:51-7. 2003
    ..The molecular mechanisms by which early developmental CPF exposure produces these behavioral impairments expressed in adulthood can now be studied in the zebrafish model...
  48. ncbi request reprint Adolescent-onset nicotine self-administration modeled in female rats
    Edward D Levin
    Neurobehavioral Research Laboratory, Department of Psychiatry, Duke University Medical Center, 341 Bell Building, Box 3412, Durham, NC 27710, USA
    Psychopharmacology (Berl) 169:141-9. 2003
    ..Although the great majority of tobacco addiction begins during adolescence, little is known about differential nicotine effects in adolescents versus adults...
  49. ncbi request reprint Nicotinic treatment for cognitive dysfunction
    E D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Curr Drug Targets CNS Neurol Disord 1:423-31. 2002
    ..Studies of the neural nicotinic mechanisms underlying cognitive function are key for opening avenues for development of safe and effective nicotinic treatments for cognitive dysfunction...
  50. pmc Attention-modulating effects of cognitive enhancers
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, NC 27710, USA
    Pharmacol Biochem Behav 99:146-54. 2011
    ..Animal models of attention can be effectively used for the development of new treatments of attentional impairment in ADHD and other syndromes in which have attentional impairments occur, such as Alzheimer's disease and schizophrenia...
  51. doi request reprint Zebrafish assessment of cognitive improvement and anxiolysis: filling the gap between in vitro and rodent models for drug development
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
    Rev Neurosci 22:75-84. 2011
    ....
  52. ncbi request reprint Neurobehavioral assessment of mice after developmental AZT exposure
    Edward D Levin
    Department of Psychiatry, Duke University Medical Center, Box 3412, Durham, NC, USA
    Neurotoxicol Teratol 26:65-71. 2004
    ....
  53. pmc Lorcaserin, a 5-HT2C agonist, decreases nicotine self-administration in female rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Pharmacol Exp Ther 338:890-6. 2011
    ..These studies support development of the 5-HT(2C) agonist lorcaserin to aid tobacco smoking cessation...
  54. ncbi request reprint Memory decline of aging reduced by extracellular superoxide dismutase overexpression
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC 27710, USA
    Behav Genet 35:447-53. 2005
    ..Enhancement of EC-SOD activity appears to improve memory performance specifically in aging mice. EC-SOD mimetic treatment during the course of aging may hold promise for aging-induced cognitive impairment...
  55. ncbi request reprint Ventral hippocampal NMDA blockade and nicotinic effects on memory function
    Edward D Levin
    Neurobehavioral Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3412, Durham, NC 27710, USA
    Brain Res Bull 61:489-95. 2003
    ..Nicotine effects on other non-NMDA hippocampal receptor systems or extra-hippocampal systems may have been left unchecked by the diminished nicotinic effect on ventral hippocampal NMDA receptors...
  56. ncbi request reprint Learning impairment caused by a toxin produced by Pfiesteria piscicida infused into the hippocampus of rats
    Edward D Levin
    Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 25:419-26. 2003
    ..This model has demonstrated the cause-and-effect relationship between exposure to a hydrophilic toxin produced by P. piscicida and learning impairment, and specifically that the ventral hippocampus was critically involved...
  57. pmc Threshold of adulthood for the onset of nicotine self-administration in male and female rats
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, United States
    Behav Brain Res 225:473-81. 2011
    ..Adolescent-onset nicotine self-administration causes persistent increases in nicotine self-administration in female rats even after they reach adulthood and disrupts control over self-administration behavior...
  58. ncbi request reprint Lobeline-induced learning improvement of rats in the radial-arm maze
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 341 Bell Building, Box 3412, Durham, NC 27710, USA
    Pharmacol Biochem Behav 76:133-9. 2003
    ..The atypical effects of lobeline may underlie its greater efficacy than nicotine for improving repeated acquisition. The effect of lobeline improving learning may be useful in the development of novel treatments for learning deficits...
  59. pmc Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 33:668-73. 2011
    ..The identification of these functional deficits in zebrafish enables further studies with this model to determine how molecular and cellular mechanisms are disturbed to arrive at this compromised state...
  60. ncbi request reprint Gestational dexamethasone treatment elicits sex-dependent alterations in locomotor activity, reward-based memory and hippocampal cholinergic function in adolescent and adult rats
    Marisa L Kreider
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:1617-23. 2005
    ....
  61. ncbi request reprint Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation
    Laura M Icenogle
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 26:95-101. 2004
    ..The resemblance of these findings to those of late gestational or neonatal CPF exposure indicates a prolonged window of vulnerability of brain development to CPF...
