Randy Jirtle

Summary

Affiliation: Duke University Medical Center
Country: USA

Publications

  1. ncbi request reprint Cancer susceptibility: epigenetic manifestation of environmental exposures
    Jennifer R Weidman
    Department of Radiation Oncology, Duke University, Durham, NC 27710, USA
    Cancer J 13:9-16. 2007
  2. ncbi request reprint Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
  3. pmc Novel retrotransposed imprinted locus identified at human 6p25
    Aiping Zhang
    Department of Radiation Oncology, Department of Community and Family Medicine and Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    Nucleic Acids Res 39:5388-400. 2011
  4. pmc Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
    Adelheid Soubry
    Duke Cancer Institute, Duke University Medical Center 2715, Durham, NC 27710, USA
    BMC Med 11:29. 2013
  5. pmc Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)
    Cathrine Hoyo
    Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University, PO Box 104006, Durham, NC 27710, USA
    BMC Public Health 11:46. 2011
  6. pmc M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis
    Timothy A Jamieson
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    BMC Cancer 3:4. 2003
  7. pmc IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University, Durham, NC 27710, USA
    Int J Cancer 125:2673-8. 2009
  8. ncbi request reprint Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 56:988-95. 2003
  9. pmc Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 23:5293-300. 2003
  10. ncbi request reprint Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nutrition 20:63-8. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Cancer susceptibility: epigenetic manifestation of environmental exposures
    Jennifer R Weidman
    Department of Radiation Oncology, Duke University, Durham, NC 27710, USA
    Cancer J 13:9-16. 2007
    ..These major deficits in knowledge markedly impair our ability to understand fully the etiology of cancer and the importance of the epigenome in diagnosing and preventing this devastating disease...
  2. ncbi request reprint Environmental epigenomics and disease susceptibility
    Randy L Jirtle
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Rev Genet 8:253-62. 2007
    ..Methods are now becoming available to investigate the relevance of these phenomena to human disease...
  3. pmc Novel retrotransposed imprinted locus identified at human 6p25
    Aiping Zhang
    Department of Radiation Oncology, Department of Community and Family Medicine and Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
    Nucleic Acids Res 39:5388-400. 2011
    ..These results also underscore the importance of accounting for parental origin in understanding the mechanism of 6p25-related diseases...
  4. pmc Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
    Adelheid Soubry
    Duke Cancer Institute, Duke University Medical Center 2715, Durham, NC 27710, USA
    BMC Med 11:29. 2013
    ....
  5. pmc Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST)
    Cathrine Hoyo
    Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University, PO Box 104006, Durham, NC 27710, USA
    BMC Public Health 11:46. 2011
    ..The primary objective is to estimate the proportion of women taking folic acid (FA) doses exceeding the TUL before and during pregnancy, and to identify correlates of high FA use...
  6. pmc M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis
    Timothy A Jamieson
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA
    BMC Cancer 3:4. 2003
    ..The purpose of this investigation was to determine if the M6P/IGF2R tumor suppressor gene is mutated in human head and neck cancer, and if allelic loss is associated with poor patient prognosis...
  7. pmc IGF2R polymorphisms and risk of esophageal and gastric adenocarcinomas
    Cathrine Hoyo
    Department of Community and Family Medicine, Duke University, Durham, NC 27710, USA
    Int J Cancer 125:2673-8. 2009
    ..5002G > A genotype and EGA was not evident. These findings suggest that nonsynonymous polymorphisms in M6P/IGF2R may contribute to the risks of EGA and noncardia adenocarcinomas. Larger studies are required to confirm these findings...
  8. ncbi request reprint Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy
    Mitchell S Anscher
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Int J Radiat Oncol Biol Phys 56:988-95. 2003
    ..To report the incidence of late complications in long-term survivors of very-high-dose thoracic radiotherapy (RT) treated on a prospective clinical trial...
  9. pmc Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell Biol 23:5293-300. 2003
    ..These findings suggest that dietary supplementation, long presumed to be purely beneficial, may have unintended deleterious influences on the establishment of epigenetic gene regulation in humans...
  10. ncbi request reprint Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    Robert A Waterland
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nutrition 20:63-8. 2004
  11. ncbi request reprint Metastable epialleles, imprinting, and the fetal origins of adult diseases
    Dana C Dolinoy
    Department of Radiation Oncology, University Program in Genetics and Genomics, Duke University Medical Center, Durham, NC 27710, USA
    Pediatr Res 61:30R-37R. 2007
    ....
