Virginia Byers Kraus

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Urea as a passive transport marker for arthritis biomarker studies
    Virginia B Kraus
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 46:420-7. 2002
  2. ncbi request reprint A comparative assessment of alignment angle of the knee by radiographic and physical examination methods
    Virginia B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 52:1730-5. 2005
  3. ncbi request reprint The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants
    Amy G Clark
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Matrix Biol 21:175-84. 2002
  4. pmc Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis
    V B Kraus
    Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 15:966-71. 2007
  5. ncbi request reprint The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes
    V B Kraus
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 15:120-7. 2007
  6. ncbi request reprint Do biochemical markers have a role in osteoarthritis diagnosis and treatment?
    Virginia B Kraus
    Division of Rheumatology, Duke University Medical Center, Box 3416, Durham, NC 27710, USA
    Best Pract Res Clin Rheumatol 20:69-80. 2006
  7. pmc Measurement of synovial fluid volume using urea
    V B Kraus
    Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 15:1217-20. 2007
  8. pmc First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis
    Virginia B Kraus
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e9739. 2010
  9. ncbi request reprint Biomarkers in osteoarthritis
    Virginia Byers Kraus
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Rheumatol 17:641-6. 2005
  10. pmc Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression
    Virginia Byers Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:3711-22. 2009

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Urea as a passive transport marker for arthritis biomarker studies
    Virginia B Kraus
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 46:420-7. 2002
    ....
  2. ncbi request reprint A comparative assessment of alignment angle of the knee by radiographic and physical examination methods
    Virginia B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 52:1730-5. 2005
    ..To compare the knee-alignment angle from a full-limb radiograph (mechanical axis) with the anatomic-axis angle as measured by physical examination using a goniometer and by 2 other radiographic methods...
  3. ncbi request reprint The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explants
    Amy G Clark
    Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
    Matrix Biol 21:175-84. 2002
    ..Therefore, this transporter may be the primary mechanism by which the L-forms of ascorbic acid enter the chondrocyte to control matrix gene activity...
  4. pmc Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritis
    V B Kraus
    Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 15:966-71. 2007
    ..We evaluated the association between hsCRP concentrations and the most common form of arthritis, osteoarthritis (OA), and assessed the applicability of hsCRP for CVD risk prediction...
  5. ncbi request reprint The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes
    V B Kraus
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 15:120-7. 2007
    ..Here we describe the study design and phenotype of the 2728 participants from the 1145 families recruited for this study...
  6. ncbi request reprint Do biochemical markers have a role in osteoarthritis diagnosis and treatment?
    Virginia B Kraus
    Division of Rheumatology, Duke University Medical Center, Box 3416, Durham, NC 27710, USA
    Best Pract Res Clin Rheumatol 20:69-80. 2006
    ....
  7. pmc Measurement of synovial fluid volume using urea
    V B Kraus
    Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 15:1217-20. 2007
    ..To examine the utility of using urea concentrations for determining Synovial Fluid (SF) joint volume in effused and non-effused joints...
  8. pmc First qualification study of serum biomarkers as indicators of total body burden of osteoarthritis
    Virginia B Kraus
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 5:e9739. 2010
    ..The goal of this study was to evaluate the ability of three OA-related biomarkers to predict various forms or subspecies of OA and total body burden of disease...
  9. ncbi request reprint Biomarkers in osteoarthritis
    Virginia Byers Kraus
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Rheumatol 17:641-6. 2005
    ..This review highlights advances in osteoarthritis-related biomarker research within the past year...
  10. pmc Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression
    Virginia Byers Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:3711-22. 2009
    ..To evaluate the effectiveness of using subchondral bone texture observed on a radiograph taken at baseline to predict progression of knee osteoarthritis (OA) over a 3-year period...
