Daniel Laskowitz

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Apolipoprotein E suppresses glial cell secretion of TNF alpha
    D T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    J Neuroimmunol 76:70-4. 1997
  2. ncbi request reprint Panel of biomarkers predicts stroke
    D T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 1053:30. 2005
  3. ncbi request reprint Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions
    Daniel T Laskowitz
    Duke University Medical Center, Department of Medicine Neurology, Box 2900, Durham, NC 27710, USA
    Pharmacogenomics 8:959-69. 2007
  4. pmc Neuroprotection in subarachnoid hemorrhage
    Daniel T Laskowitz
    Departments of Medicine Neurology, Duke University, Durham NC 27710, USA
    Stroke 41:S79-84. 2010
  5. doi request reprint Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study
    Daniel T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27719, USA
    Stroke 40:77-85. 2009
  6. ncbi request reprint Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease
    D T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Acta Neurol Scand Suppl 185:15-20. 2006
  7. doi request reprint Engaging students in dedicated research and scholarship during medical school: the long-term experiences at Duke and Stanford
    Daniel T Laskowitz
    Department of Medicine Neurology, Third Year Committee, Duke University School of Medicine, Durham, North Carolina, USA
    Acad Med 85:419-28. 2010
  8. doi request reprint Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic
    Daniel T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurotrauma 27:1983-95. 2010
  9. ncbi request reprint Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
    Haichen Wang
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 206:59-69. 2007
  10. ncbi request reprint COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury
    Daniel T Laskowitz
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Neurotrauma 24:1093-107. 2007

Research Grants

  1. APOLIPOPROTEIN E EFFECT ON THE CNS IMMUNE RESPONSE
    Daniel Laskowitz; Fiscal Year: 2002
  2. MICROGLIAL NEURON SPECIFIC TOXIN
    Daniel Laskowitz; Fiscal Year: 2003
  3. ApoE-mimetic peptides protect against brain injury
    Daniel Laskowitz; Fiscal Year: 2004

Detail Information

Publications62

  1. ncbi request reprint Apolipoprotein E suppresses glial cell secretion of TNF alpha
    D T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    J Neuroimmunol 76:70-4. 1997
    ..This effect is independent of any direct effect of apoE on cell viability and is greatest when apoE is preincubated with the cell culture for 24 h...
  2. ncbi request reprint Panel of biomarkers predicts stroke
    D T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 1053:30. 2005
  3. ncbi request reprint Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions
    Daniel T Laskowitz
    Duke University Medical Center, Department of Medicine Neurology, Box 2900, Durham, NC 27710, USA
    Pharmacogenomics 8:959-69. 2007
    ..A more complete understanding of the role that apoE plays in the injured brain has led to novel therapeutic strategies for both acute and chronic neurological disease...
  4. pmc Neuroprotection in subarachnoid hemorrhage
    Daniel T Laskowitz
    Departments of Medicine Neurology, Duke University, Durham NC 27710, USA
    Stroke 41:S79-84. 2010
    ..Our evolving understanding of the pathophysiology of delayed cerebral ischemia may offer the opportunity to test new therapeutic strategies in this area and improve clinical trial design...
  5. doi request reprint Clinical usefulness of a biomarker-based diagnostic test for acute stroke: the Biomarker Rapid Assessment in Ischemic Injury (BRAIN) study
    Daniel T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27719, USA
    Stroke 40:77-85. 2009
    ....
  6. ncbi request reprint Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease
    D T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Acta Neurol Scand Suppl 185:15-20. 2006
    ..Thus, the development of apoE-derived peptides represent a novel therapeutic strategy for the treatment of acute and chronic neurological disease...
  7. doi request reprint Engaging students in dedicated research and scholarship during medical school: the long-term experiences at Duke and Stanford
    Daniel T Laskowitz
    Department of Medicine Neurology, Third Year Committee, Duke University School of Medicine, Durham, North Carolina, USA
    Acad Med 85:419-28. 2010
    ..The authors discuss the histories, evolution, logistics, and ongoing challenges of the research programs at Duke University SOM and Stanford University SOM...
