Research Topics
Genomes and GenesSpecies | S H KollinsSummaryAffiliation: Duke University Medical Center Country: USA Publications
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Publications
Efficacy and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: sex and age effects and effect size across the daySharon B Wigal
University of California, Irvine, Child Development Center, Irvine, California, USA
Child Adolesc Psychiatry Ment Health 4:32. 2010..abstract:..
Psychomotor functioning and alertness with guanfacine extended release in subjects with attention-deficit/hyperactivity disorderScott H Kollins
Duke ADHD Program, Duke University Medical Center, Durham, North Carolina 27705, USA
J Child Adolesc Psychopharmacol 21:111-20. 2011..To determine whether treatment with guanfacine extended release (GXR) in subjects with attention-deficit/hyperactivity disorder (ADHD) disrupted psychomotor functioning and alertness, or impacted daytime sleepiness...
Advances in the pharmacotherapy of attention-deficit/hyperactivity disorderScott H Kollins
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, USA
Biol Psychiatry 62:951-3. 2007- SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their familiesS H Kollins
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
Am J Med Genet B Neuropsychiatr Genet 147:1580-8. 2008..Results also shed light on the molecular genetic basis of specific processes that may underlie the disorder... - Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHDScott H Kollins
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
Pediatrics 127:e1406-13. 2011..To assess the efficacy and safety of clonidine hydrochloride extended-release tablets (CLON-XR) combined with stimulants (ie, methylphenidate or amphetamine) for attention-deficit/hyperactivity disorder (ADHD)... - ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelinesScott H Kollins
Duke University Medical Center, Durham, NC 27705, USA
J Atten Disord 12:115-25. 2008..This review explores the relationship between ADHD and substance use disorder (SUD), factors that determine the abuse potential of psychostimulants, and strategies for identifying and treating at-risk ADHD patients... - A qualitative review of issues arising in the use of psycho-stimulant medications in patients with ADHD and co-morbid substance use disordersScott H Kollins
Department of Psychiatry, Duke ADHD Program, Duke University, Durham, NC 27705, USA
Curr Med Res Opin 24:1345-57. 2008..Strategies for identification and treatment of patients with ADHD who are at risk for, or have, co-morbid SUD are also addressed... - Effects of smoking abstinence on reaction time variability in smokers with and without ADHD: an ex-Gaussian analysisScott H Kollins
Department of Psychiatry, Duke ADHD Program, 718 Rutherford Street, Durham, NC 27705, United States
Drug Alcohol Depend 100:169-72. 2009..These findings have implications for understanding the neuropsychopharmacology of nicotine and nicotine withdrawal... - Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD)Scott H Kollins
Department of Psychiatry, Duke University Medical Center, Durham, NC 27701, USA
Psychopharmacology (Berl) 204:73-83. 2009..There has been controversy over the abuse potential of methylphenidate (MPH) in the context of treatment for attention deficit hyperactivity disorder (ADHD)... - Effects of postnatal parental smoking on parent and teacher ratings of ADHD and oppositional symptomsScott H Kollins
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27705, USA
J Nerv Ment Dis 197:442-9. 2009..The risk of maternal smoking for the development of ADHD symptoms does not end during pregnancy. Research on the mechanisms underlying the observed associations is needed... - Monetary incentives promote smoking abstinence in adults with attention deficit hyperactivity disorder (ADHD)Scott H Kollins
Duke ADHD Program, Department of Psychiatry, Duke University Medical Center, NC, USA
Exp Clin Psychopharmacol 18:221-8. 2010..Results suggest that monetary incentives may be a useful approach for promoting abstinence in adult smokers with ADHD, perhaps owing to altered reinforcement processes in these individuals... - Abuse liability of medications used to treat attention-deficit/hyperactivity disorder (ADHD)Scott H Kollins
ADHD Program, Department of Psychiatry and Behavioral Science, Duke University School of Medicine, Durham, North Carolina 27705, USA
