Research Topics
| M W KrucoffSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Detail Information
Publications
Permanently implantable diagnostic computerized devices: where is the regulatory rar?Mitchell W Krucoff
eECG Core Laboratory, Duke University Medical Center Duke Clinical Research Institute, Durham, NC 27705, USA
J Electrocardiol 37:68-70. 2004
From ST-elevation myocardial infarction to ST elevation with no myocardial infarction--review and overview of a new horizon of computerized electrocardiographic ischemia detection using high-fidelity implantable devicesMitchell W Krucoff
Duke University Medical Center, Duke Clinical Research Institute, 508 Fulton Street 111A, Durham, NC 27705, USA
J Electrocardiol 42:487-93. 2009..Rapidly progressive changes in the endocardial electrogram, with real-time alarms, could shift the timing, and hence the paradigm of care from interruption of MI to prevention of MI...
Music, imagery, touch, and prayer as adjuncts to interventional cardiac care: the Monitoring and Actualisation of Noetic Trainings (MANTRA) II randomised studyMitchell W Krucoff
Duke Clinical Research Institute, Durham, NC 27705, USA
Lancet 366:211-7. 2005..We undertook a multicentre, prospective trial of two such practices: intercessory prayer and music, imagery, and touch (MIT) therapy...
Integrative noetic therapies as adjuncts to percutaneous intervention during unstable coronary syndromes: Monitoring and Actualization of Noetic Training (MANTRA) feasibility pilotM W Krucoff
Ischemia Monitoring Laboratory, Duke Clinical Research Institute, The Cardiology Division, Duke University Medical Center, and the Durham Veterans Administration Medical Center, Durham, NC 27715, USA
Am Heart J 142:760-9. 2001..Noetic (nonpharmacologic) therapies may reduce anxiety, pain and distress, enhance the efficacy of pharmacologic agents, or affect short- and long-term procedural outcomes...
Drug-eluting stents "deliver heartburn": how do we spell relief going forward?Mitchell W Krucoff
Duke University Medical Center Duke Clinical Research Institute, Durham, NC 27705, USA
Circulation 115:2990-4. 2007
A novel bioresorbable polymer paclitaxel-eluting stent for the treatment of single and multivessel coronary disease: primary results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II studyMitchell W Krucoff
Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina 27705, USA
J Am Coll Cardiol 51:1543-52. 2008....
Comparison of ST-segment resolution with combined fibrinolytic and glycoprotein IIb/IIIa inhibitor therapy versus fibrinolytic alone (data from four clinical trials)Abdallah G Rebeiz
Duke Clinical Research Institute, Durham, North Carolina, USA
Am J Cardiol 95:611-4. 2005..7% vs 48.0% with >/=50% ST-segment resolution, p = 0.03) and sustained over 180 minutes after drug administration; this transient benefit may suggest a time frame when more optimal percutaneous coronary intervention can be performed...
Comparative prognostic significance of simultaneous versus independent resolution of ST segment depression relative to ST segment elevation during acute myocardial infarctionA Shah
Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Am Coll Cardiol 30:1478-83. 1997..We sought to determine the prognostic significance of simultaneous versus independent resolution of ST segment depression that occurs concomitant with ST segment elevation during acute myocardial infarction (AMI)...
The Cobalt chromium STent with Antiproliferative for Restenosis II (COSTAR II) trial study design: advancing the active-control evaluation of second-generation drug-eluting stentsTracy Y Wang
Duke Clinical Research Institute, Duke University, Durham, NC, USA
Am Heart J 153:743-8. 2007..The results of COSTAR II will provide information about a novel coronary stent device as well as unique data regarding both control and test DES use in more complex "real-world" patients...
A randomized factorial trial of reperfusion strategies and aspirin dosing in acute myocardial infarction. The DUCCS-II InvestigatorsC M O'Connor
Duke University Medical Center, Durham, North Carolina 27710, USA
Am J Cardiol 77:791-7. 1996..The use of low-dose aspirin did not appear to impose a loss of protection from adverse events, nor did standard-dose aspirin increase serious bleeding...
