K Ranga Rama Krishnan

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline
    K R Krishnan
    Department of Psychiatry and Behavioral Sciences and the Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:347-61. 2001
  2. ncbi request reprint Clinical experience with substance P receptor (NK1) antagonists in depression
    K Ranga
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27715, USA
    J Clin Psychiatry 63:25-9. 2002
  3. ncbi request reprint Psychiatric and medical comorbidities of bipolar disorder
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center 3050A, 4584 Hospital South, Box 3950, Durham, NC 27710, USA
    Psychosom Med 67:1-8. 2005
  4. ncbi request reprint Treatment of depression in the medically ill
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Rm 4584 White Zone, Duke South, Durham, NC 27710, USA
    J Clin Psychopharmacol 25:S14-8. 2005
  5. ncbi request reprint Psychiatric disease in the genomic era: rational approach
    K R Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 10:978-84. 2005
  6. ncbi request reprint Evidence-based decision-making in psychopharmacology
    Ranga Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 37:24-8. 2003
  7. ncbi request reprint Concept of disease in geriatric psychiatry
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:1-11. 2007
  8. ncbi request reprint Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 160:2003-11. 2003
  9. pmc Towards a scientific taxonomy of depression
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Dialogues Clin Neurosci 10:301-8. 2008
  10. doi request reprint Schizophrenia is a disorder of higher order hierarchical processing
    Ranga R Krishnan
    Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Box 3950, 4584 South Hospital, White Zone 45, Durham, NC 27710, USA
    Med Hypotheses 72:740-4. 2009

Research Grants

  1. DEPRESSION IN ELDERLY CARDIAC PATIENTS
    Ranga Krishnan; Fiscal Year: 2003
  2. BIPOLAR DISORDER IN LATE LIFE
    Ranga Krishnan; Fiscal Year: 2007
  3. Safety and Efficacy of Sertraline for Depression Congestive Heart Failure
    Ranga Krishnan; Fiscal Year: 2007
  4. BIPOLAR DISORDER IN LATE LIFE
    Ranga Krishnan; Fiscal Year: 2002

Detail Information

Publications67

  1. ncbi request reprint Clinical and treatment response characteristics of late-life depression associated with vascular disease: a pooled analysis of two multicenter trials with sertraline
    K R Krishnan
    Department of Psychiatry and Behavioral Sciences and the Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:347-61. 2001
    ..5. Sertraline was found to be a safe, well-tolerated, and effective as an antidepressant in elderly patients suffering from hypertension and other forms of vascular comorbidity...
  2. ncbi request reprint Clinical experience with substance P receptor (NK1) antagonists in depression
    K Ranga
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27715, USA
    J Clin Psychiatry 63:25-9. 2002
    ..Future trials with SPAs will focus on the identification of appropriate patients and drug regimens and will also define the role of these agents in the treatment of depression...
  3. ncbi request reprint Psychiatric and medical comorbidities of bipolar disorder
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center 3050A, 4584 Hospital South, Box 3950, Durham, NC 27710, USA
    Psychosom Med 67:1-8. 2005
    ..Medical comorbidity may be exacerbated or caused by pharmacotherapy of bipolar symptoms...
  4. ncbi request reprint Treatment of depression in the medically ill
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Rm 4584 White Zone, Duke South, Durham, NC 27710, USA
    J Clin Psychopharmacol 25:S14-8. 2005
    ..Large-scale trials are needed to assess not only the safety and effectiveness of agents for the treatment of depression in comorbid illness, but also the effects of depression on the course of the medical illness itself...
  5. ncbi request reprint Psychiatric disease in the genomic era: rational approach
    K R Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 10:978-84. 2005
    ..It is likely that a standardized approach that can develop and modify classification systems in a timely manner, based on science and free of societal and political influence, can enhance research, teaching and clinical practice...
  6. ncbi request reprint Evidence-based decision-making in psychopharmacology
    Ranga Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 37:24-8. 2003
    ..These processes are efficient and generally accurate, but can sometimes lead to errors or biases. In this review we discuss the nature of these processes and their potential effects on decision making...
