Rima Kaddurah-Daouk

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. pmc Metabolic profiling of patients with schizophrenia
    Rima Kaddurah-Daouk
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Med 3:e363. 2006
  2. pmc Alterations in metabolic pathways and networks in Alzheimer's disease
    R Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Transl Psychiatry 3:e244. 2013
  3. doi request reprint Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept
    R Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Transl Psychiatry 1:e26. 2011
  4. doi request reprint Metabolomics: a global biochemical approach to the study of central nervous system diseases
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 34:173-86. 2009
  5. pmc Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics
    Joseph McEvoy
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina, United States of America
    PLoS ONE 8:e68717. 2013
  6. doi request reprint Impaired plasmalogens in patients with schizophrenia
    Rima Kaddurah-Daouk
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, DUMC Box 3950 Durham, NC 27710, USA
    Psychiatry Res 198:347-52. 2012
  7. pmc Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging
    Alison A Motsinger-Reif
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Acta Neuropathol Commun 1:28. 2013
  8. pmc Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway
    Hongjie Zhu
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA
    PLoS ONE 8:e68283. 2013
  9. doi request reprint Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
  10. pmc Opioid use affects antioxidant activity and purine metabolism: preliminary results
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
    Hum Psychopharmacol 24:666-75. 2009

Research Grants

  1. Metabolic Signatures for Alzheimer's Disease
    Rima Kaddurah Daouk; Fiscal Year: 2009

Collaborators

Detail Information

Publications17

  1. pmc Metabolic profiling of patients with schizophrenia
    Rima Kaddurah-Daouk
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Med 3:e363. 2006
  2. pmc Alterations in metabolic pathways and networks in Alzheimer's disease
    R Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Transl Psychiatry 3:e244. 2013
    ..Metabolomics provides powerful tools to map interlinked biochemical pathway perturbations and study AD as a disease of network failure...
  3. doi request reprint Pretreatment metabotype as a predictor of response to sertraline or placebo in depressed outpatients: a proof of concept
    R Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Transl Psychiatry 1:e26. 2011
    ..Some pathways were informative for both treatments whereas other pathways were unique in predicting response to either sertraline or placebo. Metabolomics may inform the biochemical basis for the early efficacy of sertraline...
  4. doi request reprint Metabolomics: a global biochemical approach to the study of central nervous system diseases
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 34:173-86. 2009
    ..Metabolomics emerges as another powerful tool in central nervous system research...
  5. pmc Lipidomics reveals early metabolic changes in subjects with schizophrenia: effects of atypical antipsychotics
    Joseph McEvoy
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, North Carolina, United States of America
    PLoS ONE 8:e68717. 2013
    ..These changes in lipid metabolism could indicate a metabolic vulnerability in patients with schizophrenia that occurs early in development of the disease. ..
  6. doi request reprint Impaired plasmalogens in patients with schizophrenia
    Rima Kaddurah-Daouk
    Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, DUMC Box 3950 Durham, NC 27710, USA
    Psychiatry Res 198:347-52. 2012
    ..This may serve as a clue to the neurobiology of schizophrenia and should be studied as a potential biomarker for individuals at risk for schizophrenia...
  7. pmc Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging
    Alison A Motsinger-Reif
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Acta Neuropathol Commun 1:28. 2013
    ..This would aid intervention trials designed to slow the progression of AD by increasing diagnostic certainty, and provide new pathophysiologic clues and potential drug targets...
  8. pmc Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway
    Hongjie Zhu
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA
    PLoS ONE 8:e68283. 2013
    ..These results suggest that recovery from a depressed state due to treatment with drug or with placebo could be associated with preferential utilization of serotonin for production of melatonin and 5-MTPOL. ..
  9. doi request reprint Metabolomics: a global biochemical approach to drug response and disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Annu Rev Pharmacol Toxicol 48:653-83. 2008
    ..It also highlights potential metabolomic applications to pharmacology and clinical pharmacology...
  10. pmc Opioid use affects antioxidant activity and purine metabolism: preliminary results
    Paolo Mannelli
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, 2218 Elder Street, Durham, NC 27705, USA
    Hum Psychopharmacol 24:666-75. 2009
    ..Experimental opioid administration influences mechanisms and indices of oxidative stress, such as antioxidant compounds and purine metabolism. We examined perturbations of neurotransmitter-related pathways in opioid dependence (OD)...
  11. doi request reprint Alterations in tryptophan and purine metabolism in cocaine addiction: a metabolomic study
    Ashwin A Patkar
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Psychopharmacology (Berl) 206:479-89. 2009
    ..Mapping metabolic "signatures" can provide new insights into addictive mechanisms and potentially identify biomarkers and therapeutic targets...
  12. pmc Metabolomic differences in heart failure patients with and without major depression
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    J Geriatr Psychiatry Neurol 23:138-46. 2010
    ..It is unclear what role heart failure may have played in these differing concentrations...
  13. pmc Metabolomic changes in autopsy-confirmed Alzheimer's disease
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 7:309-17. 2011
    ....
  14. doi request reprint Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder
    Wei Jiang
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cardiovasc Transl Res 5:92-9. 2012
    ..1 unit) (HR 0.73, 95% CI 0.56-0.96) were significantly associated with survival of patients with HF and co-morbid MDD. The results suggest that low plasma omega-3 FA is a significant factor for reduced survival in HF patients with MDD...
  15. doi request reprint Associations between Central Nervous System Serotonin, Fasting Glucose, and Hostility in African American Females
    Stephen H Boyle
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 3366, Durham, NC, 27710, USA
    Ann Behav Med 49:49-57. 2015
    ..Previous research has shown an association between hostility and fasting glucose in African American women. Central nervous system serotonin activity is implicated both in metabolic processes and in hostility related traits...
  16. pmc Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile
    Rima Kaddurah-Daouk
    Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA
    Sci Rep 2:667. 2012
    ..The reductions in metabolites associated with tryptophan and tyrosine pathways in rMDD may relate to the vulnerability this population shows for developing depressive symptoms under tryptophan or catecholamine depletion...

Research Grants1

  1. Metabolic Signatures for Alzheimer's Disease
    Rima Kaddurah Daouk; Fiscal Year: 2009
    ..These studies may serve to highlight new impaired pathways in the disease and identify potential targets for drug developments. ..