Rima Kaddurah-Daouk

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics
    Joseph McEvoy
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina, United States of America
    PLoS ONE 8:e68717. 2013
  2. pmc Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics
    Xianlin Han
    Sanford Burnham Medical Research Institute, Orlando, Florida, United States of America
    PLoS ONE 6:e21643. 2011
  3. pmc Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment
    Miles Trupp
    Bioinformatics Research Group, AI Center, SRI International, Menlo Park, California, United States of America
    PLoS ONE 7:e38386. 2012
  4. pmc Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Sci Rep 2:667. 2012
  5. doi request reprint Impaired plasmalogens in patients with schizophrenia
    Rima Kaddurah-Daouk
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, DUMC Box 3950 Durham, NC 27710, USA
    Psychiatry Res 198:347-52. 2012
  6. ncbi request reprint Metabolomic mapping of atypical antipsychotic effects in schizophrenia
    R Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 12:934-45. 2007
  7. doi request reprint Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
  8. pmc Enteric microbiome metabolites correlate with response to simvastatin treatment
    Rima Kaddurah-Daouk
    Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25482. 2011
  9. pmc Metabolomic changes in autopsy-confirmed Alzheimer's disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 7:309-17. 2011
  10. doi request reprint Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 206:479-89. 2009

Detail Information

Publications22

  1. pmc Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics
    Joseph McEvoy
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina, United States of America
    PLoS ONE 8:e68717. 2013
    ..These changes in lipid metabolism could indicate a metabolic vulnerability in patients with schizophrenia that occurs early in development of the disease. ..
  2. pmc Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics
    Xianlin Han
    Sanford Burnham Medical Research Institute, Orlando, Florida, United States of America
    PLoS ONE 6:e21643. 2011
    ....
  3. pmc Metabolomics reveals amino acids contribute to variation in response to simvastatin treatment
    Miles Trupp
    Bioinformatics Research Group, AI Center, SRI International, Menlo Park, California, United States of America
    PLoS ONE 7:e38386. 2012
    ..Together, the findings from this study indicate that clusters of metabolites involved in multiple pathways not directly connected with cholesterol metabolism may play a role in modulating the response to simvastatin treatment...
  4. pmc Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Sci Rep 2:667. 2012
    ..The reductions in metabolites associated with tryptophan and tyrosine pathways in rMDD may relate to the vulnerability this population shows for developing depressive symptoms under tryptophan or catecholamine depletion...
  5. doi request reprint Impaired plasmalogens in patients with schizophrenia
    Rima Kaddurah-Daouk
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, DUMC Box 3950 Durham, NC 27710, USA
    Psychiatry Res 198:347-52. 2012
    ..This may serve as a clue to the neurobiology of schizophrenia and should be studied as a potential biomarker for individuals at risk for schizophrenia...
  6. ncbi request reprint Metabolomic mapping of atypical antipsychotic effects in schizophrenia
    R Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Mol Psychiatry 12:934-45. 2007
    ..A more definitive long-term randomized study of these drugs correlating global lipid changes with clinical outcomes could yield biomarkers that define drug-response phenotypes...
  7. doi request reprint Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
    ..It also highlights potential metabolomic applications to pharmacology and clinical pharmacology...
  8. pmc Enteric microbiome metabolites correlate with response to simvastatin treatment
    Rima Kaddurah-Daouk
    Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25482. 2011
    ..Metabolic profiles could provide valuable information about treatment outcomes and could contribute to a more personalized approach to therapy...
  9. pmc Metabolomic changes in autopsy-confirmed Alzheimer's disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 7:309-17. 2011
    ....
  10. doi request reprint Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 206:479-89. 2009
    ..Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets...
  11. pmc Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway
    Hongjie Zhu
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA
    PLoS ONE 8:e68283. 2013
    ..These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL. ..
  12. doi request reprint Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiovasc Transl Res 5:92-9. 2012
    ..1 unit) (HR 0.73, 95% CI 0.56-0.96) were significantly associated with survival of patients with HF and co-morbid MDD. The results suggest that low plasma omega-3 FA is a significant factor for reduced survival in HF patients with MDD...
  13. pmc Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effects
    Bertrand Perroud
    UC Davis Genome Center, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e70610. 2013
    ..The purine metabolite level, reduced in the Sca1(154Q/+) mice and restored upon lithium treatment, might relate to lithium neuroprotective properties...
  14. pmc Opioid use affects antioxidant activity and purine metabolism: preliminary results
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
    Hum Psychopharmacol 24:666-75. 2009
    ..Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant compounds and purine metabolism. We examined perturbations of neurotransmitter-related pathways in opioid dependence (OD)...
  15. pmc Metabolomic differences in heart failure patients with and without major depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Geriatr Psychiatry Neurol 23:138-46. 2010
    ..It is unclear what role heart failure may have played in these differing concentrations...
  16. pmc Pharmacometabolomics reveals racial differences in response to atenolol treatment
    William R Wikoff
    UC Davis Genome Center, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e57639. 2013
    ....
  17. ncbi request reprint A preliminary metabolomic analysis of older adults with and without depression
    Lisa A Paige
    Metabolon, Inc, Research Triangle Park, NC, USA
    Int J Geriatr Psychiatry 22:418-23. 2007
    ..Metabolic signatures for disease and its treatment could provide valuable biomarkers and insights about disease mechanisms. In this pilot study, we evaluate the potential of metabolomics in the study of older depressed patients...
  18. doi request reprint Metabolomics: a global biochemical approach to the study of central nervous system diseases
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 34:173-86. 2009
    ..Metabolomics emerges as another powerful tool in central nervous system research...
  19. pmc Metabolic profiling of patients with schizophrenia
    Rima Kaddurah-Daouk
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Med 3:e363. 2006
  20. ncbi request reprint Establishing reporting standards for metabolomic and metabonomic studies: a call for participation
    Oliver Fiehn
    UC Davis Genome Center, Davis, California 95616, USA
    OMICS 10:158-63. 2006
    ..These include biological study designs, chemical analysis, and data processing, as well as the ontologies that are necessary in this framework...
  21. ncbi request reprint Metabolomics Standards Workshop and the development of international standards for reporting metabolomics experimental results
    Arthur L Castle
    Metabolomics and Informatics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health NIH 6707 Democracy Blvd, Room 791, MSC 5460, Bethesda, Maryland 20892 5460, USA
    Brief Bioinform 7:159-65. 2006
    ..This report highlights specific aspects of what was presented and discussed at the 1st and 2nd August 2005 Metabolomics Standards Workshop...