Research Topics
Genomes and GenesSpecies | Virginia Byers KrausSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Urea as a passive transport marker for arthritis biomarker studiesVirginia B Kraus
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 46:420-7. 2002....- The effects of ascorbic acid on cartilage metabolism in guinea pig articular cartilage explantsAmy G Clark
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Matrix Biol 21:175-84. 2002..Therefore, this transporter may be the primary mechanism by which the L-forms of ascorbic acid enter the chondrocyte to control matrix gene activity... - A comparative assessment of alignment angle of the knee by radiographic and physical examination methodsVirginia B Kraus
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 52:1730-5. 2005..To compare the knee-alignment angle from a full-limb radiograph (mechanical axis) with the anatomic-axis angle as measured by physical examination using a goniometer and by 2 other radiographic methods... 
Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progressionVirginia Byers Kraus
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 60:3711-22. 2009..To evaluate the effectiveness of using subchondral bone texture observed on a radiograph taken at baseline to predict progression of knee osteoarthritis (OA) over a 3-year period...- Biomarkers in osteoarthritisVirginia Byers Kraus
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Curr Opin Rheumatol 17:641-6. 2005..This review highlights advances in osteoarthritis-related biomarker research within the past year... 
Interpretation of serum C-reactive protein (CRP) levels for cardiovascular disease risk is complicated by race, pulmonary disease, body mass index, gender, and osteoarthritisV B Kraus
Duke University Medical Center, Durham, NC 27710, USA
Osteoarthritis Cartilage 15:966-71. 2007..We evaluated the association between hsCRP concentrations and the most common form of arthritis, osteoarthritis (OA), and assessed the applicability of hsCRP for CVD risk prediction...- Do biochemical markers have a role in osteoarthritis diagnosis and treatment?Virginia B Kraus
Division of Rheumatology, Duke University Medical Center, Box 3416, Durham, NC 27710, USA
Best Pract Res Clin Rheumatol 20:69-80. 2006.... - First qualification study of serum biomarkers as indicators of total body burden of osteoarthritisVirginia B Kraus
Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 5:e9739. 2010..The goal of this study was to evaluate the ability of three OA-related biomarkers to predict various forms or subspecies of OA and total body burden of disease... - Articular hypermobility is a protective factor for hand osteoarthritisV B Kraus
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 50:2178-83. 2004..Very few studies have evaluated the association of articular hypermobility and radiographic osteoarthritis (OA) in humans. We assessed hypermobility and its relationship to radiographic hand OA in a family-based study... - Ascorbic acid increases the severity of spontaneous knee osteoarthritis in a guinea pig modelVirginia B Kraus
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 50:1822-31. 2004..To determine whether ascorbic acid might be of benefit for the treatment of spontaneous osteoarthritis (OA) when administered over a long period of time... - Urinary type II collagen neoepitope as an outcome measure for relapsing polychondritisVirginia B Kraus
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 48:2942-8. 2003..This outcome measure merits investigation in a broader spectrum of RP patients... - Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritisVirginia Byers Kraus
Division of Rheumatology, Department of Medicine, Box 3416, Duke University Medical Center, Durham, NC 27710, USA
Foot Ankle Clin 8:187-200, vii. 2003..Individuals who are at risk for thromboses should not receive unopposed COX-2 inhibitors; COX-2 should be given in combination with low-dose aspirin which is expected to be cardioprotective in high-risk patients... - The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypesV B Kraus
Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Osteoarthritis Cartilage 15:120-7. 2007..Here we describe the study design and phenotype of the 2728 participants from the 1145 families recruited for this study... - Measurement of synovial fluid volume using ureaV B Kraus
Duke University Medical Center, Durham, NC 27710, USA
Osteoarthritis Cartilage 15:1217-20. 2007..To examine the utility of using urea concentrations for determining Synovial Fluid (SF) joint volume in effused and non-effused joints... - Association of bone scintigraphic abnormalities with knee malalignment and painV B Kraus
Duke General Clinical Research Unit, Duke University Medical Center, Durham, NC 27710, USA
Ann Rheum Dis 68:1673-9. 2009..The information content of knee bone scintigraphy was evaluated, including pattern, localisation and intensity of retention relative to radiographic features of knee osteoarthritis, knee alignment and knee symptoms... - Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validationShelby Addison
Duke University Medical Center, Durham, NC 27710, USA
Arthritis Rheum 60:3366-73. 2009..To evaluate the association of serum and synovial fluid cartilage oligomeric matrix protein (COMP) with systemic and local measures of osteoarthritis (OA) activity by bone scintigraphy... - Inverse association of general joint hypermobility with hand and knee osteoarthritis and serum cartilage oligomeric matrix protein levelsHsiang Cheng Chen
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 58:3854-64. 2008..We undertook the present study to evaluate this association and to test the hypothesis that COMP levels are associated with hypermobility in patients with OA and individuals without OA... - Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large, multigenerational extended familyHsiang Cheng Chen
