C M Kuhn

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Anabolic steroids
    Cynthia M Kuhn
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 57:411-34. 2002
  2. pmc The emergence of gonadal hormone influences on dopaminergic function during puberty
    Cynthia Kuhn
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Horm Behav 58:122-37. 2010
  3. ncbi request reprint Sex, steroids, and stimulant sensitivity
    C M Kuhn
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 937:188-201. 2001
  4. pmc Oestrogen receptors enhance dopamine neurone survival in rat midbrain
    M L Johnson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    J Neuroendocrinol 22:226-37. 2010
  5. pmc Androgen decreases dopamine neurone survival in rat midbrain
    M L Johnson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    J Neuroendocrinol 22:238-47. 2010
  6. ncbi request reprint Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats
    Q David Walker
    Department of Pharmacology and Integrated Program in Toxicology, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 189:435-45. 2007
  7. ncbi request reprint Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy
    Q D Walker
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 25:118-30. 2001
  8. ncbi request reprint Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo-pituitary-adrenal axis by cocaine
    Q D Walker
    Department of Pharmacology, 401 Bryan Research Building, Duke University Medical Center, Durham, NC 27710, USA
    J Pharmacol Exp Ther 297:291-8. 2001
  9. pmc Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
    Pharmacol Biochem Behav 91:398-408. 2009
  10. ncbi request reprint Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100B Research Park Bldg 2, P O Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 191:867-77. 2007

Research Grants

  1. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia Kuhn; Fiscal Year: 2005
  2. GHB Tolerance and Dependence
    Cynthia Kuhn; Fiscal Year: 2006
  3. PHARMACOLOGICAL SCIENCES TRAINING GRANT
    Cynthia Kuhn; Fiscal Year: 2007
  4. Dopamine Function During Adolescence
    Cynthia Kuhn; Fiscal Year: 2007
  5. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia Kuhn; Fiscal Year: 2001
  6. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2010

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Anabolic steroids
    Cynthia M Kuhn
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Recent Prog Horm Res 57:411-34. 2002
    ..The terms anabolic/androgenic steroids will be used throughout to reflect the combined actions of all drugs that are currently available...
  2. pmc The emergence of gonadal hormone influences on dopaminergic function during puberty
    Cynthia Kuhn
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Horm Behav 58:122-37. 2010
    ....
  3. ncbi request reprint Sex, steroids, and stimulant sensitivity
    C M Kuhn
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann N Y Acad Sci 937:188-201. 2001
    ..These findings suggest that both the activational and organizational effects of gonadal steroids contribute to the greater response of females to cocaine...
  4. pmc Oestrogen receptors enhance dopamine neurone survival in rat midbrain
    M L Johnson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    J Neuroendocrinol 22:226-37. 2010
    ..These findings suggest that, although both ER subtypes play a role in the maintenance of TH-IR cell number in the SNpc and VTA, ERalpha may play a more significant role...
  5. pmc Androgen decreases dopamine neurone survival in rat midbrain
    M L Johnson
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, USA
    J Neuroendocrinol 22:238-47. 2010
    ..TH-IN cell number did not change after castration or hormone replacement in rat or mouse SNpc or VTA. These findings suggest that testosterone may play a suppressive role in midbrain dopaminergic pathways...
  6. ncbi request reprint Sex differences in the neurochemical and functional effects of MDMA in Sprague-Dawley rats
    Q David Walker
    Department of Pharmacology and Integrated Program in Toxicology, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacology (Berl) 189:435-45. 2007
    ..3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy") use has been associated with acute toxicities and persistent depletion of the neurotransmitter serotonin (5-HT)...
  7. ncbi request reprint Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy
    Q D Walker
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 25:118-30. 2001
    ..In summary, gonadectomy effects were sex and behavioral topography specific and indicate that activational effects of gonadal hormones partially mediate the robust sex differences in cocaine-stimulated open-field behavior...
  8. ncbi request reprint Effect of ovarian hormones and estrous cycle on stimulation of the hypothalamo-pituitary-adrenal axis by cocaine
    Q D Walker
    Department of Pharmacology, 401 Bryan Research Building, Duke University Medical Center, Durham, NC 27710, USA
    J Pharmacol Exp Ther 297:291-8. 2001
    ..These results suggest that adrenally derived progesterone could contribute to cocaine-induced physiological changes, including inhibited gonadotropin release...
  9. pmc Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
    Pharmacol Biochem Behav 91:398-408. 2009
    ..Thus, behavioral phenotypes correlated with individual differences in cocaine/saccharin consumption in an age-related manner...
  10. ncbi request reprint Differential anxiogenic, aversive, and locomotor effects of THC in adolescent and adult rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100B Research Park Bldg 2, P O Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 191:867-77. 2007
    ..Unpleasant side effects of drugs of abuse often limit their repeated use; however, such effects may be attenuated in adolescents compared to adults...