Am J Addict 16:35-42; quiz 43-4. 2007..Does stimulant drug use increase the risk for substance abuse later in life? Do ADHD medications have the potential for abuse?, and What is the distinction between drug abuse and misuse/diversion with respect to ADHD medication?.. - Rationale, design, and methods of the Preschool ADHD Treatment Study (PATS)Scott Kollins
Department of Psychiatry, Duke University Medical Center, Durham, NC 27705, USA
J Am Acad Child Adolesc Psychiatry 45:1275-83. 2006..To describe the rationale and design of the Preschool ADHD Treatment Study (PATS)... - Assessing the abuse potential of methylphenidate in nonhuman and human subjects: a reviewS H Kollins
Department of Psychiatry, Duke University Medical Center, Box 3431, Durham, NC 27710, USA
Pharmacol Biochem Behav 68:611-27. 2001.... - Association between smoking and attention-deficit/hyperactivity disorder symptoms in a population-based sample of young adultsScott H Kollins
Duke University Medical Center, Durham, NC, USA
Arch Gen Psychiatry 62:1142-7. 2005..Few studies, however, have examined ADHD symptoms in nonclinical samples to determine the extent to which the number of symptoms-independent of the full diagnosis-confer risk for smoking-related outcomes... - Comparing the abuse potential of methylphenidate versus other stimulants: a review of available evidence and relevance to the ADHD patientScott H Kollins
Duke Child and Family Study Center, Duke University Medical Center, Durham, NC 27705, USA
J Clin Psychiatry 64:14-8. 2003..Existing neuropharmacologic data suggest that methylphenidate has pharmacokinetic properties that reduce its abuse potential as compared with other stimulant drugs of abuse, such as cocaine... - Delay discounting is associated with substance use in college studentsScott H Kollins
Duke Child and Family Study Center, Duke University School of Medicine, 718 Rutherford Street, Durham, NC 27705, USA
Addict Behav 28:1167-73. 2003..73; P<.01), and total number of illicit drugs used (r=.32; P<.05). Individuals reporting more illicit drug use and younger ages of first use tend to discount the value of future hypothetical rewards more steeply than their peers... - Interactions between genotype and depressive symptoms on obesityBernard F Fuemmeler
Duke University Medical Center, Durham, NC, USA
Behav Genet 39:296-305. 2009..48; 95% CI 0.26-0.89). No similar effect was observed among females. These findings highlight that the obesity-depression relationship may vary as a function of gender and genetic polymorphism, and suggest the need for further study... - Genes implicated in serotonergic and dopaminergic functioning predict BMI categoriesBernard F Fuemmeler
Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA
Obesity (Silver Spring) 16:348-55. 2008..Interactions with gender and race/ethnicity were also examined... - Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adultsF Joseph McClernon
Department of Psychiatry and Behavioral Sciences, Duke University Medical Cneter, Durham, NC 27708, USA
Nicotine Tob Res 10:117-27. 2008..We observed neither main effects nor interactions with CYP2A6, DAT, and SLC6A4 genes. These findings suggest that genotypes associated with catecholamine neurotransmission interact with ADHD symptoms to contribute to smoking risk... - Implications of extending the ADHD age-of-onset criterion to age 12: results from a prospectively studied birth cohortGuilherme Polanczyk
Duke University, USA
J Am Acad Child Adolesc Psychiatry 49:210-6. 2010.... - Reliability and validity of self- and other-ratings of symptoms of ADHD in adultsElizabeth E Van Voorhees
Duke University Medical Center, Durham, NC 27710, USA
J Atten Disord 15:224-34. 2011..This study examined these variables using the Conners Adult ADHD Rating Scales (CAARS)... - Factor structure of parent- and teacher-rated attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Kristina K Hardy
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
J Child Adolesc Psychopharmacol 17:621-34. 2007.... - Parent versus teacher ratings of attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Desiree W Murray
Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
J Child Adolesc Psychopharmacol 17:605-20. 2007..To assess parent-teacher concordance on ratings of DSM-IV symptoms of attention-deficit/hyperactivity disorder (ADHD) in a sample of preschool children referred for an ADHD treatment study... - Psychometric properties of an adult ADHD diagnostic interviewJeffery N Epstein
