W E Kraus

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Effects of the amount and intensity of exercise on plasma lipoproteins
    William E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1483-92. 2002
  2. pmc A whole blood gene expression-based signature for smoking status
    Philip Beineke
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94303, USA
    BMC Med Genomics 5:58. 2012
  3. pmc Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5
    Daniel K Nolan
    Center for Human Genetics, Duke University, 905 S, LaSalle Street, Duke Univeristy Medical Center, Durham, NC 27710, USA
    BMC Genet 13:12. 2012
  4. pmc Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
    Michael R Elashoff
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94602, USA
    BMC Med Genomics 4:26. 2011
  5. pmc Genetic and functional association of FAM5C with myocardial infarction
    Jessica J Connelly
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Med Genet 9:33. 2008
  6. pmc Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer
    Lee W Jones
    Duke University Medical Center, Durham, NC, USA
    BMC Cancer 10:531. 2010
  7. pmc The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design
    Lee W Jones
    Duke University Medical Center, Durham, NC, USA
    BMC Cancer 10:155. 2010
  8. ncbi request reprint Studies of a targeted risk reduction intervention through defined exercise (STRRIDE)
    W E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Sports Exerc 33:1774-84. 2001
  9. doi request reprint Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect
    William E Kraus
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Obesity (Silver Spring) 17:S21-6. 2009
  10. ncbi request reprint Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations
    B D Duscha
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 33:1956-63. 1999

Detail Information

Publications93

  1. ncbi request reprint Effects of the amount and intensity of exercise on plasma lipoproteins
    William E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    N Engl J Med 347:1483-92. 2002
    ..However, the amount of exercise training required for optimal benefit is unknown. In a prospective, randomized study, we investigated the effects of the amount and intensity of exercise on lipoproteins...
  2. pmc A whole blood gene expression-based signature for smoking status
    Philip Beineke
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94303, USA
    BMC Med Genomics 5:58. 2012
    ..We sought to identify genes whose levels of expression in whole blood correlate with self-reported smoking status...
  3. pmc Fine mapping of a linkage peak with integration of lipid traits identifies novel coronary artery disease genes on chromosome 5
    Daniel K Nolan
    Center for Human Genetics, Duke University, 905 S, LaSalle Street, Duke Univeristy Medical Center, Durham, NC 27710, USA
    BMC Genet 13:12. 2012
    ..e., a qualitative phenotype) using linkage and association in the presence of linkage (APL; GENECARD) and logistic regression (CATHGEN and aortas)...
  4. pmc Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients
    Michael R Elashoff
    CardioDx, Inc, 2500 Faber Place, Palo Alto, CA 94602, USA
    BMC Med Genomics 4:26. 2011
    ..A non-invasive blood test that could reliably assess obstructive CAD likelihood would have diagnostic utility...
  5. pmc Genetic and functional association of FAM5C with myocardial infarction
    Jessica J Connelly
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, NC, USA
    BMC Med Genet 9:33. 2008
    ..59, D1S1589/D1S518). The overlap of genetic screens in independent data sets provides evidence for the existence of a gene or genes for CAD in this region...
  6. pmc Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer
    Lee W Jones
    Duke University Medical Center, Durham, NC, USA
    BMC Cancer 10:531. 2010
    ....
  7. pmc The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design
    Lee W Jones
    Duke University Medical Center, Durham, NC, USA
    BMC Cancer 10:155. 2010
    ....
  8. ncbi request reprint Studies of a targeted risk reduction intervention through defined exercise (STRRIDE)
    W E Kraus
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Sports Exerc 33:1774-84. 2001
    ....
  9. doi request reprint Exercise training, lipid regulation, and insulin action: a tangled web of cause and effect
    William E Kraus
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Obesity (Silver Spring) 17:S21-6. 2009
    ....
  10. ncbi request reprint Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations
    B D Duscha
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 33:1956-63. 1999
    ..The study was conducted to determine if the capillary density of skeletal muscle is a potential contributor to exercise intolerance in class II-III chronic heart failure (CHF)...