Shifting the open-artery hypothesis downstream: the quest for optimal reperfusionM T Roe
Duke Clinical Research Institute, Durham, North Carolina 27715, USA
J Am Coll Cardiol 37:9-18. 2001..Thus, as the reperfusion era moves into the next millennium, the open-artery hypothesis is expected to shift downstream and guide efforts to further improve myocardial salvage and clinical outcomes after acute MI...
Postmarket evaluation of breakthrough technologiesSunil V Rao
Duke Clinical Research Institute and Duke University Medical Center, Durham, NC 27705, USA
Am Heart J 156:201-8. 2008....
Reperfusion ventricular arrhythmia 'bursts' predict larger infarct size despite TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarctionMohamed Majidi
eECG Core Laboratory, Duke Clinical Research Institute, 508 Fulton Street, Durham, NC 27705, USA
Eur Heart J 30:757-64. 2009..Well-characterized reperfusion VAs may provide a novel biomarker of reperfusion injury...
Simultaneous restenosis of Taxus and Cypher drug-eluting stentsKent R Nilsson
Department of Medicine, Division of Cardiology, Box 31097, Duke University Medical Center, Durham, NC, USA
J Invasive Cardiol 18:557-60. 2006
Clinical utility of the Food and Drug Administration Electrocardiogram Warehouse: a paradigm for the critical pathway initiativeChristopher H Cabell
Department of Medicine, Duke University School of Medicine, Durham, NC, USA Duke Clinical Research Institute, Durham, NC 27715, USA
J Electrocardiol 38:175-9. 2005..The FDA Electrocardiogram Warehouse is 1 example where a government resource could be used by a confluence of groups to improve the science surrounding important components of the drug approval process such as cardiac safety evaluation...
Planning the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a Collaborative Pan-Stakeholder Critical Path Registry Model: a Cardiac Safety Research Consortium "Incubator" Think TankSana M Al-Khatib
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Am Heart J 159:17-24. 2010..The meeting took place on April 27 to 28, 2009, at the US Food and Drug Administration headquarters in Silver Spring, MD. This article summarizes the issues and directions presented and discussed at the meeting...
Clinical utility of serial and continuous ST-segment recovery assessment in patients with acute ST-elevation myocardial infarction: assessing the dynamics of epicardial and myocardial reperfusionMitchell W Krucoff
eECG Core Laboratory, Duke University Medical Center/Duke Clinical Research Institute, Durham, North Carolina, USA
Circulation 110:e533-9. 2004
Developing the Safety of Atrial Fibrillation Ablation Registry Initiative (SAFARI) as a collaborative pan-stakeholder critical path registry model: a Cardiac Safety Research Consortium "Incubator" Think TankSana M Al-Khatib
Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Am Heart J 160:619-26. 2010....
ST-segment monitoring in patients with acute coronary syndromesPer Johanson
Duke University Medical Center, Duke Clinical Research Institute, PO Box 17969, Durham, NC 27705, USA
Curr Cardiol Rep 5:278-83. 2003..Continuous multilead ST-monitoring during ACS is no longer a cumbersome source of more nuisance than benefit, but can be an accurate and useful tool in multicenter clinical trials, as well as in clinical medicine...
Reduction of myocardial ischemic injury following coronary intervention (the MC-1 to Eliminate Necrosis and Damage trial)David E Kandzari
Duke Clinical Research Institute, Durham, NC 27715, USA
Am J Cardiol 92:660-4. 2003..These results support the evaluation of MC-1 in pivotal trials of patients at risk for developing myocardial ischemia, infarction, or reperfusion injury...
Improved speed and stability of ST-segment recovery with reduced-dose tenecteplase and eptifibatide compared with full-dose tenecteplase for acute ST-segment elevation myocardial infarctionMatthew T Roe
Duke Clinical Research Institute and Division of Cardiology, Duke Medical Center, Durham, North Carolina 27715, USA
J Am Coll Cardiol 43:549-56. 2004....
Predicting outcome after thrombolysis in acute myocardial infarction according to ST-segment resolution at 90 minutes: a substudy of the GUSTO-III trial. Global Use of Strategies To Open occluded coronary arteriesR David Anderson
Duke Clinical Research Institute, Durham, NC, USA
Am Heart J 144:81-8. 2002..Whether prognostically useful information can be achieved as early as 90 minutes after thrombolysis is unknown...