  62. pmc Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depression
    Justin E Aldridge
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27701, USA
    Environ Health Perspect 113:527-31. 2005
    ..Our results indicate that neonatal CPF exposures, classically thought to be subtoxic, produce lasting changes in 5HT-related behaviors that resemble animal models of depression...
  63. ncbi request reprint Nicotine interactions with haloperidol, clozapine and risperidone and working memory function in rats
    Nii Addy
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 27:534-41. 2002
    ..These studies demonstrate interactions between nicotine and antipsychotic drugs in terms of memory, which may have important impacts on the treatment of schizophrenia...
  64. doi request reprint Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function
    Reginald Cannady
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biochem Pharmacol 78:788-94. 2009
    ..Heterogeneity in response to nicotinic drugs given systemically may be due to anatomically distinct nicotinic systems in the brain and their unique roles in the neural bases of cognitive function...
  65. pmc Zebrafish provide a sensitive model of persisting neurobehavioral effects of developmental chlorpyrifos exposure: comparison with nicotine and pilocarpine effects and relationship to dopamine deficits
    Donnie Eddins
    Dept of Psychiatry and Behavioral Sciences, Duke University Medical Ctr, Durham, NC 27710, USA
    Neurotoxicol Teratol 32:99-108. 2010
    ..This may be helpful in screening for persisting neurobehavioral defects from a variety of toxicants...
  66. pmc The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish
    Zachary Bencan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Physiol Behav 95:408-12. 2008
    ..This nicotine-induced anxiolytic effect was reversed by both MLA and DHbetaE, indicating that both nicotinic alpha7 and alpha4beta2 receptors are involved in the nicotinic effect on anxiety in zebrafish...
  67. pmc Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats
    Ana Pocivavsek
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 188:597-604. 2006
    ..Nicotinic systems in the hippocampus play important roles in memory function. Decreased hippocampal nicotinic receptor concentration is associated with cognitive impairment in schizophrenia and Alzheimer's disease...
  68. pmc Persistent cognitive alterations in rats after early postnatal exposure to low doses of the organophosphate pesticide, diazinon
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neurotoxicol Teratol 30:38-45. 2008
    ..Both molecular/neurochemical and behavioral effects of developmental OP exposure have been seen at doses below those which cause appreciable cholinesterase inhibition...
  69. ncbi request reprint Chronic nicotine and dizocilpine effects on regionally specific nicotinic and NMDA glutamate receptor binding
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1041:132-42. 2005
    ..Chronic nicotine effects on receptor regulation are significantly affected by concurrent blockade of NMDA glutamate receptors...
  70. ncbi request reprint Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory
    Alexi Nott
    Department of Psychiatry and Behavioral Sciences, Neurobehavioral Research Laboratory, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1081:72-8. 2006
    ..These results confirm the importance of alpha4beta2 and alpha7 nicotinic acetylcholine receptors in the dorsal hippocampus for appetitively-motivated spatial cognitive function...
  71. ncbi request reprint Chronic transdermal nicotine patch treatment effects on cognitive performance in age-associated memory impairment
    Heidi K White
    Department of Medicine, Duke University Medical Center, Box no 3003, Durham, NC 27710, USA
    Psychopharmacology (Berl) 171:465-71. 2004
    ..The current study was performed to determine the clinical and neuropsychological effects of chronic transdermal nicotine in AAMI subjects over a 4-week period...
  72. pmc Interaction of nicotinic and histamine H(3) systems in the radial-arm maze repeated acquisition task
    Ehsan Kholdebarin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Pharmacol 569:64-9. 2007
    ..The repeated acquisition test can help differentiate acute drug effects on learning. Nicotine and thioperamide effectively reversed each other's choice accuracy impairment even though each by itself impaired accuracy...
  73. pmc Neonatal exposure to parathion alters lipid metabolism in adulthood: Interactions with dietary fat intake and implications for neurodevelopmental deficits
    T Leon Lassiter
    Department of Pharmacology, Box 3813 DUMC, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 81:85-91. 2010
    ..Our results are consistent with impaired fat utilization and prediabetes, as well as exposing a potential relationship between effects on fat metabolism and on synaptic function in the brain...
  74. pmc Mercury-induced cognitive impairment in metallothionein-1/2 null mice
    Donnie Eddins
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Neurotoxicol Teratol 30:88-95. 2008
    ..This work shows that deleting metallothioneins increase the vulnerability to developmental mercury-induced neurocognitive impairment. Metallothionein effects on monoamine transmitters may be related to this cognitive effect...