  11. ncbi request reprint The effect of the PREMIER interventions on insulin sensitivity
    Jamy D Ard
    Duke Hypertension Center, Duke University Medical Center, and Center for Health Services Research in Primary Care, VA Medical Center, Durham, North Carolina, USA
    Diabetes Care 27:340-7. 2004
    ..This ancillary study of PREMIER sought to determine the effects on insulin sensitivity of a comprehensive behavioral intervention for hypertension with and without the Dietary Approaches to Stop Hypertension (DASH) dietary pattern...
  12. pmc Peakwide mapping on chromosome 3q13 identifies the kalirin gene as a novel candidate gene for coronary artery disease
    Liyong Wang
    Center for Human Genetics, Department of Medicine, Duke Univeristy Medical Center, Durham, NC, USA
    Am J Hum Genet 80:650-63. 2007
    ..KALRN and two other associated genes identified in this study (CDGAP and MYLK) belong to the Rho GTPase-signaling pathway. Our data suggest the importance of the KALRN gene and the Rho GTPase-signaling pathway in the pathogenesis of CAD...
  13. pmc GATA2 is associated with familial early-onset coronary artery disease
    Jessica J Connelly
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States
    PLoS Genet 2:e139. 2006
    ....
  14. ncbi request reprint Inactivity, exercise, and visceral fat. STRRIDE: a randomized, controlled study of exercise intensity and amount
    Cris A Slentz
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    J Appl Physiol 99:1613-8. 2005
    ..Importantly, a modest increase over the CDC/ACSM exercise recommendations resulted in significant decreases in visceral, subcutaneous, and total abdominal fat without changes in caloric intake...
  15. pmc Exercise dose response in muscle
    B D Duscha
    Division of Rheumatology, Medical Center, Duke University, Durham, NC, USA
    Int J Sports Med 33:218-23. 2012
    ..05 and capillaries/mm2 r= - 0.310, p<0.05). These data suggest muscle adaptations occur following both low and high exercise doses, but are only related to improved peak VO2 following high amount-high intensity training...
  16. doi request reprint Reclassification of cardiovascular risk using integrated clinical and molecular biosignatures: Design of and rationale for the Measurement to Understand the Reclassification of Disease of Cabarrus and Kannapolis (MURDOCK) Horizon 1 Cardiovascular Disease
    Svati H Shah
    Duke University Medical Center, Durham, NC, USA
    Am Heart J 160:371-379.e2. 2010
    ..Clinical predictive models leave gaps in our ability to stratify cardiovascular risk. High-throughput molecular profiling promises to improve risk classification...
  17. ncbi request reprint Deconditioning fails to explain peripheral skeletal muscle alterations in men with chronic heart failure
    Brian D Duscha
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Am Coll Cardiol 39:1170-4. 2002
    ....
  18. pmc Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Tr
    Allen E Atchley
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 158:S53-63. 2009
    ..This article addresses the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) gated SPECT imaging (gSPECT) substudy baseline results...
  19. pmc Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case-control and family datasets
    Beth S Sutton
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:1318-28. 2008
    ..Further functional studies involving a combination of risk alleles are warranted...
  20. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  21. ncbi request reprint Cardiac rehabilitation and survival in patients with left ventricular systolic dysfunction
    D J Whellan
    Department of Medicine Cardiology, Duke University Medical Center, Durham, NC, USA
    Am Heart J 142:160-6. 2001
    ..It remains unproven whether exercise training improves survival...
  22. pmc Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis
    David R Crosslin
    Center for Human Genetics, Duke University Medical Center, 595 LaSalle Street, Durham, NC 27710, USA
    Hum Genet 125:217-29. 2009
    ....
  23. pmc ALOX5AP variants are associated with in-stent restenosis after percutaneous coronary intervention
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, United States
    Atherosclerosis 201:148-54. 2008
    ..There is no accurate way to predict in-stent restenosis, although risk factors for atherosclerosis overlap those for in-stent restenosis. Therefore, we evaluated atherosclerosis candidate genes for association with in-stent restenosis...
  24. pmc Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:577-83. 2008
    ..In contradiction to our hypothesis, despite significant alterations in body composition, exercise training produced limited cytokine responses...
  25. pmc Exercise training amount and intensity effects on metabolic syndrome (from Studies of a Targeted Risk Reduction Intervention through Defined Exercise)
    Johanna L Johnson
    Department of Medicine, Division of Cardiology, Duke University Medical Center and Duke Center for Living, Durham, North Carolina, USA
    Am J Cardiol 100:1759-66. 2007
    ..A higher amount of vigorous exercise had greater and more widespread benefits. Finally, there was an indication that moderate-intensity may be better than vigorous-intensity exercise for improving MS...