Feasibility of endovascular cooling as an adjunct to primary percutaneous coronary intervention (results of the LOWTEMP pilot study)David E Kandzari
Duke Clinical Research Institute, Durham, North Carolina 27715, USA
Am J Cardiol 93:636-9. 2004..5 degrees C) and was well tolerated, which supports the evaluation of adjunctive hypothermia in pivotal trials to limit infarct size and decrease reperfusion injury...
Prognostic implications of TIMI flow grade in the infarct related artery compared with continuous 12-lead ST-segment resolution analysis. Reexamining the "gold standard" for myocardial reperfusion assessmentA Shah
Duke University Medical Center, Durham, North Carolina, USA
J Am Coll Cardiol 35:666-72. 2000....
Combining baseline clinical descriptors and real-time response to therapy: the incremental prognostic value of continuous ST-segment monitoring in acute myocardial infarctionArthur C P Maas
Duke University Medical Center, Durham, NC, USA
Am Heart J 147:698-704. 2004....
Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path InitiativeJonathan P Piccini
Duke Clinical Research Institute and Duke University Medical Center, Durham, NC 27705, USA
Am Heart J 158:317-26. 2009..Priority pursuit of these consensus-based directions should facilitate both safer drugs and accelerated access to new drugs, as concomitant public health benefits...
Myocardial ischemia correlates with reduced fibrinolytic activity following peripheral vascular surgeryD A Lubarsky
Department of Anesthesiology, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
J Clin Anesth 12:136-41. 2000..We hypothesized that patients at increased risk of perioperative myocardial ischemia might be identified preoperatively by abnormal hemostatic indices...
Reperfusion ventricular arrhythmia 'bursts' in TIMI 3 flow restoration with primary angioplasty for anterior ST-elevation myocardial infarction: a more precise definition of reperfusion arrhythmiasMohamed Majidi
Duke Clinical Research Institute, 508 Fulton Street, Room A3012, Durham, NC 27705, USA
Europace 10:988-97. 2008....
The first ISCE Board of "Trustees" overview panel session: ischemia monitoring, state of the art. International Society of Computerized ElectrocardiologyKatherine J Booker
Duke University Medical Center, Durham, NC 27705, USA
J Electrocardiol 35:207-30. 2002
Clopidogrel use and clinical events after drug-eluting stent implantation: findings from the HealthCore Integrated Research DatabaseJohn L Petersen
Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, USA
Am Heart J 159:462-470.e1. 2010..Relationships between long-term use and level of dual antiplatelet therapy and outcomes after drug-eluting stent implantation are not well established...
Correlations between preprocedure mood and clinical outcome in patients undergoing coronary angioplastyGregory E Grunberg
Division of Cardiology, Department of Medicine, Durham Veterans Administration Medical Center and the Duke Clinical Research Institute, Durham, North Carolina, USA
Cardiol Rev 11:309-17. 2003..Our data suggest correlations between simple mood assessments before PCI and clinical outcomes during and after the procedure. More study is needed to understand whether attempts to alter patient mood can affect clinical outcomes...
Thrombosis and drug-eluting stents: an objective appraisalDavid R Holmes
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55955, USA
J Am Coll Cardiol 50:109-18. 2007....
Comparison of myocardial reperfusion in patients undergoing percutaneous coronary intervention in ST-segment elevation acute myocardial infarction with versus without diabetes mellitus (from the EMERALD Trial)Steven P Marso
The Mid America Heart Institute, Saint Luke s Hospital, Kansas City, Missouri, USA
Am J Cardiol 100:206-10. 2007....
The truth and consequences of the COURAGE trialDean J Kereiakes
Christ Hospital Heart and Vascular Center the Lindner Research Center, Cincinnati, Ohio 45219, USA
J Am Coll Cardiol 50:1598-603. 2007..An in-depth analysis of the COURAGE trial design and execution is provided...
Evaluation of novel ECG signal processing on quantification of transient ischemia and baseline wander suppressionMarko N Kostic
Signalife, Inc, Studio City, CA 91607, USA
Conf Proc IEEE Eng Med Biol Soc 2007:2199-202. 2007..A qualitative performance of baseline wander suppression was done on all five systems. The results showed that the Fidelity 100 system provided excellent detection and quantification of transient ischemia and baseline wander suppression...