  12. ncbi request reprint Imprinting of opossum Igf2r in the absence of differential methylation and air
    Jennifer R Weidman
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Epigenetics 1:49-54. 2006
    ..Thus, the regulatory mechanisms of Igf2r imprinting did not evolve convergently within the Therian subclass of mammals...
  13. ncbi request reprint Imprinting evolution and the price of silence
    Susan K Murphy
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Bioessays 25:577-88. 2003
    ..Such comparative studies will also further our understanding of the molecular evolution and phylogenetic distribution of imprinted genes...
  14. pmc Tissue-specific inactivation of murine M6P/IGF2R
    Andrew A Wylie
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Pathol 162:321-8. 2003
    ....
  15. pmc Depression in pregnancy, infant birth weight and DNA methylation of imprint regulatory elements
    Ying Liu
    School of Medicine, Duke University, Durham, NC, USA
    Epigenetics 7:735-46. 2012
    ..9% higher methylation at the PLAGL1 DMR compared with normal birth weight infants. Our findings confirm that severe maternal depressed mood in pregnancy is associated with LBW, and that MEG3 and IGF2 plasticity may play important roles...
  16. ncbi request reprint Epigenetic gene regulation: linking early developmental environment to adult disease
    Dana C Dolinoy
    Department of Radiation Oncology, Duke University Medical Center, Box 3433, Durham, NC 27710, United States
    Reprod Toxicol 23:297-307. 2007
    ....
  17. pmc Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
    Dana C Dolinoy
    Department of Radiation Oncology and University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:13056-61. 2007
    ..Thus, we present compelling evidence that early developmental exposure to BPA can change offspring phenotype by stably altering the epigenome, an effect that can be counteracted by maternal dietary supplements...
  18. doi request reprint Environmental epigenomics in human health and disease
    Dana C Dolinoy
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Mol Mutagen 49:4-8. 2008
    ....
  19. pmc Phylogenetic footprint analysis of IGF2 in extant mammals
    Jennifer R Weidman
    Department of Radiation Oncology, Duke University, Durham, North Carolina 27710, USA
    Genome Res 14:1726-32. 2004
    ....
  20. ncbi request reprint M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan
    Yoshihiko Oka
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Hepatology 35:1153-63. 2002
    ..Loss of heterozygosity in dysplastic liver nodules provides additional evidence that M6P/IGF2R haploid insufficiency is an early event in human hepatocarcinogenesis...
  21. ncbi request reprint Comparative phylogenetic analysis reveals multiple non-imprinted isoforms of opossum Dlk1
    Jennifer R Weidman
    Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mamm Genome 17:157-67. 2006
    ..These findings clearly demonstrate that imprinted genes did not all evolve before the divergence of marsupials and eutherians...
  22. pmc Computational and experimental identification of novel human imprinted genes
    Philippe P Luedi
    Center for Bioinformatics and Computational Biology, Duke University, Durham, North Carolina 27708, USA
    Genome Res 17:1723-30. 2007
    ..Our findings demonstrate that DNA sequence characteristics, including recombination hot spots, are sufficient to accurately predict the imprinting status of individual genes in the human genome...
  23. ncbi request reprint Abnormal postnatal maintenance of elevated DLK1 transcript levels in callipyge sheep
    Susan K Murphy
    Department of Radiation Oncology, Duke University, Box 3433, Durham, North Carolina 27710, USA
    Mamm Genome 16:171-83. 2005
    ..They suggest that the effect of the callipyge mutation is to interfere with the normal postnatal downregulation of DLK1 expression...
  24. ncbi request reprint Comparative phylogenetic analysis of blcap/nnat reveals eutherian-specific imprinted gene
    Heather K Evans
    Department of Radiation Oncology, Duke University, Durham, North Carolina, USA
    Mol Biol Evol 22:1740-8. 2005
    ..This finding also suggests that the complexity of imprinting regulation observed at other loci may, in part, be directly related to the amount of time they have been imprinted...
  25. pmc Genome-wide prediction of imprinted murine genes
    Philippe P Luedi
    Center for Bioinformatics and Computational Biology, Duke University, Durham, North Carolina 27708, USA
    Genome Res 15:875-84. 2005
    ..We observe that the number, type, and relative orientation of repeated elements flanking a gene are particularly important in predicting whether a gene is imprinted...