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, USA
J Atten Disord 9:504-14. 2006..69). Concurrent validity was demonstrated for adult hyperactive-impulsive symptoms and child inattentive symptoms. The findings are discussed in the context of overall issues pertaining to adult ADHD assessment... - Effects of smoking abstinence on adult smokers with and without attention deficit hyperactivity disorder: results of a preliminary studyF Joseph McClernon
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 2701, Durham, NC, 27708, USA
Psychopharmacology (Berl) 197:95-105. 2008..Individuals with attention deficit hyperactivity disorder (ADHD) smoke at higher rates than the general population; however, little is known about the mechanisms underlying this comorbidity... - Sensitization to the cardiovascular but not subject-rated effects of oral cocaine in humansScott H Kollins
Department of Psychiatry and Behavioral Science, Duke University Medical Center, Durham, North Carolina, USA
Biol Psychiatry 51:143-50. 2002..CONCLUSIONS: These results indicate that, under controlled laboratory conditions, repeated oral cocaine administration may result in sensitization to the cardiovascular effects, but not subject-rated effects... - Attention deficit hyperactivity disorder symptoms predict nicotine dependence and progression to regular smoking from adolescence to young adulthoodBernard F Fuemmeler
Community and Family Medicine, University Medical Center, Duke University Medical Center, USA
J Pediatr Psychol 32:1203-13. 2007..To examine the association between retrospectively reported attention deficit hyperactivity disorder (ADHD) symptoms and progression to smoking and the association with nicotine dependence... - Alpha-2 adrenergic receptors and attention-deficit/hyperactivity disorderL Cinnamon Bidwell
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, 27710, USA
Curr Psychiatry Rep 12:366-73. 2010..Integrating knowledge of pathophysiologic mechanisms and mechanisms of drug action may inform our medication choices and facilitate treatment of ADHD and related disorders... - Increases in impulsivity following smoking abstinence are related to baseline nicotine intake and boredom susceptibilityJasmine Pettiford
Duke University Medical Center, Durham, NC 27707, United States
Addict Behav 32:2351-7. 2007..These results suggest that smoking abstinence significantly increases errors of response inhibition and that the magnitude of this increase is related to trait impulsivity and nicotine intake variables... - Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based studyB F Fuemmeler
Community and Family Medicine, Duke University Medical Center, Durham, NC 27710, USA
Int J Obes (Lond) 35:852-62. 2011..To examine the associations between attention-deficit/hyperactivity disorder (ADHD) symptoms, obesity and hypertension in young adults in a large population-based cohort... - Double-blind, placebo-controlled study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorderLenard A Adler
Department of Psychiatry, New York University School of Medicine, 530 First Ave 7D, New York, NY 10016, USA
J Clin Psychiatry 69:1364-73. 2008..To evaluate the efficacy and safety of 30, 50, and 70 mg/day lisdexamfetamine dimesylate compared with placebo in adults with attention-deficit/hyperactivity disorder (ADHD)... - Psychosocial treatments for preschool-aged children with Attention-Deficit Hyperactivity DisorderDoré R LaForett
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27705, USA
Dev Disabil Res Rev 14:300-10. 2008..The body of research suggests that the most effective treatments for clinical samples of preschoolers with ADHD and their families may be individually delivered, developmentally appropriate, and multimodal... - Genetic variants in SLC9A9 are associated with measures of attention-deficit/hyperactivity disorder symptoms in familiesChristina A Markunas
Center for Human Genetics, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
Psychiatr Genet 20:73-81. 2010..Based on this report, these genes were selected to be evaluated in a family-based attention-deficit/hyperactivity disorder (AD/HD) association study... - Effects of guanfacine extended release on oppositional symptoms in children aged 6-12 years with attention-deficit hyperactivity disorder and oppositional symptoms: a randomized, double-blind, placebo-controlled trialDaniel F Connor