Electrocardiographic factors playing a role in ischemic ventricular fibrillation in ST elevation myocardial infarction are related to the culprit arteryMiguel E Lemmert
Department of Cardiology, University Hospital Maastricht, Maastricht, The Netherlands
Heart Rhythm 5:71-8. 2008..Sudden cardiac death caused by ischemic ventricular fibrillation (VF) associated with ST elevation myocardial infarction (STEMI) is one of the most frequent causes of death...
Contemporary outcomes of rescue percutaneous coronary intervention for acute myocardial infarction: comparison with primary angioplasty and the role of distal protection devices (EMERALD trial)George Dangas
Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY, USA
Am Heart J 155:1090-6. 2008..The value of distal protection devices during rescue PCI has not been studied...
Practice standards for electrocardiographic monitoring in hospital settings: an American Heart Association scientific statement from the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the Young: endorsed by the InteBarbara J Drew
Circulation 110:2721-46. 2004..Currently available ECG lead systems are described, and recommendations related to staffing, training, and methods to improve quality are provided...
"Mirror-lake" serial relationship of electrocardiographic and biochemical indices for the detection of reperfusion and the prediction of salvage in patients with acute myocardial infarctionBirgit Jurlander
The Heart Center, Copenhagen University Hospital, Rigshospitalet, , Sygehus, Copenhagen, Denmark
Am Heart J 146:757-63. 2003..CONCLUSION: Myocardial salvage (measured by ECG indices) is greatest when an early increase in serum MG is "mirrored" by early resolution of ST-segment elevation...
Real-time detection and alerting for acute ST-segment elevation myocardial ischemia using an implantable, high-fidelity, intracardiac electrogram monitoring system with long-range telemetry in an ambulatory porcine modelTim A Fischell
Borgess Heart Institute, Michigan State University, Kalamazoo, Michigan 49048, USA
J Am Coll Cardiol 48:2306-14. 2006....
Pre-hospital synthesized 12-lead ECG ischemia monitoring with trans-telephonic transmission in acute coronary syndromes: pilot study results of the ST SMART trialBarbara J Drew
Department of Physiological Nursing, University of California, San Francisco, CA 94143 0610, USA
J Electrocardiol 37:214-21. 2004..The present analysis reports results of the feasibility pilot study...
Assessment of derived 12-lead electrocardiograms using general and patient-specific reconstruction strategies at rest and during transient myocardial ischemiaStefan P Nelwan
Thoraxcentrum, Erasmus MC, Rotterdam, The Netherlands
Am J Cardiol 94:1529-33. 2004..These approaches appear to be more practical than conventional 10-electrode monitoring but preserve high accuracy...
Association of the timing of ST-segment resolution with TIMI myocardial perfusion grade in acute myocardial infarctionC Michael Gibson
TIMI Study Group, The Department of Medicine, Brigham and Women's Hospital, Boston, Mass, USA
Am Heart J 147:847-52. 2004....
Distal microcirculatory protection during percutaneous coronary intervention in acute ST-segment elevation myocardial infarction: a randomized controlled trialGregg W Stone
Columbia University Medical Center and Cardiovascular Research Foundation, New York, NY 10022, USA
JAMA 293:1063-72. 2005....
A dynamic model forecasting myocardial infarct size before, during, and after reperfusion therapy: an ASSENT-2 ECG/VCG substudyPer Johanson
Division of Cardiology, Sahlgrenska University Hospital Ostra, SE 41685 Goteborg, Sweden
Eur Heart J 26:1726-33. 2005..We investigated a model for such forecasting, using time and the ECG...
Surrogates, substudies, and real clinical end points in trials of drug-eluting stentsDean J Kereiakes
J Am Coll Cardiol 45:1206-12. 2005
AHA scientific statement: practice standards for electrocardiographic monitoring in hospital settings: an American Heart Association Scientific Statement from the Councils on Cardiovascular Nursing, Clinical Cardiology, and Cardiovascular Disease in the YBarbara J Drew
J Cardiovasc Nurs 20:76-106. 2005..Currently available ECG lead systems are described, and recommendations related to staffing, training, and methods to improve quality are provided...