  26. ncbi request reprint Increased levels of apoptosis in gastrocnemius skeletal muscle in patients with peripheral arterial disease
    Robert G Mitchell
    Division of Cardiology, Department of Medicine, Durham VA and Duke University Medical Center, Durham, NC 27710, USA
    Vasc Med 12:285-90. 2007
    ..53% +/- 0.96; p < 0.001). In conclusion, PAD is associated with increased levels of apoptosis in the peripheral skeletal muscle. Further study is required to ascertain whether apoptosis plays a role in decreased functional capacity...
  27. pmc Dietary carbohydrate intake and high-sensitivity C-reactive protein in at-risk women and men
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 154:962-8. 2007
    ..Our objective was to determine if GL is related to hsCRP and other measures of CVD risk in a population of sedentary, overweight, dyslipidemic middle-aged women and men enrolled in an exercise intervention trial (STRRIDE)...
  28. pmc N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study
    G Michael Felker
    Duke Clinical Research Institute, Durham, NC 27705, USA
    Am Heart J 158:S37-44. 2009
    ..To examine the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and exercise capacity in a large contemporary cohort of patients with chronic heart failure...
  29. pmc Effects of exercise on lipoprotein particles in women with polycystic ovary syndrome
    Ann J Brown
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Sports Exerc 41:497-504. 2009
    ..The purpose of this study was to examine the effects of a moderate-intensity exercise program without weight loss on lipoprotein profiles in women with PCOS...
  30. ncbi request reprint Main outcomes of the FRESH START trial: a sequentially tailored, diet and exercise mailed print intervention among breast and prostate cancer survivors
    Wendy Demark-Wahnefried
    Duke School of Nursing, Duke Comprehensive Cancer Center, and Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 25:2709-18. 2007
    ..The FRESH START trial tested the efficacy of sequentially tailored versus standardized mailed materials on improving cancer survivors' diet and exercise behaviors...
  31. pmc Relationships between exercise-induced reductions in thigh intermuscular adipose tissue, changes in lipoprotein particle size, and visceral adiposity
    Michael T Durheim
    Duke University Medical Center, 1300 Morreene Rd, Durham, NC 27705, USA
    Am J Physiol Endocrinol Metab 295:E407-12. 2008
    ..Reducing IMAT through aerobic exercise may be functionally related to some improvements in atherogenic dyslipidemia in men...
  32. pmc Impact of hormone replacement therapy on exercise training-induced improvements in insulin action in sedentary overweight adults
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Metabolism 57:888-95. 2008
    ..These findings have implications for the relative utility of ET for improving insulin action in middle-aged men and women, particularly in the setting of differences in HRT use...
  33. pmc Effects of exercise training intensity on pancreatic beta-cell function
    Cris A Slentz
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Diabetes Care 32:1807-11. 2009
    ..Insulin resistance and beta-cell dysfunction both are important contributors to the pathogenesis of type 2 diabetes. Exercise training improves insulin sensitivity, but its effects on beta-cell function are less well studied...
  34. pmc Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Diabetes Care 32:1678-83. 2009
    ..To determine whether circulating metabolic intermediates are related to insulin resistance and beta-cell dysfunction in individuals at risk for type 2 diabetes...
  35. pmc Comparing the 7-day physical activity recall with a triaxial accelerometer for measuring time in exercise
    Richard Sloane
    The Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Sports Exerc 41:1334-40. 2009
    ....
  36. pmc High heritability of metabolomic profiles in families burdened with premature cardiovascular disease
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Mol Syst Biol 5:258. 2009
    ..27). We report a novel finding of high heritabilities of metabolites in premature CAD, establishing a possible genetic basis for these profiles. These results have implications for understanding CAD pathophysiology and genetics...
  37. pmc Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    JAMA 301:1451-9. 2009
    ..Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent...
  38. pmc Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial
    CHRISTOPHER M O'CONNOR
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    JAMA 301:1439-50. 2009
    ..Guidelines recommend that exercise training be considered for medically stable outpatients with heart failure. Previous studies have not had adequate statistical power to measure the effects of exercise training on clinical outcomes...
