Motonari Kondo

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 201:1197-203. 2005
  2. pmc Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 203:1867-73. 2006
  3. pmc Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 238:37-46. 2010
  4. ncbi request reprint Multitalented E2A: a new role in lymphoid-lineage priming
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, USA
    Immunity 29:169-70. 2008
  5. ncbi request reprint Biology of hematopoietic stem cells and progenitors: implications for clinical application
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 21:759-806. 2003
  6. pmc Pertussis toxin-sensitive G proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 113:5757-64. 2009
  7. pmc Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17852-7. 2006
  8. pmc IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 181:383-92. 2008
  9. pmc IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia
    Yoshihiro Ueda
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 182:6477-84. 2009
  10. pmc Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    Chia Lin Hsu
    Department of Immunology, Duke University Medical Center, DUMC 3010, Research Drive, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:672-7. 2006

Research Grants

  1. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2010
  2. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2004
  3. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
  4. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2007
  5. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2007
  6. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2006
  7. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2006
  8. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2005
  9. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2005
  10. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2004

Collaborators

Detail Information

Publications26

  1. pmc IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 201:1197-203. 2005
    ..Thus, IL-7 receptor signaling is a participant in the formation of the transcription factor network during B lymphopoiesis by up-regulating EBF, allowing stage transition from the pre-pro-B to further maturational stages...
  2. pmc Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 203:1867-73. 2006
    ..Our results suggest that the first step of lineage commitment from HSCs is not simply a selection between the lymphoid and the myeloid lineage...
  3. pmc Lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 238:37-46. 2010
    ..We also discuss the importance of bone marrow microenvironment in lymphoid and myeloid lineage choice...
  4. ncbi request reprint Multitalented E2A: a new role in lymphoid-lineage priming
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, USA
    Immunity 29:169-70. 2008
    ..How do hematopoietic stem cells choose to be lymphocytes? In this issue of Immunity, Dias et al. (2008) uncover the requirement for E2A during lymphoid-lineage priming in the multipotent progenitor population...
  5. ncbi request reprint Biology of hematopoietic stem cells and progenitors: implications for clinical application
    Motonari Kondo
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Annu Rev Immunol 21:759-806. 2003
    ....
  6. pmc Pertussis toxin-sensitive G proteins regulate lymphoid lineage specification in multipotent hematopoietic progenitors
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 113:5757-64. 2009
    ..These results clearly demonstrate that specific microenvironments that favorably support lymphoid or myeloid lineage development exist at structurally distinct regions in the bone marrow...
  7. pmc Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:17852-7. 2006
    ..In contrast, BM HSCs in mice older than 2 weeks of age absolutely requires IL-7Ralpha for B lymphopoiesis. These results demonstrate that fetal HSCs acquired adult characteristics between 1 and 2 weeks after birth in mouse BM...
  8. pmc IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 181:383-92. 2008
    ..Therefore, the primary function of IL-7 before the pre-proB stage in B cell development is to maintain the EBF expression level above a certain threshold, which is necessary for pre-proB cells to further transit to the proB stage...
  9. pmc IL-1R type I-dependent hemopoietic stem cell proliferation is necessary for inflammatory granulopoiesis and reactive neutrophilia
    Yoshihiro Ueda
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 182:6477-84. 2009
    ..Thus, IL-1 plays a necessary, but indirect, role in the support of alum-induced neutrophilias by expanding both pluripotent and myeloid progenitor compartments to accelerate granulopoiesis...
  10. pmc Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    Chia Lin Hsu
    Department of Immunology, Duke University Medical Center, DUMC 3010, Research Drive, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 103:672-7. 2006
    ..Furthermore, complete loss of Pax5 expression triggered by up-regulation of C/EBPalpha is a critical event for lineage conversion from lymphoid to myeloid lineage in CLPs and proB cells...
  11. pmc Constitutive MAP kinase activation in hematopoietic stem cells induces a myeloproliferative disorder
    Eva Chung
    Department of Immunology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e28350. 2011
    ..Our results clearly demonstrate the proto-oncogenic property of the MEK/ERK pathway in hematopoietic cells, which manifest in MDS/MPN development...
  12. ncbi request reprint Heterogeneity of Flt3-expressing multipotent progenitors in mouse bone marrow
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 175:5016-23. 2005
    ..These results establish a hierarchy of developmental relationship between MPP subsets and lymphoid and myeloid progenitors. In addition, VCAM-1(+) MPPs may represent the branching point between the lymphoid and myeloid lineages...
  13. pmc A tamoxifen inducible knock-in allele for investigation of E2A function
    Mary E Jones
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    BMC Dev Biol 9:51. 2009
    ..We have characterized and analyzed the efficiency and kinetics of this inducible E2AER system in the context of B cell development...
  14. pmc E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression
    Jason Wojciechowski
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 178:5717-26. 2007
    ..These results suggest that E2A and HEB are not only critical for T cell differentiation but also necessary to retain developing thymocytes in cell cycle arrest before pre-TCR expression...
  15. pmc Inflammation and the reciprocal production of granulocytes and lymphocytes in bone marrow
    Yoshihiro Ueda
    Department of Immunology, Duke University, Durham, NC 27710, USA
    J Exp Med 201:1771-80. 2005
    ..We demonstrate that granulopoiesis and lymphopoiesis are coupled specifically in the bone marrow by development in a common niche and propose that the leukopoietic equilibrium is specified by limiting amounts of developmental resources...
  16. pmc Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment
    Chia Lin Hsu
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Blood 110:1420-8. 2007
    ..These results demonstrate that activation of MEK/ERK plays an important role in GM lineage commitment...
  17. pmc Effects of acute and chronic inflammation on B-cell development and differentiation
    Derek Cain
    Department of Immunology, Duke University, Durham, North Carolina 27710, USA
    J Invest Dermatol 129:266-77. 2009
    ..In this Perspective, we review inflammation's effects on central and extramedullary B lymphopoiesis and discuss the potential consequences of peripheral B-cell development in the context of systemic autoimmune diseases...
  18. pmc T and B lymphocyte differentiation from hematopoietic stem cell
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, United States
    Semin Immunol 20:207-12. 2008
    ..This review focuses on the recent advances in understanding the developmental events that occur during hematopoietic stem cell specification into the T and B lymphocyte lineages in adult mice...
  19. pmc Identification of a bone marrow precursor of the earliest thymocytes in adult mouse
    Anne Y Lai
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:6311-6. 2007
    ..In addition, our data suggest that before transition from BM to thymus, MPPs are lymphoid-specified and primed for T lineage differentiation...
  20. pmc Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression
    Yoshihiro Ueda
    Department of Immunology, Box 3010, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 199:47-58. 2004
    ..We propose that TNFalpha and IL-1beta transiently specialize the BM to support acute granulocytic responses and consequently promote extramedullary lymphopoiesis...
  21. doi request reprint Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development
    Eva Chung
    Department of Immunology, Duke University Medical Center, 101 Jones Building, DUMC Box 3010, Research Drive, Durham, NC 27710, USA
    Immunol Res 49:248-68. 2011
    ..We also discuss the challenges and success of targeting this pathway...
  22. pmc Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion
    Jingquan Jia
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    EMBO J 26:2387-99. 2007
    ..Results presented here suggest that germline transcription, although necessary for V(D)J recombination, is not sufficient to instruct allelic exclusion...
  23. ncbi request reprint [Commitment into the lymphoid lineage]
    Yukie Matsumoto
    Tanpakushitsu Kakusan Koso 47:2166-71. 2002
  24. ncbi request reprint Developmental plasticity of lymphoid progenitors
    Susan S Prohaska
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Immunol 14:377-84. 2002
    ....
  25. pmc TSLP is involved in expansion of early thymocyte progenitors
    Qi Jiang
    Lineberger Comprehensive Cancer Center, School of Medicine, UNC at Chapel Hill, Chapel Hill, NC 27599, USA
    BMC Immunol 8:11. 2007
    ..Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear...
  26. pmc Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling
    Angela G King
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 99:4508-13. 2002
    ..In addition, Dbeta1 and Dbeta2 DJ rearrangement of the TCRbeta gene may be differentially regulated and thus serve as markers for distinct proT cell maturational stages...