  11. pmc Association of bone scintigraphic abnormalities with knee malalignment and pain
    V B Kraus
    Duke General Clinical Research Unit, Duke University Medical Center, Durham, NC 27710, USA
    Ann Rheum Dis 68:1673-9. 2009
    ..The information content of knee bone scintigraphy was evaluated, including pattern, localisation and intensity of retention relative to radiographic features of knee osteoarthritis, knee alignment and knee symptoms...
  12. ncbi request reprint Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis
    Virginia Byers Kraus
    Division of Rheumatology, Department of Medicine, Box 3416, Duke University Medical Center, Durham, NC 27710, USA
    Foot Ankle Clin 8:187-200, vii. 2003
    ..Individuals who are at risk for thromboses should not receive unopposed COX-2 inhibitors; COX-2 should be given in combination with low-dose aspirin which is expected to be cardioprotective in high-risk patients...
  13. ncbi request reprint Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritis
    Virginia B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 48:2942-8. 2003
    ..This outcome measure merits investigation in a broader spectrum of RP patients...
  14. ncbi request reprint Articular hypermobility is a protective factor for hand osteoarthritis
    V B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 50:2178-83. 2004
    ..Very few studies have evaluated the association of articular hypermobility and radiographic osteoarthritis (OA) in humans. We assessed hypermobility and its relationship to radiographic hand OA in a family-based study...
  15. ncbi request reprint Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig model
    Virginia B Kraus
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 50:1822-31. 2004
    ..To determine whether ascorbic acid might be of benefit for the treatment of spontaneous osteoarthritis (OA) when administered over a long period of time...
  16. doi request reprint Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression
    Virginia Byers Kraus
    Duke University, Durham, NC, USA
    Arthritis Rheum 65:1812-21. 2013
    ..To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression...
  17. pmc Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levels
    Hsiang Cheng Chen
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 58:3854-64. 2008
    ..We undertook the present study to evaluate this association and to test the hypothesis that COMP levels are associated with hypermobility in patients with OA and individuals without OA...
  18. pmc Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validation
    Shelby Addison
    Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Rheum 60:3366-73. 2009
    ..To evaluate the association of serum and synovial fluid cartilage oligomeric matrix protein (COMP) with systemic and local measures of osteoarthritis (OA) activity by bone scintigraphy...
  19. pmc Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended family
    Hsiang Cheng Chen
    Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Rheum 62:781-90. 2010
    ..The goal of the current study was to use OA-related biomarkers of severity and disease burden as quantitative traits to identify genetic susceptibility loci for OA...
  20. pmc Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations
    Mukundan Attur
    Division of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA
    Ann Rheum Dis 69:856-61. 2010
    ..A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs...
  21. pmc Racial differences in gait mechanics associated with knee osteoarthritis
    Ershela L Sims
    Department of Surgery, Duke University, Durham, NC, USA
    Aging Clin Exp Res 21:463-9. 2009
    ....
  22. pmc Performance of global assessments of hip, knee, and back symptom change
    Kelli D Allen
    Health Services Research and Development 152, Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
    Clin Rheumatol 30:331-8. 2011
    ..Results support the concordance of these global assessments of joint symptom change with actual changes in self-reported symptoms. These global assessments may be useful for assessing change over time when baseline data are unavailable...
  23. pmc Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartate
    Jonathan B Catterall
    Department of Medicine, Duke University, Durham, NC 27710, USA
    Arthritis Res Ther 11:R55. 2009
    ....
  24. pmc Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen
    Kyle D Allen
    Duke University Medical Center and Duke University, Durham, NC 27710, USA
    Arthritis Rheum 60:2684-93. 2009
    ..The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be associated with these pathologies...
  25. pmc Plasma acylcarnitines are associated with physical performance in elderly men
    Helen Lum
    Department of Medicine, Division of Geriatrics, Gerontology and Palliative Medicine, University of Texas Health Science Center, San Antonio, USA
    J Gerontol A Biol Sci Med Sci 66:548-53. 2011
    ..Metabolic profiling might provide insight into the biologic underpinnings of disability in older adults...
  26. pmc Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis
    Timothy M Griffin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 60:2935-44. 2009
    ..To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology...