  39. pmc A sex-specific relationship between capillary density and anaerobic threshold
    Jennifer L Robbins
    Duke University Medical Center, Division of Cardiology, Durham, North Carolina 27710, USA
    J Appl Physiol 106:1181-6. 2009
    ..05) between the change in these variables. These findings suggest that, although enhanced capillary density is associated with training-induced improvements in submaximal performance in men, this relationship is different in women...
  40. doi request reprint Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events
    Svati H Shah
    Department of Medicine, Duke University, Durham, NC, USA
    Circ Cardiovasc Genet 3:207-14. 2010
    ..Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events...
  41. pmc Sex-specific alterations in mRNA level of key lipid metabolism enzymes in skeletal muscle of overweight and obese subjects following endurance exercise
    Ira J Smith
    Center for the Study of Aging, Duke University Medical Center, Durham, North Carolina 27710, USA
    Physiol Genomics 36:149-57. 2009
    ..Future studies should determine whether these adaptations in mRNA levels translate into changes in protein function...
  42. doi request reprint Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study
    Lee W Jones
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Cancer 113:3430-9. 2008
    ..A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted...
  43. pmc Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failure
    Kathryn E Flynn
    Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC 27715, USA
    Am Heart J 158:S64-71. 2009
    ..We examined associations between patient-reported measures of health-related quality of life and clinical indicators of disease severity in a large, heterogeneous sample of patients with heart failure...
  44. ncbi request reprint Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells
    Deborah M Muoio
    Department of Medicine and Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Diabetes 51:901-9. 2002
    ..These results demonstrate a role for hPPAR-alpha in regulating muscle lipid homeostasis...
  45. ncbi request reprint Effects of the amount of exercise on body weight, body composition, and measures of central obesity: STRRIDE--a randomized controlled study
    Cris A Slentz
    Divisions of Cardiology, Geriatric Medicine, and General Internal Medicine, Department of Medicine, Duke Center for Living, Center for Health Policy Research, Durham, NC 27710, USA
    Arch Intern Med 164:31-9. 2004
    ..Obesity is a major health problem due, in part, to physical inactivity. The amount of activity needed to prevent weight gain is unknown...
  46. ncbi request reprint Obesity and physical activity: a review
    Daniel R Bensimhon
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Clinical Research Institute, Durham, NC, USA
    Am Heart J 151:598-603. 2006
    ..This article reviews the available literature regarding the role of exercise in the prevention and treatment of obesity and evaluates the adequacy of current national guidelines...
  47. ncbi request reprint Effects of exercise training amount and intensity on peak oxygen consumption in middle-age men and women at risk for cardiovascular disease
    Brian D Duscha
    Department of Medicine, Division of Cardiology, Duke University Medical Center, Box 3022, Durham, NC 27710, USA
    Chest 128:2788-93. 2005
    ..Although increasing aerobic fitness by exercise training is advocated as part of a healthy lifestyle, studies examining the different effects of intensity and amount on peak consumption (V(O2)) remain sparse...
  48. pmc Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy
    James Rochon
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    J Gerontol A Biol Sci Med Sci 66:97-108. 2011
    ..This article presents the design and implementation of this study...
  49. pmc Exercise and health: can biotechnology confer similar benefits?
    R Sanders Williams
    School of Medicine at Duke University, Durham, North Carolina, USA
    PLoS Med 2:e68. 2005
  50. ncbi request reprint Agreement between a brief mailed screener and an in-depth telephone survey: observations from the Fresh Start study
    Denise Clutter Snyder
    Department of Surgery, Center for the Study of Aging and Human Development, Duke University Medical Center, Box 3003, Durham, NC 27710, USA
    J Am Diet Assoc 104:1593-6. 2004
    ..Decisions to use brief screening instruments should be based on available resources and tolerance for misclassification...
  51. ncbi request reprint Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study
    Johanna L Johnson
    Divisions of Cardiology, Duke Center for Living, Duke University Medical Center, 1300 Morreene Road, DUMC Box 3022 Durham, NC 27710, USA
    Atherosclerosis 176:371-7. 2004
    ..Within this homogenous population, there were distinct differences between gender and racial groups. Blacks and women had less atherogenic profiles than whites and men, which was not evident from the standard lipid panel...
