Andrew Krystal

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc The relationship of sleep with temperature and metabolic rate in a hibernating primate
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS ONE 8:e69914. 2013
  2. ncbi request reprint Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Sleep Med Rev 17:263-72. 2013
  3. pmc Psychiatric disorders and sleep
    Andrew D Krystal
    Sleep Research Laboratory and Insomnia Program, Department of Psychiatry, Duke University Medical Center, Box 3309, Durham, NC 27710, USA
    Neurol Clin 30:1389-413. 2012
  4. doi request reprint A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression
    Andrew D Krystal
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Duke Clinic, 200 Trent Dr, 4th Fl, White Zone, Durham, NC 27710, USA
    J Clin Psychiatry 71:32-40. 2010
  5. ncbi request reprint Sleep and psychiatric disorders: future directions
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Psychiatr Clin North Am 29:1115-30; abstract xi. 2006
  6. ncbi request reprint A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice
    Andrew D Krystal
    Insomnia and Sleep Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke South Hospital, Trent Drive, Durham, NC 27710, USA
    Sleep Med Rev 13:265-74. 2009
  7. ncbi request reprint The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA
    Biol Psychiatry 61:925-7. 2007
  8. ncbi request reprint Treating the health, quality of life, and functional impairments in insomnia
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Sleep Med 3:63-72. 2007
  9. ncbi request reprint Measuring sleep quality
    Andrew D Krystal
    Duke University, School of Medicine, Durham, North Carolina, USA
    Sleep Med 9:S10-7. 2008
  10. doi request reprint Effects of antipsychotic medications on sleep in schizophrenia
    Andrew D Krystal
    Duke Insomnia and Sleep Research Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int Clin Psychopharmacol 23:150-60. 2008

Detail Information

Publications49

  1. pmc The relationship of sleep with temperature and metabolic rate in a hibernating primate
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
    PLoS ONE 8:e69914. 2013
    ....
  2. ncbi request reprint Review of the histamine system and the clinical effects of H1 antagonists: basis for a new model for understanding the effects of insomnia medications
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Sleep Med Rev 17:263-72. 2013
    ....
  3. pmc Psychiatric disorders and sleep
    Andrew D Krystal
    Sleep Research Laboratory and Insomnia Program, Department of Psychiatry, Duke University Medical Center, Box 3309, Durham, NC 27710, USA
    Neurol Clin 30:1389-413. 2012
    ..Such work promises to improve comprehension of these phenomena and lead to better treatment for the many patients with sleep disorders and psychiatric disorders...
  4. doi request reprint A double-blind, placebo-controlled study of armodafinil for excessive sleepiness in patients with treated obstructive sleep apnea and comorbid depression
    Andrew D Krystal
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Duke Clinic, 200 Trent Dr, 4th Fl, White Zone, Durham, NC 27710, USA
    J Clin Psychiatry 71:32-40. 2010
    ..This study evaluating armodafinil, a nonamphetamine wakefulness-promoting medication, is the first trial for treatment of excessive sleepiness in patients with treated OSA and comorbid depression...
  5. ncbi request reprint Sleep and psychiatric disorders: future directions
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Psychiatr Clin North Am 29:1115-30; abstract xi. 2006
    ....
  6. ncbi request reprint A compendium of placebo-controlled trials of the risks/benefits of pharmacological treatments for insomnia: the empirical basis for U.S. clinical practice
    Andrew D Krystal
    Insomnia and Sleep Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke South Hospital, Trent Drive, Durham, NC 27710, USA
    Sleep Med Rev 13:265-74. 2009
    ..Issues related to the application of these data to clinical practice are discussed in the text...
  7. ncbi request reprint The use of prazosin for the treatment of trauma nightmares and sleep disturbance in combat veterans with post-traumatic stress disorder
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA
    Biol Psychiatry 61:925-7. 2007
  8. ncbi request reprint Treating the health, quality of life, and functional impairments in insomnia
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Sleep Med 3:63-72. 2007
    ..It is not even known if the nonsleep deficits improve with current treatment. We hypothesized that therapy that improves sleep also improves these nonsleep difficulties and carried out this review to test that hypothesis...
  9. ncbi request reprint Measuring sleep quality
    Andrew D Krystal
    Duke University, School of Medicine, Durham, North Carolina, USA
    Sleep Med 9:S10-7. 2008
    ....
  10. doi request reprint Effects of antipsychotic medications on sleep in schizophrenia
    Andrew D Krystal
    Duke Insomnia and Sleep Research Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int Clin Psychopharmacol 23:150-60. 2008
    ..In this study, we review the effects of schizophrenia medications and discuss their relevance to optimizing the clinical treatment of people with schizophrenia with regard to sleep-wake function...
