Alexander M Kulminski

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data
    Alexander Kulminski
    Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC 27708, USA
    Mech Ageing Dev 127:840-8. 2006
  2. pmc An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey
    Alexander M Kulminski
    Department of Sociology, Duke University, Durham, North Carolina, USA
    Rejuvenation Res 11:251-7. 2008
  3. pmc Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample
    Alexander Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Trent Hall, Room 002, Durham, NC 27708, USA
    Age Ageing 37:288-93. 2008
  4. pmc Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    J Am Geriatr Soc 56:898-903. 2008
  5. pmc Unraveling genetic origin of aging-related traits: evolving concepts
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 16:304-12. 2013
  6. pmc The role of lipid-related genes, aging-related processes, and environment in healthspan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708, USA
    Aging Cell 12:237-46. 2013
  7. pmc Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Box 90408, Trent Hall, Room 002, Durham, NC 27708, USA
    J Gerontol A Biol Sci Med Sci 68:760-8. 2013
  8. pmc Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 16:28-34. 2013
  9. pmc Genomics of human health and aging
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Box 90408, Trent Hall, Room 002, Durham, NC 27708, USA
    Age (Dordr) 35:455-69. 2013
  10. pmc Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 132:195-201. 2011

Detail Information

Publications41

  1. pmc Accumulation of health disorders as a systemic measure of aging: Findings from the NLTCS data
    Alexander Kulminski
    Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC 27708, USA
    Mech Ageing Dev 127:840-8. 2006
    ..In this study we provide further support toward this view focusing on the analysis of the FI age patterns in the participants of the National Long Term Care Survey (NLTCS)...
  2. pmc An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey
    Alexander M Kulminski
    Department of Sociology, Duke University, Durham, North Carolina, USA
    Rejuvenation Res 11:251-7. 2008
    ....
  3. pmc Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample
    Alexander Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Trent Hall, Room 002, Durham, NC 27708, USA
    Age Ageing 37:288-93. 2008
    ..early studies reported controversial findings on association of apolipoprotein E (APOE) polymorphism with disability...
  4. pmc Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    J Am Geriatr Soc 56:898-903. 2008
    ..To compare how well frailty measures based on a phenotypic frailty approach proposed in the Cardiovascular Health Study (CHS) and a cumulative deficits approach predict mortality...
  5. pmc Unraveling genetic origin of aging-related traits: evolving concepts
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 16:304-12. 2013
    ..Investigation of mechanisms will help determine conditions that activate specific genetic variants or profiles and explore to what extent these conditions that shape genetic effects are conserved across human lives and generations...
  6. pmc The role of lipid-related genes, aging-related processes, and environment in healthspan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708, USA
    Aging Cell 12:237-46. 2013
    ..The results suggest that aging-related processes in changing environments may play key roles in the genetics of healthspan. Detailed systemic integrative analyses may substantially advance the progress...
  7. pmc Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Box 90408, Trent Hall, Room 002, Durham, NC 27708, USA
    J Gerontol A Biol Sci Med Sci 68:760-8. 2013
    ..The results suggest that the role of aging-related processes in changing environment may be conceptually underestimated in current genetic association studies using genome wide resources...
  8. pmc Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 16:28-34. 2013
    ..The puzzling complexity of genetic mechanisms working in different genders, ages, and environments calls for more detail and systemic analyses beyond those adapted in current large-scale genetic association studies...
  9. pmc Genomics of human health and aging
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Box 90408, Trent Hall, Room 002, Durham, NC 27708, USA
    Age (Dordr) 35:455-69. 2013
    ..These results document challenging role of gene networks in regulating human health and aging and call for broadening focus on genomics of such phenotypes...
  10. pmc Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 132:195-201. 2011
    ..This study highlights importance of aggregated approaches to better understand systemic mechanisms of health deterioration in long-living individuals...
  11. pmc Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Durham, NC 27708, USA
    Exp Gerontol 43:1052-7. 2008
    ..The time-trends suggest the presence of a strong exogenous effect modifier affecting the rate of health deterioration and mortality risk...
  12. pmc Cumulative deficits and physiological indices as predictors of mortality and long life
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Durham, NC 27708, USA
    J Gerontol A Biol Sci Med Sci 63:1053-9. 2008
    ..The DI appears to be a more important determinant of long-term risks of death and longevity than are the physiological indices...