  52. pmc Changes in functional performance measures in adults undergoing chemoradiation for primary malignant glioma: a feasibility study
    Lee W Jones
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncologist 15:636-47. 2010
    ..To investigate the feasibility of longitudinal assessment of functional performance measures in newly diagnosed postsurgical malignant glioma patients...
  53. pmc Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites
    Gerda G Fillenbaum
    Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Gerontol A Biol Sci Med Sci 65:1123-9. 2010
    ..To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age...
  54. pmc Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Diabetes Care 34:174-6. 2011
    ..To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators...
  55. ncbi request reprint Nutrition as a contributor and treatment option for overweight and obesity
    Julie D Pruitt
    Center for Living, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 151:628-32. 2006
  56. ncbi request reprint Total nitrogen oxide following exercise testing reflects endothelial function and discriminates health status
    Jason D Allen
    Department of Medicine, Duke University Medical Center, Center for Living Campus, DUMC 3022, Durham, NC 27710, USA
    Free Radic Biol Med 41:740-7. 2006
    ..46 to 66.48 + 21.11 microM; P <or= 0.01). These findings suggest that plasma NO(x) following GXT discriminate cardiovascular disease status, are related to regional endothelial function, and respond favorably to exercise training...
  57. ncbi request reprint Modest exercise prevents the progressive disease associated with physical inactivity
    Cris A Slentz
    Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Exerc Sport Sci Rev 35:18-23. 2007
    ..There seems to be a critical minimal level of physical activity required to maintain metabolic health. A modest amount of exercise seems to prevent metabolic deterioration...
  58. pmc A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study
    Elizabeth R Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 75:436-47. 2004
    ..These data provide initial areas of the human genome where further investigation may reveal susceptibility genes for early-onset CAD...
  59. ncbi request reprint Response of high-sensitivity C-reactive protein to exercise training in an at-risk population
    Kim M Huffman
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 152:793-800. 2006
    ..Our objective was to determine if modulating fitness with exercise training imposes changes in high-sensitivity C-reactive protein in a mixed-sex population at risk for cardiovascular disease...
  60. ncbi request reprint Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount
    Cris A Slentz
    Division of Cardiology, Duke Univ Medical Center, Durham, NC 27710, USA
    J Appl Physiol 103:432-42. 2007
    ..Moderate-intensity but not vigorous-intensity exercise resulted in sustained VLDL-triglyceride lowering. Thirty minutes per day of vigorous exercise, like jogging, has sustained beneficial effects on HDL metabolism...
  61. ncbi request reprint Minimal versus umbilical waist circumference measures as indicators of cardiovascular disease risk
    Leslie H Willis
    Division of Cardiology, Department of Medicine, Duke University Medical Center, P O Box 102903, Durham, NC 27710, USA
    Obesity (Silver Spring) 15:753-9. 2007
    ..We examined two WC locations to determine which was more highly correlated with CVD risk factors and metabolic syndrome (MS)...
  62. ncbi request reprint Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002
    ....
  63. ncbi request reprint Design of FRESH START: a randomized trial of exercise and diet among cancer survivors
    Wendy Demark-Wahnefried
    Duke University Medical Center DUMC, Durham, NC 27710, USA
    Med Sci Sports Exerc 35:415-24. 2003
    ....
  64. pmc Exercise, abdominal obesity, skeletal muscle, and metabolic risk: evidence for a dose response
    Cris A Slentz
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Obesity (Silver Spring) 17:S27-33. 2009
    ..Finally, favorable modulation of mitochondrial oxidative capacity in skeletal muscle by exercise training may reduce a block for complete oxidation of fatty acids in muscle and thereby relieve a block to effective insulin signaling...
  65. pmc Quantitative assessment of cardiorespiratory fitness, skeletal muscle function, and body composition in adults with primary malignant glioma
    Lee W Jones
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer 116:695-704. 2010
    ..The study was undertaken to evaluate cardiorespiratory fitness, skeletal muscle function, and body composition of patients with newly diagnosed and untreated, postsurgical primary malignant glioma...
  66. doi request reprint Effects of exercise training amount on physical activity energy expenditure
    Robert P Hollowell
    Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Med Sci Sports Exerc 41:1640-4. 2009
    ....