  7. ncbi request reprint Concept of disease in geriatric psychiatry
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 15:1-11. 2007
    ..In turn, this strategy should improve our ability to discern particular features of a disease and refine our notion of its clinical presentation and lead toward novel and improved treatments for our patients...
  8. ncbi request reprint Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Am J Psychiatry 160:2003-11. 2003
    ..The authors examined the effect of the acetylcholinesterase inhibitor donepezil on magnetic resonance markers of neurodegeneration in Alzheimer's disease...
  9. pmc Towards a scientific taxonomy of depression
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Dialogues Clin Neurosci 10:301-8. 2008
    ..The first is early life stress disorder, and the second vascular depression. These conditions have reached a point where the data supports them as distinct entities. In this paper, the rationale for this is discussed...
  10. doi request reprint Schizophrenia is a disorder of higher order hierarchical processing
    Ranga R Krishnan
    Department of Psychiatry and Behavioural Sciences, Duke University Medical Center, Box 3950, 4584 South Hospital, White Zone 45, Durham, NC 27710, USA
    Med Hypotheses 72:740-4. 2009
    ..We present evidence that this model explains many of the features of schizophrenia and we make a series of predictions about schizophrenia...
  11. doi request reprint Hierarchical temporal processing deficit model of reality distortion and psychoses
    R R Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 16:129-44. 2011
    ....
  12. ncbi request reprint Evidence-based practice: how to evaluate what you read
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 37:88-91. 2003
    ..In addition there can be a differential impact based on the quality and comparability of studies. In this article we review the potential significance of these biases...
  13. ncbi request reprint Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression
    K Ranga Rama Krishnan
    Department of Psychiatry, Duke University Medical Center, DUMC 3950, Durham, NC 27710, USA
    Biol Psychiatry 55:390-7. 2004
    ..We sought to investigate this diagnosis as a construct by examining differences between depressed subjects with and without magnetic resonance imaging defined subcortical ischemic vascular depression...
  14. ncbi request reprint Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 277120, USA
    Am J Psychiatry 161:1293-6. 2004
    ..The purpose of this study was to determine whether microstructural abnormalities in the white matter of the dorsolateral prefrontal cortex are associated with late-life depression...
  15. ncbi request reprint Does antidepressant therapy improve cognition in elderly depressed patients?
    P Murali Doraiswamy
    Departments of Psychiatry and Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gerontol A Biol Sci Med Sci 58:M1137-44. 2003
    ..To analyze the effects of antidepressants on cognitive functioning in elderly depression...
  16. ncbi request reprint Lobar distribution of lesion volumes in late-life depression: the Biomedical Informatics Research Network (BIRN)
    James R MacFall
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:1500-7. 2006
    ..These changes are thought to disrupt neural circuits involved in mood regulation, thus increasing the risk of developing depression...
  17. ncbi request reprint White matter hyperintensity progression and late-life depression outcomes
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Arch Gen Psychiatry 60:1090-6. 2003
    ..Because they are associated with age, they should increase in number and size over time. To our knowledge, this is the first longitudinal, volumetric MRI study of WMHs in depression...
  18. ncbi request reprint Medical comorbidity in late-life depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Int J Geriatr Psychiatry 19:935-43. 2004
    ..Additionally, differences between subgroups of depressed populations, including those with MRI-defined vascular depression and those with late-onset compared with early-onset depression are not well described...
  19. ncbi request reprint Prefrontal neuropsychological predictors of treatment remission in late-life depression
    Guy G Potter
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2266-71. 2004
    ..By extension, we suggest that orbitofrontal prefrontal cortex may play a role in sustaining perseverative processing in geriatric depression...