  8. doi request reprint Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic
    Daniel T Laskowitz
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurotrauma 27:1983-95. 2010
    ..These results demonstrate that TBI accelerates the cardinal neuropathological features of neurodegenerative disease, and establishes the potential for apoE mimetic therapies in reducing pathology associated with neurodegeneration...
  9. ncbi request reprint Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
    Haichen Wang
    Department of Medicine, Division of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 206:59-69. 2007
    ..Furthermore, statin treatment improved cerebral hemodynamics following head injury. Thus, the administration of statins may represent a viable therapeutic strategy in the acute treatment of closed head injury...
  10. ncbi request reprint COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury
    Daniel T Laskowitz
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    J Neurotrauma 24:1093-107. 2007
    ..This represents a novel therapeutic strategy in the treatment of TBI...
  11. ncbi request reprint Novel diagnostic test for acute stroke
    John R Lynch
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 35:57-63. 2004
    ..The objective of this study was to examine the feasibility of developing a diagnostic panel of blood-borne biochemical markers of cerebral ischemia...
  12. doi request reprint Simvastatin treatment duration and cognitive preservation in experimental subarachnoid hemorrhage
    Ken Takata
    Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    J Neurosurg Anesthesiol 21:326-33. 2009
    ..However, treatment had to be extended beyond 2 weeks, the traditional risk period for angiographic vasospasm, to improve long-term outcome...
  13. pmc Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury
    David L McDonagh
    Department of Anesthesiology and Medicine, Division of Cardiothoracic Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Anesthesiology 112:852-9. 2010
    ..Identified risk factors are largely limited to demographic characteristics. We hypothesized that POCD was associated with apolipoprotein E4 (APOE4) genotype and plasma biomarkers of brain injury and inflammation...
  14. ncbi request reprint A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage
    Junling Gao
    Multidisciplinary Neuroprotection Laboratories, Durham, NC, USA
    Neurocrit Care 4:25-31. 2006
    ..We then test the hypothesis that an apoE-derived therapeutic peptide reduces vasospasm and improves functional recovery after SAH...
  15. ncbi request reprint Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage
    Haichen Wang
    Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neurocrit Care 5:71-8. 2006
    ..In the current study, we test the hypothesis that levetiracetam, an anticonvulsant with favorable interaction and adverse event profiles, is neuroprotective in clinically relevant models of SAH and closed head injury (CHI)...
  16. ncbi request reprint Early biomarkers of stroke
    Mark A Reynolds
    Biosite Incorporated, 11030 Roselle St, San Diego, CA 92121 Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Clin Chem 49:1733-9. 2003
    ..The ability to correlate blood-borne protein biomarkers with stroke phenotypes would aid in the development of such rapid tests...
  17. ncbi request reprint Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema
    John R Lynch
    Multidisciplinary Neuroprotection Laboratory, Duke University Medical Center, Durham, NC 27710, USA
    Ann Neurol 51:113-7. 2002
    ..Thus, modulation of the endogenous central nervous system inflammatory response may be one mechanism by which apolipoprotein E affects outcome following acute brain injury...
  18. ncbi request reprint APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response
    John R Lynch
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 278:48529-33. 2003
    ....
  19. ncbi request reprint Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage
    Matthew J McGirt
    Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Duke University School of Medicine Duke University Medical Center, Durham, NC, USA
    Stroke 33:2950-6. 2002
    ..Simvastatin increases eNOS activity. We hypothesized that simvastatin would increase eNOS protein and ameliorate SAH-induced cerebral vasospasm...
  20. ncbi request reprint Mouse model of subarachnoid hemorrhage associated cerebral vasospasm: methodological analysis
    Augusto Parra
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurol Res 24:510-6. 2002
    ..This allows measurement of both anatomical and clinical DCV in the mouse...
  21. ncbi request reprint Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage
    Rachel G Mesis
    Multidisciplinary Neuroprotection Laboratories and the Department of Medicine Neurology, Duke University Medical Center and Duke University School of Medicine, Durham, North Carolina, USA
    Neurosurg Focus 21:E4. 2006
    ..The effects of carboxyamidotriazole (CAI), a non-voltage-gated calcium channel blocker, were explored using the same animal paradigm...
