DAVID GUY KIRSCH

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi Imaging primary lung cancers in mice to study radiation biology
    David G Kirsch
    The David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Int J Radiat Oncol Biol Phys 76:973-7. 2010
  2. ncbi Using genetically engineered mice for radiation research
    David G Kirsch
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 176:275-9. 2011
  3. ncbi p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis
    David G Kirsch
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 327:593-6. 2010
  4. ncbi Future of early detection of lung cancer: the role of mouse models
    Alice T Shaw
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Clin Cancer Res 11:4999s-5003s. 2005
  5. ncbi A spatially and temporally restricted mouse model of soft tissue sarcoma
    David G Kirsch
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Med 13:992-7. 2007
  6. ncbi Dicer1 functions as a haploinsufficient tumor suppressor
    Madhu S Kumar
    Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:2700-4. 2009

Research Grants

  1. Mechanisms of Late Effects of Exposure to Radiation
    DAVID GUY KIRSCH; Fiscal Year: 2010
  2. Dissecting Mechanisms of Metastasis Through Comparative Systems Genetics
    DAVID GUY KIRSCH; Fiscal Year: 2010
  3. Mechanisms of Late Effects of Exposure to Radiation
    DAVID GUY KIRSCH; Fiscal Year: 2010

Collaborators

  • Madhu S Kumar
  • Tyler Jacks
  • Alice T Shaw
  • Jun Lu
  • Keara Lane
  • Todd R Golub
  • Ryan E Pester
  • Cindy Y Chen
  • Christine Chin

Detail Information

Publications6

  1. ncbi Imaging primary lung cancers in mice to study radiation biology
    David G Kirsch
    The David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA
    Int J Radiat Oncol Biol Phys 76:973-7. 2010
    ..To image a genetically engineered mouse model of non-small-cell lung cancer with micro-computed tomography (micro-CT) to measure tumor response to radiation therapy...
  2. ncbi Using genetically engineered mice for radiation research
    David G Kirsch
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Radiat Res 176:275-9. 2011
    ..These advances in genetic engineering provide a powerful model system to dissect both the mechanisms of normal tissue injury after irradiation and the mechanisms by which radiation cures cancer...
  3. ncbi p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis
    David G Kirsch
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 327:593-6. 2010
    ..These results suggest that the GI syndrome is caused by the death of GI epithelial cells and that these epithelial cells die by a mechanism that is regulated by p53 but independent of apoptosis...
  4. ncbi Future of early detection of lung cancer: the role of mouse models
    Alice T Shaw
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Clin Cancer Res 11:4999s-5003s. 2005
    ..The application of innovative technologies to accurate mouse models promises to accelerate the discovery of new molecular targets and imaging biomarkers for the early detection of lung cancer...
  5. ncbi A spatially and temporally restricted mouse model of soft tissue sarcoma
    David G Kirsch
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Med 13:992-7. 2007
    ..Therefore, the intrinsic pathway of apoptosis seems sufficient to mediate p53 tumor suppression in an epithelial cancer, but not in this model of soft tissue sarcoma...
  6. ncbi Dicer1 functions as a haploinsufficient tumor suppressor
    Madhu S Kumar
    Massachusetts Institute of Technology Koch Institute for Integrative Cancer Research, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:2700-4. 2009
    ..These findings suggest Dicer1 may be an important haploinsufficient tumor suppressor gene and, furthermore, that other factors controlling miRNA biogenesis may also function in this manner...

Research Grants8

  1. Mechanisms of Late Effects of Exposure to Radiation
    DAVID GUY KIRSCH; Fiscal Year: 2010
    ..These in vivo studies will provide a mechanistic foundation for the design of safe and effective countermeasures against radiation that do not inadvertently increase late effects of radiation. ..
  2. Dissecting Mechanisms of Metastasis Through Comparative Systems Genetics
    DAVID GUY KIRSCH; Fiscal Year: 2010
    ..Moreover, new insights into mechanisms of lung metastasis may identify novel molecular targets for sarcoma therapy. ..
  3. Mechanisms of Late Effects of Exposure to Radiation
    DAVID GUY KIRSCH; Fiscal Year: 2010
    ..These in vivo studies will provide a mechanistic foundation for the design of safe and effective countermeasures against radiation that do not inadvertently increase late effects of radiation. ..