  11. ncbi request reprint Central nervous system serotonin function and cardiovascular responses to stress
    R B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychosom Med 63:300-5. 2001
    ..The objective of this study was to evaluate the impact of indices of central nervous system (CNS) serotonin function on cardiovascular reactivity to mental stress...
  12. pmc Positive affect is associated with cardiovascular reactivity, norepinephrine level, and morning rise in salivary cortisol
    B H Brummett
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychophysiology 46:862-9. 2009
    ..149). Positive affect was inversely related to the increase in cortisol 30 min post awakening (p=.042), and unrelated to the evening decline in cortisol levels (p=.174). Positive emotions may be relevant to good health...
  13. pmc HPA axis function in male caregivers: effect of the monoamine oxidase-A gene promoter (MAOA-uVNTR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychol 79:250-5. 2008
    ..5/4 repeats) (cortisol p<.043). Individuals with less active MAOA-uVNTR alleles who are under chronic stress may be at increased risk for exhaustion of the HPA response to such stress...
  14. pmc 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Behav Genet 38:476-83. 2008
    ..013), and trended towards predicting anger-hostility (P = .084). Males in the HiHi group had greater increases in negative affect during infusion, compared to all groups except LoLo females, who also showed increased negative affect...
  15. pmc Associations among central nervous system serotonergic function and neuroticism are moderated by gender
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Biol Psychol 78:200-3. 2008
    ..Remaining personality domains were not related to prolactin levels. Findings add to literature suggesting the serotonin system functions differently, in important ways, in males and females...
  16. ncbi request reprint Childhood socioeconomic status and serotonin transporter gene polymorphism enhance cardiovascular reactivity to mental stress
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Box 3926, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 70:32-9. 2008
    ..We found the long allele associated with larger CVR to mental stress in a preliminary study of 54 normal volunteers...
  17. pmc Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models
    Nicole L Schramm-Sapyta
    Duke University, Durham, NC, USA
    Psychopharmacology (Berl) 206:1-21. 2009
    ..Animal models, in which age of onset can be tightly controlled, offer a platform for testing causality. Many animal models address drug effects that might promote or discourage drug intake and drug-induced neuroplasticity...
  18. pmc Serotonin shapes risky decision making in monkeys
    ARWEN B LONG
    Department of Neurobiology, Duke University, Box 3209, Durham, NC 27710, USA
    Soc Cogn Affect Neurosci 4:346-56. 2009
    ..These results implicate serotonin in risk-sensitive decision making and, further, suggest pharmacological therapies for treating pathological risk preferences in disorders such as problem gambling and addiction...
  19. pmc Hostility and fasting glucose in African American women
    Anastasia Georgiades
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Psychosom Med 71:642-5. 2009
    ..HOST has been associated with abnormalities in glucose metabolism. Prior studies suggested that this association may be more prevalent in women and in African American (AA) individuals...
  20. pmc The effect of acute tryptophan depletion on emotional distraction and subsequent memory
    Lihong Wang
    Brain Imaging and Analysis Center, Duke University Medical Center, 2424 Erwin Road, Suite 501 Durham, NC 27705, USA
    Soc Cogn Affect Neurosci 4:357-68. 2009
    ..These findings highlight the importance of serotonin in negative memory with implications for mood disorders...
  21. pmc Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c
    Beverly H Brummett
    Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    J Psychiatr Res 44:373-7. 2010
    ....
  22. doi request reprint Stressful politics: voters' cortisol responses to the outcome of the 2008 United States Presidential election
    Steven J Stanton
    Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA
    Psychoneuroendocrinology 35:768-74. 2010
    ..The present research provides novel evidence that societal shifts in political dominance can impact biological stress responses in voters whose political party becomes socio-politically subordinate...
  23. pmc Central nervous system serotonin and clustering of hostility, psychosocial, metabolic, and cardiovascular endophenotypes in men
    Redford B Williams
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 72:601-7. 2010
    ....
  24. pmc Aversive effects of ethanol in adolescent versus adult rats: potential causes and implication for future drinking
    Nicole L Schramm-Sapyta
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 34:2061-9. 2010
    ..First, do reduced aversive effects of ethanol in younger rats correlate with increased ethanol consumption? Second, are the reduced aversive effects in adolescents attributable to reduced sensitivity to ethanol's physiologic effects?..
  25. pmc The synthetic cannabinoid WIN 55212-2 differentially modulates thigmotaxis but not spatial learning in adolescent and adult animals
    Shawn K Acheson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, United States
    Neurosci Lett 487:411-4. 2011
    ..We suggest that the role of thigmotaxis be carefully evaluated in future neurodevelopmental studies of spatial learning, especially those investigating the endocannabinoid system...