  20. ncbi request reprint An 8-week multicenter, parallel-group, double-blind, placebo-controlled study of sertraline in elderly outpatients with major depression
    Lon S Schneider
    Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, and the Leonard Davis School of Gerontology, University of SouthernCalifornia, Los Angeles, CA 90033, USA
    Am J Psychiatry 160:1277-85. 2003
    ..There have been few placebo-controlled trials of selective serotonin reuptake inhibitors for depressed elderly patients. This placebo-controlled study of sertraline was designed to confirm the results of non-placebo-controlled trials...
  21. ncbi request reprint Diffusion tensor imaging: background, potential, and utility in psychiatric research
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC Box 3903, Durham, NC 27710, USA
    Biol Psychiatry 55:201-7. 2004
    ..It is only beginning to be utilized in psychiatric research. This article reviews the theory behind diffusion tensor imaging, its potential to map fiber tracts in the brain, and its recent use in psychiatric research...
  22. ncbi request reprint Is there a definition of remission in late-life depression that predicts later relapse?
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 29:2272-7. 2004
    ..Definitions of remission that are better associated with longer-term outcomes are needed...
  23. ncbi request reprint Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors
    Warren D Taylor
    Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    AJR Am J Roentgenol 181:571-6. 2003
    ..Mean change in lesion volume and mean percentage of change were determined between the two time points. Logistic regression models were used to examine the differential effects of age, sex, race, and self-reported medical morbidity...
  24. ncbi request reprint Localization of age-associated white matter hyperintensities in late-life depression
    Warren D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, DUMC 3903, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:539-44. 2003
    ..Deep white matter hyperintense lesions are associated with advanced age and late-life depression. The authors examined where age-related cerebral lesions occurred in elderly depressed and healthy control subjects...
  25. ncbi request reprint MRI lesion severity and mortality in geriatric depression
    Robert M Levy
    Department of Psychaitry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 11:678-82. 2003
    ..The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients...
  26. ncbi request reprint Response inhibition predicts poor antidepressant treatment response in very old depressed patients
    Joel R Sneed
    Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Geriatr Psychiatry 15:553-63. 2007
    ..There have been mixed findings regarding the prognostic significance of age of onset, executive dysfunction, and hyperintensity burden on treatment outcome in late-life depression...
  27. ncbi request reprint Subcortical lesion severity and orbitofrontal cortex volume in geriatric depression
    Shwu Hua Lee
    Neuropsychiatric Imaging Research Laboratory and Department of Psychiatry and Social Behavior, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 54:529-33. 2003
    ..We also suggest that subcortical lesions may decrease OFC volume. Further studies are needed to understand how subcortical lesions may be related to OFC volume changes...
  28. ncbi request reprint Sociodemographic and clinical predictors of mortality in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3903, Durham, NC 27710 0001, USA
    Am J Geriatr Psychiatry 10:531-40. 2002
    ..The authors report on prospectively observed mortality in elderly depressed patients, comparing differences in sex and vascular risk...
  29. ncbi request reprint Left orbital frontal cortex volume and performance on the benton visual retention test in older depressives and controls
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 28:2179-83. 2003
    ..These results add to the literature linking mood and cognitive disturbances to the PFC. Future studies with a larger sample employing functional measures are warranted...
  30. ncbi request reprint Cholesterol-lowering medication and relapse of depression
    David C Steffens
    Division of Geriatric Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Psychopharmacol Bull 37:92-8. 2003
    ..Future studies of depression outcomes in the elderly will need to include serial examination of cholesterol levels...
  31. ncbi request reprint Progression of subcortical ischemic disease from vascular depression to vascular dementia
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham NC 27710, USA
    Am J Psychiatry 160:1751-6. 2003
  32. ncbi request reprint Smaller orbital frontal cortex volumes associated with functional disability in depressed elders
    Warren D Taylor
    Department of Psychiatry and Behavioral Medicine at Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 53:144-9. 2003
    ..Recent evidence has linked the orbital frontal cortex (OFC) with depression. We examined the relationship between OFC volumes in older subjects and impairment in the basic (BADL) and instrumental (IADL) activities of daily living...
