Chris R Kelsey

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. doi request reprint Local recurrence after surgery for non-small cell lung cancer: a recursive partitioning analysis of multi-institutional data
    Chris R Kelsey
    Department of Radiation Oncology, Duke Cancer Institute, Durham, NC Electronic address
    J Thorac Cardiovasc Surg 146:768-773.e1. 2013
  2. pmc Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Lung Cancer 14:267-74. 2013
  3. ncbi request reprint Combined-modality therapy for early-stage Hodgkin lymphoma: maintaining high cure rates while minimizing risks
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Oncology (Williston Park) 26:1182-9, 1193. 2012
  4. doi request reprint A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 82:e247-55. 2012
  5. doi request reprint Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 81:812-8. 2011
  6. ncbi request reprint Radiation therapy in the management of diffuse large B-cell lymphoma: still relevant?
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 24:1204-12. 2010
  7. pmc Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3085, Durham, NC 27710, USA
    Neuro Oncol 12:145-52. 2010
  8. doi request reprint Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer 115:5218-27. 2009
  9. ncbi request reprint Postoperative radiation therapy for lung cancer: where do we stand?
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 22:301-10; discussion 310, 314-5, 319. 2008
  10. ncbi request reprint Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:770-6. 2007

Detail Information

Publications42

  1. doi request reprint Local recurrence after surgery for non-small cell lung cancer: a recursive partitioning analysis of multi-institutional data
    Chris R Kelsey
    Department of Radiation Oncology, Duke Cancer Institute, Durham, NC Electronic address
    J Thorac Cardiovasc Surg 146:768-773.e1. 2013
    ..To define subgroups at high risk of local recurrence (LR) after surgery for non-small cell lung cancer using a recursive partitioning analysis (RPA)...
  2. pmc Analysis of single nucleotide polymorphisms and radiation sensitivity of the lung assessed with an objective radiologic endpoin
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Clin Lung Cancer 14:267-74. 2013
    ..The primary objective of this study was to evaluate the association between radiation sensitivity of the lungs and candidate single nucleotide polymorphisms (SNP) in genes implicated in radiation-induced toxicity...
  3. ncbi request reprint Combined-modality therapy for early-stage Hodgkin lymphoma: maintaining high cure rates while minimizing risks
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Oncology (Williston Park) 26:1182-9, 1193. 2012
    ..In favorable patients, as few as 2 cycles of ABVD have been shown to be effective. The current combined-modality approach seeks to maintain high cure rates but minimize risks by optimizing both chemotherapy and radiation therapy..
  4. doi request reprint A polymorphism within the promoter of the TGFβ1 gene is associated with radiation sensitivity using an objective radiologic endpoint
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 82:e247-55. 2012
    ..To evaluate whether single nucleotide polymorphisms (SNPs) in the transforming growth factor-β1 (TGFβ1) gene are associated with radiation sensitivity using an objective radiologic endpoint...
  5. doi request reprint Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 81:812-8. 2011
    ..To assess factors associated with severe pulmonary toxicity after myeloablative conditioning using total body irradiation (TBI) followed by allogeneic stem cell transplantation...
  6. ncbi request reprint Radiation therapy in the management of diffuse large B-cell lymphoma: still relevant?
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 24:1204-12. 2010
    ..Finally, for patients with advanced DLBCL who are no longer responsive to systemic therapy, RT may provide rapid and durable palliation of local lymphoma-related symptoms...
  7. pmc Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, DUMC Box 3085, Durham, NC 27710, USA
    Neuro Oncol 12:145-52. 2010
    ..003), followed by a decline to baseline between days +30 and +90 (P = .03). We did not observe a significant decline in NAA/Cr or change in Cho/Cr peak heights in uninvolved brain parenchyma after SRS...
  8. doi request reprint Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer 115:5218-27. 2009
    ..The objective of the current study was to evaluate the actuarial risk of local failure (LF) after surgery for stage I to II nonsmall cell lung cancer (NSCLC) and assess surgical and pathologic factors affecting this risk...
  9. ncbi request reprint Postoperative radiation therapy for lung cancer: where do we stand?