  22. pmc Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:953-9. 2008
    ..To assess genetic variability in two serotonin-related gene polymorphisms (MAOA-uVNTR and 5HTTLPR) and their relationships to depression and adverse cardiac events in a sample of patients undergoing coronary artery bypass surgery...
  23. ncbi request reprint Central nervous system injury associated with cardiac surgery
    Mark F Newman
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 277110, USA
    Lancet 368:694-703. 2006
    ..We describe these issues and the controversies that merit continued investigation...
  24. pmc S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage
    Michael L James
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Biomarkers 14:388-94. 2009
    ..To determine the predictive value of S100b and brain natriuretic peptide (BNP) in order to determine accurately and quickly a discharge prognosis after primary supratentorial intracerebral haemorrhage (ICH)...
  25. pmc Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans
    Michael L James
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Stroke Cerebrovasc Dis 18:144-9. 2009
    ....
  26. pmc Randomized, double-blinded, placebo controlled study of neuroprotection with lidocaine in cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:880-7. 2009
    ..Based on experimental and clinical evidence, this study assessed the potential of intravenously administered lidocaine to reduce postoperative cognitive dysfunction after cardiac surgery using cardiopulmonary bypass...
  27. pmc Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage
    Michael L James
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 40:632-9. 2009
    ..The purpose of the study was to evaluate the effect of APOE genotype and the feasibility of administering an apolipoprotein E-mimetic therapeutic to modify outcomes in a murine model of intracerebral hemorrhage...
  28. doi request reprint The ultrasound brain helmet: feasibility study of multiple simultaneous 3D scans of cerebral vasculature
    Stephen W Smith
    Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA
    Ultrasound Med Biol 35:329-38. 2009
    ..We are motivated by the urgency for rapid diagnosis of stroke due to the short time window of effective therapeutic intervention...
  29. ncbi request reprint Preclinical models of intracerebral hemorrhage: a translational perspective
    Michael Lucas James
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    Neurocrit Care 9:139-52. 2008
    ..In particular, transgenic rodent models may be helpful in addressing genetic influences on recovery from ICH...
  30. pmc Real-time 3-D contrast-enhanced transcranial ultrasound and aberration correction
    Nikolas M Ivancevich
    Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA
    Ultrasound Med Biol 34:1387-95. 2008
    ..These preliminary results suggest that RT3D CE transcranial US and RT3D CE transcranial US with phase aberration correction have the potential to greatly impact the field of neurosonology...
  31. doi request reprint Clinical application of blood biomarkers in cerebrovascular disease
    Nada El Husseini
    Department of Medicine Neurology, Box 2900, Duke University School of Medicine, Durham, NC 27710, USA
    Expert Rev Neurother 10:189-203. 2010
    ..This review describes the most promising biomarkers of cerebrovascular disease and the context and limitations in which they have been studied...
  32. ncbi request reprint Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis
    Feng Qiao Li
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Pharmacol Exp Ther 318:956-65. 2006
    ....
  33. ncbi request reprint Association of neurocognitive function and quality of life 1 year after coronary artery bypass graft (CABG) surgery
    Barbara Phillips-Bute
    Department of Anesthesiology, Box 3094, DUMC, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 68:369-75. 2006
    ..We sought to determine the impact of this postoperative cognitive dysfunction on quality of life (QOL) and to characterize the dysfunction from the patient's perspective...
  34. ncbi request reprint A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury
    John R Lynch
    The Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 192:109-16. 2005
    ..The development of an apoE-based intervention represents a novel therapeutic strategy in the management of acute brain injury...
  35. ncbi request reprint Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage
    Matthew J McGirt
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosurg 98:1222-6. 2003
    ..The goal of this study was to assess whether clinical, radiographic, or serological variables could be used to identify patients at an increased risk for cerebral vasospasm...
  36. doi request reprint Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice
    Michael L James
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurotrauma 27:217-28. 2010
    ..hBNP improves neurological function in murine models of TBI and ICH, and was associated with enhanced CBF and downregulation of neuroinflammatory responses. hBNP may represent a novel therapeutic strategy after acute CNS injury...
  37. ncbi request reprint Simvastatin reduces vasospasm after aneurysmal subarachnoid hemorrhage: results of a pilot randomized clinical trial
    John R Lynch
    Departments of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 36:2024-6. 2005
    ..Cerebral vasospasm remains a major source of morbidity after aneurysmal subarachnoid hemorrhage (SAH). We demonstrate that simvastatin reduces serum markers of brain injury and attenuates vasospasm after SAH...