  33. pmc Prominent reduction in pyramidal neurons density in the orbitofrontal cortex of elderly depressed patients
    Grazyna Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Biol Psychiatry 58:297-306. 2005
    ..Elderly depressed patients have more vascular hyperintensities in frontal white matter and basal ganglia than elderly control subjects. Cell pathology that might be related to increased vascular hyperintensities has not been examined...
  34. ncbi request reprint Partial response as a predictor of outcome in geriatric depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am J Geriatr Psychiatry 11:340-8. 2003
    ..Data are lacking on the eventual outcomes of individuals who are partial responders or poor responders to initial treatment...
  35. ncbi request reprint The Duke Somatic Treatment Algorithm for Geriatric Depression (STAGED) approach
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3903, Durham, NC 27710, USA
    Psychopharmacol Bull 36:58-68. 2002
    ..6% of patients responded, and 65.35% of patients were able to achieve full remission of symptoms. The STAGED approach appears to be a clinically useful method of successfully treating elderly depressed patients...
  36. ncbi request reprint The Depression Interview and Structured Hamilton (DISH): rationale, development, characteristics, and clinical validity
    Kenneth E Freedland
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Psychosom Med 64:897-905. 2002
    ..This article describes the development and characteristics of the DISH and presents a validity study and data on its use in ENRICHD...
  37. pmc BDNF Val66Met genotype and 6-month remission rates in late-life depression
    W D Taylor
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Pharmacogenomics J 11:146-54. 2011
    ..Thus in this exploratory analysis, the Met66 allele may be associated with increased odds of remission in older subjects, but also with increased time to remission as there was no 3-month effect...
  38. ncbi request reprint Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure
    W Jiang
    Department of Psychiatry, Duke University Medical Center, Durham, NC, USA
    Arch Intern Med 161:1849-56. 2001
    ..Patients with congestive heart failure (CHF) may have a high prevalence of depression, which may increase the risk of adverse outcomes...
  39. ncbi request reprint The case for practical clinical trials in psychiatry
    John S March
    Department of Psychiatry and Behavioral Sciences, Duke Child and Family Study Center, 718 Rutherford St, Durham, NC 27705, USA
    Am J Psychiatry 162:836-46. 2005
    ..The authors present the case for psychiatry's adoption of the practical clinical trials model, which is widely used in research in other areas of medicine...
  40. ncbi request reprint Clinical Computing: Clinical Management Research Information System (CRIS)
    Ken Gersing
    Department of Psychiatry, Duke University Medical Center, Box 3018, Durham, NC 27719, USA
    Psychiatr Serv 54:1199-200. 2003
  41. pmc Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial
    CHRISTOPHER M O'CONNOR
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 56:692-9. 2010
    ..The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo...
  42. pmc Opioid use affects antioxidant activity and purine metabolism: preliminary results
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
    Hum Psychopharmacol 24:666-75. 2009
    ..Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant compounds and purine metabolism. We examined perturbations of neurotransmitter-related pathways in opioid dependence (OD)...
  43. ncbi request reprint The Child and Adolescent Psychiatry Trials Network (CAPTN)
    John S March
    Department of Psychiatry and Behavioral Sciences and the Duke Clinical Research Institute at Duke University Medical Center, Durham, NC 27710, USA
    J Am Acad Child Adolesc Psychiatry 43:515-8. 2004
    ..The current generation of clinical trials in pediatric psychiatry often fails to maximize clinical utility for practicing clinicians, thereby diluting its impact...
  44. pmc Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure
    Wei Jiang
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 156:437-44. 2008
    ..The impact of sertraline on the prognosis and depression of patients with chronic heart failure (HF) and comorbid major depressive disorder (MDD) is unknown...
  45. pmc Characteristics of depression remission and its relation with cardiovascular outcome among patients with chronic heart failure (from the SADHART-CHF Study)
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Am J Cardiol 107:545-51. 2011
    ..5, Beck Depression Inventory scale 17.9 ± 6.5 vs 20.3 ± 7.2, p <0.001 for the 2 comparisons). In conclusion, this study indicates that remission from depression may improve the cardiovascular outcome of patients with heart failure...