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Oncology (Williston Park) 22:301-10; discussion 310, 314-5, 319. 2008
    ..Clinicians must therefore counsel patients regarding the risk of disease recurrence after surgery, the potential but unproven benefit of postoperative radiation therapy, and the possibility of treatment-related complications...
  10. ncbi request reprint Paclitaxel-based chemoradiotherapy in the treatment of patients with operable esophageal cancer
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:770-6. 2007
    ..To compare a neoadjuvant regimen of cisplatin/5-fluorouracil (5-FU) and concurrent radiation therapy (RT) with paclitaxel-based regimens and RT in the management of operable esophageal (EC)/gastroesophageal junction (GEJ) cancer...
  11. ncbi request reprint Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy
    Chris R Kelsey
    Department of Radiation Oncology, Division of Medical Oncology and Transplantation, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 69:1436-41. 2007
    ..To report patterns of disease recurrence after resection of adenocarcinoma of the duodenum and compare outcomes between patients undergoing surgery only vs. surgery with concurrent chemotherapy and radiation therapy (CT-RT)...
  12. ncbi request reprint Somnolence syndrome after focal radiation therapy to the pineal region: case report and review of the literature
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    J Neurooncol 78:153-6. 2006
    ..Prednisone was prescribed and within 1 week her symptoms had largely resolved. This is the first report of the somnolence syndrome after focal radiation therapy. The possible etiology of the somnolence syndrome is discussed...
  13. ncbi request reprint Local recurrence following initial resection of NSCLC: salvage is possible with radiation therapy
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cancer J 12:283-8. 2006
    ..This retrospective study evaluates the utility of salvage radiation therapy in this setting...
  14. doi request reprint Lymphovascular invasion in non-small-cell lung cancer: implications for staging and adjuvant therapy
    Kristin A Higgins
    Department of Radiation Oncology, Emory University, Atlanta, GA, USA
    J Thorac Oncol 7:1141-7. 2012
    ..The purpose of this study was to evaluate LVI in patients with early-stage non-small-cell lung cancer, undergoing surgical resection...
  15. ncbi request reprint A phase I study of UFT/leucovorin, carboplatin, and paclitaxel in combination with external beam radiation therapy for advanced esophageal carcinoma
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 70:1066-72. 2008
    ..We evaluated the safety and preliminary efficacy of a combination of UFT/leucovorin, carboplatin, and paclitaxel with RT in a Phase I study of patients with advanced esophageal cancer...
  16. doi request reprint Are discordant positron emission tomography and pathological assessments of the mediastinum in non-small cell lung cancer significant?
    Daniel J Tandberg
    Department of Radiation Oncology, Duke University School of Medicine, Durham, NC Electronic address
    J Thorac Cardiovasc Surg 146:796-801. 2013
    ..The prognostic significance of this discordance was assessed...
  17. doi request reprint Preoperative chemotherapy versus preoperative chemoradiotherapy for stage III (N2) non-small-cell lung cancer
    Kristin Higgins
    Department of Radiation Oncology, Duke University of Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 75:1462-7. 2009
    ..To compare preoperative chemotherapy (ChT) and preoperative chemoradiotherapy (ChT-RT) in operable Stage III non-small-cell lung cancer...
  18. doi request reprint Effect of increasing experience on dosimetric and clinical outcomes in the management of malignant pleural mesothelioma with intensity-modulated radiation therapy
    Pretesh R Patel
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Int J Radiat Oncol Biol Phys 83:362-8. 2012
    ..To assess the impact of increasing experience with intensity-modulated radiation therapy (IMRT) after extrapleural pneumonectomy (EPP) for malignant pleural mesothelioma (MPM)...
  19. doi request reprint Local failure in resected N1 lung cancer: implications for adjuvant therapy
    Kristin A Higgins
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 83:727-33. 2012
    ..To evaluate actuarial rates of local failure in patients with pathologic N1 non-small-cell lung cancer and to identify clinical and pathologic factors associated with an increased risk of local failure after resection...
  20. ncbi request reprint A Phase I study of capecitabine, carboplatin, and paclitaxel with external beam radiation therapy for esophageal carcinoma
    Brian G Czito
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 67:1002-7. 2007
    ..The optimal combination of chemotherapeutic agents with RT is undefined. We evaluated a combination of capecitabine, carboplatin, and paclitaxel with RT in a phase I study...