  11. ncbi request reprint Sleep disturbance in psychiatric disorders: effects on function and quality of life in mood disorders, alcoholism, and schizophrenia
    Andrew D Krystal
    Duke Insomnia and Sleep Research Program, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Ann Clin Psychiatry 20:39-46. 2008
    ..In psychiatric disorders, not only is there a relationship between sleep disturbances and impaired function, problems with sleep also appear to affect the course of the disorder...
  12. pmc Long-term efficacy and safety of zolpidem extended-release 12.5 mg, administered 3 to 7 nights per week for 24 weeks, in patients with chronic primary insomnia: a 6-month, randomized, double-blind, placebo-controlled, parallel-group, multicenter study
    Andrew D Krystal
    Duke University Medical Center, Durham, NC 27710, USA
    Sleep 31:79-90. 2008
    ..To evaluate long-term efficacy and safety of zolpidem extended-release 3 to 7 nights/week for chronic primary insomnia...
  13. pmc Sleep EEG predictors and correlates of the response to cognitive behavioral therapy for insomnia
    Andrew D Krystal
    Duke University Medical Center, Durham VA Medical Center, Durham, NC 27710, USA
    Sleep 33:669-77. 2010
    ..Determine the relationship of non-rapid eye movement (NREM) electroencephalographic (EEG) spectral measures and the response to cognitive behavioral therapy (CBT) in primary insomnia (PI)...
  14. ncbi request reprint Depression and insomnia in women
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Clin Cornerstone 6:S19-28. 2004
    ..However, few data exist for many key areas related to the treatment of these disorders in women, and research is greatly needed...
  15. pmc Efficacy and safety of doxepin 3 and 6 mg in a 35-day sleep laboratory trial in adults with chronic primary insomnia
    Andrew D Krystal
    Duke University School of Medicine, Durham, NC 27710, USA
    Sleep 34:1433-42. 2011
    ..To evaluate the efficacy and safety of doxepin (DXP) 3 mg and 6 mg in adults diagnosed with primary insomnia...
  16. doi request reprint Detrusor overactivity persisting at night and preceding nocturia in patients with overactive bladder syndrome: a nocturnal cystometrogram and polysomnogram study
    Andrew D Krystal
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Urol 184:623-8. 2010
    ..We established methods to study the physiology of overactive bladder associated nocturia and better understand this phenomenon...
  17. pmc The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia
    Andrew D Krystal
    Duke University School of Medicine, Durham, NC 27710, USA
    J Clin Sleep Med 6:315-21. 2010
    ..To determine if vestibular stimulation is an effective therapy for transient insomnia in a sleep phase advance model...
  18. pmc Efficacy and Safety of Doxepin 1 mg and 3 mg in a 12-week Sleep Laboratory and Outpatient Trial of Elderly Subjects with Chronic Primary Insomnia
    Andrew D Krystal
    Duke University School of Medicine, Durham, NC 27710, USA
    Sleep 33:1553-61. 2010
    ..to evaluate the efficacy and safety of doxepin 1 mg and 3 mg in elderly subjects with chronic primary insomnia...
  19. doi request reprint Comparison of polysomnographic data in age-, sex- and Axis I psychiatric diagnosis matched HIV-seropositive and HIV-seronegative insomnia patients
    Yinghui Low
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Neurophysiol 123:2402-5. 2012
    ..We carried out this study to determine if there are differences in polysomnographic (PSG) sleep data in age-, sex- and Axis I diagnoses- matched HIV-seropositive and HIV-seronegative patients...
  20. ncbi request reprint Evaluation of eszopiclone discontinuation after cotherapy with fluoxetine for insomnia with coexisting depression
    Andrew Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Sleep Med 3:48-55. 2007
    ..Insomnia and major depressive disorder (MDD) may coexist. This study evaluated hypnotic discontinuation effects following an 8-week placebo-controlled study of eszopiclone/fluoxetine cotherapy in patients with insomnia and comorbid MDD...
  21. pmc A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia
    Sonia Ancoli-Israel
    Department of Psychiatry, University of California San Diego, San Diego, CA 92093 0733, USA
    Sleep 33:225-34. 2010
    ..Longer-term pharmacologic studies for insomnia in older individuals are sparse...
  22. ncbi request reprint Long-term, non-nightly administration of zolpidem in the treatment of patients with primary insomnia
    Michael L Perlis
    Sleep and Neurophysiology Laboratory, Department of Psychiatry, University of Rochester, and the University of Rochester Medical Center, Neurosciences Program, Rochester, NY 14642, USA
    J Clin Psychiatry 65:1128-37. 2004
    ..The present study was designed to further evaluate this issue within a large scale, double-blind, placebo-controlled, long-term trial...