  38. ncbi request reprint Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients
    Lian K Ti
    Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Thorac Cardiovasc Surg 125:211-3. 2003
  39. ncbi request reprint Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass
    Joseph P Mathew
    Division of Cardiothoracic Anesthesiology and Critical Care Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiothorac Vasc Anesth 19:294-9. 2005
    ....
  40. ncbi request reprint Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury
    Jessica D McAdoo
    Neonatal Perinatal Research Institute, Duke University Medical Center, Box 2900, Durham, NC 27710, USA
    Neurosci Lett 381:305-8. 2005
    ..These results suggest that administration of an apoE-derived therapeutic peptide represents a novel therapeutic strategy in the clinical setting of perinatal hypoxic-ischemic injury...
  41. ncbi request reprint APOE polymorphism is associated with risk of severe sepsis in surgical patients
    Eugene W Moretti
    Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA
    Crit Care Med 33:2521-6. 2005
    ..To test for an association between apolipoprotein E (APOE) genotypes and the occurrence of severe sepsis in an elective surgical cohort...
  42. ncbi request reprint Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model
    Stephen B Leinenweber
    Department of Pediatrics, Duke University Medical Center, Durham NC 27710, USA
    Eur J Pharmacol 531:126-32. 2006
    ..Closed head injury altered performance in both tests. No statistically significant effect of MnTE-2-PyP5+ was observed. We conclude that single dose MnTE-2-PyP5+ does not alter outcome in this mouse closed head injury model...
  43. ncbi request reprint Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase
    Matthew J McGirt
    Duke University School of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Stroke 33:2317-23. 2002
    ..We examined whether overexpression of murine extracellular superoxide dismutase (EC-SOD) alters SAH-induced cerebral vasospasm, oxidative stress, and neurological outcome...
  44. ncbi request reprint Apolipoprotein E protects against NMDA excitotoxicity
    Mitsuo Aono
    Multidisciplinary Neuroprotection Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurobiol Dis 11:214-20. 2002
    ..These results suggest that one mechanism by which apolipoprotein E modifies the central nervous system response to ischemia may be by reducing glutamate-induced excitotoxicity...
  45. ncbi request reprint Apolipoprotein E isoform mediated regulation of nitric oxide release
    Candice M Brown
    University Program in Genetics, Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 32:1071-5. 2002
    ..These data suggest a potentially novel mechanism for gender-dependent and apoE isoform-dependent immune responses that parallel the genetic susceptibility of APOE4 carriers for the development of Alzheimer's disease...
  46. ncbi request reprint The impact of postoperative atrial fibrillation on neurocognitive outcome after coronary artery bypass graft surgery
    Timothy O Stanley
    Departments of Anesthesiology, Psychiatry and Behavioral Sciences, Medicine Neurology, and Surgery, Duke University Medical Center, Durham, North Carolina
    Anesth Analg 94:290-5, table of contents. 2002
    ..Atrial fibrillation was associated with poorer cognitive function 6 wk after surgery. Although the mechanism of this association is yet to be determined, prevention of atrial fibrillation may result in improved neurocognitive function...
  47. doi request reprint Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives
    Ken Takata
    Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Exp Neurol 213:336-44. 2008
    ....
  48. ncbi request reprint Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity
    Yoonki Lee
    Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Neurochem Int 44:107-18. 2004
    ..Taken together, these findings suggest that ApoE protects mixed neuronal-glial cell cultures against irreversible oxidative injury from H2O2 by reducing secondary glutamate excitotoxicity...
  49. ncbi request reprint Serum von Willebrand factor, matrix metalloproteinase-9, and vascular endothelial growth factor levels predict the onset of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
    Matthew J McGirt
    Multidisciplinary Neuroprotection Laboratory, Medical Center, Duke University School of Medicine, Durham, NC 27710, USA
    Neurosurgery 51:1128-34; discussion 1134-5. 2002
    ..We hypothesized that serum von Willebrand factor (vWF) (a marker of endothelial cell death), MMP-9, and VEGF levels could serve as prognostic markers in predicting the occurrence of cerebral vasospasm...