Duke University Medical Center, Durham, NC 27710, USA
Arthritis Rheum 62:781-90. 2010..The goal of the current study was to use OA-related biomarkers of severity and disease burden as quantitative traits to identify genetic susceptibility loci for OA... - Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variationsMukundan Attur
Division of Rheumatology, New York University Hospital for Joint Diseases, New York, NY 10003, USA
Ann Rheum Dis 69:856-61. 2010..A lack of biomarkers that identify patients at risk for severe osteoarthritis (OA) complicates development of disease-modifying OA drugs... - Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouseBenjamin D Ward
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 58:744-53. 2008..The MRL/MpJ mouse has shown unique regenerative abilities in response to injury. The objective of this study was to determine if the MRL/MpJ mouse is protected from posttraumatic arthritis after intraarticular fractures... - Post-translational aging of proteins in osteoarthritic cartilage and synovial fluid as measured by isomerized aspartateJonathan B Catterall
Department of Medicine, Duke University, Durham, NC 27710, USA
Arthritis Res Ther 11:R55. 2009.... - Plasma acylcarnitines are associated with physical performance in elderly menHelen Lum
Department of Medicine, Division of Geriatrics, Gerontology and Palliative Medicine, University of Texas Health Science Center, San Antonio, USA
J Gerontol A Biol Sci Med Sci 66:548-53. 2011..Metabolic profiling might provide insight into the biologic underpinnings of disability in older adults... - Decreased physical function and increased pain sensitivity in mice deficient for type IX collagenKyle D Allen
Duke University Medical Center and Duke University, Durham, NC 27710, USA
Arthritis Rheum 60:2684-93. 2009..The aim of this study was to investigate Col9a1(-/-) mice for functional and symptomatic changes that may be associated with these pathologies... - Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)Jonathan B Catterall
Division of Rheumatology, Department of Medicine, Duke University, Genome Science Research Building I, 905 South LaSalle Street, Durham, NC 27710, USA
Arthritis Res Ther 12:R229. 2010..In this study, to better understand the early biological changes which occur after acute injury, we investigated synovial fluid and serum biomarkers... - Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritisTimothy M Griffin
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 60:2935-44. 2009..To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology... - Performance of global assessments of hip, knee, and back symptom changeKelli D Allen
Health Services Research and Development 152, Veterans Affairs Medical Center, 508 Fulton Street, Durham, NC 27705, USA
Clin Rheumatol 30:331-8. 2011..Results support the concordance of these global assessments of joint symptom change with actual changes in self-reported symptoms. These global assessments may be useful for assessing change over time when baseline data are unavailable... - Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand IndexKelli D Allen
Durham Veterans Affairs Medical Center, Durham, North Carolina, USA
Arthritis Rheum 54:551-6. 2006..In this study, we examined the clinimetric properties and clinical relevance of the AUSCAN index in a large sample of patients with familial hand OA... - Sex differences in biomechanics associated with knee osteoarthritisErshela L Sims
Department of Biological Anthropology and Anatomy, Duke University Medical Center, 202 Biological Sciences Building, Box 90383, Durham, NC 27708, USA
J Women Aging 21:159-70. 2009..Within female subjects, variations in gait mechanics were primarily explained by weight, BMI, pain, and disability. In males, variations in gait mechanics were primarily explained by age and disability... - Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the jointAmy L McNulty
Duke University Medical Center, Durham, North Carolina 27710, USA
Arthritis Rheum 52:2676-85. 2005..These results demonstrate that DHA is a physiologically relevant source of Asc for chondrocytes, particularly in the setting of an inflammatory arthritis, such as RA... - Racial differences in gait mechanics associated with knee osteoarthritisErshela L Sims
Department of Surgery, Duke University, Durham, NC, USA
Aging Clin Exp Res 21:463-9. 2009.... - Critical appraisal of four IL-6 immunoassaysDana K Thompson
Division of Rheumatology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
PLoS ONE 7:e30659. 2012..Serial plasma samples from intravenous glucose tolerance tests (IVGTTs), with expected rises in IL-6 concentrations, were used to test the face validity of the various assays... - Ascorbic acid accumulates in cartilage in vivoThomas V Stabler
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Clin Chim Acta 334:157-62. 2003..This concentrating ability is consistent with the chondrocyte expression of SVCT2, a sodium-dependent ascorbic acid transporter... - Cartilage mechanics in the guinea pig model of osteoarthritis studied with an osmotic loading methodCharlene M Flahiff
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Osteoarthritis Cartilage 12:383-8. 2004..CONCLUSION: Histological evidence of cartilage degeneration was associated with impaired cartilage mechanics in the aging Hartley guinea pig... - The relationship of self-reported pain and functional impairment to gait mechanics in overweight and obese persons with knee osteoarthritisMary Beth Nebel
Department of Biological Anthropology and Anatomy, Duke University, Durham, NC, USA
Arch Phys Med Rehabil 90:1874-9. 2009.... - Serum hyaluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis ProjectAlan L Elliott
Division of Rheumatology, School of Medicine, University of North Carolina at Chapel Hill, Thurston Arthritis Research Center, 3330 Thurston Building, CB #7280, Chapel Hill, NC 27599, USA