  67. pmc Gene expression patterns in peripheral blood correlate with the extent of coronary artery disease
    Peter R Sinnaeve
    Duke University Medical Center and Duke Clinical Research Institute, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 4:e7037. 2009
    ..In conclusion, the simultaneous expression pattern of 160 genes in whole blood correlates with the severity of coronary artery disease and mirrors expression changes in the atherosclerotic vascular wall...
  68. pmc Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis
    Svati H Shah
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 5:e1000318. 2009
    ..We conclude that NPY contributes to atherosclerosis pathogenesis...
  69. pmc Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies
    Lisheng Zhang
    Department of Medicine Cardiology, Duke University Medical Center, Durham, NC, USA
    Hum Mol Genet 19:2754-66. 2010
    ..We conclude that TNFR1 polymorphisms associate with aging-related CAD in humans, and TNFR1 contributes to aging-dependent atherosclerosis in mice...
  70. ncbi request reprint Differences in skeletal muscle between men and women with chronic heart failure
    B D Duscha
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Appl Physiol 90:280-6. 2001
    ..These observations were not reproduced in CHF women. This suggests that differences may exist in how skeletal muscle adapts to decreasing peak VO(2) in patients with CHF...
  71. ncbi request reprint Effects of chronic exposure to simulated microgravity on skeletal muscle cell proliferation and differentiation
    D H Slentz
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    In Vitro Cell Dev Biol Anim 37:148-56. 2001
    ..Therefore, this model provides conditions wherein cellular differentiation and proliferation appear to be uncoupled...
  72. ncbi request reprint Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy
    A B Mathur
    Center for Cellular and Biosurface Engineering, Department of Biomedical Engineering, Duke University, Box 90281, 136 Hudson Hall, Durham, NC 27708-0281, USA
    J Biomech 34:1545-53. 2001
    ..4 kPa) depending on the location of the cell surface tested. Cardiac and skeletal muscle exhibited nonlinear elastic behavior. These passive mechanical properties are generally consistent with the function of these different cell types...
  73. ncbi request reprint Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q
    S H Shah
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Ann Hum Genet 70:738-48. 2006
    ..06). Our findings suggest the presence of etiologic heterogeneity in families with early-onset CAD, potentially due to differential effects of lipoprotein phenotypes. Candidate genes are under investigation...
  74. ncbi request reprint Regulation of type II adenylyl cyclase mRNA in rabbit skeletal muscle by chronic motor nerve pacing
    C E Torgan
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol 271:E253-60. 1996
    ....
  75. pmc Skeletal muscle dictates the fibrinolytic state after exercise training in overweight men with characteristics of metabolic syndrome
    Dustin S Hittel
    Research Center for Genetic Medicine, Children s National Medical Center and George Washington University, Washington, DC, USA
    J Physiol 548:401-10. 2003
    ..We conclude that aerobic exercise training induces both local and systemic changes in fibrinolysis and vascular homeostasis that are probably protective against cardiovascular disease...
  76. ncbi request reprint Differential effects of exercise training in men and women with chronic heart failure
    Steven J Keteyian
    Henry Ford Heart and Vascular Institute, Detroit, Mich, USA
    Am Heart J 145:912-8. 2003
    ..We described and compared the effects of exercise training on exercise capacity and skeletal muscle histochemistry in men and women with chronic heart failure...
  77. ncbi request reprint Adiponectin is not altered with exercise training despite enhanced insulin action
    Matthew W Hulver
    Department of Physiology, East Carolina University, Greenville North Carolina 27858, USA
    Am J Physiol Endocrinol Metab 283:E861-5. 2002
    ..These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity...
  78. ncbi request reprint PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
    Jessica Norrbom
    Department of Physiology and Pharmacology, Section of Molecular Exercise Physiology, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Appl Physiol 96:189-94. 2004
    ..This suggests that calcineurin may be activated by exercise in humans and does not exclude that calcineurin could play a role in PGC-1 transcription activation in human skeletal muscle...
  79. ncbi request reprint Exercise training increases electron and substrate shuttling proteins in muscle of overweight men and women with the metabolic syndrome
    Dustin S Hittel
    Research Center for Genetic Medicine, Children s National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010, USA
    J Appl Physiol 98:168-79. 2005
    ..These biochemical adaptations complement existing molecular models for improved glucose tolerance with exercise intervention in prediabetic individuals...
  80. ncbi request reprint Where does fitness fit in?