  21. doi request reprint Timing of local and distant failure in resected lung cancer: implications for reported rates of local failure
    Jessamy A Boyd
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Thorac Oncol 5:211-4. 2010
    ..e., local/regional) versus distant recurrence after surgery could potentially affect reported rates of local failure. We assessed this phenomenon in a large group of patients undergoing surgery for early-stage lung cancer...
  22. doi request reprint How well does the new lung cancer staging system predict for local/regional recurrence after surgery?: A comparison of the TNM 6 and 7 systems
    Joseph M Pepek
    Department of Radiation Oncology, Duke University School of Medicine, Durham, NC 27710, USA
    J Thorac Oncol 6:757-61. 2011
    ..To evaluate how well the tumor, node, metastasis (TNM) 6 and TNM 7 staging systems predict rates of local/regional recurrence (LRR) after surgery alone for non-small cell lung cancer...
  23. doi request reprint Adaptive stereotactic body radiation therapy planning for lung cancer
    Yujiao Qin
    Medical Physics Graduate Program, Duke University, Durham, North Carolina, USA
    Int J Radiat Oncol Biol Phys 87:209-15. 2013
    ..To investigate the dosimetric effects of adaptive planning on lung stereotactic body radiation therapy (SBRT)...
  24. doi request reprint Persistent N2 disease after neoadjuvant chemotherapy for non-small-cell lung cancer
    Kristin A Higgins
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    J Thorac Cardiovasc Surg 142:1175-9. 2011
    ..How to best manage this latter group of patients is unknown, prompting a review of our institutional experience...
  25. ncbi request reprint Estimating the magnitude and field-size dependence of radiotherapy-induced mortality and tumor control after postoperative radiotherapy for non-small-cell lung cancer: calculations from clinical trials
    Edward F Miles
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 68:1047-52. 2007
    ....
  26. doi request reprint Impact of consolidation radiation therapy in stage III-IV diffuse large B-cell lymphoma with negative post-chemotherapy radiologic imaging
    Jennifer A Dorth
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 84:762-7. 2012
    ..While consolidation radiation therapy (i.e., RT administered after chemotherapy) is routine treatment for patients with early-stage diffuse large B-cell lymphoma (DLBCL), the role of consolidation RT in stage III-IV DLBCL is controversial...
  27. doi request reprint Factors associated with the development of brain metastases: analysis of 975 patients with early stage nonsmall cell lung cancer
    Jessica L Hubbs
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer 116:5038-46. 2010
    ..The risk for patients with early stage disease is less defined. The authors sought to investigate this further and to study potential risk factors...
  28. doi request reprint Metastasis dynamics for non-small-cell lung cancer: effect of patient and tumor-related factors
    Chris R Kelsey
    Department of Radiation Oncology, Duke Cancer Institute, Durham, NC, USA
    Clin Lung Cancer 14:425-32. 2013
    ..We studied event dynamics (probability of an event occurring over a specific time interval) in patients undergoing surgery for early-stage non-small-cell lung cancer (NSCLC) according to patient and tumor characteristics...
  29. doi request reprint Quantification and minimization of uncertainties of internal target volume for stereotactic body radiation therapy of lung cancer
    Hong Ge
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Radiat Oncol Biol Phys 85:438-43. 2013
    ....
  30. ncbi request reprint Radiation-induced narrowing of the tracheobronchial tree: an in-depth analysis
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, DUMC 3085, Durham, NC 27710, USA
    Lung Cancer 52:111-6. 2006
    ..This in-depth study quantifies changes in the caliber of the trachea and mainstem bronchi after high-dose external beam radiation therapy (EBRT)...
  31. ncbi request reprint Stage III lung cancer: two or three modalities? The continued role of thoracic radiotherapy
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
    Oncology (Williston Park) 20:1210-9; discussion 1219, 1223, 1225. 2006
    ..In summary, locally advanced NSCLC remains a formidable challenge with few cures, and optimal treatment requires the careful use of surgery, chemotherapy, and radiation therapy...