  26. pmc Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR)
    Beverly H Brummett
    Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27710, USA
    Behav Genet 38:34-43. 2008
    ..Findings from two independent samples suggest that the association of 5-HTTLPR with depression varies according to gender and stressful life events...
  27. pmc Sleep quality varies as a function of 5-HTTLPR genotype and stress
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:621-4. 2007
    ..A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro...
  28. ncbi request reprint Ethnicity, gender, and age effects on adrenoceptors and physiological responses to emotional stress
    Edward C Suarez
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Psychophysiology 41:450-60. 2004
    ..Relative to Whites and Black females, arousal of negative affect in Black males led to a pattern of sympathetic nervous system activity that may help explain the higher prevalence of hypertension in this population...
  29. ncbi request reprint Serotonin-related gene polymorphisms and central nervous system serotonin function
    Redford B Williams
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3926, Durham, NC 27710, USA
    Neuropsychopharmacology 28:533-41. 2003
    ....
  30. ncbi request reprint Caffeine affects cardiovascular and neuroendocrine activation at work and home
    James D Lane
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 64:595-603. 2002
    ....
  31. ncbi request reprint Differential sensitivity of GABA A receptor-mediated IPSCs to cannabinoids in hippocampal slices from adolescent and adult rats
    Maeng hee Kang-Park
    Department of Psychiatry, Durham Veterans Affairs Medical Center, Durham, NC 27705, USA
    J Neurophysiol 98:1223-30. 2007
    ..These results indicate that inhibitory synaptic function in the adolescent hippocampus is more sensitive to cannabinoid effects and may account, in part, for the greater sensitivity of adolescent animals to THC-induced memory impairment...
  32. pmc Hostility and minimal model of glucose kinetics in African American women
    Richard S Surwit
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Psychosom Med 71:646-51. 2009
    ....
  33. pmc Maturation of coordinated immediate early gene expression by cocaine during adolescence
    J M Caster
    Department of Pharmacology and Cancer Biology, Research Park Building 2, Room 100B, Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Neuroscience 160:13-31. 2009
    ..The immature regulation of transcription factors by cocaine could explain why adolescents show unique sensitivity to specific long-term behavioral alterations following cocaine treatment...
  34. pmc Personality and inflammation: the protective effect of openness to experience
    Charles R Jonassaint
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, USA
    Ethn Dis 20:11-4. 2010
    ....
  35. pmc Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats
    Nicole L T Moore
    Duke University Medical Center, Room 100B, Research Park II, Box 3813, Durham, NC 27710, USA
    J Pharmacol Exp Ther 335:294-301. 2010
    ..THC may impair learning in adolescents more than in adults because of delayed activation of cellular homeostatic adaptive mechanisms underlying cannabinoid tolerance in the hippocampus...
  36. ncbi request reprint Enhanced behavioral response to repeated-dose cocaine in adolescent rats
    Joseph M Caster
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100 B, Research Park Building 2, P O Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 183:218-25. 2005
    ..However, few studies have explored behavioral responses to the repeated dosing that is characteristic of human abuse of these substances...
  37. ncbi request reprint Differential effects of delta9-THC on learning in adolescent and adult rats
    Young May Cha
    Department of Psychiatry, Duke University Medical Center, USA
    Pharmacol Biochem Behav 83:448-55. 2006
    ..This developmental sensitivity is analogous to the effects of ethanol, another commonly used recreational drug...
  38. ncbi request reprint Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chloride
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 84:344-52. 2006
    ..This contributes to our understanding of why adolescence is a particularly vulnerable period for development of drug abuse...
  39. pmc Effects of stress and sex on acquisition and consolidation of human fear conditioning
    Michael Zorawski
    Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    Learn Mem 13:441-50. 2006
    ..The findings have implications for understanding the role of stress, sex, and hormones in different stages of fear learning and memory...
  40. ncbi request reprint Sex differences in the effects of delta9-tetrahydrocannabinol on spatial learning in adolescent and adult rats
    Young May Cha
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Behav Pharmacol 18:563-9. 2007
    ..The developmental sensitivity to subchronic THC confirms previous work carried out in our laboratory, and the sex-dependent effects highlight the importance of including females in drug abuse and addiction research...
  41. ncbi request reprint Sex differences in neurochemical effects of dopaminergic drugs in rat striatum
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:1193-202. 2006
    ..These results contribute to understanding sex differences in stimulant-induced locomotor activity in rats and may have broader implications for neurologic disorders and their pharmacotherapies in humans...
  42. pmc Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Pharmacol Exp Ther 335:124-32. 2010
    ..Immaturity of DAT and/or DAT associated signaling systems in adolescence specifically enhances behavioral and dopaminergic responses in adolescence...