  46. doi request reprint Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychopharmacol 31:207-13. 2011
    ..In conclusion, 4-week pregabalin treatment improved HRV in patients with painful diabetic peripheral neuropathy. Trial Registration: NCT00573261 (clinicaltrials.gov)...
  47. ncbi request reprint Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study
    David C Steffens
    Duke University Medical Center, Department of Psychiatry, Durham, NC 27710, USA
    Stroke 33:1636-44. 2002
    ..The Cardiovascular Health Study (CHS) provides an opportunity to examine the relationship between vascular brain pathology seen on neuroimaging and changes in depressive symptoms...
  48. ncbi request reprint Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype
    Eileen P Ahearn
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Med Genet 114:652-8. 2002
    ..Multipoint linkage analysis yielded negative results except for Model 1a, in which a maximal LOD score was -1.24. A mutation screen of Exons 3 and 4 was negative. Notch3 does not appear to be a candidate gene for BPD in this family...
  49. ncbi request reprint Effect of bupropion SR on specific symptom clusters of depression: analysis of the 31-item Hamilton Rating Scale for depression
    Brenda D Jamerson
    Department of Clinical Research, Campbell University, Durham, NC 27703, USA
    Psychopharmacol Bull 37:67-78. 2003
    ..Bupropion SR demonstrated a significant reduction (p<.01, least square mean change) in symptoms over placebo on 4 domains (cognitive, retardation, fatigue/interest, and anxiety items)...
  50. ncbi request reprint Evidence-based mental health use of anticonvulsants during pregnancy
    Jane P Gagliardi
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacol Bull 37:59-66. 2003
    ....
  51. ncbi request reprint Comorbidity and depression treatment
    K Ranga Rama Krishnan
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Psychiatry 53:701-6. 2003
    ..The best designed studies reported the least effects of these factors on treatment outcome. Clinically, this suggests that these factors should not be seen as impediments to treatment...
  52. ncbi request reprint Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits?
    P Murali Doraiswamy
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    Prog Neuropsychopharmacol Biol Psychiatry 26:705-12. 2002
    ..The results support the value of early treatment of AD patients, particularly those with moderately severe AD...
  53. ncbi request reprint MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex
    Dennis M Kim
    School of Medicine, Duke University Medical Center, 27710, Durham, NC, USA
    Psychiatry Res 114:149-61. 2002
    ..Implications for brain morphometry, the use of fat as a reference standard, and other issues in neuroimaging are discussed...
  54. doi request reprint Metabolomics: a global biochemical approach to the study of central nervous system diseases
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 34:173-86. 2009
    ..Metabolomics emerges as another powerful tool in central nervous system research...
  55. ncbi request reprint Allelic differences in the serotonin transporter-linked polymorphic region in geriatric depression
    David C Steffens
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    Am J Geriatr Psychiatry 10:185-91. 2002
    ..The findings raise the possibility that this genetic locus may exert differential effects based on gender, increasing risk in men, and increasing risk of recurrence in women...
  56. ncbi request reprint Depression and ischemic heart disease: what have we learned so far and what must we do in the future?
    Wei Jiang
    Department of Internal Medicine and Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 150:54-78. 2005
  57. ncbi request reprint Effects of paroxetine and venlafaxine XR on heart rate variability in depression
    Jonathan Davidson
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Psychopharmacol 25:480-4. 2005
    ..Further comparisons of selective serotonin reuptake inhibitor and serotonin and norepinephrine reuptake inhibitor drugs on HRV are warranted...
  58. ncbi request reprint Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction
    C Barr Taylor
    Department of Psychiatry and Behavioral Sciences, Stanford Medical Center, Stanford University School of Medicine, Stanford, CA 94305 5722, USA
    Arch Gen Psychiatry 62:792-8. 2005
    ..Depression after myocardial infarction (MI) is associated with higher morbidity and mortality. Although antidepressants are effective in reducing depression, their use in patients with cardiovascular disease remains controversial...
