Joanne M Kingsbury

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e39405. 2012
  2. pmc Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Microbiology 156:929-39. 2010
  3. pmc Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 9:717-28. 2010
  4. pmc Threonine biosynthetic genes are essential in Cryptococcus neoformans
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Microbiology 154:2767-75. 2008
  5. pmc Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 9:729-37. 2010
  6. pmc Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 5:816-24. 2006
  7. ncbi request reprint Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence
    Renata C Pascon
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Microbiology 150:3013-23. 2004

Collaborators

  • Renata C Pascon
  • Tonya M Ganous
  • Gary M Cox
  • John H McCusker

Detail Information

Publications7

  1. pmc Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 7:e39405. 2012
    ..albicans. Therefore, our studies identify novel fungal inhibitors and drug interactions, offering promise for combination topical treatment regimes for superficial mycoses...
  2. pmc Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Microbiology 156:929-39. 2010
    ..albicans ilv1Delta and ilv2 Delta viability was influenced by the carbon source present during starvation, supporting a role for glucose wasting in the Ca. albicans cidal phenotype...
  3. pmc Homoserine toxicity in Saccharomyces cerevisiae and Candida albicans homoserine kinase (thr1Delta) mutants
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 9:717-28. 2010
    ..Since the doa4Delta and proteasome mutants identified have reduced ubiquitin- and/or proteasome-mediated proteolysis, the degradation of a particular protein or subset of proteins likely contributes to homoserine toxicity...
  4. pmc Threonine biosynthetic genes are essential in Cryptococcus neoformans
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Microbiology 154:2767-75. 2008
    ..The necessity of these genes for C. neoformans growth, particularly at physiologically relevant temperatures, makes threonine biosynthetic genes ideal anti-cryptococcal drug targets...
  5. pmc Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 9:729-37. 2010
    ..neoformans threonine synthesis, the cross-species serum sensitivity of thr1Delta mutants makes the fungus-specific Thr1p, and likely Thr4p, ideal antifungal drug targets...
  6. pmc Role of nitrogen and carbon transport, regulation, and metabolism genes for Saccharomyces cerevisiae survival in vivo
    Joanne M Kingsbury
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 5:816-24. 2006
    ..Our studies provide insights into the yeast-host environment interaction and identify potential antifungal drug targets...
  7. ncbi request reprint Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence
    Renata C Pascon
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Microbiology 150:3013-23. 2004
    ..The phenotypic differences between the met3 and met6 mutants may be due to the accumulation in met6 mutants of homocysteine, a toxic metabolic intermediate that inhibits sterol biosynthesis...