  50. ncbi request reprint Differential cerebral gene expression during cardiopulmonary bypass in the rat: evidence for apoptosis?
    Yukie Sato
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Anesth Analg 94:1389-94, table of contents. 2002
    ....
  51. doi request reprint Statins in traumatic brain injury
    Elissa F Wible
    Department of Medicine Neurology, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Neurotherapeutics 7:62-73. 2010
    ..Statins are currently positioned to be translated into clinical trials in acute brain injury and have the potential to improve outcomes after TBI...
  52. ncbi request reprint Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway
    Brian E Mace
    Department of Medicine Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Neurol Res 29:243-50. 2007
    ..These results suggest that apoE modifies secondary neuronal injury caused by histamine release and are consistent with previous observations that apoE affects the CNS inflammatory response in an isoform-specific manner...
  53. ncbi request reprint Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase
    Matthew J McGirt
    Department of Neurosurgery, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Clin Neurosurg 52:371-8. 2005
  54. ncbi request reprint Risk of cerebral vasopasm after subarachnoid hemorrhage reduced by statin therapy: A multivariate analysis of an institutional experience
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    J Neurosurg 105:671-4. 2006
    ..The authors hypothesized that patients chronically treated with statins would have a decreased risk of symptomatic vasospasm after SAH...
  55. ncbi request reprint Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients
    E Wesley Ely
    Department of Medicine, Saint Thomas Hospital, and Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Crit Care Med 35:112-7. 2007
    ..To test for an association between apolipoprotein E (APOE) genotypes and duration of intensive care unit delirium...
  56. ncbi request reprint Synthes Award for Resident Research in Spinal Cord & Spinal Column Injury: Statins for the treatment of neurological injury: a role beyond cholesterol lowering
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Clin Neurosurg 51:320-8. 2004
  57. ncbi request reprint Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery
    Joseph P Mathew
    Department of Anesthesiology
    Stroke 34:508-13. 2003
    ..We therefore sought to determine the association of decreased EndoCAb and the incidence of postoperative cognitive decline...
  58. ncbi request reprint Statins in acute brain injury: getting the cart before the horse
    Daniel T Laskowitz
    Neurocrit Care 8:3-5. 2008
  59. ncbi request reprint Correlation of serum brain natriuretic peptide with hyponatremia and delayed ischemic neurological deficits after subarachnoid hemorrhage
    Matthew J McGirt
    Department of Neurosurgery, The Johns Hopkins Hospital, Baltimore, Maryland, USA
    Neurosurgery 54:1369-73; discussion 1373-4. 2004
    ..We examined the temporal relationship between serum BNP elevation, hyponatremia, and the onset of delayed ischemic neurological deficits and determined whether serum BNP levels correlated with the 2-week outcome after SAH...
  60. ncbi request reprint Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation
    Yoshinori Higuchi
    Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA
    J Radiat Res 43:S219-24. 2002
    ..In the present studies, we have investigated whether apoE affects the behavioral toxicity of high charge, high energy (HZE) particle radiation...
  61. ncbi request reprint Changing outcome from aneurysmal subarachnoid hemorrhage: another step closer
    David S Warner
    Anesthesiology 104:629-30. 2006
  62. doi request reprint The use of S100B as a biomarker in subarachnoid hemorrhage: clarity in its promise and limits
    Daniel T Laskowitz
    Crit Care Med 36:2452-3. 2008

Research Grants8

  1. APOLIPOPROTEIN E EFFECT ON THE CNS IMMUNE RESPONSE
    Daniel Laskowitz; Fiscal Year: 2002
    ..abstract_text> ..
  2. MICROGLIAL NEURON SPECIFIC TOXIN
    Daniel Laskowitz; Fiscal Year: 2003
    ..Conversely, drugs that show promise against AD and PD will be examined in this model system to see if they inhibit the production or action of the neuron- specific toxin. ..
  3. ApoE-mimetic peptides protect against brain injury
    Daniel Laskowitz; Fiscal Year: 2004
    ..We will use this system to investigate possible pharmacogenomic interactions between the therapeutic apoE peptide and the humanized apoE background in the targeted replacement mice. ..