  13. pmc Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Aging Cell 10:533-41. 2011
    ..Deeper insights into biological mechanisms mediating gene action are critical for understanding the genetic regulation of a healthy lifespan and for personalizing medical care...
  14. pmc Health-related phenotypes and longevity in danish twins
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Durham, North Carolina 27708, USA
    J Gerontol A Biol Sci Med Sci 64:1-8. 2009
    ..The cumulative-trait approach is more promising for such studies compared with the individual-trait approach. Heritable health dimensions contributing to a decrease of life span have sex-insensitive and sex-specific components...
  15. pmc Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute and Department of Sociology, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 13:13-21. 2010
    ..Multimarker genetic analyses should benefit studies of complex aging-associated phenotypes...
  16. doi request reprint Complex phenotypes and phenomenon of genome-wide inter-chromosomal linkage disequilibrium in the human genome
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, NC 27708, USA
    Exp Gerontol 46:979-86. 2011
    ..This phenomenon can challenge our understanding of the role of genes and gene networks in regulating complex, polygenic phenotypes in humans...
  17. pmc Cumulative index of health disorders as an indicator of aging-associated processes in the elderly: results from analyses of the National Long Term Care Survey
    A Kulminski
    Center for Demographic Studies, Duke University, 2117 Campus Drive, Box 90408, Durham, NC 27708, United States
    Mech Ageing Dev 128:250-8. 2007
    ....
  18. pmc Cumulative index of health deficiencies as a characteristic of long life
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, and Department of Sociology, Duke University, Durham, NC 27708, USA
    J Am Geriatr Soc 55:935-40. 2007
    ....
  19. pmc Accelerated accumulation of health deficits as a characteristic of aging
    Alexander Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Trent Drive, Box 90408, Durham, NC 27708, USA
    Exp Gerontol 42:963-70. 2007
    ..Longitudinal analysis provides strong evidence that the cumulative index of health/well-being deficits can characterize aging-associated processes in humans and predict death better than chronological age during short-term periods...
  20. ncbi request reprint Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals
    Alexander M Kulminski
    Department of Sociology, Center for Population Health and Aging, Population Research Institute, Duke University, Durham, North Carolina 27708, USA
    J Am Geriatr Soc 56:105-10. 2008
    ..To investigate the relationship between body mass index (BMI) and 9-year mortality in older (> or = 65) Americans with and without disability...
  21. pmc Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Trent Drive, Box 90408, Durham, NC 27708, USA
    J Am Geriatr Soc 56:478-83. 2008
    ....
  22. pmc Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Department of Sociology, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708, USA
    Exp Gerontol 44:718-26. 2009
    ..We present evidence for the presence of two frailty-sensitive weakly interacting mechanisms of longevity in female flies associated with differences in predisposed fitness...
  23. ncbi request reprint Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Durham, North Carolina, United States of America Institute for Genome Science and Policy, Duke University, Durham, North Carolina, United States of America Social Science Research Institute, Duke University, Durham, North Carolina, United States of America
    PLoS Genet 10:e1004141. 2014
    ..The analyses suggest the existence of age- and gender-sensitive systemic mechanisms linking the e4 allele to lifespan which can non-additively interfere with cancer-related mechanisms...
  24. pmc Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, Durham, NC 27708, USA
    Mech Ageing Dev 131:338-45. 2010
    ..The ADRB2 gene can play an important systemic role in healthy aging in evolutionary context that warrants exploration in other populations...
  25. pmc Age trajectories of physiological indices in relation to healthy life course
    Konstantin G Arbeev
    Centre for Population Health and Aging, Duke University, Department of Sociology, Durham, NC 27708 0408, USA
    Mech Ageing Dev 132:93-102. 2011
    ....
  26. pmc Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data
    Konstantin G Arbeev
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708 0408, USA
    J Theor Biol 258:103-11. 2009
    ..Simulation studies illustrate the increase in the accuracy in different scenarios for datasets structurally similar to the Framingham Heart Study. Possible applications of the model and its further generalizations are discussed...
  27. pmc Maintaining physiological state for exceptional survival: What is the normal level of blood glucose and does it change with age?
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 130:611-8. 2009
    ..The results show that analyzing longitudinal data using advanced methods may substantially increase our knowledge on factors and mechanisms responsible for aging-related changes in humans...
  28. pmc Evaluation of genotype-specific survival using joint analysis of genetic and non-genetic subsamples of longitudinal data
    Konstantin G Arbeev
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Biogerontology 12:157-66. 2011
    ....