Simultaneous comparison of three derived 12-lead ECGs with standard ECG at rest and during percutaneous coronary occlusionStephan P Nelwan
Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
J Electrocardiol 37:171-2. 2004
Potential of an intracardiac electrogram for the rapid detection of coronary artery occlusionTim A Fischell
Borgess Heart Institute, Kalamazoo, MI 49048, USA
Cardiovasc Revasc Med 6:14-20. 2005..Early identification of acute MI and prompt intervention can improve clinical outcomes. It would be valuable to identify a method that could allow the earliest possible detection of myocardial injury or ischemia...
Usefulness of frequent arrhythmias after epicardial recanalization in anterior wall acute myocardial infarction as a marker of cellular injury leading to poor recovery of left ventricular functionDomien J Engelen
Department of Cardiology, University Hospital Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
Am J Cardiol 92:1143-9. 2003..This supports the hypothesis that these reperfusion arrhythmias are probably a noninvasive marker of cellular injury...
Clinical end points in coronary stent trials: a case for standardized definitionsDonald E Cutlip
Harvard Clinical Research Institute, Harvard Medical School, 930 Commonwealth Avenue, Boston, MA 02215, USA
Circulation 115:2344-51. 2007..Although most clinical trials of coronary stents have measured nominally identical safety and effectiveness end points, differences in definitions and timing of assessment have created confusion in interpretation...
The touch that heals: the uses and meanings of touch in the clinical encounterDrew Leder
Department of Philosophy, Loyola College in Maryland, Baltimore, MD 21210, USA
J Altern Complement Med 14:321-7. 2008..This paper explores the unique properties of touch as a medium of perception, action, and expression that can render touch a healing force within the clinical encounter...
Increased mortality after implantation of first generation drug-eluting stents: seeing the smoke, where is the fire?William C Wijns
Eur Heart J 27:2737-9. 2006
Impact of collateral flow on myocardial reperfusion and infarct size in patients undergoing primary angioplasty for acute myocardial infarctionPaul Sorajja
Mayo Clinic, Rochester, MN, USA
Am Heart J 154:379-84. 2007..We sought to examine the impact of baseline collateral flow to the IRA on reperfusion success, infarct size, and clinical outcomes in patients undergoing primary PCI for acute myocardial infarction (AMI)...
Results of the first clinical study of adjunctive CAldaret (MCC-135) in patients undergoing primary percutaneous coronary intervention for ST-Elevation Myocardial Infarction: the randomized multicentre CASTEMI studyFrits W Bär
Department of Cardiology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
Eur Heart J 27:2516-23. 2006..To examine the safety and efficacy of intravenous caldaret in patients with large acute ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI)...
Acute Myocardial Infarction with Hyperoxemic Therapy (AMIHOT): a prospective, randomized trial of intracoronary hyperoxemic reperfusion after percutaneous coronary interventionWilliam W O'Neill
Leonard M Miller School of Medicine, University of Miami, P O Box 016099 R 699, Miami, Florida 33101, USA
J Am Coll Cardiol 50:397-405. 2007..This study sought to determine whether hyperoxemic reperfusion with aqueous oxygen (AO) improves recovery of ventricular function after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI)...
Novel electrocardiogram configurations and transmission procedures in the prehospital setting: effect on ischemia and arrhythmia determinationBarbara J Drew
Department of Physiological Nursing, N631H, University of California, San Francisco, CA 94143 0610, USA
J Electrocardiol 39:S157-60. 2006....
From efficacy to safety concerns: a STEP forward or a step back for clinical research and intercessory prayer? The Study of Therapeutic Effects of Intercessory Prayer (STEP)Mitchell W Krucoff
Am Heart J 151:762-4. 2006
Simultaneous comparison of 3 derived 12-lead electrocardiograms with standard electrocardiogram at rest and during percutaneous coronary occlusionStefan P Nelwan
Thoraxcentrum, Erasmus MC, Rotterdam, The Netherlands
J Electrocardiol 41:230-7. 2008..The aim of the study was to simultaneously test the EASI lead system and two other derived ECG methods against the standard 12-lead ECG during percutaneous coronary intervention (PCI)...
Integrating complementary medicine into cardiovascular medicine. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and InJohn H K Vogel
J Am Coll Cardiol 46:184-221. 2005