  75. pmc Histamine H1 receptor involvement in prepulse inhibition and memory function: relevance for the antipsychotic actions of clozapine
    Cindy S Roegge
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 86:686-92. 2007
    ..Pyrilamine impaired working memory but improved reference memory in rats. Thus, H(1) antagonism seems to play a role in part of the beneficial actions of antipsychotics, such as clozapine...
  76. ncbi request reprint Nicotinic mechanisms of memory: effects of acute local DHbetaE and MLA infusions in the basolateral amygdala
    Nii A Addy
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Cogn Brain Res 16:51-7. 2003
    ..Unlike in the ventral hippocampus, the addition of DHbetaE to MLA in the basolateral amygdala significantly reduced the MLA-induced working memory deficit...
  77. ncbi request reprint Chronic inhibition of alpha4beta2 nicotinic receptors in the ventral hippocampus of rats: impacts on memory and nicotine response
    David Arthur
    Neurobehavioral Research Laboratory, Box 3412, Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 160:140-5. 2002
    ..Acute ventral hippocampal infusions of dihydro-beta-erythroidine (DHbetaE), an alpha4beta2 nicotinic receptor antagonist, impaired spatial memory of rats in the radial-arm maze...
  78. ncbi request reprint Reversal of clozapine effects on working memory in rats with fimbria-fornix lesions
    Nii A Addy
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 30:1121-7. 2005
    ....
  79. ncbi request reprint NMDA systems in the amygdala and piriform cortex and nicotinic effects on memory function
    Helen May-Simera
    Neurobehavioral Research Laboratory, Department of Psychiatry, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Cogn Brain Res 17:475-83. 2003
    ..This study demonstrated the importance of NMDA glutamate systems in the amygdala for appetitively-motivated spatial memory performance...
  80. ncbi request reprint Anxiolytic effects of nicotine in zebrafish
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
    Physiol Behav 90:54-8. 2007
    ..Nicotine-induced anxiolytic effects can be modeled in the zebrafish. This preparation will help in the investigation of the molecular bases of this effect...
  81. pmc Adolescent vs. adult-onset nicotine self-administration in male rats: duration of effect and differential nicotinic receptor correlates
    Edward D Levin
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA Department of Pharmacology and Cancer Biology, Duke University Medical Center, USA
    Neurotoxicol Teratol 29:458-65. 2007
    ..Our results thus reinforce the concept that the adolescent brain is unusually receptive to the effects of nicotine in a manner that reinforces the potential for addiction...
  82. pmc Neonatal parathion exposure and interactions with a high-fat diet in adulthood: Adenylyl cyclase-mediated cell signaling in heart, liver and cerebellum
    Abayomi A Adigun
    Department of Pharmacology and Cancer Biology, Durham, NC 27710, USA
    Brain Res Bull 81:605-12. 2010
    ....
  83. pmc Hippocampal infusions of MARCKS peptides impair memory of rats on the radial-arm maze
    Olga A Timofeeva
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res 1308:147-52. 2010
    ..Our present behavioral study, together with the earlier in vitro study by Gay et al. (2008), suggests that effector domain MARCKS peptides could play a significant role in memory regulation and impairment...
  84. pmc Exposure of neonatal rats to parathion elicits sex-selective reprogramming of metabolism and alters the response to a high-fat diet in adulthood
    T Leon Lassiter
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA
    Environ Health Perspect 116:1456-62. 2008
    ..Developmental exposures to organophosphate pesticides are virtually ubiquitous. These agents are neurotoxicants, but recent evidence also points to lasting effects on metabolism...
  85. ncbi request reprint Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats
    Amir H Rezvani
    Department of Psychiatry, Duke University, Durham, NC, USA
    Alcohol Clin Exp Res 31:57-63. 2007
    ..Furthermore, unlike the benzodiazepines, JNJ-5234801 does not have an adverse interaction with ethanol even at doses 20 to 40 times the minimal effective dose in the rat elevated plus maze (MED=1.0 mg/kg, p.o.)...
  86. doi request reprint Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 92:141-6. 2009
    ..These findings further validate the operant visual signal detection task for assessing attentional impairments and their reversal...
  87. pmc Effects of sazetidine-A, a selective alpha4beta2 nicotinic acetylcholine receptor desensitizing agent on alcohol and nicotine self-administration in selectively bred alcohol-preferring (P) rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 104790, Durham, NC 27710, USA
    Psychopharmacology (Berl) 211:161-74. 2010
    ..Sazetidine-A [6-(5(((S)-azetidine-2-yl)methoxy)pyridine-3-yl)hex-5-yn-1-ol] is a novel compound that potently and selectively desensitizes alpha4beta2 nicotinic receptors with only modest receptor activation...