  32. ncbi request reprint Patterns of failure after resection of non-small-cell lung cancer: implications for postoperative radiation therapy volumes
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 65:1097-105. 2006
    ..To analyze local-regional patterns of failure after surgical resection of non-small-cell lung cancer (NSCLC)...
  33. pmc Radiotherapy dose-response analysis for diffuse large B-cell lymphoma with a complete response to chemotherapy
    Jennifer A Dorth
    Department of Radiation Oncology, University Hospitals Seidman Cancer Center and Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Radiat Oncol 7:100. 2012
    ..To examine the efficacy of different radiation doses after achievement of a complete response to chemotherapy in diffuse large B-cell lymphoma (DLBCL)...
  34. doi request reprint Outcomes after surgical management of synchronous bilateral primary lung cancers
    Asad A Shah
    Division of Cardiovascular and Thoracic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    Ann Thorac Surg 93:1055-60; discussion 1060. 2012
    ..The objective of this study is to examine outcomes associated with a strategy of performing staged bilateral resections in patients without N2 disease based on invasive mediastinal staging and without distant metastases...
  35. pmc Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial
    Oana I Craciunescu
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 79:1248-55. 2011
    ..To describe renal shielding techniques and dosimetry in delivering total body irradiation (TBI) to patients with severe systemic sclerosis (SSc) enrolled in a hematopoietic stem cell transplant protocol...
  36. doi request reprint Uncertainties of 4-dimensional computed tomography-based tumor motion measurement for lung stereotactic body radiation therapy
    Fan Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina
    Pract Radiat Oncol 4:e59-65. 2014
    ..To evaluate how well tumor motion measured prior to treatment based on 4-dimensional computer tomography (4DCT) reflects actual tumor motion during beam-on throughout the course of treatment...
  37. ncbi request reprint Thoracoscopic approach to lobectomy for lung cancer does not compromise oncologic efficacy
    Mark F Berry
    Division of Thoracic Surgery, Duke University Medical Center, Durham, North Carolina Electronic address
    Ann Thorac Surg 98:197-202. 2014
    ..We compared survival between video-assisted thoracoscopic surgery (VATS) and thoracotomy approaches to lobectomy for non-small cell lung cancer...
  38. doi request reprint Dosimetric effects of rotational offsets in stereotactic body radiation therapy (SBRT) for lung cancer
    Yun Yang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC
    Med Dosim 39:117-21. 2014
    ..Small dosimetric differences were found owing to rotational offsets up to 5° in lung SBRT for medially located tumors. Larger intersubject variations were observed at larger rotational offsets. ..
  39. doi request reprint Reproducibility of tumor motion probability distribution function in stereotactic body radiation therapy of lung cancer
    Fan Zhang
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Int J Radiat Oncol Biol Phys 84:861-6. 2012
    ..To evaluate the reproducibility of tumor motion probability distribution function (PDF) in stereotactic body radiation therapy (SBRT) of lung cancer using cine megavoltage (MV) images...
  40. doi request reprint Stereotactic body radiation therapy for treatment of primary and metastatic pulmonary malignancies
    Chris R Kelsey
    Department of Radiation Oncology, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA
    Surg Oncol Clin N Am 22:463-81. 2013
    ..Ongoing studies are examining whether SBRT can replace surgery for certain patients, the optimal dose-fractionation scheme, and how best to treat patients having central tumors near the primary tracheobronchial tree...
  41. doi request reprint Recurrence dynamics for non-small-cell lung cancer: effect of surgery on the development of metastases
    Romano Demicheli
    Scientific Directorate, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    J Thorac Oncol 7:723-30. 2012
    ..We study event rates over time (event dynamics) in patients undergoing surgery for early-stage non-small-cell lung cancer (NSCLC)...
  42. ncbi request reprint Retrospective clinicopathologic correlation of gross tumor size of hepatocellular carcinoma: implications for stereotactic body radiotherapy
    Chris R Kelsey
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Clin Oncol 28:576-80. 2005
    ..To determine the degree of correlation between radiographic size and true gross pathologic size for subjects with primary hepatocellular carcinoma (HCC)...