  27. pmc Sex differences in biomechanics associated with knee osteoarthritis
    Ershela L Sims
    Department of Biological Anthropology and Anatomy, Duke University Medical Center, 202 Biological Sciences Building, Box 90383, Durham, NC 27708, USA
    J Women Aging 21:159-70. 2009
    ..Within female subjects, variations in gait mechanics were primarily explained by weight, BMI, pain, and disability. In males, variations in gait mechanics were primarily explained by age and disability...
  28. pmc Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)
    Jonathan B Catterall
    Division of Rheumatology, Department of Medicine, Duke University, Genome Science Research Building I, 905 South LaSalle Street, Durham, NC 27710, USA
    Arthritis Res Ther 12:R229. 2010
    ..In this study, to better understand the early biological changes which occur after acute injury, we investigated synovial fluid and serum biomarkers...
  29. doi request reprint Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse
    Benjamin D Ward
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 58:744-53. 2008
    ..The MRL/MpJ mouse has shown unique regenerative abilities in response to injury. The objective of this study was to determine if the MRL/MpJ mouse is protected from posttraumatic arthritis after intraarticular fractures...
  30. ncbi request reprint Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand Index
    Kelli D Allen
    Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
    Arthritis Rheum 54:551-6. 2006
    ..In this study, we examined the clinimetric properties and clinical relevance of the AUSCAN index in a large sample of patients with familial hand OA...
  31. ncbi request reprint Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint
    Amy L McNulty
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Arthritis Rheum 52:2676-85. 2005
    ..To evaluate the dehydroascorbate (DHA) transport mechanisms in human chondrocytes...
  32. pmc Critical appraisal of four IL-6 immunoassays
    Dana K Thompson
    Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e30659. 2012
    ..Serial plasma samples from intravenous glucose tolerance tests (IVGTTs), with expected rises in IL-6 concentrations, were used to test the face validity of the various assays...
  33. ncbi request reprint Ascorbic acid accumulates in cartilage in vivo
    Thomas V Stabler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Clin Chim Acta 334:157-62. 2003
    ..Ascorbic acid plays an important role in collagen synthesis. Though ascorbic acid concentrations in many tissues and in plasma have been characterized, little is known about in vivo levels in cartilage...
  34. ncbi request reprint Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading method
    Charlene M Flahiff
    Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
    Osteoarthritis Cartilage 12:383-8. 2004
    ..To determine the material properties of articular cartilage in the Hartley guinea pig model of spontaneous osteoarthritis...
  35. pmc The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritis
    Mary Beth Nebel
    Department of Biological Anthropology and Anatomy, Duke University, Durham, NC, USA
    Arch Phys Med Rehabil 90:1874-9. 2009
    ....
  36. ncbi request reprint Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project
    Alan L Elliott
    Division of Rheumatology, School of Medicine, University of North Carolina at Chapel Hill, Thurston Arthritis Research Center, 3330 Thurston Building, CB 7280, Chapel Hill, NC 27599, USA
    Arthritis Rheum 52:105-11. 2005
    ..Serum hyaluronan (HA) has been proposed as a potential biomarker of osteoarthritis (OA). We examined associations between serum HA and radiographic OA in an ethnically diverse, population-based sample...
  37. pmc Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee pain
    Jennifer J Pells
    Duke University Medical Center, Box 90399, Durham, NC 27708, USA
    Pain 136:340-7. 2008
    ..Moreover, the contributions of self-efficacy were domain specific. Interventions targeting both arthritis self-efficacy and self-efficacy for resisting eating may be helpful in this population...
  38. ncbi request reprint Relationship of radiographic and clinical variables to pinch and grip strength among individuals with osteoarthritis
    Kelli L Dominick
    Durham Veterans Affairs Medical Center and Duke University Medical Center, Durham, North Carolina, USA
    Arthritis Rheum 52:1424-30. 2005
    ..This study examined associations of radiographic variables with pinch and grip strength among individuals with radiographic hand OA...