  43. pmc Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats
    Sarah L Parylak
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 89:314-23. 2008
    ..Our results suggest that gonadal steroids exert lasting and opposing effects on the sensitivity of males and females to psychostimulants during development...
  44. ncbi request reprint A single high dose of cocaine induces differential sensitization to specific behaviors across adolescence
    Joseph M Caster
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Room 100 B, Research Park Building 2, Box 3813, Durham, NC 27710, USA
    Psychopharmacology (Berl) 193:247-60. 2007
    ..The same biological differences that mediate age-specific behavioral responsiveness to stimulants in rodents could contribute to increased addiction vulnerability in adolescent humans...
  45. ncbi request reprint Sex, stress, and fear: individual differences in conditioned learning
    Michael Zorawski
    Duke University, Durham, North Carolina 27708 0999, USA
    Cogn Affect Behav Neurosci 5:191-201. 2005
    ..These findings have implications for the understanding of individual differences in fear acquisition and risk factors for the development of affective disorders...
  46. pmc Early ethanol consumption predicts relapse-like behavior in adolescent male rats
    Nicole L Schramm-Sapyta
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Alcohol Clin Exp Res 32:754-62. 2008
    ..We assessed an array of behavioral and hormonal characteristics in adolescent (28-day-old) male rats before exposure to ethanol, and then determined which rats were most prone to high levels of alcohol drinking...
  47. ncbi request reprint Role of leptin in fat regulation
    S Collins
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 380:677. 1996
  48. pmc Cocaine increases stimulated dopamine release more in periadolescent than adult rats
    Q David Walker
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, United States
    Neurotoxicol Teratol 30:412-8. 2008
    ..Immaturity of dopamine neurotransmission in dorsal striatum may underlie enhanced acute responses to psychostimulants in adolescent rats and suggests a mechanism for the greater vulnerability of adolescent humans to drug addiction...
  49. ncbi request reprint Vaginal lavage attenuates cocaine-stimulated activity and establishes place preference in rats
    Q David Walker
    Department of Pharmacology, 401 Bryan Research Building, Box 3813, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacol Biochem Behav 73:743-52. 2002
    ..These results suggest that vaginal lavage serves as a reinforcing stimulus and interacts with a neural substrate that mediates enhanced locomotor responses to cocaine during proestrus and estrus...
  50. ncbi request reprint Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells
    Heather L Rincavage
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Endocrinology 144:2829-35. 2003
    ..Cath.a cells may prove to be a useful tool in elucidating basic pharmacologic properties of ERbeta. It may also help reveal the molecular mechanisms involved in mood regulation by estrogen...
  51. ncbi request reprint Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study
    Qun Wu
    Cellular and Integrative Physiology Section, Department of Biological Sciences, Illinois State University, Normal, Illinois 61790 4120, USA
    J Neurosci 22:6272-81. 2002
    ..We conclude that presynaptic DA autoreceptors concurrently downregulate release and upregulate uptake, and that the mechanisms are also independently controlled during neurotransmission...
  52. ncbi request reprint Effect of maternal smoking on fetal catecholamine concentrations at birth
    Cheryl A Oncken
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, U S A
    Pediatr Res 53:119-24. 2003
    ..Further studies are needed to validate these findings and to examine the specific mechanism by which these differences may arise...
  53. ncbi request reprint UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y(6) receptors
    Mingyan Hou
    Division of Experimental Vascular Research, Department of Medicine, University Hospital, SE 221 85 Lund, Sweden
    Am J Physiol Heart Circ Physiol 282:H784-92. 2002
    ..The results demonstrate that UDP stimulates mitogenesis through activation of P2Y(6) receptors and that the receptor is regulated by factors important in the development of vascular disease...

Research Grants26

  1. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia Kuhn; Fiscal Year: 2005
    ..abstract_text> ..
  2. GHB Tolerance and Dependence
    Cynthia Kuhn; Fiscal Year: 2006
    ..These experiments should ultimately lead to the development of more effective pharmacotherapies for GHB dependence, which is an emerging drug abuse problem. ..
  3. PHARMACOLOGICAL SCIENCES TRAINING GRANT
    Cynthia Kuhn; Fiscal Year: 2007
    ..The program in Pharmacological Sciences has a long-standing active and effective minority recruitment program ..
  4. Dopamine Function During Adolescence
    Cynthia Kuhn; Fiscal Year: 2007
    ..These studies should provide insight into potential biologic mechanisms that influence the onset of drug taking during adolescence. ..
  5. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia Kuhn; Fiscal Year: 2001
    ..These studies should provide insight into basic mechanisms which mediate gender differences in dopaminergic function and the effects of locomotor stimulants which depend upon dopaminergic transmission. ..
  6. GENDER DIFFERENCES IN STIMULANT ACTION
    Cynthia M Kuhn; Fiscal Year: 2010
    ....