  88. doi request reprint Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:1030-40. 2008
    ..In conclusion, the data suggest attentional impairments with clozapine alone and no modification of this effect with nicotine or dizocilpine. Moreover, cortical low affinity nicotinic receptors may have a role in attentional functions...
  89. pmc Neonatal exposure to low doses of diazinon: long-term effects on neural cell development and acetylcholine systems
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 116:340-8. 2008
    ..The developmental neurotoxicity of organophosphate pesticides involves mechanisms other than their shared property of cholinesterase inhibition...
  90. ncbi request reprint Adolescent and adult rats respond differently to nicotine and alcohol: motor activity and body temperature
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 341 Bell Building, Box 3412, Durham, NC 27710, USA
    Int J Dev Neurosci 22:349-54. 2004
    ..These preliminary results suggest that adolescent rats may have an increased sensitivity to nicotine and alcohol, which may consequently impact their initial addiction to these two drugs...
  91. ncbi request reprint Effects of nicotine and mecamylamine on choice accuracy in an operant visual signal detection task in female rats
    Amir H Rezvani
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 164:369-75. 2002
    ..In the current study, we explored the effects of nicotine and mecamylamine using an operant visual signal detection task designed to model sustained attention processes common to rats and humans...
  92. ncbi request reprint Nicotine-antipsychotic drug interactions and attentional performance in female rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Box 3412, Duke University Medical Center, Durham, NC 27710, USA
    Eur J Pharmacol 486:175-82. 2004
    ..Chronic nicotine diminished the adverse effects of haloperidol on performance. This study establishes a paradigm to reliably determine the attentional impairment caused by antipsychotic drugs...
  93. ncbi request reprint Chronic nicotine interactions with clozapine and risperidone and attentional function in rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, 341 Bell Building, Box 3412 Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:190-7. 2006
    ..Clozapine was more detrimental than risperidone but the adverse effects of both clozapine and risperidone on attentional performance were masked in rats chronically treated with nicotine...
  94. ncbi request reprint Nicotinic-glutamatergic interactions and attentional performance on an operant visual signal detection task in female rats
    Amir H Rezvani
    Department of Psychiatry, Duke University Medical Center, 341 Bell Building, Box 3412, Durham, NC 27710, USA
    Eur J Pharmacol 465:83-90. 2003
    ..This study shows that dizocilpine reduces signal detection accuracy in a dose-dependent fashion. Nicotine can partially counteract an aspect of this reduction by reversing the dizocilpine-induced reduction of correct rejection...
  95. ncbi request reprint Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial
    F Joseph McClernon
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 189:125-33. 2006
    ..Despite established links between nicotine dependence and depression, little research has examined the effects of nicotine on depression symptoms...
  96. ncbi request reprint Nicotine-alcohol interactions and cognitive function in rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 72:865-72. 2002
    ..This interaction may be an important consideration for nicotine and ethanol coabuse and the possible therapeutic use of nicotinic drugs for memory dysfunction...
  97. ncbi request reprint Nicotine and clozapine effects on attentional performance impaired by the NMDA antagonist dizocilpine in female rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 3412, USA
    Int J Neuropsychopharmacol 11:63-70. 2008
    ....
  98. pmc Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3412, Durham, NC 27710, USA
    Alcohol Alcohol 45:219-22. 2010
    ..In this study, we tested the impact of pretreatment with alcohol on subsequent alcohol drinking in outbred Sprague-Dawley and selectively bred alcohol-preferring (P) rats...
  99. pmc Developmental neurotoxicity of low dose diazinon exposure of neonatal rats: effects on serotonin systems in adolescence and adulthood
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Bull 75:640-7. 2008
    ..The effects on 5HT circuits expand the scope of behavioral endpoints that need to be considered in evaluating the developmental neurotoxicity of organophosphates...
  100. ncbi request reprint Nicotinic-serotonergic drug interactions and attentional performance in rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 179:521-8. 2005
    ..The current study served to determine the impact of a relatively selective 5-HT2A receptor antagonist, ketanserin, on attentional function in rats and the interactions of ketanserin with nicotine administration...
  101. doi request reprint Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats
    Amir H Rezvani
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 33:269-75. 2009
    ....

Research Grants12

  1. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2003
    ..abstract_text> ..
  2. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2004
    ..abstract_text> ..
  3. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2002
    ..abstract_text> ..
  4. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2007
    ....
  5. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2006
    ....
  6. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  7. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2005
    ....
  8. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2005
    ..abstract_text> ..
  9. Adolescence: A Sensitive Period for Nicotine Addiction
    Edward Levin; Fiscal Year: 2004
    ....
  10. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  11. Behavioral Genetics and Toxic Response
    Edward Levin; Fiscal Year: 2002
    ....