  39. pmc Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI
    Bavornrit Chuckpaiwong
    Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, North Carolina 27710, USA
    J Orthop Res 28:1149-54. 2010
    ..These findings provide intriguing preliminary data on the potential role of the infrapatellar fat pad in OA, although additional study is required to better understand the mechanisms of this relationship...
  40. ncbi request reprint Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral disc
    Lawrence M Boyd
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Spine (Phila Pa 1976) 29:2217-22. 2004
    ..Matrix protein gene expression was determined for cells of the anulus fibrosus (AF) and nucleus pulposus (NP) regions of the intervertebral disc when cultured in AF or NP cell-conditioned medium...
  41. ncbi request reprint Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2
    Amy L McNulty
    Department of Pathology, Duke University Medical Center, Box 3416, Durham, NC 27710, USA
    Biochim Biophys Acta 1712:212-21. 2005
    ..Thus, we provide the first evidence that SVCT2 mediates the secondary active and concentrative transport of ascorbic acid in human chondrocytes...
  42. ncbi request reprint Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilage
    Charlene M Flahiff
    Department of Biomedical Engineering, Duke University, Box 90281, 136 Hudson Hall, Durham, NC 22708 0281, USA
    J Biomech 35:1285-90. 2002
    ....
  43. pmc Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages
    Thomas V Stabler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Res Ther 11:R34. 2009
    ..We hypothesized that diseased tissue, as found in an osteoarthritic (OA) joint, would have increased turnover reflected by a decrease in the racemized amino acid content...
  44. pmc Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity
    Kim M Huffman
    Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
    Diabetes Care 34:174-6. 2011
    ..To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators...
  45. pmc Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disability
    Tamara J Somers
    Duke University Medical Center, Durham, North Carolina 27708, USA
    J Pain Symptom Manage 37:863-72. 2009
    ....
  46. ncbi request reprint Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritis
    Jane Chang
    Duke University Medical Center, Durham, NC 27715, USA
    Arthritis Rheum 52:2366-75. 2005
    ..To describe the health state preferences of patients with osteoarthritis (OA) according to the level of pain and disability and the extent of gastrointestinal side effects from nonsteroidal antiinflammatory drugs (NSAIDs)...
  47. ncbi request reprint Variation of serum hyaluronan with activity in individuals with knee osteoarthritis
    Lisa G Criscione
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Osteoarthritis Cartilage 13:837-40. 2005
    ..Serum hyaluronan (HA) was evaluated for diurnal variation in participants with osteoarthritis (OA) of the knee...
  48. ncbi request reprint Biochemistry of amino acid racemization and clinical application to musculoskeletal disease
    Christopher R McCudden
    Division of Rheumatology, Department of Medicine, Box 3416, Duke University, Medical Center, Durham, NC 27710, USA
    Clin Biochem 39:1112-30. 2006
    ..This review discusses the biochemistry of amino acid racemization in proteins and its clinical application to musculoskeletal disease...
  49. ncbi request reprint A thermally responsive biopolymer for intra-articular drug delivery
    Helawe Betre
    Department of Biomedical Engineering, 136 Hudson Hall, Box 90821, Duke University, Durham, NC 27708, USA
    J Control Release 115:175-82. 2006
    ..These results suggest that the intra-articular joint delivery of ELP-based fusion proteins may be a viable strategy for the prolonged release of disease-modifying protein drugs for osteoarthritis and other arthritides...
  50. pmc Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy
    Mohammed F Shamji
    Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA
    Spine (Phila Pa 1976) 34:648-54. 2009
    ..Further evaluation involved assessing how nucleus pulposus (NP) injury affected systemic cytokine expression and molecular changes at the dorsal root ganglion (DRG)...
  51. ncbi request reprint Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCR
    Lawrence M Boyd
    Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
    Ann Biomed Eng 33:1071-7. 2005
    ....
  52. ncbi request reprint Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation
    Thomas Stabler
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Arthritis Rheum 50:3663-7. 2004
    ....