Arthritis Rheum 52:105-11. 2005..The lack of strong confounding between serum HA and comorbidities further supports a role for serum HA as a potential biomarker... - Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRIBavornrit Chuckpaiwong
Division of Orthopaedic Surgery, Department of Surgery, Duke University Medical Center, 375 MSRB, Box 3093, Durham, North Carolina 27710, USA
J Orthop Res 28:1149-54. 2010..These findings provide intriguing preliminary data on the potential role of the infrapatellar fat pad in OA, although additional study is required to better understand the mechanisms of this relationship... - Osmotic loading to determine the intrinsic material properties of guinea pig knee cartilageCharlene M Flahiff
Department of Biomedical Engineering, Duke University, Box 90281, 136 Hudson Hall, Durham, NC 22708-0281, USA
J Biomech 35:1285-90. 2002.... - Conditioned medium differentially regulates matrix protein gene expression in cells of the intervertebral discLawrence M Boyd
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Spine 29:2217-22. 2004..Understanding these differences between cells of the intervertebral disc may reveal unique stimulatory factors important to repair and regeneration of the degenerated intervertebral disc... - Relationship of radiographic and clinical variables to pinch and grip strength among individuals with osteoarthritisKelli L Dominick
Durham Veterans Affairs Medical Center and Duke University Medical Center, Durham, North Carolina, USA
Arthritis Rheum 52:1424-30. 2005..Individuals with radiographic OA in specific locations (CMC joints, MCP joints, and ray 1) may be at particular risk for reduced hand strength... - Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2Amy L McNulty
Department of Pathology, Duke University Medical Center, Box 3416, Durham, NC 27710, USA
Biochim Biophys Acta 1712:212-21. 2005..Thus, we provide the first evidence that SVCT2 mediates the secondary active and concentrative transport of ascorbic acid in human chondrocytes... - Arthritis self-efficacy and self-efficacy for resisting eating: relationships to pain, disability, and eating behavior in overweight and obese individuals with osteoarthritic knee painJennifer J Pells
Duke University Medical Center, Box 90399, Durham, NC 27708, USA
Pain 136:340-7. 2008..Moreover, the contributions of self-efficacy were domain specific. Interventions targeting both arthritis self-efficacy and self-efficacy for resisting eating may be helpful in this population... - Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilagesThomas V Stabler
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Arthritis Res Ther 11:R34. 2009..We hypothesized that diseased tissue, as found in an osteoarthritic (OA) joint, would have increased turnover reflected by a decrease in the racemized amino acid content... - Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivityKim M Huffman
Physical Medicine and Rehabilitation, Veterans Affairs Medical Center, Durham, North Carolina, USA
Diabetes Care 34:174-6. 2011..To understand relationships between exercise training-mediated improvements in insulin sensitivity (S(I)) and changes in circulating concentrations of metabolic intermediates, hormones, and inflammatory mediators... - Impact of disease severity and gastrointestinal side effects on the health state preferences of patients with osteoarthritisJane Chang
Duke University Medical Center, Durham, NC 27715, USA
Arthritis Rheum 52:2366-75. 2005..Future research should attempt to determine whether patients prefer reductions in their OA-related pain and disability over improvements in treatment side effect profiles... - Pain catastrophizing and pain-related fear in osteoarthritis patients: relationships to pain and disabilityTamara J Somers
Duke University Medical Center, Durham, North Carolina 27708, USA
J Pain Symptom Manage 37:863-72. 2009.... - Variation of serum hyaluronan with activity in individuals with knee osteoarthritisLisa G Criscione
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Osteoarthritis Cartilage 13:837-40. 2005..These results suggest that serum sampling for HA in OA clinical trials should be performed more than 1h after arising in the morning and at least 1h after breaking an overnight fast... - Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activationThomas Stabler
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
Arthritis Rheum 50:3663-7. 2004.... - A thermally responsive biopolymer for intra-articular drug deliveryHelawe Betre
Department of Biomedical Engineering, 136 Hudson Hall, Box 90821, Duke University, Durham, NC 27708, USA
J Control Release 115:175-82. 2006..These results suggest that the intra-articular joint delivery of ELP-based fusion proteins may be a viable strategy for the prolonged release of disease-modifying protein drugs for osteoarthritis and other arthritides... - Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathyMohammed F Shamji
Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA
Spine (Phila Pa 1976) 34:648-54. 2009..Further evaluation involved assessing how nucleus pulposus (NP) injury affected systemic cytokine expression and molecular changes at the dorsal root ganglion (DRG)... - Osmolarity regulates gene expression in intervertebral disc cells determined by gene array and real-time quantitative RT-PCRLawrence M Boyd
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Ann Biomed Eng 33:1071-7. 2005.... - Biochemistry of amino acid racemization and clinical application to musculoskeletal diseaseChristopher R McCudden
Division of Rheumatology, Department of Medicine, Box 3416, Duke University, Medical Center, Durham, NC 27710, USA
Clin Biochem 39:1112-30. 2006..This review discusses the biochemistry of amino acid racemization in proteins and its clinical application to musculoskeletal disease...