  26. pmc Callipyge mutation affects gene expression in cis: a potential role for chromatin structure
    Susan K Murphy
    Department of Radiation Oncology, Duke University, Durham, North Carolina 27710, USA
    Genome Res 16:340-6. 2006
    ..We propose a model incorporating these results that can also account for the enigmatic normal phenotype of homozygous mutant sheep...
  27. pmc Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome
    Dana C Dolinoy
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Environ Health Perspect 114:567-72. 2006
    ..Thus, we provide the first evidence that in utero dietary genistein affects gene expression and alters susceptibility to obesity in adulthood by permanently altering the epigenome...
  28. doi request reprint Imprinting evolution and human health
    Radhika Das
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC 27710, USA
    Mamm Genome 20:563-72. 2009
    ..This review discusses the evolution of imprinting in Therian mammals, and the importance of imprinted genes in human health and disease...
  29. pmc Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma
    Hong Seok Jang
    Department of Radiation Oncology, The Catholic University of Korea, School of Medicine, Seoul, Korea
    World J Gastroenterol 14:1394-8. 2008
    ..To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy...
  30. ncbi request reprint An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa
    Tao Li
    Medical Service, Veterans Affairs Palo Alto Health Care System and the Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA
    J Biol Chem 277:13518-27. 2002
    ..Of interest, PEG1-AS was expressed predominantly in testis and in mature motile spermatozoa, indicating a possible role for this transcript in human sperm physiology and fertilization...
  31. ncbi request reprint Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
    Robert A Waterland
    Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children s Nutrition Research Center, Houston, TX 77030 2600, USA
    Hum Mol Genet 15:705-16. 2006
    ..These results indicate that post-weaning diet can permanently affect expression of Igf2, suggesting that childhood diet could contribute to IGF2 LOI in humans...
  32. ncbi request reprint Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
    Tarjei S Mikkelsen
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 447:167-77. 2007
    ..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation...
  33. doi request reprint Randy L. Jirtle, PhD: epigenetics a window on gene dysregulation, disease. Interview by Bridget M. Kuehn
    Randy L Jirtle
    JAMA 299:1249-50. 2008
  34. ncbi request reprint Mannose 6-phosphate receptors in an ancient vertebrate, zebrafish
    Catherine M Nolan
    School of Biological and Environmental Science, University College Dublin, Belfield, Dublin 4, Ireland
    Dev Genes Evol 216:144-51. 2006
    ..Our study establishes zebrafish as a novel, genetically tractable model for in vivo studies of MPR function and lysosome biogenesis...
  35. ncbi request reprint IGF2 loss of imprinting: a potential heritable risk factor for colorectal cancer
    Randy L Jirtle
    Gastroenterology 126:1190-3. 2004
  36. pmc Identification of the single base change causing the callipyge muscle hypertrophy phenotype, the only known example of polar overdominance in mammals
    Brad A Freking
    U S Department of Agriculture, Agricultural Research Service, U S Meat Animal Research Center, Clay Center, Nebraska 68933 0166, USA
    Genome Res 12:1496-506. 2002
    ..Initial functional analysis indicates sequence encompassing the mutation is part of a novel transcript expressed in sheep fetal muscle we have named CLPG1...
  37. ncbi request reprint Epigenetic silencing of genes in human colon cancer
    Rodger A Liddle
    Gastroenterology 131:960-2. 2006

Research Grants42

  1. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2007
    ..abstract_text> ..
  2. SURVIVAL AND CARCINOGENESIS IN TRANSPLANTED HEPATOCYTES
    Randy Jirtle; Fiscal Year: 1991
    ..In summary, we will utilize hepatocyte transplantation, primary culture and molecular biological techniques to investigate at the organismal, cellular and molecular level the mechanism(s) of hepatocellular tumor formation with PB...
  3. SURVIVAL AND CARCINOGENESIS IN TRANSPLANTED HEPATOCYTES
    Randy Jirtle; Fiscal Year: 1980
    ....
  4. Identification and Characterization of Epigenetically Labile Genes
    Randy Jirtle; Fiscal Year: 2006
    ..They will also be helpful in determining under what circumstances the mouse is an appropriate toxicological model for assessing human risk from agents that elicit their biological effect primarily by altering the epigenome. ..