Research Grants12

  1. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2010
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor, which drive specific steps in lymphocyte development, and to determine the genes involved in this process. ..
  2. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2004
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor that drive specific steps in lymphocyte development. ..
  3. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2009
    ..abstract_text> ..
  4. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2007
    ..The results obtained from this research proposal will allow us to better understand not only normal hematopoiesis but also aberrant hemato/lymphopoiesis that can result in leukemia or immunodeficiency. ..
  5. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2007
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor that drive specific steps in lymphocyte development. ..
  6. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2006
    ..The results obtained from this research proposal will allow us to better understand not only normal hematopoiesis but also aberrant hemato/lymphopoiesis that can result in leukemia or immunodeficiency. ..
  7. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2006
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor that drive specific steps in lymphocyte development. ..
  8. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2005
    ..The results obtained from this research proposal will allow us to better understand not only normal hematopoiesis but also aberrant hemato/lymphopoiesis that can result in leukemia or immunodeficiency. ..
  9. Il-7 receptor signaling in lymphopoiesis
    Motonari Kondo; Fiscal Year: 2005
    ..The goal of this project is to elucidate the signaling pathways downstream of IL-7 receptor that drive specific steps in lymphocyte development. ..
  10. Commitment mechanisms in hemato/lymphopoiesis
    Motonari Kondo; Fiscal Year: 2004
    ..The results obtained from this research proposal will allow us to better understand not only normal hematopoiesis but also aberrant hemato/lymphopoiesis that can result in leukemia or immunodeficiency. ..