    William E Kraus
    N Engl J Med 353:517-9. 2005
  81. ncbi request reprint Effect of the volume and intensity of exercise training on insulin sensitivity
    Joseph A Houmard
    Department of Exercise and Sports Science, East Carolina University, Greenville, NC 27858, USA
    J Appl Physiol 96:101-6. 2004
    ..Total exercise duration should thus be considered when designing training programs with the intent of improving insulin action...
  82. ncbi request reprint Genetic association studies; the good, the bad, and the ugly
    Mark P Donahue
    Am Heart J 154:610-2. 2007
  83. ncbi request reprint Effect of exercise training on ventricular function, dyssynchrony, resting myocardial perfusion, and clinical outcomes in patients with heart failure: a nuclear ancillary study of Heart Failure and A Controlled Trial Investigating Outcomes of Exercise Tra
    Daniel R Bensimhon
    Moses Cone Hospital, Greensboro, NC, USA
    Am Heart J 154:46-53. 2007
    ....
  84. doi request reprint Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol
    Amy J Sehnert
    CardioDx, Inc, Palo Alto, California 94303, USA
    J Am Coll Cardiol 52:644-51. 2008
    ..This study investigated the role of adrenergic receptor genetics on transplant-free survival in heart failure (HF)...
  85. ncbi request reprint Introduction: exercise in patients with chronic heart failure
    Steven J Keteyian
    Division of Cardiovascular Medicine, Henry Ford Hospital, 6525 Second Avenue, Detroit, MI, 48202, USA
    Heart Fail Rev 13:1-2. 2008
  86. ncbi request reprint Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study
    Elizabeth R Hauser
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 145:602-13. 2003
    ..Early onset (premature) coronary artery disease (EOCAD) is known to have a particularly strong genetic component. However, the actual genes leading to this increased risk of CAD remain obscure...
  87. ncbi request reprint Exercise training for diabetes: the "strength" of the evidence
    William E Kraus
    Ann Intern Med 147:423-4. 2007
  88. ncbi request reprint Heart failure and a controlled trial investigating outcomes of exercise training (HF-ACTION): design and rationale
    David J Whellan
    Department of Medicine, Jefferson Medical College, Philadelphia, PA 19107, USA
    Am Heart J 153:201-11. 2007
    ..Although there are limited clinical data to support the use of exercise training as a means to reduce mortality and morbidity in patients with heart failure, current guidelines state that exercise is beneficial...
  89. ncbi request reprint Morphology and ultrastructure of differentiating three-dimensional mammalian skeletal muscle in a collagen gel
    Caroline Rhim
    Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, North Carolina 27708, USA
    Muscle Nerve 36:71-80. 2007
    ..Our results suggest that this culture model can be used to evaluate the effects of various mechanical and biochemical cues on muscle development under normal and pathological conditions...
  90. ncbi request reprint Stretch-induced nitric oxide modulates mechanical properties of skeletal muscle cells
    Jingying Sarah Zhang
    Dept of Biomedical Engineering, Box 90281, Duke University, Durham, NC 27708 0281, USA
    Am J Physiol Cell Physiol 287:C292-9. 2004
    ..Together, our data suggest that NO modulates the mechanical behavior of skeletal muscle cells through the combined action of increased talin and vinculin levels and a decrease in calpain-mediated talin proteolysis...
  91. ncbi request reprint Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation
    Amy M Collinsworth
    Department of Biomedical Engineering, 136 Hudson Hall, Duke University, Durham, NC 27708, USA
    Am J Physiol Cell Physiol 283:C1219-27. 2002
    ..Major contributors to changes in the transverse elastic modulus during differentiation were actin and myosin...
  92. ncbi request reprint Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA
    Sarah Jingying Zhang
    Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA
    Am J Physiol Cell Physiol 292:C2057-69. 2007
    ....
  93. pmc Reproducibility of peak oxygen uptake and other cardiopulmonary exercise testing parameters in patients with heart failure (from the Heart Failure and A Controlled Trial Investigating Outcomes of exercise traiNing)
    Daniel R Bensimhon
    LeBauer Cardiovascular Research Foundation, Greensboro, North Carolina, USA
    Am J Cardiol 102:712-7. 2008
    ..Therefore, in multicenter trials, there is no need to perform >1 baseline cardiopulmonary exercise test...

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