  59. ncbi request reprint Sertraline treatment of major depression in patients with acute MI or unstable angina
    Alexander H Glassman
    Department of Clinical Psychopharmacology, New York State Psychiatric Institute, 1051 Riverside Dr, Unit 116, New York, NY 10032, USA
    JAMA 288:701-9. 2002
    ..However, no published evidence exists that antidepressant drugs are safe or efficacious in patients with unstable ischemic heart disease...
  60. ncbi request reprint Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial
    Steven P Roose
    New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 161:2050-9. 2004
    ..This study determined the efficacy of antidepressant medication for the treatment of depression in the "old-old."..
  61. ncbi request reprint MRI subcortical hyperintensities in old and very old depressed outpatients: the important role of age in late-life depression
    Stephen Salloway
    Brown Medical School, Providence, RI, USA
    J Neurol Sci 203:227-33. 2002
    ..This study examined the severity of subcortical hyperintensities (SH) and the relationship between SH and depression characteristics in two samples of elderly depressed outpatients differing in age...
  62. ncbi request reprint Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892, USA
    Biol Psychiatry 54:744-50. 2003
    ..Using automated multivoxel two-dimensional CSI (1)H-MRS techniques, we tested the hypothesis that patients with MDD have focal neuronal and membrane abnormalities localized in the subcortical region...
  63. ncbi request reprint The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients
    Stephen Salloway
    Department of Neurology, Butler Hospital Providence, RI 02906, USA
    Am J Geriatr Psychiatry 10:107-11. 2002
    ..The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation...
  64. ncbi request reprint Provisional diagnostic criteria for depression of Alzheimer disease
    Jason T Olin
    Adult and Geriatric Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9635, USA
    Am J Geriatr Psychiatry 10:125-8. 2002
    ....
  65. ncbi request reprint Magnitude of placebo response and drug-placebo differences across psychiatric disorders
    Arif Khan
    Northwest Clinical Research Center, Bellevue, WA, USA
    Psychol Med 35:743-9. 2005
    ..Placebo response, drug response, and drug-placebo differences appear to vary among psychiatric conditions...
  66. ncbi request reprint Mood disorders in the medically ill: scientific review and recommendations
    Dwight L Evans
    School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA 19104, USA
    Biol Psychiatry 58:175-89. 2005
    ....
  67. ncbi request reprint Research design features and patient characteristics associated with the outcome of antidepressant clinical trials
    Arif Khan
    Northwest Clinical Research Center, Number 112, 1900 116th Avenue NE, Bellevue, WA 98004, USA
    Am J Psychiatry 161:2045-9. 2004
    ..The authors examined which, if any, research design features and patient characteristics would significantly differ between successful and unsuccessful antidepressant trials...

Research Grants22

  1. DEPRESSION IN ELDERLY CARDIAC PATIENTS
    Ranga Krishnan; Fiscal Year: 2003
    ....
  2. BIPOLAR DISORDER IN LATE LIFE
    Ranga Krishnan; Fiscal Year: 2007
    ..This research is unique and is likely to enhance our understanding of the phenomenology, course, outcome and relationship of MRI changes to the pathophysiology of bipolar disorder in late life. ..
  3. Safety and Efficacy of Sertraline for Depression Congestive Heart Failure
    Ranga Krishnan; Fiscal Year: 2007
    ..Information collected in these follow-up contacts will include deaths, re-hospitalizations, cardiac events, functional status/quality of life measures, and level of depressive symptoms. ..
  4. BIPOLAR DISORDER IN LATE LIFE
    Ranga Krishnan; Fiscal Year: 2002
    ..This research is likely to be valuable in developing an understanding of the psychobiology of bipolar disorder and could lead to improving diagnosis and management of late life bipolar disorder. ..