  5. Dietary Supplements, Imprint Gene Expression and Cancer
    Randy Jirtle; Fiscal Year: 2006
    ....
  6. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2004
    ..abstract_text> ..
  7. TUMOR SUPPRESSOR FUNCTION OF THE M6P/IGF2 RECEPTOR
    Randy Jirtle; Fiscal Year: 1999
    ..Finally, for Aim 4 studies, a transgenic mouse will be constructed with inducible knock-out of the M6P/IGF2r gene for evaluation in the carcinogenesis models. ..
  8. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2000
    ..The proposed studies will determine if mammalian cancer susceptibility is a detrimental result of genomic imprinting evolution. ..
  9. TUMOR SUPPRESSOR FUNCTION OF THE M6P/IGF2 RECEPTOR
    Randy Jirtle; Fiscal Year: 2001
    ..Finally, for Aim 4 studies, a transgenic mouse will be constructed with inducible knock-out of the M6P/IGF2r gene for evaluation in the carcinogenesis models. ..
  10. Identification and Characterization of Epigenetically Labile Genes
    Randy Jirtle; Fiscal Year: 2009
    ..They will also be helpful in determining under what circumstances the mouse is an appropriate toxicological model for assessing human risk from agents that elicit their biological effect primarily by altering the epigenome. ..
  11. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2004
    ..abstract_text> ..
  12. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2003
    ..abstract_text> ..
  13. GROWTH FACTORS AND LIVER TUMOR PROMOTION
    Randy Jirtle; Fiscal Year: 1993
    ..alpha1-adrenergic co-mitogenic activities). In summary, we will investigate at the cellular, biochemical, and molecular levels the mechanisms by which PB promotes hepatocellular tumor formation...
  14. GROWTH FACTORS AND LIVER TUMOR PROMOTION
    Randy Jirtle; Fiscal Year: 1992
    ..alpha1-adrenergic co-mitogenic activities). In summary, we will investigate at the cellular, biochemical, and molecular levels the mechanisms by which PB promotes hepatocellular tumor formation...
  15. GROWTH FACTORS AND LIVER TUMOR PROMOTION
    Randy Jirtle; Fiscal Year: 1999
    ..The results of these studies should provide a better understanding of the role of the M6P/IGFII receptor and TGFbeta in liver tumor promotion, and enable us to assess substances for human carcinogenic risk with greater accuracy. ..
  16. SURVIVAL AND CARCINOGENESIS IN TRANSPLANTED HEPATOCYTES
    Randy Jirtle; Fiscal Year: 1990
    ..In summary, we will utilize hepatocyte transplantation, primary culture and molecular biological techniques to investigate at the organismal, cellular and molecular level the mechanism(s) of hepatocellular tumor formation with PB...
  17. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2006
    ..abstract_text> ..
  18. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2003
    ..The proposed studies will determine if mammalian cancer susceptibility is a detrimental result of genomic imprinting evolution. ..
  19. Identification and Characterization of Epigenetically Labile Genes
    Randy Jirtle; Fiscal Year: 2007
    ..They will also be helpful in determining under what circumstances the mouse is an appropriate toxicological model for assessing human risk from agents that elicit their biological effect primarily by altering the epigenome. ..
  20. TUMOR SUPPRESSOR FUNCTION OF THE M6P/IGF2 RECEPTOR
    Randy Jirtle; Fiscal Year: 2000
    ..Finally, for Aim 4 studies, a transgenic mouse will be constructed with inducible knock-out of the M6P/IGF2r gene for evaluation in the carcinogenesis models. ..
  21. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2001
    ..The proposed studies will determine if mammalian cancer susceptibility is a detrimental result of genomic imprinting evolution. ..
  22. Phylogenetic Comparisons of Imprinted Domains
    Randy Jirtle; Fiscal Year: 2005
    ..abstract_text> ..
  23. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2002
    ..The proposed studies will determine if mammalian cancer susceptibility is a detrimental result of genomic imprinting evolution. ..
  24. IMPRINTING EVOLUTION AND CANCER SUSCEPTIBILITY
    Randy Jirtle; Fiscal Year: 2004
    ..The proposed studies will determine if mammalian cancer susceptibility is a detrimental result of genomic imprinting evolution. ..