  29. pmc Inter-chromosomal level of genome organization and longevity-related phenotypes in humans
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University, Box 90408, Trent Hall, Room 002, Durham, NC 27708, USA
    Age (Dordr) 35:501-18. 2013
    ..Our results suggest the presence of inter-chromosomal level of functional organization in the human genome and highlight a challenging problem of genomics of human health and aging...
  30. pmc Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits
    Alexander M Kulminski
    Center for Population Health and Aging, Duke University Population Research Institute, and Department of Sociology, Duke University
    Ann Epidemiol 18:696-701. 2008
    ..Health of the general population is improving along a number of major health dimensions. Using a cumulative deficits approach, we investigated whether such improvements were evident at the level of minor health traits...
  31. ncbi request reprint Cumulative index of elderly disorders and its dynamic contribution to mortality and longevity
    Anatoli I Yashin
    Sociology Department, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 10:75-86. 2007
    ..This suggests increasing the role of senescence per se in the increasing risk of death with age compared to the role of specific pathology...
  32. pmc Model of hidden heterogeneity in longitudinal data
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Trent Hall, Room 002, Box 90408, Durham, NC 27708 0408, USA
    Theor Popul Biol 73:1-10. 2008
    ..Simulation experiments confirm identifiability of model's parameters...
  33. ncbi request reprint ROS effects on neurodegeneration in Alzheimer's disease and related disorders: on environmental stresses of ionizing radiation
    Kenneth G Manton
    Center for Demographic Studies Duke University 2117 Campus Drive Durham, NC 27708, USA
    Curr Alzheimer Res 1:277-93. 2004
    ..After reviewing human population evidence, we propose a model of neurodegeneration based upon the complexity of CNS functions...
  34. pmc Trade-offs between cancer and other diseases: do they exist and influence longevity?
    Svetlana V Ukraintseva
    Center for Population Health and Aging, Duke University, Durham, North Carolina 27708, USA
    Rejuvenation Res 13:387-96. 2010
    ..We discuss factors modulating the potential trade-offs between major disorders in populations, e.g., disease treatments. Further study is needed to clarify possible impact of such trade-offs on longevity...
  35. pmc What age trajectories of cumulative deficits and medical costs tell us about individual aging and mortality risk: Findings from the NLTCS-Medicare data
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 129:191-200. 2008
    ..We found that males show a faster decline in stress resistance with age than females...
  36. pmc Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Mech Ageing Dev 130:98-104. 2009
    ..Possible mechanisms of the observed dependencies and emerging perspectives of using dependent competing risks models for evaluating the effects of reduction of mortality from cancer on life expectancy are discussed...
  37. pmc "Predicting" parental longevity from offspring endophenotypes: data from the Long Life Family Study (LLFS)
    Anatoli I Yashin
    Duke University, Center for Population Health and Aging, Durham, NC 27708 0408, USA
    Mech Ageing Dev 131:215-22. 2010
    ..We conclude that the study of endophenotypes within families is a valid approach to the genetics of human longevity...
  38. pmc Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data
    Anatoli I Yashin
    Center for Population Health and Aging, Duke University, Durham, NC 27708 0408, USA
    Biogerontology 11:257-65. 2010
    ..We concluded that individuals whose age trajectories of BG are located around the curve minimizing chances of premature death at each given age have highest chances of reaching exceptional longevity...
  39. pmc Trends in survival and recovery from stroke: evidence from the national long-term care survey/medicare data
    Anatoli Yashin
    ScD, Center for Population Health and Aging, Duke University, Box 90408, Durham, NC 27708 0408
    Stroke 41:563-5. 2010
    ..CONCLUSIONS: Time trends in recovery rate from stroke exist and can be detected from available data. The roles of influential factors and causes of sex difference in recovery improvement deserve further studies...
  40. pmc Studying health histories of cancer: a new model connecting cancer incidence and survival
    Anatoli I Yashin
    Department of Sociology, Duke University, 002 Trent Hall, Box 90408 Durham, NC 27708 0408, USA
    Math Biosci 218:88-97. 2009
    ..Further developments of this model are discussed...
  41. ncbi request reprint The apolipoprotein E epsilon2 allele and aging-associated health deterioration in older males
    Alexander M Kulminski
    J Am Geriatr Soc 55:1479-80. 2007