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 1410, USA
CNS Drugs 24:755-68. 2010..Wayne, PA, USA) in the treatment of oppositional symptoms in children aged 6-12 years with a diagnosis of attention-deficit hyperactivity disorder (ADHD) and the presence of oppositional symptoms... - Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Howard B Abikoff
New York University Child Study Center, 215 Lexington Avenue, New York, NY 10016, USA
J Child Adolesc Psychopharmacol 17:581-92. 2007.... - A pilot study of atomoxetine in young children with attention-deficit/hyperactivity disorderChristopher J Kratochvil
University of Nebraska Medical Center, Omaha, Nebraska, USA
J Child Adolesc Psychopharmacol 17:175-85. 2007..The purpose of this study was to assess the effectiveness and tolerability of atomoxetine during acute treatment of attention-deficit/hyperactivity disorder (ADHD) in 5 and 6 year olds... - Comments on 'Cytogenetic effects in children treated with methylphenidate' by El-Zein et alR Julian Preston
Cancer Lett 230:292-4. 2005 - Comorbidity moderates response to methylphenidate in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Jaswinder K Ghuman
University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
J Child Adolesc Psychopharmacol 17:563-80. 2007..The aim of this study was to examine whether demographic or pretreatment clinical and social characteristics influenced the response to methylphenidate (MPH) in the Preschoolers with ADHD Treatment Study (PATS)... - Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)Benedetto Vitiello
Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA
J Child Adolesc Psychopharmacol 17:593-604. 2007..The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS)... - Assessing methylphenidate preference in ADHD patients using a choice procedureEmily MacDonald Fredericks
Department of Pediatrics, University of Michigan Health System, 1924 Taubman Center, P.O. Box 0318 Ann Arbor, MI, 48109-0318, USA
Psychopharmacology (Berl) 175:391-8. 2004..Future work should examine MPH choice in diagnosed and non-diagnosed populations to further explore the role of clinical efficacy in the preference of this stimulant drug... - Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)James M Swanson
Child Development Center, University of California Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
J Child Adolesc Psychopharmacol 17:635-46. 2007.... - A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorderSharon B Wigal
Child Development Center, University of California, Irvine, CA 92612, USA
J Atten Disord 9:275-89. 2005..001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD... - A pilot study of methylphenidate preference assessment in children diagnosed with attention-deficit/hyperactivity disorderEmily MacDonald Fredericks
Department of Pediatrics, University of Michigan Health System, Ann Arbor, MI, USA
J Child Adolesc Psychopharmacol 15:729-41. 2005..CONCLUSIONS: These findings add to the literature on the reinforcing effects of MPH and are the first reported in a clinical sample of children. Further research exploring the role of clinical efficacy in MPH preference is warranted...
Research Grants
- Smoking reinforcement in adults with and without ADHDScott Kollins; Fiscal Year: 2009..This project will help identify some of the reasons why people with ADHD smoke more and will potentially lead to better prevention and treatment programs. ..
- Mechanisms of Nicotine Dependence in ADHD AdultsScott Kollins; Fiscal Year: 2007..Data generated will also lead to subsequent clinical projects to develop more effective interventions for nicotine dependence in this high risk group. ..
- Follow up of the PATS sampleScott Kollins; Fiscal Year: 2007..Aim 4 is to determine the stability of the ADHD diagnosis and other comorbidities made for study entry at age 3-5 years across subsequent development ..
- Methylphenidate Abuse Potential in ADHD AdultsScott Kollins; Fiscal Year: 2007....
- Smoking reinforcement in adults with and without ADHDScott H Kollins; Fiscal Year: 2010..This project will help identify some of the reasons why people with ADHD smoke more and will potentially lead to better prevention and treatment programs. ..