  23. ncbi request reprint The effect of insomnia definitions, terminology, and classifications on clinical practice
    Andrew D Krystal
    Sleep Research Laboratory and Insomnia Program, Duke University Medical Center, Durham, North Carolina 22710, USA
    J Am Geriatr Soc 53:S258-63. 2005
    ..All of these developments point to an increasing ability to tailor therapy to the particular needs of patients and to optimize the clinical management of insomnia...
  24. pmc Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia
    Jack D Edinger
    VA Medical Center, Durham, NC 27705, USA
    Sleep 31:599-607. 2008
    ..To examine psychomotor (reaction time) performance deficits and their relation to subjective and objective sleep measures among individuals with primary insomnia (PI)...
  25. pmc Sleep-wake functioning along the cancer continuum: focus group results from the Patient-Reported Outcomes Measurement Information System (PROMIS(®))
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Psychooncology 19:1086-93. 2010
    ..As part of an effort to improve measurement of sleep-wake functioning, we explored the scope of difficulties with sleep in a diverse group of patients diagnosed with cancer...
  26. pmc Sleep quality varies as a function of 5-HTTLPR genotype and stress
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:621-4. 2007
    ..A common 44-base pair deletion (s allele) polymorphism in the 5-HTTLPR is associated with reduced 5HTT transcription efficiency and 5HT uptake in vitro...
  27. ncbi request reprint A comparison of rates of residual insomnia symptoms following pharmacotherapy or cognitive-behavioral therapy for major depressive disorder
    Colleen E Carney
    Duke Insomnia and Sleep Research Program, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychiatry 68:254-60. 2007
    ..This study was the first to date to examine residual insomnia after cognitive-behavioral therapy (CBT) for depression and to compare CBT with pharmacotherapy for depression on residual insomnia rates...
  28. ncbi request reprint The changing perspective on chronic insomnia management
    Andrew D Krystal
    Duke University Medical Center, Durham, NC, USA
    J Clin Psychiatry 65:20-5. 2004
    ..They suggest that clinical practice is evolving toward an improved capacity to treat insomnia, with treatments that can safely lead to sustained efficacy...
  29. ncbi request reprint Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Sleep 26:793-9. 2003
    ..To determine the long-term efficacy of eszopiclone in patients with chronic insomnia...
  30. ncbi request reprint Insomnia in women
    Andrew D Krystal
    Sleep Research Laboratory, Duke University Medical Center, Durham, North Carolina, USA
    Clin Cornerstone 5:41-50. 2003
    ..This article reviews the available literature related to these conditions with a focus on the epidemiologic data and diagnosis and treatment of insomnia and highlights the need for further research...
  31. pmc Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality
    Beverly H Brummett
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychosom Med 69:396-401. 2007
    ..MAOA-uVNTR genotype has been associated with both psychological and physical measures...
  32. ncbi request reprint Subtyping primary insomnia: is sleep state misperception a distinct clinical entity?
    Jack D Edinger
    VA Medical Centers, Durham, NC, USA
    Sleep Med Rev 7:203-14. 2003
    ..We conclude by advocating continued study of the subjective insomnia phenomenon and by providing specific directions for relevant future research...
  33. ncbi request reprint Comparison of seizure duration, ictal EEG, and cognitive effects of ketamine and methohexital anesthesia with ECT
    Andrew D Krystal
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
    J Neuropsychiatry Clin Neurosci 15:27-34. 2003
    ..Thus, a switch to ketamine may be useful when it is difficult to elicit a robust seizure. Faster post-treatment reorientation with ketamine may suggest a lower level of associated cognitive side effects...
  34. ncbi request reprint NREM sleep EEG frequency spectral correlates of sleep complaints in primary insomnia subtypes
    Andrew D Krystal
    Sleep 25:630-40. 2002
    ....
  35. ncbi request reprint Behavioral insomnia therapy for fibromyalgia patients: a randomized clinical trial
    Jack D Edinger
    Psychology Service, Veterans Affairs Medical Center, Durham, NC 27705, USA
    Arch Intern Med 165:2527-35. 2005
    ..This study compared CBT with an alternate behavioral therapy and usual care for improving sleep and other FM symptoms...
  36. ncbi request reprint Insomnia in HIV-infected patients: pathophysiologic implications
    Yinghui Low
    Insomnia and Sleep Research Program, Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA
    AIDS Rev 16:3-13. 2014
    ..Instead, this rate is best compared with the rate of sleep disturbance in the general population, which is roughly 33%...
  37. doi request reprint Durability of clinical benefit with transcranial magnetic stimulation (TMS) in the treatment of pharmacoresistant major depression: assessment of relapse during a 6-month, multisite, open-label study
    Philip G Janicak
    Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612, USA
    Brain Stimul 3:187-99. 2010
    ..Although transcranial magnetic stimulation (TMS) can be an effective acute antidepressant treatment, few studies systematically examine persistence of benefit...
  38. pmc Report of two cases where sleep related eating behavior occurred with the extended-release formulation but not the immediate-release formulation of a sedative-hypnotic agent
    Ambrose Chiang
    Division of Pulmonary and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Sleep Med 4:155-6. 2008
    ..These cases illustrate how even relatively small differences such as formulation can affect the likelihood of experiencing such events...
  39. ncbi request reprint Introduction: Definitions, measurements, and management in insomnia
    Andrew D Krystal
    Duke University Medical Center, Durham, NC, USA
    J Clin Psychiatry 65:5-7. 2004
  40. pmc The pharmacologic management of insomnia in patients with HIV
    Toma S Omonuwa
    Duke University School of Medicine, Durham, NC, USA
    J Clin Sleep Med 5:251-62. 2009
    ..The means by which these factors affect the expected risk-benefit profile of insomnia therapies is discussed, and recommendations are made for choosing medications in patients encountered in clinical practice...
  41. ncbi request reprint Hypnotics should be considered for the initial treatment of chronic insomnia. Pro
    William K Wohlgemuth
    Sleep Research Laboratory and Insomnia Program, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Sleep Med 1:120-4. 2005
  42. doi request reprint Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial
    Sarah H Lisanby
    Division of Brain Stimulation and Therapeutic Modulation, Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 34:522-34. 2009
    ..Shorter duration of current illness and lack of anxiety comorbidity may also confer an increased likelihood of good antidepressant response to TMS...
  43. doi request reprint Modeling slow-wave activity dynamics: does an exponentially dampened periodic function really fit a single night of normal human sleep?
    Xavier A Preud'homme
    Quantitative EEG and Sleep Research Laboratory, Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 2908, Durham, NC 27710, USA
    Clin Neurophysiol 119:2753-61. 2008
    ..The objective of this study is to carry out the first rigorous statistical test of this hypothesized dynamical behavior...
  44. pmc Nightly treatment of primary insomnia with eszopiclone for six months: effect on sleep, quality of life, and work limitations
    James K Walsh
    Sleep Medicine and Research Center, St John s St Luke s Hospitals and the Department of Psychology, Saint Louis University, St Louis, MO 63017, USA
    Sleep 30:959-68. 2007
    ..To evaluate 6 months' eszopiclone treatment upon patient-reported sleep, fatigue and sleepiness, insomnia severity, quality of life, and work limitations...
  45. ncbi request reprint Long-term issues in the treatment of sleep disorders
    Thomas Roth
    Sleep Disorders and Research Center, Henry Ford Health System, Detroit, MI, USA
    CNS Spectr 12:1-14. 2007
    ..Krystal, MD, MS, reviews morbidities associated with insomnia. Finally, Joseph A. Lieberman III, MD, MPH, provides an overview of therapeutics utilized in patients with insomnia, including behavioral therapies and pharmacologic options...
  46. ncbi request reprint A polysomnography study of eszopiclone in elderly patients with insomnia
    W Vaughn McCall
    Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Curr Med Res Opin 22:1633-42. 2006
    ..To evaluate the safety and efficacy of eszopiclone 2 mg in elderly patients (aged 64-86 years) with chronic insomnia...
  47. ncbi request reprint Panel discussion: changing how we think about insomnia
    Sonia Ancoli-Israel
    J Clin Psychiatry 65:44-6. 2004
  48. ncbi request reprint The possibility of preventing functional impairment due to sleep loss by pharmacologically enhancing sleep
    Andrew D Krystal
    Sleep 28:16-7. 2005
  49. ncbi request reprint Case report: Successful riluzole augmentation therapy in treatment-resistant bipolar depression following the development of rash with lamotrigine
    Jaskaran Singh
    Psychopharmacology (Berl) 173:227-8. 2004

Research Grants3

  1. Biomarkers of the Response to CBT for Insomnia in Major Depression
    Andrew Krystal; Fiscal Year: 2009
    ..End of Abstract) ..
  2. Biomarkers of the Response to CBT for Insomnia in Major Depression
    Andrew D Krystal; Fiscal Year: 2010
    ..End of Abstract) ..
  3. Nocturnal Deterusor Overactivity In Overactive Bladder Syndrome
    Andrew D Krystal; Fiscal Year: 2010
    ....